Challenges Faced by Prehospital Emergency Physicians Providing Emergency Care to Patients with Advanced Incurable Diseases by Anne Kamphausen, Hanna Roese, Karin Oechsle, Malte Issleib, Christian Zöllner, Carsten Bokemeyer, Anneke Ullrich

“…We identified nine categories of challenges: structural conditions of prehospital emergency care, medical documentation and orders, finding optimal patient-centered therapy, uncertainty about legal consequences, challenges at the individual (EP) level, challenges at the emergency team level, family caregiver’s emotions, coping and understanding of patient’s illness, patient’s wishes, coping and understanding of patient’s illness, and social, cultural, and religious background of patients and families. …”
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Predicting the risk of cardiovascular disease in adults exposed to heavy metals: Interpretable machine learning by Meiyue Shen, Yine Zhang, Runqing Zhan, Tingwei Du, Peixuan Shen, Xiaochuan Lu, Shengnan Liu, Rongrong Guo, Xiaoli Shen

“…The random forest-based CVD prediction model demonstrated excellent predictive power and provided valuable insights for personalized patient care and optimal resource allocation in populations exposed to heavy metals.…”
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Structural evolution mechanisms and design strategies of layered cathodes for sodium-ion batteries by Li Zhang, Jun Wang, Wenhai Ji, Nuria Tapia-Ruiz, Martin Winter, Jie Li

“…Based on this structure information, strategies are introduced to optimize the electrochemical performance of layered NaxTMO2 using design of their bulk crystal structures, local configurations around TM atoms and surface structures.…”
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Removal of the Rhodamine B Dye at Ti/Ru0.3Ti0.7O2 Anode Using Flow Cell System by Ali Baddouh, Brahim El Ibrahimi, Elhassan Amaterz, M. Mohamed Rguiti, Lahcen Bazzi, Mustapha Hilali

“…Meanwhile, the highest COD removal rate (93.0%) was obtained for an applied current density of 3.9 mA·cm−2 as the optimal operating condition after 180 min reaction time, with 2.98 kW h·m−3 as energy consumption. …”
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Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction by Etukudo Okon Jimmy, Grace Edet Bassey, Abijah Ekwere, Udoh Idorenyin Umoh, Adeyemi Fatai Odetayo, Udoh Nsikan Malachy

“…Further investigations are necessary to elucidate the underlying mechanisms of action, determine optimal dosages, and evaluate the long-term safety profiles of these herbal extracts for potential human applications.…”
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Gel–sol synthesis of hierarchical CaO using pollen as biotemplate for biodiesel production by Zheng, Jingdi, Tao, Shuang, Yang, Ying, Tang, Ying

“…Moreover, the yield of no-glycerol biodiesel, 96.62%, has been investigated after 3 h under optimized conditions (temperature = 65 °C, dosage of CaO(S) = 10 wt%, oil/methyl acetate/methanol = 1/1/8), by the yield presence of 91.37% after 3 cycles, which indicated that the 1/1-CaO(S)-700 prepared by sol–gel-biotemplate method had good stability.…”
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The distribution, phenology, host range and pathogen prevalence of Ixodes ricinus in France: a systematic map and narrative review by Perez, Grégoire, Bournez, Laure, Boulanger, Nathalie, Fite, Johanna, Livoreil, Barbara, McCoy, Karen D., Quillery, Elsa, René-Martellet, Magalie, Bonnet, Sarah I.

“…The review highlights the gaps in our knowledge of tick-host-pathogen interactions, their ecologies and their distributions, and demonstrates the need to address these gaps in order to optimize tick and tick-borne diseases prevention and control. …”
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Progress Analysis and Development Prospects of Soil Ecological and Environmental Effects of Interlayer Construction by JIA Zhenjiang, WU Yangyang, LI Wangcheng, MA Dongxiang, CHEN Jihong, GAO Susu, NIU Xiaoxiao, XU Tianyuan

“…This also includes developing and integrating cost-effective and practical interlayer laying technology and supporting equipment, as well as screening and optimizing key technologies and operational parameters for interlayer construction suitable for various climate conditions, soil textures, crop layouts, and farmland management methods. …”
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Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Eff... by Anastasia Latanova, Stefan Petkov, Yulia Kuzmenko, Athina Kilpeläinen, Alexander Ivanov, Olga Smirnova, Olga Krotova, Sergey Korolev, Jorma Hinkula, Vadim Karpov, Maria Isaguliants, Elizaveta Starodubova

“…Inactivated multidrug-resistant RT (RT1.14opt-in) was N-terminally fused to the signal providing secretion of NS1 protein of TBEV (Ld) generating optimized inactivated Ld-carrying enzyme RT1.14oil. …”
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Neutrophil to Lymphocyte Ratio as a Predictor of Adverse Outcome in Patients with Decompensated Liver Cirrhosis by Valeriy D. Lunkov, Marina V. Maevskaya, Ekaterina K. Tsvetaeva, Ana G. Mendez, Maria S. Zharkova, Petr E. Tkachenko, Vladimir T. Ivashkin

“…Correlation analysis, univariate and multivariable analysis were provided to find factors statistically significantly associated with lethal outcome and SIRS. The optimal cut-off levels for the NLR associated with adverse outcome were determined.Results. …”
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Epigallocatechin-3-gallate inhibits the collagen accumulation of oral submucous fibrosis induced by arecoline by Ge Gao, Ge Gao, Caipeng Lin, Caipeng Lin, Ruibo Li, Xi Xie, Hai-Bin Luo, Hai-Bin Luo

