The Impact on Emergency Department Utilization and Patient Flows after Integrating with a General Practitioner Cooperative: An Observational Study by W. A. M. H. Thijssen, M. Wijnen-van Houts, J. Koetsenruijter, P. Giesen, M. Wensing

“…Overall, increased collaboration with after-hours primary care and emergency care seemed to optimize ED utilization.…”
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Resiquimod induces a mixed Th1 and Th2 response via STAT1 and STAT3 signalling in chickens by Deepthi Kappala, Saravanan Ramakrishnan, Patel Nikunjkumar Prakashbhai, Abinaya Kaliappan, Prasad Thomas, Jörg Linde, Mithilesh Singh, Sohini Dey, Madhan Mohan Chellappa

“…These insights provide a foundation for optimizing R-848 as an immunomodulatory agent in avian species.…”
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Tetracyclines in Rheumatoid Arthritis: Dual Anti-Inflammatory and Immunomodulatory Roles, Effectiveness, and Safety Insights by Mislav Radić, Andrej Belančić, Hana Đogaš, Marijana Vučković, Andrea Gelemanović, Andrea Faour, Ivan Vlak, Josipa Radić

“…This review highlights the need for further research to address gaps in evidence, including the development of modified tetracyclines with reduced antimicrobial effects and improved safety profiles, as well as the integration of personalized medicine approaches to optimize patient outcomes.…”
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Flowering characteristics and breeding system of Deutzia parviflora by WANG Qi, LI Jinyu, WANG Xinyi, WANG Yixuan, GUO Wei, YUAN Tao

“…Its flowering type is concentrated flowering, with a group flowering period of 22-23 d and a single flowering period of 8 d, which can be divided into 8 stages. (2) The stigma acceptability at the petal flattening stage was the strongest, and the pollen viability at the stamen expansion stage was the highest. (3) The optimal medium for pollen viability determination was: 100.0 g/L sucrose + 0.3 g/L H3BO3 + 0.2 g/L CaCl2. (4) Pollen can be dried and stored in the short term (within 10 d), at -20 ℃ and -80 ℃ in the medium term (10-30 d), and at -80 ℃ for a long time (more than 30 d). (5) The pollen-ovule ratio of D . parviflora was 23 695.93, the out-crossing index was 3, the fruit setting rate of xenogamy was the highest. …”
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Supplementation of lake extender with cysteamine preserves quality parameters and fertility potential of post-thawed rooster sperm during cryopreservation process by Reza Masoudi, Saeid Esmaeilkhanian, Maryam Hatami, Mohsen Sharafi, Ali Hatefi, Fatemeh Zarei, Reihaneh Nateghi, Mohammad Reza Tohidkia

“…Conclusion using the optimal concentration of CYS (1 mM) in the Lake extender is useful for protecting rooster sperm during the cryopreservation process and it could be used for reproductive programs.…”
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Effects of Annealing Conditions on the Catalytic Performance of Anodized Tin Oxide for Electrochemical Carbon Dioxide Reduction by Nicolò B. D. Monti, Juqin Zeng, Micaela Castellino, Samuele Porro, Mitra Bagheri, Candido F. Pirri, Angelica Chiodoni, Katarzyna Bejtka

“…Electrochemical measurements revealed that SnO_x catalysts annealed in air at 525 °C exhibited the highest formate selectivity and current density, attributed to the optimized oxidation state and the presence of oxygen vacancies. …”
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Photovoltaic Solar Technologies: Solution to Affordable, Sustainable, and Reliable Energy Access for All in Rwanda by Samuel Bimenyimana, Godwin Norense Osarumwense Asemota, Jean De Dieu Niyonteze, Cyprien Nsengimana, Paula Jeanne Ihirwe, Lingling Li

