Adenoviral Vector-Based Vaccine Expressing Hemagglutinin Stem Region with Autophagy-Inducing Peptide Confers Cross-Protection Against Group 1 and 2 Influenza A Viruses by Wen-Chien Wang, Ekramy E. Sayedahmed, Marwa Alhashimi, Ahmed Elkashif, Vivek Gairola, Muralimanohara S. T. Murala, Suryaprakash Sambhara, Suresh K. Mittal

“…The goal was to identify the optimal combination for enhanced immune responses and cross-protection. …”
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Simultaneous production during biogas upgrading: Foundational insights from numerical simulation of dual-reflux pressure swing adsorption by Mohd Hardyianto Vai Bahrun, Awang Bono, Norasikin Othman, Muhammad Abbas Ahmad Zaini

“…Further work is recommended to investigate several operating parameters to achieve optimal binary separation with the highest possible recoveries.…”
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Clinical and molecular analyses of isolated central congenital hypothyroidism based on a survey conducted in Japan by Nao Shibata, Chikahiko Numakura, Takashi Hamajima, Kenichi Miyako, Ikuma Fujiwara, Jun Mori, Akihiko Saitoh, Keisuke Nagasaki

“…The neonatal period is the optimal time for the diagnosis of central CH, particularly IGSF1 abnormalities, and the introduction of T4 screening should be considered in the future, taking cost-effectiveness into consideration.…”
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Effect of Pressure, Post-Pressing Time, and Polymerization Cycle on the Degree of Conversion of Thermoactivated Acrylic Resin by Rafaella de S. Leão, Sandra L. D. de Moraes, Kátia A. da S. Aquino, Cristina P. Isolan, Bruno G. da S. Casado, Marcos A. J. R. Montes

“…Herein, the effect of different post-pressing times and pressure in two cycles of polymerization on the degree of conversion (DC) of thermally activated acrylic resin (TRRA) is analyzed to optimize the polymerization of this material. After post-pressing for 0, 6, or 12 h, polymerization was performed with or without a pressure of 60 psi (0.41 MPa) in a short (4 h) or a long (11 h) cycle, totaling 12 groups. …”
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TDCN: A novel temporal depthwise convolutional network for short-term load forecasting by Mingping Liu, Chenxu Xia, Yuxin Xia, Suhui Deng, Yuhao Wang

“…First, a dilated causal convolution is employed to optimize the depthwise convolution, taking advantage of its ability to exponentially increase sampling points and expand the receptive field, thereby improving the capture of temporal information within low-dimensional channels. …”
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Novel Fast-Setting and Mechanically-Strong Calcium Phosphate Pulp-Capping Cement with Metformin Release to Enhance Dental Pulp Stem Cells by Mohammad Alenizy, Abdullah Alhussein, Nader Almutairi, Ibrahim Ba-Armah, Tao Ma, Suping Wang, Nageswara R. Pilli, Maureen A. Kane, Michael D. Weir, Abraham Schneider, Hockin H. K. Xu

“…CPCC was mixed at different powder-to-liquid ratios to evaluate physio-mechanical properties compared to MTA. The optimized CPCC formulation was loaded with 0, 50, 100, and 150 µg of metformin to measure release and assess hDPSCs attachment and proliferation (1, 4, and 7 d) via live/dead imaging and SEM. …”
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Implications for cost and access of site-of-service referrals for ancillary medical services in a US Medicaid population: analysis of claims data from Maryland, USA by Maqbool Dada, Simrita Singh, Kelsey J Rydland, Chester Chambers, Vishal Mundlye, Edward Kumian, Kayode Ayodele Williams

