Effect on Physical and Mechanical Properties of Conventional Glass Ionomer Luting Cements by Incorporation of All-Ceramic Additives: An In Vitro Study by Runki Saran, Nagraj P. Upadhya, Kishore Ginjupalli, Arul Amalan, Bharath Rao, Saurabh Kumar

“…Conclusion. 10% concentration of the two all-ceramic powders can be regarded as the optimal concentration for enhancing the glass ionomer luting cements’ strength. …”
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Development and Evaluation of selective nitroxanthone Derivatives: A promising compound for Targeting MCF-7 breast cancer cells by Pavithren Devakrishnan, Nadiah Mad Nasir, Johnson Stanslas, Muhammad Alif M. Latif, Ahmad Zaidi Ismail, Fatin Farhana Baharuddin

“…Molecular docking analysis showed that compound 1 binds more efficiently to the target enzyme aromatase compared to other derivatives, likely due to its optimal number of nitro groups, orientations, and polarizabilities. …”
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Cancer stem cell populations are resistant to 5-aminolevulinic acid-photodynamic therapy (5-ALA-PDT) by Chantel P. J. Rice, Vipin Shankar Chelakkot, Noah T. Conohan, Kensuke Hirasawa

“…PDT involves the administration of photoactive substances called photosensitizers (PS) that selectively accumulate in cancer cells and are subsequently excited/activated by irradiation with light at wavelengths of optimal absorbance. Activated PS leads to the generation of singlet oxygen and other reactive oxygen species (ROS), promoting cancer cell death. 5-aminolevulinic acid (5-ALA) is a naturally occurring PS precursor, which is metabolically converted to the PS, protoporphyrin IX (PPIX). …”
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Dosage of joint mobilisation for the management of rotator cuff-related shoulder pain: protocol for a scoping review by Steve Tumilty, Daniel C Ribeiro, Sizhong Wang, Cathy M Chapple, Dusty Quinn

“…Mapping and summarising the reported type and dosage of joint mobilisations for patients with rotator cuff-related shoulder pain from previous studies will provide a foundation for further optimal selection of type and dosage of joint mobilisations for treating patients with rotator cuff-related shoulder pain. …”
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Unlocking faba bean (Vicia faba L.) potential: How cattle manure and fertilizer boost yields in Kaffa Zone, South-Western Ethiopia by Isreal Zewide, Asrat Ademe

“…This study aimed to optimize faba bean (Vicia faba L.) productivity in Adiyo, southwest Ethiopia, by evaluating the influence of cattle manure (CAM) and blended nitrogen phosphrous sulfur and boron (NPSB) fertilizer rates during the 2023 crop season. …”
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U-shaped association between TC/HDL-C ratio and osteoporosis risk in older adults by Chuanwei Zhao, Xiaochun Zhang, Xu Zhang, Bo Zhao, Yane Yang, Mu Lin, Wenli Qiao, Zeyao Hu, Haijie Yang

“…Further longitudinal studies are required to validate these findings and determine optimal lipid management strategies for osteoporosis prevention.…”
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Carbon Budget Assessment and Influencing Factors for Forest Enterprises in the Key State-Owned Forest Area of the Greater Khingan Range, Northeast China by Hui Wang, Wenshu Lin, Jinzhuo Wu, Zhaoping Luan

“…Influencing factors are identified through correlation analysis and the optimal parameter geographical detector (OPGD), while their spatial-temporal variations and causal relationships are analyzed using the geographical and temporal weighted regression model (GTWR) and structural equation modeling (SEM). …”
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A Rapid and Nondestructive Quality Detection Approach for Yongchuan Xiuya Tea Based on NIRS and siPLS-ANN Method by Ying Zhang, Jie Wang, Xiuhong Wu, Rui Chang, Hongyu Luo, Juan Yang, Quan Wu, Ze Xu, Yingfu Zhong

“…Through preprocessing the spectral data and employing the synergy interval partial least squares (siPLS) method to identify characteristic spectral regions, principal component analysis (PCA) is applied, followed by the development of a Jordan–Elman artificial neural network prediction model (ANN) for tea quality assessment. The optimal spectral preprocessing approach identified in this study is a combination of multiplicative scatter correction and second derivative processing. …”
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Factors influencing breast milk donation to a human milk bank in Iran: implications for policymakers and planners by Leila Doshmangir, Maryam Naghshi, Kamal Gholipour, Ayat Ahmadi, Hosein Azizi, Vladimir Sergeevich Gordeev

“…Abstract Background The World Health Organization (WHO) actively promotes breastfeeding as the optimal source of nourishment for infants and young children. …”
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Use of Multiple Doses of Intravenous Infusion of Umbilical Cord-Mesenchymal Stem Cells for the Treatment of Adult Patients with Severe COVID-19-Related Acute Respiratory Distress S... by Po-Ren Hsueh, Sung-Jung Ho, Po-Chuen Hsieh, I-Min Liu, Shio-Shin Jean