“…This paper used the HOMER software for modeling the optimal, sustainable, reliable, and affordable photovoltaic solar technologies as energy solutions for all (off-grid and on-grid users) in Rwanda. …”
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Hydrolysis of Methionine- and Histidine-Containing Peptides Promoted by Dinuclear Platinum(II) Complexes with Benzodiazines as Bridging Ligands: Influence of Ligand Structure on th... by Snežana Rajković, Beata Warżajtis, Marija D. Živković, Biljana Đ. Glišić, Urszula Rychlewska, Miloš I. Djuran

“…The crystal structure of 1 was determined by single-crystal X-ray diffraction analysis, while the DFT M06-2X method was applied in order to optimize the structures of 1–3. The chlorido Pt(II) complexes 1–3 were converted into the corresponding aqua species 1a–3a, and their reactions with an equimolar amount of Ac–L–Met–Gly and Ac–L–His–Gly dipeptides were studied by 1H NMR spectroscopy in the pH range 2.0 < pH < 2.5 at 37°C. …”
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Voxel-Wise Brain-Wide Functional Connectivity Abnormalities in Patients with Primary Blepharospasm at Rest by Pan Pan, Shubao Wei, Huabing Li, Yangpan Ou, Feng Liu, Wenyan Jiang, Wenmei Li, Yiwu Lei, Yanqing Tang, Wenbin Guo, Shuguang Luo

“…SVM analysis showed that increased GFC values in the right postcentral gyrus/precentral gyrus/paracentral lobule could discriminate patients from controls with optimal accuracy, specificity, and sensitivity of 83.33%, 83.33%, and 83.33%, respectively. …”
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Evaluation of Chest CT Scan as a Screening and Diagnostic Tool in Trauma Patients with Coronavirus Disease 2019 (COVID-19): A Cross-Sectional Study by Hossein Abdolrahimzadeh Fard, Salahaddin Mahmudi-Azer, Sepideh Sefidbakht, Pooya Iranpour, Shahram Bolandparvaz, Hamid Reza Abbasi, Shahram Paydar, Golnar Sabetian, Mohamad Mahdi Mahmoudi, Masoume Zare, Leila Shayan, Maryam Salimi

“…The lack of enough medical evidence about COVID-19 regarding optimal prevention, diagnosis, and treatment contributes negatively to the rapid increase in the number of cases globally. …”
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Electric field-assisted embedding of fiber optic sensors in structural materials for structural health monitoring by Xinchang Zhang, Joshua Daw, Charles Payne, Bibo Zhong, Austin Fleming, Zilong Hua, Jorgen Rufner

“…Samples fabricated under optimal conditions passed helium leak testing, confirming effective interfacial bonding. …”
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Cold-induced metabolic adaptations in the large yellow croaker Larimichthys crocea by Yang Gao, Huirong Lv, Chengzhang Huang, Xiaoyu Qu, Zhangjie Chu, Weiye Li, Xiaolong Yin, Jungyeol Park, Dejun Feng, Junwook Hur

“…Omics data revealed that the ABC transporter, glycolysis and oxidative phosphorylation pathways were downregulated, whereas the citrate cycle pathway was upregulated, suggesting a metabolic adjustment to optimize ATP production and cellular transport mechanisms for efficient energy utilization and metabolic homeostasis. …”
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Spatiotemporal variation and influencing factors of phosphorus in Asia’s longest river based on receptor model and machine learning by Gege Cai, Jiamei Zhang, Wanlu Li, Jiejun Zhang, Yun Liu, Shanshan Xi, Guolian Li, Haibin Li, Xing Chen, Fanhao Song, Fazhi Xie

“…This study provides useful information for optimizing phosphorus pollution management and strategies for eutrophication control in the Yangtze River as well as in other large watersheds.…”
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Application of metagenomic next-generation sequencing (mNGS) to describe the microbial characteristics of diabetic foot ulcers at a tertiary medical center in South China by Hongteng Xie, Zhaohong Chen, Guohua Wu, Pei Wei, Teng Gong, Shun Chen, Zhaorong Xu

