Patient perspectives on acromegaly disease burden: insights from a community meeting by Shruti N. Shah, Kevin C. J. Yuen, Vivien Bonert, Wenyu Huang, Jill Sisco, Chrystal Palaty, Kristen Dancel-Manning, Nidhi Agrawal

“…ObjectiveA profound mismatch between biological and symptom control in acromegaly creates a high disease burden despite achieving optimal biological control. There is a great need to learn more about the perspectives of patients living with acromegaly.MethodsAcromegaly Community hosted a virtual meeting in January 2021 and prepared a detailed report capturing participants’ input on acromegaly symptoms and current and future treatment approaches. …”
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Deep Joint Demosaicking and Super-Resolution for Spectral Filter Array Images by Abdelhamid N. Fsian, Jean-Baptiste Thomas, Jon Y. Hardeberg, Pierre Gouton

“…This holistic approach ensures a more coherent and optimized restoration process, mitigating the risk of error accumulation and preserving image quality throughout the reconstruction pipeline. …”
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Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort study by John Kinuthia, R Scott McClelland, Barbra A Richardson, Elizabeth Maleche-Obimbo, Brent R Collett, Sarah Benki-Nugent, Faridah H Were, Anne M Riederer, Michael Gatari, CJ Karr, Edmund YW Seto, Beatrice C Mutai, Susan Wamithi, Priscilla Wanini Edemba, Timothy V Larson, Julian D Marshall

“…Longitudinal pregnancy cohort studies are optimal for individual exposure assessment during critical windows of brain development and examination of neurodevelopment. …”
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Co-Cultivations of <i>Beauveria bassiana</i>, <i>Metarhizium anisopliae</i>, and <i>Trichoderma harzianum</i> to Produce Bioactive Compounds for Application in Agriculture by Pauline Flores da Silva, Maicon Sérgio Nascimento dos Santos, Beatriz de Andrade Araújo, Bruno Douglas Kerber, Heloisa Alves Pinto de Oliveira, Jerson Vanderlei Carús Guedes, Marcio Antonio Mazutti, Marcus Vinícius Tres, Giovani Leone Zabot

“…As a way forward, this product demonstrated integrated bioactivities as insecticide and fungicide and can be optimized to substitute chemical pesticides that have negative impacts on the environment.…”
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Revealing intra- and inter-container fruit quality heterogeneity within overseas refrigerated container shipments using a physics-based digital twin by Celine Verreydt, Tarl Berry, Leo Lukasse, Deniz Turan, Paul Cronje, Thijs Defraeye

“…The air temperature and relative humidity inside refrigerated containers should be kept at optimal conditions to prevent fruit losses. However, each shipment evolves differently in terms of shipping duration and temperature. …”
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Integration of ground-based and remote sensing data with deep learning algorithms for mapping habitats in Natura 2000 protected oak forests by Lucia Čahojová, Ivan Jarolímek, Barbora Klímová, Michal Kollár, Michaela Michalková, Karol Mikula, Aneta A. Ožvat, Denisa Slabejová, Mária Šibíková

“…The study also seeks to evaluate the accuracy of this approach, specifically in oak-dominated forests, as well as identify the optimal time period within a year for effective habitat identification.Using the specialised software NaturaSat, automated segmentations were performed based on the coordinates of phytosociological relevés and forest strands defined in database. …”
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Rational design of a triple-type HPV53/56/66 vaccine with one preferable base particle incorporating two identified immunodominant sites by Ciying Qian, Jie Chen, Yurou Yang, Yihan Lu, Tianyu Ren, Yanan Jiang, Yang Huang, Xin Chi, Shuyue Zhang, Chengzong Zhang, Kewei Li, Jingjia Shen, Sibo Zhang, Daning Wang, Lizhi Zhou, Tingting Li, Qingbing Zheng, Hai Yu, Ying Gu, Ningshao Xia, Shaowei Li