“…In Taiwan, few adult patients with severe COVID-19-induced ARDS receiving compassionate adjuvant treatment consisting of either a single dose (1–10 × 106 cells/kg body weight (kg BW)) or three doses (5 × 106 cells/kg BW in each dose) of IVF-UC-MSCs had good outcomes. However, the optimal dosage and rounds of IVF-UC-MSCs administration for the treatment of severe COVID-19 patients with ARDS are undetermined. …”
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Deep-TEMNet: A Hybrid U-Net–2D LSTM Network for Efficient and Accurate 2.5D Transient Electromagnetic Forward Modeling by Zhijie Qu, Yuan Gao, Kang Xing, Xiaojuan Zhang

“…The U-Net component enables high-resolution spatial feature extraction, while the 2D LSTM module enhances temporal modeling by processing spatial sequences in two dimensions, thereby optimizing the representation of electromagnetic field dynamics over time. …”
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Effect of Biofloc Culture on the Daily Rhythmicity of the Activity and Expression of Digestive Enzymes in Tilapia, Oreochromis niloticus by María del Carmen Monroy-Dosta, Daniel Becerril-Cortés, Juan Pablo Lazo, Arturo Mena-López, Pilar Negrete-Redondo, Eliasid Nogueda-Torres, Carmen Navarro-Guillén, José Antonio Mata-Sotres

“…These findings should be considered when establishing new optimized culture protocols.…”
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The clinical journey of belantamab mafodotin in relapsed or refractory multiple myeloma: lessons in drug development by Pralay Mukhopadhyay, Hesham A. Abdullah, Joanna B. Opalinska, Prani Paka, Eric Richards, Katja Weisel, Suzanne Trudel, Maria-Victoria Mateos, Meletios Athanasios Dimopoulos, Sagar Lonial

“…Protocol amendments reflecting DREAMM-3 learnings could also be implemented prospectively on the combinations trials to optimize the follow-up duration and mitigate risk. …”
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Efficacy of high-dose steroids versus low-dose steroids in the treatment of immune checkpoint inhibitor-associated myocarditis: a case series and systematic review by Xiuyue Man, Hong Wang, Chen Chen, Xiaofeng Cong, Lemeng Sun, Xueru Sun, Chen Chen, Jing Zhang, Lei Yang

“…This intervention rapidly lowers myocardial injury biomarkers (cTnI/T, CK, NT-proBNP) while minimizing the risk of biomarker rebound, thus optimizing clinical management. Notably, it significantly reduces the incidence of major adverse cardiovascular events (MACE), thereby enhancing patient prognosis. …”
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An X-Linked Hyper-IgM Patient Followed Successfully for 23 Years without Hematopoietic Stem Cell Transplantation by Necil Kutukculer, Neslihan Edeer Karaca, Guzide Aksu, Ayca Aykut, Erhan Pariltay, Ozgur Cogulu

“…When caring for patients with life-limiting diseases, improving survival and optimizing quality of life are the primary goals. For patients with X-linked hyper-IgM syndrome (XHIGM), the treatment modality has to be decided for a particular patient regarding hematopoietic stem cell transplantation or intravenous immunoglobulin replacement therapy with P. jiroveci prophylaxis. …”
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The Life Mission Theory III. Theory of Talent by Soren Ventegodt, Niels Jorgen Andersen, Joav Merrick

“…Thus, self-actualisation is a result of a person fully expressing and realizing his core talent.The theory of talent states that a core talent can be expressed optimally when a human being takes possession of a three-dimensional space with the axis of purpose, power and gender, as we have a threefold need: 1-Acknowledging our core talent (our purpose of life) and intending it 2-Understanding our potential powers and manifesting them 3-Accepting our human form including our sex and expressing itThe first dimension is spiritual, the next dimension is mental, emotional and physical, and the third dimension is bodily and sexual. …”
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Removal of Ammonium from Aqueous Solutions Using Zeolite Synthesized from Electrolytic Manganese Residue by Changxin Li, Yuan Yu, Qingwu Zhang, Hong Zhong, Shuai Wang

“…Maximum ammonium uptake capacity was achieved at pH value 8.0, EMRZ dosage 0.2 g/100 mL, contact time 100 min, initial ammonium concentration 200 mg/L, and temperature 35°C. Under optimized conditions, ammonium uptake capacity onto EMRZ was up to 27.89 mg/g. …”
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Developing a Predictive Tool for Hospital Discharge Disposition of Patients Poststroke with 30-Day Readmission Validation by Jin Cho, Krystal Place, Rebecca Salstrand, Monireh Rahmat, Misagh Mansouri, Nancy Fell, Mina Sartipi

“…Early prediction of discharge destination can optimize poststroke care and improve outcomes. Previous attempts to predict discharge disposition outcome after stroke have limited clinical validations. …”
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Effects of different doses of skt-b vibrio probiotic bacteria addition on survival and growth rate of tiger shrimp (Penaeus monodon) larva by . Widanarni, M.A. Lidaenni, Dinamella Wahjuningrum

“…Hasil penelitian menunjukkan bahwa dosis optimal untuk larva udang windu adalah 104 CFU/ml dengan nilai kelangsungan hidup 94,67%. …”
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Health-related quality of life after prosthodontic rehabilitation in patients with COVID-19-associated mucormycosis: A systematic review by Gunjan Chouksey, Rupali Choure, Kritika Singhal

“…Health-related quality of life (HRQOL) measures an individual’s ability to function optimally in various aspects of life and their subjective sense of well-being across the physical, mental, and social dimensions of health. …”
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