“…We used location-allocation optimisation models to find the optimal sites to minimise net costs.Setting Coverage area included Medicaid patients throughout the state of Maryland.Participants All rural and urban members of this Medicaid cohort.Primary and secondary outcome measures Change in payer costs and member travel times on shifting ancillary bundles from regulated to unregulated sites.Results Procedure cost and travel time differentials between regulated and unregulated sites strongly correlated with the percentage of procedures referred to regulated sites. …”
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Jet Injection of Naked mRNA Encoding the RBD of the SARS-CoV-2 Spike Protein Induces a High Level of a Specific Immune Response in Mice by Denis N. Kisakov, Larisa I. Karpenko, Lyubov A. Kisakova, Sergey V. Sharabrin, Mariya B. Borgoyakova, Ekaterina V. Starostina, Oleg S. Taranov, Elena K. Ivleva, Oleg V. Pyankov, Anna V. Zaykovskaya, Elena V. Dmitrienko, Vladimir A. Yakovlev, Elena V. Tigeeva, Irina Alekseevna Bauer, Svetlana I. Krasnikova, Nadezhda B. Rudometova, Andrey P. Rudometov, Artemiy A. Sergeev, Alexander A. Ilyichev

“…<b>Methods:</b> In the first part of the study, the optimal conditions providing low traumatization and high expression of the model mRNA-GFP molecule in the tissues of laboratory animals were determined. …”
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Exploring the general practitioners’ perception of the inter-professional care of rheumatoid arthritis patients (GEPRA—II): a qualitative interview study by Anne-Laure Yailian, Audrey Janoly-Dumenil, Emmanuelle Vignot, Aurélie Fontana, Charline Estublier, Cyrille Confavreux, Roland Chapurlat, Claude Dussart, Humbert de Freminville

“…Inter-professional collaborations seem essential for an optimal therapeutic management of patients. The aim of this study was to analyse the barriers and facilitators of general practitioners (GPs) for the implementation of collaborative support programmes in RA. …”
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Accelerated Storage Testing of Vacuum-Dried <i>Lactobacillus acidophilus TISTR 1338</i> for Feed by Apichet Muenaram, Bhundit Innawong, Imrana Niaz Sultan, Muhammad Waseem Khan, Hamza Ghilzai, Afrasiab Khan Tareen, Pramuk Parakulsuksatid

“…Molasses and spent cell yeast serve as promising carbon and nitrogen sources when optimized conditions are employed. The study also suggests that vacuum drying is a promising method for producing dried cells suitable for non-refrigerated storage conditions.…”
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Variants of the Sliding Mode Control in Presence of External Disturbance for Quadrotor by Irfan Ahmad, Muwaida Liaquat, Fahad Mumtaz Malik, Hameed Ullah, Usman Ali

“…Secondly, kinodynamic Rapidly Exploring Random Tree with Fixed Node (RRT&#x002A;FN) which is an incremental sampling-based optimal algorithm has been implemented for online navigation and flight control of the quadrotor system. …”
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Development of an Efficient and Generalized MTSCAM Model to Predict Liquid Chromatography Retention Times of Organic Compounds by Mengdie Fan, Chenhui Sang, Hua Li, Yue Wei, Bin Zhang, Yang Xing, Jing Zhang, Jie Yin, Wei An, Bing Shao

“…Finally, by training the optimal quantitative structure–retention relationship (QSRR) models for each category of compounds and selecting the best-fitting model for prediction via discriminant analysis during the prediction period, a novel and universal high-throughput retention time prediction model was established. …”
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Algae extract-based nanoemulsions for photoprotection against UVB radiation: an electrical impedance spectroscopy study by Aura Rocío Hernández, Lady Sepulveda, Yoshie Hata, Leonardo Castellanos, Sebastian Björklund, Tautgirdas Ruzgas, Marcela Aragón

“…A Box–Behnken experimental design was used to identify the most promising formulation composition, resulting in optimal physical properties. These properties, including droplet size, polydispersity index (PDI), and zeta potential, were evaluated using dynamic light scattering (DLS). …”
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Number plate recognition smart parking management system using IoT by Allah Ditta, Muhammad Maroof Ahmed, Tehseen Mazhar, Tariq Shahzad, Yazan Alahmed, Habib Hamam

