Squared diffusion-weighted imaging for improving the detection of clinically significant prostate cancer by Birte Valentin, Lars Schimmöller, Matthias Boschheidgen, Tim Ullrich, Thomas Andreas Thiel, Alexandra Ljimani, Jan Philipp Radtke, Thomas Benkert, Peter Albers, Gerald Antoch, Hans-Jörg Wittsack, Michael Quentin

“…Abstract Aim of this study was to proof the concept of optimizing the contrast between prostate cancer (PC) and healthy tissue by DWI post-processing using a quadrature method. …”
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Evaluation of urban water cycle health status based on DPSIRM framework and AHP-FCE-Cloud model by Jiageng Hu, Fuqiang Wang, Peiheng Liu, Subing Lü, Cheng Lü, Furong Yu

“…This study employs the Driving force-Pressure-State-Impact-Response-Management (DPSIRM) framework, using key policy implementation milestones as benchmarks to divide the timeline into three evaluation phases, thereby optimizing the urban water cycle health evaluation system. …”
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Preservation of cfRNA in cytological supernatants for cfDNA & cfRNA double detection in non‐small cell lung cancer patients by Yidan Ma, Yifei Wang, Lei He, Jun Du, Lin Li, Zhixin Bie, Yuanming Li, Xiaomao Xu, Wei Zhou, Xiaonan Wu, Li Yang, Jing Di, Chenyang Li, Xiaoguang Li, Dongge Liu, Zheng Wang

“…Furthermore, we collected an additional set of malignant cytological and matched tumor samples from 84 NSCLC patients, cfDNA & cfRNA extraction and double detection for driver gene mutations was validated using the multi‐gene mutations detection by RT‐qPCR. Results Under the optimal protection system, 91.0% (101/111) of cfRNA were protected effectively. …”
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Bacteroides Fragilis Exacerbates T2D Vascular Calcification by Secreting Extracellular Vesicles to Induce M2 Macrophages by Cong Chen, Zhengfeng Liang, Yuqi He, Yan Gao, Shuhui Ouyang, Lili Wang, Jianghua Liu, Jingsong Cao

“…The findings provide a new theoretical and experimental bases for optimizing the strategies for prevention and treatment of T2D VC.…”
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Newborn screening for congenital hypothyroidism: worldwide coverage 50 years after its start by Marta Arrigoni, Nitash Zwaveling-Soonawala, Stephen H LaFranchi, A S Paul van Trotsenburg, Christiaan F Mooij

“…Europe, North America, Oceania, China, Japan and Israel have efficient programs with optimal coverage. Recently, some countries of Central and Western Asia have implemented NBS programs for CH, and coverage has increased in several Asian countries. …”
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Foliar application of nano biochar solution elevates tomato productivity by counteracting the effect of salt stress insights into morphological physiological and biochemical indice... by Javeria Shahzadi, Zaib-un-Nisa, Naila Ali, Muhammad Iftikhar, Anis Ali Shah, M. Yasin Ashraf, Chen Chao, Shifa Shaffique, Mansour K. Gatasheh

“…In future, studies on nano biochar interactions with soil microbiota, surface modifications, long-term environmental impacts, reduced methane gas emissions, and biocompatibility could provide insights into optimizing its use in sustainable agriculture.…”
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Lesion-specific coronary artery calcium score to predict stent underexpansion by Wentao Yang, Ke Xu, Xi Fu, Weifeng Zhang, Ziyong Hao, Zhenchi Sang, Lisheng Jiang, Xingbiao Qiu, Shengxian Tu, Linghong Shen, Ben He

