Development and validation of a prognostic nomogram for predicting of patients with acute sedative-hypnotic overdose admitted to the intensive care unit by Guo Tang, Tianshan Zhang, Ping Zhang, Sha Yang, Tao Cheng, Rong Yao

“…Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to optimize variables, followed by a multivariate logistic regression analysis to identify independent risk factors for ICU admission. …”
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Navigating the shots: Parental willingness to immunize their children with COVID-19 vaccines in Saudi Arabia explored through a systematic review and meta-analysis. by Moustafa Abdelaal Hegazi, Mohamed Hesham Sayed, Nadeem Shafique Butt, Turki Saad Alahmadi, Nadeem Alam Zubairi, Wesam Abdelaziz Elson

“…<h4>Conclusion</h4>This was the first SRMA from Saudi Arabia which emphasized the priority to focus on vaccine-related factors as main/key strategy of COVID-19 vaccines' drivers to convince parents in a logical way based on accurate cumulative and emerging scientific data about efficacy and safety of COVID-19 vaccines to optimize their uptake by children/adolescents. This SRMA can provide valuable insights for development of evidence-based policies to improve parental willingness to vaccinate children, which is crucial for controlling SARS-CoV-2 spread and promoting herd immunity in the community particularly if the virus continues to pose a major threat.…”
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Transitioning from wet lab to artificial intelligence: a systematic review of AI predictors in CRISPR by Ahtisham Fazeel Abbasi, Muhammad Nabeel Asim, Andreas Dengel

“…Following the success of artificial intelligence (AI) in various fields, researchers are now leveraging AI algorithms to catalyze and optimize the multi-step process of CRISPR-Cas9 system. …”
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Tannin with sodium carbonate: A single additive for poured earth concrete with tropical soils by Lily Walter, Gildas Medjigbodo, Yannick Estevez, Laurent Linguet, Ouahcène Nait-Rabah

“…This study investigated whether tannins could react with the iron oxides naturally present in tropical soil and be used as a single additive for poured earth. Optimal reactions between soils, tannins and iron oxides require an elevated soil pH, and tannins were combined with sodium carbonate (Na2CO3), a low-cost, eco-friendly alkali. …”
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A comprehensive analysis of percutaneous liver biopsy characteristics and pathological manifestations in a large patient cohort (2009–2024) by Minling Cao, Jiayi Zeng, Jiayu Wang, Junmin Jiang

“…Further research is warranted to explore optimal management strategies for these patient subpopulations.…”
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Exploring Clec9a in dendritic cell-based tumor immunotherapy for molecular insights and therapeutic potentials by Zubair Hussain, Yueteng Zhang, Lu Qiu, Shanshan Gou, Kangdong Liu

“…The exceptional ability of Clec9a to cross-present dead cell-associated antigens and enhance both humoral and CTL responses makes it an optimal receptor for DC-based strategies aimed at strengthening antitumor immunity. …”
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Global, regional, and national burdens of low back pain in women of childbearing age from 1990 to 2021: an analysis based on the global burden of disease study 2021 by Shiwen Zhang, Xuan Ma, Yao Yao, Huashan Pan, Lijuan Zou

“…Age- and region-specific prevention and healthcare strategies should be optimized to meet the needs of WCBA and reduce the burden of disease.…”
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Exploring the Association Between Gastroesophageal Reflux and Temporomandibular Joint Disorder in European Populations: A Bidirectional Mendelian Randomization Analysis by Renjie Gu, Liangqiong Chen, Minhui Hua, Huangtai Miao, Yongwei Qin

“…Clinical relevance: The findings of this study hold potential clinical significance in guiding early management strategies for GERD, reducing the incidence of TMD, and optimizing healthcare resource allocation, thereby improving patient quality of life. …”
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Levobupivacaine versus ropivacaine for brachial plexus block: A systematic review and meta-analysis of randomised controlled trials by Abdullah M. Alharran, Muteb N. Alotaibi, Yaqoub Y. Alenezi, Yousef M. Alharran, Ahmad A. Alahmad, Abdulmuhsen Alqallaf, Mohammad F. Al-Mutairi, Abdulbadih R. Saad, Mohammed H. Alazemi, Duaij S. Saif, Ebraheem Albazee, Ahmad Y. Almohammad

“…Background and Aims: Brachial plexus block (BPB) is advantageous for elective orthopaedic or reconstructive upper limb surgery. However, the optimal local anaesthetic in BPB remains debatable. …”
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Smart Healthy Schools: An IoT-enabled concept for multi-room dynamic air quality control by Alessandro Zivelonghi, Alessandro Giuseppi