“…Comprehensive evaluations identified unique dominant immunogenic loops for each type: the FG loop for HPV53, the HI loop for HPV56, and the DE loop for HPV66, with HPV66 emerging as the optimal chimeric backbone virus-like particle (VLP). …”
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Coloration and functionalization of organic cotton fabric using Chinese fringe leaf extraction: A greener approach by Md Shazzat Hossain, Mohammad Ullah, Rony Mia, Mohammed A. Assiri, Yahui Zhou, Haroon A.M. Saeed, Sakil Mahmud

“…Spectroscopic analyses, including UV−visible (UV−vis) spectroscopy and Fourier transform infrared spectroscopy (FTIR), confirmed the presence of flavonoid compounds as the key bio−colorants in the dye solution. Optimal dyeing conditions were established with a 10 % Al2(SO4)3 mordant, resulting in dyed OCF exhibiting a significant color strength (K/S) of 5.90 and excellent fastness including rubbing, washing and light. …”
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The effect of resizing on the natural appearance of scintigraphic images: an image similarity analysis by Siraj Ghassel, Amir Jabbarpour, Jochen Lang, Eric Moulton, Eric Moulton, Ran Klein, Ran Klein, Ran Klein, Ran Klein

“…These image quality metrics were subsequently compared to those of two independent count-matched images at the target grid size (representing variance due to natural noise permutations) as a reference to establish an optimal resizing method.ResultsOnly upsampled images with the Poisson resampling correction after linear interpolation produced images that were similar to those acquired at the target grid size. …”
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Increased Intra-Abdominal Pressure as One of the Links in the Pathogenesis of Secondary Diffuse Purulent Peritonitis by D. V. Cherdantsev, O. V. Ovchinnikova, Yu. G. Trofimovich, I. G. Noskov, O. V. Pervova, A. A. Kovalenko

“…According to reference values, the optimal level of intra-abdominal pressure does not exceed 5 mmHg. …”
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Contemporary Management of Patent Foramen Ovale: A Multinational Survey on Cardiologists’ Perspective by Maciej Dębski, Amr Abdelrahman, Halia Alshehri, Marloe Prince, Andrew Wiper, Shajil Chalil, Dariusz Dudek, Christopher J. White, David Hildick-Smith, David H. Roberts

“…The study shows a vast spectrum of opinions on the optimal approach to PFO closure with significant differences between the US, UK, and Gulf countries. …”
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Non-classical pulmonary exacerbation in cystic fibrosis revealing ALK-Translocated lung cancer: A case report by Mohamad Hadhud, Johnathan Arnon, Anat Hershko-Moshe, Adi Hollander, Noa Hurvitz-Lehmann, Assaf Potruch, Henny Azmanov, Rottem Kuint, Nurith Hiller, Elie Picard, Naama Sebbag-Sznajder, Shira Leebhoff, Michael Wilschanski, Myriam Grunewald, Liron Birimberg-Schwartz, Malena Cohen-Cymberknoh

“…Care for pwCF with lung cancer requires a unique multi-disciplinary approach to optimize their complex multifactorial treatment.…”
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Integrating Analytical Procedures in Routine Practices of Centralized Antiblastic Compounding Units for Valorization of Residual Compounded Drugs by Rita Patrizia Aquino, Giovanni Falcone, Paola Russo, Fabrizio Dal Piaz, Giulia Auriemma, Ferdinando Maria de Francesco, Stefania Cascone, Eduardo Nava, Pasquale Del Gaudio

“…In relation to their different physicochemical properties, two analytical approaches were optimized and involved in the stability investigation: HPLC-DAD for small molecules and a combined approach of LC-MS/MS with size exclusion chromatography for monoclonal antibodies analysis. …”
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Protective Efficacy of Decreasing Antigen Doses of a <i>Chlamydia abortus</i> Subcellular Vaccine Against Ovine Enzootic Abortion in a Pregnant Sheep Challenge Model by Morag Livingstone, Kevin Aitchison, Javier Palarea-Albaladejo, Francesco Ciampi, Clare Underwood, Antonia Paladino, Francesca Chianini, Gary Entrican, Sean Ranjan Wattegedera, David Longbottom