“…Lesion-specific CAC score was significantly negatively correlated with the stent expansion rate (in NCCT cohort, r = 0.8113, P < 0.05; in CCTA cohort, r = 0.8024, P < 0.05). The optimal cutoff values of lesion-specific CAC score to predict stent underexpansion were >200 in both NCCT (sensitivity, 91.4%; specificity, 66.8%) and CCTA (sensitivity, 84.6%; specificity, 64.3%) cohort, which were associated with 24.94-fold increased risk of stent underexpansion in NCCT cohort and 13.56-fold increased risk of stent underexpansion in CCTA cohort.ConclusionsIn this study, we found that lesion-specific CAC scores in both NCCT and CCTA cohorts were significantly independently associated with an increased risk of stent underexpansion, and the cutoff value to predict stent underexpansion was >200.…”
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Efficacy and safety of pharmacotherapy for cancer cachexia: A systematic review and network meta‐analysis by Hao Chen, Masashi Ishihara, Hiroki Kazahari, Ryusuke Ochiai, Shigeru Tanzawa, Takeshi Honda, Yasuko Ichikawa, Nobuyuki Horita, Hisashi Nagai, Kiyotaka Watanabe, Nobuhiko Seki

“…Evidence‐based approaches are urgently needed to optimize treatment. Methods A systematic review and network meta‐analysis were conducted to assess the effectiveness and safety of different pharmacotherapies for cancer cachexia. …”
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Consequences of Surface Composition and Aggregation Conditions of Ag Nanoparticles on Surface-Enhanced Raman Scattering (SERS) of Pesticides by Marcelo José dos Santos Oliveira, Gilia Cristine Marques Ruiz, Rafael Jesus Gonçalves Rubira, Santiago Sanchez-Cortes, Carlos José Leopoldo Constantino, Leonardo Negri Furini

“…The selection of suitable substrates is crucial for optimizing SERS performance. Herein, we investigated the dependence of two pesticide SERS signals, thiabendazole (TBZ) and carbendazim (MBC), on both Ag nanoparticles (reduced by hydroxylamine—AgH or citrate—AgCT) and the aggregation conditions induced by adding different salts (NaCl, KCl or KNO₃). …”
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Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dog... by Yoonhee Kim, Wonhee Lee, Byunggak Kim, Bonghwan Jang, Kyung‐Rok Yu, Hong Sook Kim, Minok Ryu, Yein Oh, Kyoungwon Seo, Chul Park, Ulsoo Choi, Dongha Bhang, Hwayoung Youn

“…Objectives To investigate the most optimal model by combining thymidine kinase 1 (TK1) autoantibody, extracellular protein kinase A (ECPKA) autoantibody, TK1 antigen, C‐reactive protein (CRP), age, breed, and sex. …”
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Elevated mepolizumab levels in patients with severe asthma responsive to 1 year’s mepolizumab treatment by Takayasu Nishimaki, MD, Hitoshi Sasano, MD, PhD, Sonoko Harada, PhD, Tomohito Takeshige, MD, PhD, Yuuki Sandhu, MD, PhD, Yuki Tanabe, MD, Kei Matsuno, MD, PhD, Tetsutaro Nagaoka, MD, PhD, Jun Ito, MD, PhD, Ryo Atsuta, MD, PhD, Mayu Ohuchi, PhD, Shigehiro Yagishita, MD, PhD, Akinobu Hamada, PhD, Kazuhisa Takahashi, MD, PhD, Norihiro Harada, MD, PhD

“…Further research is needed to validate these findings and optimize treatment strategies for patients with severe asthma.…”
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UNet-Att: a self-supervised denoising and recovery model for two-photon microscopic image by Yuer Lu, Yongfa Ying, Chen Lin, Yan Wang, Jun Jin, Xiaoming Jiang, Jianwei Shuai, Xiang Li, Jinjin Zhong

“…Additionally, the model supports end-to-end training, optimizing its denoising efficacy. The UNet-Att model proves to surpass mainstream algorithms in the dual objectives of denoising and preserving the textural intricacies of original images, which is evidenced by an increase of 9.42 dB in the high Peak Signal-to-Noise Ratio (PSNR) coupled with an improvement of 0.1131 in the Structural Similarity Index Measurement (SSIM). …”
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Effect of daily alcohol consumption and age over 40 years on COVID-19 vaccination antibody titers in the Delta era among hospital workers in northern Okinawa, Japan: A retrospectiv... by Takuji Kishimoto, Daisuke Tasato, Yoshitaka Nagasawa, Akihiro Yamashiro, Hayashi Shokita

