Synthesis and Characterization of Lyophilized Chitosan-Based Hydrogels Cross-Linked with Benzaldehyde for Controlled Drug Release by Fouad Damiri, Yahya Bachra, Chaimaa Bounacir, Asmae Laaraibi, Mohammed Berrada

“…In vitro drug releases were evaluated in PBS, and the obtained results show that the maximum drug release after 24 h was 42% for caffeine, 99% for 5-FU, and 94% for ascorbic acid. Then, to optimize the cumulative release of caffeine, Tween 20 was added and 98% as a release percentage was obtained. …”
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Increasing incidences and changes in treatment trends of clavicle fractures in adults during 2 decades in Denmark: a nationwide study on data from the Danish National Patient Regis... by Ida Tryggedsson, Bjarke Viberg, Per Hviid Gundtoft, Ilija Ban, Søren Overgaard, Tazio Maleitzke, Arvind von Keudell

“…Despite ongoing research there is still no consensus on the optimal treatment choice. We aimed to report national incidences and trends in treatment of clavicle fractures in Denmark across 2 decades. …”
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Comparison of intraoperative neurophysiological monitoring between propofol and remimazolam during total intravenous anesthesia in the cervical spine surgery: a prospective, double... by Myoung Hwa Kim, Jinyoung Park, Yoon Ghil Park, Yong Eun Cho, Dawoon Kim, Dong Jun Lee, Kyu Wan Kwak, Jongyun Lee, Dong Woo Han

“…Background Although total intravenous anesthesia (TIVA) with propofol and remifentanil is frequently used to optimize intraoperative neurophysiological monitoring (IONM), the exact effect of remimazolam on IONM remains unknown. …”
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Delta-radiomics analysis based on magnetic resonance imaging to identify radiation proctitis in patients with cervical cancer after radiotherapy by Jing Xue, Menghan Wu, Jing Zhang, Jiayang Yang, Guannan Lv, Baojun Qu, Yanping Zhang, Xia Yan, Xia Yan, Jianbo Song, Jianbo Song

“…Logistic regression (LR), Pearson correlation coefficient, and least absolute shrinkage and selection operator (LASSO) methods were utilized to select optimal imaging features, leading to a combined prediction model developed using a random forest (RF) algorithm. …”
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Enhancing surface integrity of medical Ti–6Al–4V alloy via magnetic field-assisted mass polishing by Rui Gao, Dawei Luo, Yee Man Loh, Chi Fai Cheung, Chen Jiang, Chunjin Wang

“…This research provides pivotal insights and recommendations for the ultra-precision mass polishing of medical TC4 alloys, potentially offering an optimal solution for polishing various medical components. …”
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Development and validation of a LAMP-based method for rapid and reliable detection of Xanthomonas albilineans, the causal agent of sugarcane leaf scald by Moutoshi Chakraborty, Moutoshi Chakraborty, Shamsul Arafin Bhuiyan, Shamsul Arafin Bhuiyan, Simon Strachan, Simon Strachan, Muhammad J. A. Shiddiky, Nam-Trung Nguyen, Rebecca Ford, Rebecca Ford

“…This assay also effectively determined optimal sampling times and plant parts by monitoring the progression of the disease over time.DiscussionThis diagnostic assay holds significant potential as a commercial opportunity for a kit-based DNA extraction/purification-free molecular detection alternative. …”
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Impact of trace elements (total and labile fraction) on the anaerobic digestion activity and microbial community structure by Rahul H.M. Pires, Maria P. Tomasino, Stéphane Simon, Rémy Buzier, Gilles Guibaud, C. Marisa R. Almeida, Ana P. Mucha

“…Trace elements (TEs) in anaerobic digestion (AD) are known to be essential for optimal biogas production, but inhibitive in excessive concentrations. …”
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Experimental investigation on fresh, hardened and durability characteristics of partially replaced E-waste plastic concrete: A sustainable concept with machine learning approaches by Md. Hamidul Islam, Zannatun Noor Prova, Md. Habibur Rahman Sobuz, Nusrat Jahan Nijum, Fahim Shahriyar Aditto

“…Compressive and splitting tensile tests evaluated the mechanical properties of e-waste concrete, whereas water permeability and electrical resistivity tests assessed durability to determine the optimal e-waste proportion for construction. The compressive and tensile strengths of e-waste concrete were reduced by 13.41%–25.50 % and 11%–19.26 %, respectively, for replacement levels ranging from 10 % to 20 % at 28 days. …”
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A multi-task model for failure identification and GPS assessment in metro trains by Pratik Vinayak Jadhav, Sairam V. A, Siddharth Sonkavade, Shivali Amit Wagle, Preksha Pareek, Ketan Kotecha, Tanupriya Choudhury

“…The algorithm was trained for 20 epochs with a batch size of 5000 using the using Adam optimizer. The local interpretable model agnostic explanations (LIME) technique was used to provide explanations for the model predictions. …”
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Combining habitat selection, behavioural states, and individual variation to predict fish spatial usage near a barrier by Rachel Mawer, Jelger Elings, Stijn P. Bruneel, Ine S. Pauwels, Eliezer Pickholtz, Renanel Pickholtz, Johan Coeck, Peter L.M. Goethals

“…Effective management requires understanding of fish movement and behaviour as they approach a barrier and fish pass, which can inform optimal mitigation options and barrier management. …”
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Investigating the needs and barriers for prevention, control, and treatment of HIV/AIDS in transgender population: a systematic review of literature by Heshmatollah Sofimajidpour, Ghobad Moradi, Hojat Dehghanbanadaki, Marzieh Mahboobi, Mobin Azami, Parisa Khodakhah, Mohammad Aziz Rasouli, Yousef Moradi