“…The study aims to create an efficient system that eliminates manual vehicle registration and optimizes space utilization. ANPR and IoT-based sensors help users identify the available slots and pay only for the actual parking duration, which will help to minimize the fixed billing rates. …”
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Recovery Analysis of Sequentially Irradiated and NBT-Stressed VDMOS Transistors by Snežana Djorić-Veljković, Emilija Živanović, Vojkan Davidović, Sandra Veljković, Nikola Mitrović, Goran Ristić, Albena Paskaleva, Dencho Spassov, Danijel Danković

“…These insights additionally highlight the importance of understanding stress-induced degradation and recovery mechanisms for optimizing VDMOS transistor reliability in advanced electronic systems.…”
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Investigation into the Prediction of Ship Heave Motion in Complex Sea Conditions Utilizing Hybrid Neural Networks by Yuchen Liu, Xide Cheng, Kunyu Han, Zhechun Liu, Baiwei Feng

“…Sensitivity analysis was conducted to optimize the prediction performance of the CNN-BiLSTM-Attention hybrid neural network method, resulting in a significant improvement in MAPE and enhancing the accuracy of ship motion prediction. …”
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Functional Connectivity and MRI Radiomics Biomarkers of Cognitive and Brain Reserve in Post-Stroke Cognitive Impairment Prediction—A Study Protocol by Hanna Maria Dragoș, Adina Stan, Livia Livinț Popa, Roxana Pintican, Diana Feier, Nicu Cătălin Drăghici, Dragoș-Cătălin Jianu, Diana Chira, Ștefan Strilciuc, Dafin F. Mureșanu

“…Cognitive reserve involves the brain’s ability to optimize performance and use alternative networks to maintain function. …”
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The Neutrophil-to-Monocyte Ratio and Platelet-to-White Blood Cell Ratio Represent Novel Prognostic Markers in Patients with Pancreatic Cancer by Feng Tang, Penghui Dai, Qiongqiong Wei, Ke Gan, Zijie Wang, Huan Chen, Ting Li, Muhan Lv, Mingming Deng, Gang Luo

“…Kaplan-Meier curves and the Cox proportional hazard model were employed to analyze the relationships among NMR, PWR, and overall survival (OS). Results. The optimal cutoff values of NMR and PWR were 48 and 6, respectively. …”
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Newcastle Disease Virus Displaying an Ectodomain of Middle East Respiratory Syndrome Coronavirus Spike Protein Elicited Robust Humoral and Cellular Immunity in Mice by Jaturawitt Prasopsiri, Kanjana Srisutthisamphan, Benjamas Liwnaree, Juggragarn Jengarn, Jarin Kramyu, Payuda Hansoongnern, Papon Muangsanit, Nathiphat Tanwattana, Challika Kaewborisuth, Suttipun Sungsuwan, Anan Jongkaewwattana, Nanchaya Wanasen

“…With recent advancements in stabilizing coronavirus spike proteins to enhance their antigenicity, this study aimed to determine whether modifications to the MERS-CoV spike protein could improve its presentation on NDV particles, allowing the resulting virus to be used as an inactivated vaccine. Methods: We codon-optimized the gene encoding the ectodomain of the MERS-CoV spike protein and incorporated modifications at the S1/S2 and S2’ cleavage sites, along with a proline substitution at residues V1060-L1061. …”
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Tracing the Origin of Oxide Inclusions in Vacuum Arc Remelted Steel Ingots Using Trace Element Profiles and Strontium Isotope Ratios by Christoph Walkner, Gulnaz Mukhametzianova, Stefan Wagner, Jörg C. Korp, Andreas Graf, Johanna Irrgeher, Thomas C. Meisel, Thomas Prohaska

“…This is particularly evident in the case of macroscopic inclusions (>100 µm), which are rarely observed in steel castings produced using state-of-the-art technologies, whereby casting parameters are optimized towards steel cleanliness, and post-treatment steps such as vacuum arc remelting (VAR) are used, but frequently result in the rejection of the affected product. …”
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