“…Conclusions: The results of this study indicate that shortening vaccination intervals for individuals over 40 years and discontinuing daily alcohol consumption are associated with the preservation of acquired antibody titers for optimizing vaccine efficacy.…”
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Establishing a preoperative predictive model for gallbladder adenoma and cholesterol polyps based on machine learning: a multicentre retrospective study by Yubing Wang, Chao Qu, Jiange Zeng, Yumin Jiang, Ruitao Sun, Changlei Li, Jian Li, Chengzhi Xing, Bin Tan, Kui Liu, Qing Liu, Dianpeng Zhao, Jingyu Cao, Weiyu Hu

“…Results Among the 110 combination predictive models, the Support Vector Machine + Random Forest (SVM + RF) model demonstrated the highest AUC values of 0.972 and 0.922 in the training and internal validation sets, respectively, indicating an optimal predictive performance. The model-selected features included gallbladder wall thickness, polyp size, polyp echo, and pedicle. …”
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Efficacy of first-line radiofrequency ablation combined with systemic chemotherapy plus targeted therapy for initially unresectable colorectal liver metastases by Yaqing Kong, Xiaoyu Huang, Gang Peng, Xiaojing Cao, Xiang Zhou

“…Background/Objective The optimal strategy for patients with colorectal liver metastases is still controversially discussed. …”
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Droplets Cas13a‐RPA measurement delineates potential role for plasma circWDR37 in colorectal cancer by Jingsong Xu, Li Cao, Shuang Yang, Ying Jian, Yu Liu, Zhen Shen, Qian Liu, Xiang Chen, Min Li, Shun Li, Xiaolei Zuo, Min Li, Hua Wang

“…Furthermore, our innovative µDCR method for detecting circWDR37 demonstrates impressive attributes such as streamlined operation, rapidity, and high‐throughput, making it an optimal technology platform for the noninvasive screening of CRC.…”
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Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer by Abhishek Chauhan, Hemant Joshi, Divya Kandari, Diwakar Aggarwal, Ritu Chauhan, Hardeep Singh Tuli, Arpit Mehrotra, Abhilasha Sood, Ujjawal Sharma, Darin Mansor Mathkor, Shafiul Haque, Naveen Chandra Joshi, Laurent Dufossé

“…Its derivatives and novel delivery systems offer promising avenues for overcoming drug resistance and optimizing its therapeutic efficacy. Further research, including clinical trials, is necessary to fully harness its potential as a cancer treatment alternative.…”
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Reimagining habitat suitability modeling for Pacific saury (Cololabis saira) in the Northwest Pacific Ocean through acoustic data analysis from fishing vessels by Minghua Xue, Jianfeng Tong, Wen Ma, Zhenhong Zhu, Weiqi Wang, Shuo Lyu, Xinjun Chen

“…The suitability index model determined the optimal habitat ranges for the four environmental variables. …”
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Immunomodulatory Effect of Phage Depolymerase Dep_kpv74 with Therapeutic Potential Against K2-Hypervirulent <i>Klebsiella pneumoniae</i> by Nikolay V. Volozhantsev, Maria A. Makarova, Alena S. Kartseva, Marina V. Silkina, Valentina M. Krasilnikova, Egor A. Denisenko, Alexander I. Borzilov, Victoria V. Firstova

“…<b>Results:</b> The stability tests showed that Dep_kpv74 remained active in the temperature range from 8 °C to 55 °C. The optimal pH value for maintaining the activity of Dep_kpv74 ranged from 5.0 to 9.0. …”
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Activated Human Umbilical Cord Blood Platelet-Rich Plasma Enhances the Beneficial Effects of Human Umbilical Cord Mesenchymal Stem Cells in Chemotherapy-Induced POF Rats by Jiawei Wang, Yunxiao Zhao, Fengque Zheng, Nana Ma, Rongyan Qin, Weili Qin, Bo Liu, Aiping Qin

“…At present, human umbilical cord mesenchymal stem cells (HucMSCs) have been used in the treatment of POF, but the effect is still not optimal. The purpose of this study was to determine whether human umbilical cord blood platelet-rich plasma (ucPRP) enhances the beneficial effects of HucMSCs in the treatment of POF. …”
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