“…Results The results showed that from the perspective of health policy-makers, the needs related to control, prevention, and treatment of HIV/AIDS in transgender population were the need for optimal access to AIDS-related services, such as easy access to diagnostic tests, and the need to increase insufficient awareness of the ways of transmission of the disease and its symptoms. …”
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The association between short-term apparent temperature exposure and human coagulation: A time-series study from Beijing, 2014–2023 by Yi Zhang, Tiancheng Wang, Jiaqi Shi, Ying Ma, Nairui Yu, Xinyan Zhou, Pai Zheng, Zhangjian Chen, Guang Jia

“…A growing body of evidence suggests that non-optimal ambient temperatures are associated with increased incidence rate and mortality of thromboembolic diseases. …”
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Impact of climate change over distribution and potential range of chestnut in the Iberian Peninsula by Pedro Álvarez-Álvarez, Adrián Aviñoa-Arias, Adrián Aviñoa-Arias, Emilio Díaz-Varela, José Vicente López-Bao, José Carlos Pérez-Girón

“…Favourable chestnut habitats were linked to wetter regions, and included factors associated with annual and seasonal precipitations, coldest quarter temperature, soil pH and annual mean temperature. Optimal conditions for chestnut trees include precipitation exceeding 800 mm/year and mean temperature ranging from 10-15°C. …”
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Integrating testing and modeling methods to examine the feasibility of blended waste materials for the compressive strength of rubberized mortar by Amin Muhammad Nasir, Nassar Roz-Ud-Din, Khan Kaffayatullah, Ul Arifeen Siyab, Khan Mubasher, Qadir Muhammad Tahir

“…The study determined that the optimal substitution levels for GP, MP, and SF in rubberized mortar were 15, 10, and 15%, respectively. …”
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Efficacy and safety of sublingual immunotherapy using a combination of Dermatophagoides pteronyssinus and Blomia tropicalis extracts in patients with allergic rhinitis: A randomize... by Priscilla Rios Cordeiro Macedo, MD, MSc, Priscila Moraes, MD, Luísa Karla Arruda, MD, PhD, Fábio Fernandes Morato Castro, MD, PhD, Jorge Kalil, MD, PhD, Clóvis Eduardo Santos Galvão, MD, PhD

“…Few studies currently exist related to optimal dosing for Blomia tropicalis. Methods: This was a double-blind, randomized, placebo-controlled trial of SLIT to treat house dust mite-induced Allergic Rhinitis (AR). …”
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Grazoprevir and Elbasvir in Patients with Genotype 1 Hepatitis C Virus Infection: A Comprehensive Efficacy and Safety Analysis by Yinan Yao, Ming Yue, Jie Wang, Hongbo Chen, Mei Liu, Feng Zang, Jun Li, Yun Zhang, Peng Huang, Rongbin Yu

“…It is urgent for patients with hepatitis C virus (HCV) infection to find a safe, effective, and interferon-free regimen to optimize therapy. A comprehensive analysis was performed to evaluate the efficacy and safety of the grazoprevir combined with elbasvir, with or without ribavirin (RBV), in 777 treatment-naive and treatment-experienced patients with HCV genotype 1 infection from 3 randomized controlled trials (RCTs). …”
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Blockade of TIPE2-Mediated Ferroptosis of Myeloid-Derived Suppressor Cells Achieves the Full Potential of Combinatory Ferroptosis and Anti-PD-L1 Cancer Immunotherapy by Hafiza Kashaf Tariq, Zihao Liang, Lawan Rabiu, Abdulrahman Ibrahim, Nada Mohamady Farouk Abdalsalam, Rong Li, Qiong Yang, Xiaochun Wan, Dehong Yan

“…However, whether blocking the intrinsic ferroptosis pathways of MDSCs can relieve imidazole ketone erastin (IKE)-initiated ferroptosis-induced immune suppression and ultimately trigger the optimal therapeutic effect of the combined ferroptosis and ICB therapy is still unknown. …”
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Trade-off strategies between growth and defense of spring ephemeral plants in early spring by Liben Pan, Liben Pan, Tianqi Wang, Tianqi Wang, Vladimir L. Gavrikov, Xiaorui Guo, Xiaorui Guo, Liqiang Mu, Zhonghua Tang, Zhonghua Tang

“…Understanding the adaptive strategies of spring ephemerals is crucial for the introduction and cultivation of early spring plants, as well as for optimizing light energy utilization and nutrient cycling within ecosystems.MethodsWe evaluated 26 functional traits across four spring ephemerals and four spring non-ephemeral plants along an elevation gradient. …”
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Mineralization Potential of Electrospun PDO-Hydroxyapatite-Fibrinogen Blended Scaffolds by Isaac A. Rodriguez, Parthasarathy A. Madurantakam, Jennifer M. McCool, Scott A. Sell, Hu Yang, Peter C. Moon, Gary L. Bowlin

“…These mineralized scaffolds were still porous and will be further optimized as an effective bone substitute in future studies.…”
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Rapid Determination of the Monosaccharide Composition and Contents in Tea Polysaccharides from Yingshuang Green Tea by Pre-Column Derivatization HPLC by Yujie Ai, Zhi Yu, Yuqiong Chen, Xiaojing Zhu, Zeyi Ai, Shuyuan Liu, Dejiang Ni

“…A pre-column derivatization high-performance liquid chromatography (HPLC) method was developed and optimized to characterize and quantify the monosaccharides present in tea polysaccharides (TPS) isolated from Yingshuang green tea. …”
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