“…However, the research on OSF regarding EGCG is relatively limited.PurposeWe aimed to investigate the potential therapeutic effect of EGCG against OSF using an arecoline (ARE) -induced rat model and primary rat oral fibroblasts.MethodsPrimary rat oral mucosal fibroblasts (ROMF) were isolated and identified. Optimal ARE concentrations were established using the Cell Counting Kit-8. …”
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Effect of continuous theta burst stimulation on the glymphatic system, brain network and cognitive function in patients with cerebral small vessel disease by Pei Dai, Hui-xian Yu, Zhao-xia Wang, Si-hao Liu, Chang-bin Liu, Guang-qing Xu

“…The Digital Span Test-backward (DST-backward) scores were significantly higher in the cTBS group than those in the control.ConclusionApplying cTBS to the DLPFC in CSVD may enhance the efficiency of brain glymphatic clearance, optimize network connectivity and improve cognitive function to a certain extent.…”
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Microstructure Evolution and Mechanical Properties of B₄C-Reinforced TC11 + xFe Composites Fabricated by HIP by Shenwei Qian, Nan Wang, Feng Chen, Yangyang Sun, Jiong Zhao, Hui Chang, Liang Feng, Lian Zhou

“…However, the addition of 2 wt% Fe at the same B₄C level (2 wt% B₄C + 2 wt% Fe-reinforced composites) resulted in a significant increase in hardness by 37.5% and 15.2% in compressive strengths of TMC and can be attributed to the solid solution strengthening effect and higher dislocation density provided by the addition of Fe. In addition, the optimal overall properties can be achieved by strictly regulating the addition ratio of 2 wt% Fe and 1 wt% B₄C, allowing for a compressive strength of 2301 MPa while still maintaining a compressive strain of 24.6%.…”
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Comparison of the Effects of Sugammadex Recommended Dose (2 mg/kg) and Fixed Dose of 200 mg on the Reversal of Moderate Neuromuscular Block and Recovery Profile in Adult Patients by Ji-Yoon Jung, Sung-Ae Cho, Woojin Kwon, Hongwook Kim, Tae-Yun Sung

“…<i>Background and Objectives</i>: Neuromuscular blocking agents are essential to ensure optimal surgical conditions during general anesthesia. …”
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Enhancing immunotherapy efficacy with synergistic low-dose radiation in metastatic melanoma: current insights and prospects by Zahid Rafiq, Mingyo Kang, Hampartsoum B. Barsoumian, Gohar S. Manzar, Yun Hu, Carola Leuschner, Ailing Huang, Fatemeh Masrorpour, Weiqin Lu, Nahum Puebla-Osorio, James W. Welsh

“…Furthermore, we explore the challenges associated with LDRT’s integration into combination therapies, addressing crucial factors such as optimal dosage, fractionation, treatment frequency, and synergy with other pharmacological agents. …”
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Impact of Bone Marrow Aspirate Tregs on the Response Rate of Younger Newly Diagnosed Acute Myeloid Leukemia Patients by Mario Delia, Paola Carluccio, Anna Mestice, Claudia Brunetti, Francesco Albano, Giorgina Specchia

“…We studied 23 AML young patients, all treated with standard induction chemotherapy: OR (complete remission (CR) + CR incomplete (CRi)) was documented in 10 of 23 patients (44%); there were two partial responder patients. The optimal dBMA Treg cut-off value for predicting response to treatment (≥21/μL) was obtained by ROC curve analysis. …”
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Directional Topography Influences Adipose Mesenchymal Stromal Cell Plasticity: Prospects for Tissue Engineering and Fibrosis by Gabriel Romero Liguori, Qihui Zhou, Tácia Tavares Aquinas Liguori, Guilherme Garcia Barros, Philipp Till Kühn, Luiz Felipe Pinho Moreira, Patrick van Rijn, Martin C. Harmsen

“…Progenitor cells cultured on biomaterials with optimal physical-topographical properties respond with alignment and differentiation. …”
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Estimating population attributable risk fraction of determinants of pediatric obesity by Maryam Yazdi, Ibrahim Abdollahpour, Mostafa Qorbani, Saba Karimi, Mohammad Esmail Motlagh, Majid Khademian, Roya Kelishadi

“…These findings may provide insights for planning and optimizing future obesity intervention endeavors.…”
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Insulator–metal transition in VO2 film on sapphire studied by broadband dielectric spectroscopy by Arsenii A. Gavdush, Vladislav A. Zhelnov, Kirill B. Dolganov, Alexander A. Bogutskii, Sergey V. Garnov, Maria G. Burdanova, Dmitry S. Ponomarev, Qiwu Shi, Kirill I. Zaytsev, Gennadii A. Komandin

“…Finally, we estimate somewhat optimal thickness and temperature of the $$\hbox {VO}_2$$ film in metallic phase for the THz optoelectronic applications. …”
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Therapeutic potential and mechanisms of umbilical cord mesenchymal stem cells differentiating into tendon cells and promotion of rotator cuff tendon-bone healing by Youliang Shen, Yuelei Wang, Yidan Xu, Jie Wang, Chuqiang Yin, Zengshuai Han, Feng Shen, Ting Wang

“…Hes1 overexpression and animal models were constructed to study its role in UCMSCs differentiation and rotator cuff injury repair. CTGF was the optimal factor for inducing the differentiation of UCMSCs into tendon cells. …”
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