“…Conclusion The mNGS method had a higher positive detection rate and identified a broader spectrum of microorganisms in DFUs, thus, mNGS provided a more comprehensive understanding of the microbiome of DFUs to facilitate the development of timely and optimal treatment. Trial registration The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethical Review Committee of the Fujian Medical University Union Hospital (approval number 2021KY054).…”
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A thermo-responsive chitosan-based injectable hydrogel for delivery of curcumin-loaded polycaprolactone microspheres to articular cartilage: in-vitro and in-vivo assessments by Farnoosh Kalantarnia, Sasan Maleki, Amir Shamloo, Kazem Akbarnataj, Sayed Navid Tavoosi

“…While injectable hydrogels have shown potential as a treatment, achieving an optimal balance between bio-compatibility, mechanical properties, and drug delivery remains a challenge. …”
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A Method and Engineering Practice for a Fully Mechanized Caving Coalface to Rapidly Pass Through a Large Fault by Wei Zhang, Feili Yang, Jingyu Chang, Shengxun Zhao, Bin Xu, Jinyong Xiang

“…Based on the occurrence characteristics of the F₆ fault (maximum throw: 13.5 m) in the #3_up1101 fully mechanized caving coalface at Gaozhuang Coal Mine, two different solutions allowing the coalface to pass through this fault were proposed, and the solution of pre-driven roadways with rock pillars was optimally determined. The main implementation steps of the method include designing the layout parameters of the pre-driven roadways, determining the width for rock pillars between the adjacent pre-driven roadways, construction of pre-driven roadways by smooth wall blasting, and controlling the surrounding rock deformation of the pre-driven roadways. …”
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Rapid and simple detection of Candida albicans using closed dumbbell-mediated isothermal amplification by Yanli Zhang, Xuhan Chen, Yeling Zhong, Fei Guo, Guifang Ouyang, Rui Mao

“…All primers were selected and evaluated by real-time fluorescence monitoring and endpoint visual judgement indicated by hydroxy naphthol blue (HNB). Optimal primers and accelerate primers (out primers and loop primers) were designed and selected after confirmation of the fundamental CDA primers to achieve more efficient CDA reaction for C. albicans detection (CA-OL-CDA).ResultsAfter establishment of the assay, 9 non-Candida albicans strains, including 3 Candida species were tested to negative by adopting the established CA-OL-CDA assay, indicated high specificity. …”
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Development and design validation of a novel network meta-analysis presentation tool for multiple outcomes: a qualitative descriptive study by Lehana Thabane, Jason W Busse, Behnam Sadeghirad, Gordon H Guyatt, Mohit Bhandari, Romina Brignardello-Petersen, Fernando Kenji Nampo, Carlos A Cuello-Garcia, Raveendhara R Bannuru, Mark R Phillips, Yu Jia Guo, Sofia Bzovsky

“…Objective The Grades of Recommendations, Assessment, Development and Evaluation working group recently developed an innovative approach to interpreting results from network meta-analyses (NMA) through minimally and partially contextualised methods; however, the optimal method for presenting results for multiple outcomes using this approach remains uncertain. …”
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Factors Determining the Removal Efficiency of Procion MX in Waters Using Titanate Nanotubes Catalyzed by UV Irradiation by Vo Nguyen Xuan Que, Tran Tien Khoi, Nguyen Thi Thuy, Ta Thi Minh Dung, Dao Thi Thanh Binh, Nguyen Nhat Huy

“…Particularly, the PMX degradation using titanate nanotubes was optimized under the UV-A intensity of 100 W/m2. The dye was degraded by more than 95% at the TNTs concentration of 75 mg/L and pH 8.0 after 90 min. …”
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Combining a Standardized Growth Class Assessment, UAV Sensor Data, GIS Processing, and Machine Learning Classification to Derive a Correlation with the Vigour and Canopy Volume of... by Ronald P. Dillner, Maria A. Wimmer, Matthias Porten, Thomas Udelhoven, Rebecca Retzlaff

“…Model overall performance metrics were optimized with grid search-based hyperparameter tuning and repeated-k-fold-cross-validation. …”
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