“…Conclusions: The results show that a dose of 10 µg antigen in the vaccine will be optimal in terms of maximising efficacy, reducing shedding at parturition, and ensuring it is cost-effective to produce for commercial manufacture.…”
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Supplemental oxygen strategies in infants with bronchopulmonary dysplasia after the neonatal intensive care unit period: study protocol for a randomised controlled trial (SOS BPD s... by Anton H van Kaam, Wes Onland, Irwin K M Reiss, Peter H Dijk, Arend F Bos, Eleni-Rosalina Andrinopoulou, E Villamor, LGM van Rooij, M de Jong, JS von Lindern, Lucas Goossens, Stephanie Balink, Elianne J L E Vrijlandt, Anthon R Hulsmann, Debbie H Nuytemans, Arwen J Sprij, André A Kroon, Marielle Pijnenburg, MGA Baartmans, GJ Blok, WP de Boode, HD Buiter, CE Counsilman, CA Dalen Meurs, ACM Dassel, AM de Grauw, MEN van den Heuvel, JLAM van Hillegersberg, JCR van Hoften, JHL van Hoorn, CH ten Hove, A Kamerbeek, AAMW van Kempen, LH van der Meer, RMJ Moonen, EEM Mulder, HJ Niemarkt, MAG van Scherpenzeel-de Vries, IAM Schiering, RNGB Tan

“…However, it is unknown what oxygen saturation levels are optimal to improve outcomes in infants with established BPD from 36 weeks postmenstrual age (PMA) onwards. …”
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Water quality characteristics of municipal wastewater treatment plants and the prospect of reclaimed water utilization in lower-middle income and water-scarce areas: A case study o... by Yutong Duan, Hongbo Xi, Zhikai Qin, Ruili Guo, Fang Wang, Yue Yuan

“…Influent water quality analysis showed high concentrations of COD, NH₃-N, TN, and TP, and nutrient ratios that often exceeded the optimal level for biological nutrient removal. Effluent water quality generally met the discharge standards, though TN removal efficiency was unsatisfactory in some cases. …”
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Cystic Fibrosis and Reproductive Outcomes: The Latest Insights into Fertility and Pregnancy by Weronika Małagocka, Karol Zagórski, Mateusz Kozik, Nina Skalska-Dziobek, Karolina Chybowska, Maria Naruszewicz, Przemysław Cetnarowski

“…Planning the pregnancy gives time to prepare the mother, optimize her nutrition status and make sure medications she takes are safe for the fetus. …”
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Experimental investigation on the anti-detonation performance of composite structure containing foam geopolymer backfill material by Hang Zhou, Hujun Li, Zhen Wang, Dongming Yan, Wenxin Wang, Guokai Zhang, Zirui Cheng, Song Sun, Mingyang Wang

“…The results of this study provide a scientific basis for optimizing underground composite structure interlayer parameters.…”
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Effect of Flaxseed Gum and Konjac Gum on the 3D Printing Properties of Pea Protein Isolate Emulsion Gels by Congjin BAI, Jingjing GUO, Yifan WANG, Zhenrong LI, Bo JIAO, Lei DAI

“…At a concentration of 1.1%, the emulsion gel exhibited the smallest particle size, the highest G' and G'' values, and optimal viscoelasticity. Furthermore, the printed structures displayed the most distinct textures, stable frameworks, and superior printing adaptability. …”
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Quantifying Joystick Interactions and Movement Patterns of Toddlers With Disabilities Using Powered Mobility With an Instrumented Explorer Mini by Kimberly A. Ingraham, Nicole L. Zaino, Claire Feddema, Mia E. Hoffman, Liesbeth Gijbels, Alexis Sinclair, Andrew N. Meltzoff, Patricia K. Kuhl, Heather A. Feldner, Katherine M. Steele

“…However, many open questions persist regarding how joystick-based mobility technologies should be designed to optimally suit the developmental needs of toddlers. …”
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