“…In the post-pandemic era, equipping schools with a network of smart IoT sensors has become critical to aspire for the optimal control of the IAQ and lowering the airborne infection risk of several pathogens, indirectly related to cumulated human emitted CO2 levels over time. …”
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Mechanisms and regulatory pathways of recessive land use transition by TAN Lin, CHEN Lan

“…Clarifying the scientific connotation and intrinsic mechanisms of recessive land use transition and exploring regulatory pathways to address urban-rural economic and social transitions can provide a basis for optimizing territorial spatial patterns and promoting high-quality development. …”
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Forensic tactics: a review of the formation history and current trends by O. P. Shaituro

“…It is noted that forensic tactics in the modern interpretation is considered as part of criminology, as a system of scientific provisions and recommendations for the organization and planning of pre-trial and judicial investigation, which are developed on the basis of determining the optimal course of action examination of evidence and establishment of circumstances that contributed to the commission of the crime. …”
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Derivation of Sa-MoDEI score from DEI. Tak for prognostication in Buerger's Disease - Preliminary data of a prospective observational cohort by Gregory Pathrose, Albert A Kota, Prabhu Premkumar, Prasanna Samuel, Shivraj Padiyar, Deepak Selvaraj, Prasanta Padhan, Debashish Danda

“…Duration of smoking was 15.35 years (S.D ± 6.2); 65 patients were in good outcome and 19 patients in bad outcome group. The optimal Sa-MoDEI score cut-off for the bad outcome was 8 which corresponded with Youden's Index. …”
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University proceedings. Volga region. Social sciences by A.D. Gulyakov, A.Yu. Salomatin

“…The liberation of Trans-caucasia from bourgeois nationalist governments during April 1920-March 1921 was com-pleted by the creation in March 1922 of the Federal Union of Socialist Republics of Transcaucasia, which was the most optimal way to combat manifestations of localism and territorial disputes. …”

Numerical Investigation of Ultra-Wide Low-Frequency Wave Attenuation Using Seismic Metamaterials with Auxetic Slender Strips by Haosheng Liu, Hongbo Zhang

“…Additionally, we systematically explored the influence of geometric parameters on the first complete band gap. We found that optimal results were achieved with a slender strip length of 0.05 m, its width between 0.05 and 0.1 m, and a steel structure width of 0.1 m. …”
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Ensemble machine learning models for lung cancer incidence risk prediction in the elderly: a retrospective longitudinal study by Songjing Chen, Sizhu Wu

“…Results The DQN model achieved the optimal prediction performance in stratified subgroups, with AUROC ranging from 0.937 to 0.953, recall ranging from 0.932 to 0.943, F 2 -score ranging from 0.929 to 0.946, precision ranging from 0.926 to 0.952, F 1 -score ranging from 0.933 to 0.963 and RMSE ranging from 0.21 to 0.27. …”
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Potentials of Presepsin as a Novel Sepsis Biomarker in Critically Ill Adults: Correlation Analysis with the Current Diagnostic Markers by Mai S. Sater, Nourah Almansour, Zainab Hasan Abdulla Malalla, Salim Fredericks, Muhalab E. Ali, Hayder A. Giha

“…Rapid diagnosis of sepsis assists in optimizing treatments and improves outcomes. Several biomarkers are employed to aid in the diagnosis, prognostication, severity grading, and sub-type discrimination of severe septic infections (SSIs), including current diagnostic parameters, hemostatic measures, and specific organ dysfunction markers. …”
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Effect of Fiber Angles on Hybrid Double-Tube Concrete Columns under Monotonic Axial Compression by Bing Zhang, Yu-Jun Qi, Tao Huang, Qian-Biao Zhang, Yu Hu, Xia-Min Hu

“…., FRP, concrete, and steel) in hybrid DTCCs are combined optimally to deliver excellent performances, such as excellent ductility and remarkable corrosion resistance. …”
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Design of an Improved Method for Visual Rendering in the Metaverse Using CIEM and MSRANet by Janapati Venkata Krishna, Priyanka Singh, Regonda Nagaraju, Setti Vidya Sagar Appaji, Attuluri Uday Kiran, K. Spandana

“…This paper alleviates these challenges by proposing a set of innovative models tailored to optimize visual rendering in deployments of the metaverse. …”
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A recurrence model for non-puerperal mastitis patients based on machine learning. by Gaosha Li, Qian Yu, Feng Dong, Zhaoxia Wu, Xijing Fan, Lingling Zhang, Ying Yu

“…<h4>Results</h4>The logistic regression model emerged as the optimal model for predicting recurrence of NPM with machine learning, primarily utilizing three variables: FIB, bacterial infection, and CD4+ T cell count. …”
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