Integrative analysis of Ewing’s sarcoma reveals that the MIF-CD74 axis is a target for immunotherapy by Fangzhou He, Jiuhui Xu, Fanwei Zeng, Boyang Wang, Yi Yang, Jie Xu, Xin Sun, Tingting Ren, Xiaodong Tang

“…Methods Since novel immunotherapies may address this need, we performed an integrative analysis involving single-cell RNA sequencing, cell function experiments, and humanized models to dissect the immunoregulatory interactions in EwS and identify strategies for optimizing immunotherapeutic efficacy. Results EwS is infiltrated by immunosuppressive myeloid populations, T and B lymphocytes, and natural killer cells. …”
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Promoting Immortalized Adipose-Derived Stem Cell Transdifferentiation and Proliferation into Neuronal-Like Cells through Consecutive 525 nm and 825 nm Photobiomodulation by Madeleen Jansen van Rensburg, Anine Crous, Heidi Abrahamse

“…Research has shown that this process may be optimized by the introduction of laser irradiation in the form of photobiomodulation (PBM) to cells. …”
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Power flow and power quality improvement of a residential-industrial microgrid using 72-pulse inverter-based UIPC by Mahyar Abasi, Ali Nahavandi, Javad Ebrahimi, Gevork B. Gharehpetian

“…The design presented in this work was modeled and implemented in MATLAB software, and the results of different test scenarios validated the optimal performance of the suggested design.…”
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What factors influence the willingness and intensity of regular mobile physical activity?— A machine learning analysis based on a sample of 290 cities in China by Hao Shen, Bo Shu, Jian Zhang, Yaoqian Liu, Ali Li

“…., walking) tend to amplify both promotional and inhibitory effects of the factors. (3) Some influencing factors display typical non-linear effects, consistent with findings from micro-scale studies.DiscussionThe findings provide comprehensive theoretical support for understanding and optimizing physical activity among urban residents. …”
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Social, Racial, and Economic Disparities Affecting Outcomes of Hypertensive Adolescents by Kanya Singhapakdi, Amelia Haydel, Marla Johnston, Shengping Yang, Tamara Bradford, Dedrick Moulton, Thomas R. Kimball

“…The results of this study provide both a deeper understanding of the challenges these patients face and the opportunity to develop real‐life interventions that can optimize clinical outcomes.…”
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Synbiotics effects of d-tagatose and Lactobacillus rhamnosus GG on the inflammation and oxidative stress reaction of Gallus gallus based on the genus of cecal bacteria and their me... by Yuanqiang Lv, Jie Chu, Xiaoxiao Zhang, Xuan Li, Aijiao Yin, Industrial Microbiology Laboratory

“…Treat Gallus gallus exhibiting oxidative stress and immune response caused by aflatoxin b1 with optimal synbiotics for 14 days, detect the changes of inflammatory markers and oxidative stress markers of Gallus gallus using qRT-PCR, and identified the intestinal bacteria genera and their metabolites in the cecum of Gallus gallus using gut microbiota and metabolomics analysis.…”
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Modelling and Simulation of Perturb and Observe MPPT Algorithm Based on The PI Controller for Photovoltaic System by Ahlam Mohamad Shakoor, Hersh Hasan Taha

“…The proposed model is used to simulate and optimize the photovoltaic array output current, voltage and power features under various environmental conditions including solar temperature and radiation. …”
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Comparison of Different IOL Types in the Flanged IOL Fixation Technique by Yusaku Miura, Yosuke Harada, Yoshiaki Kiuchi

“…On the other hand, PN6A IOLs was easy to maneuver within the anterior chamber, and the operation time was shorter when using PN6A IOLs. Selection of optimal IOLs for flanged IOL fixation necessitates an understanding of their characteristics in terms of intraoperative and postoperative complications.…”
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Fake News Detection and Classification: A Comparative Study of Convolutional Neural Networks, Large Language Models, and Natural Language Processing Models by Konstantinos I. Roumeliotis, Nikolaos D. Tselikas, Dimitrios K. Nasiopoulos

“…These findings emphasize the importance of fine-tuning large language models (LLMs) to optimize the performance for complex tasks such as fake news classifier development, where capturing subtle contextual relationships in text is crucial. …”
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Drop-size-dependent effects in leading-edge rain erosion and their impact on erosion-safe mode operation by N. Barfknecht, D. von Terzi

“…This paper also provides a formal derivation of impingement and describes a method for finding optimal ESM strategies.</p>…”
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Effect of Emission Penalty and Annual Interest Rate on Cogeneration of Electricity, Heat, and Hydrogen in Karachi: 3E Assessment and Sensitivity Analysis by Mehdi Jahangiri, Ali Mostafaeipour, Habib Ur Rahman Habib, Hamed Saghaei, Asad Waqar

“…To this end, 4500000 possible cases were analyzed, simulated, and optimized with the HOMER software using 20-year average meteorological data from the NASA website. …”
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A framework for the continuous monitoring of person-centred hospital care: validation of a checklist for participatory service improvement by F. Cardinali, S. Carzaniga, L. Martini, M. T. Loiudice, Fabrizio Carinci

“…Varimax rotation with eigenvalues > 1 was used to optimize factor structure. Items with an item-total correlation > 0.30 and factor loadings > 0.4 were attributed to individual factors. …”
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Challenges in Diagnosis and Management of SLE in Africa: An Online Survey by Farhanah Paruk, Dzifa Dey, Anisa Mosam, Oluwaytoyin Amira Christina, Mohammed Tikly

“…Conclusion Variable availability of laboratory tests, medications, and supportive services coupled with cost constraints are major impediments to early diagnosis and optimal management of SLE in most of Africa and are likely factors contributing to underreporting and poor prognosis of SLE in Africa.…”
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Counterfactual thinking in psychiatric and neurological diseases: A scoping review. by Sofia Tagini, Federica Solca, Silvia Torre, Agostino Brugnera, Andrea Ciammola, Ketti Mazzocco, Roberta Ferrucci, Vincenzo Silani, Gabriella Pravettoni, Barbara Poletti

“…Thus, acknowledging the presence and possible consequences of CFT impairments might be essential for optimal clinical management.<h4>Objectives</h4>This scoping review aims to summarize the previous evidence about CFT in psychiatric and neurological diseases to determine the extent of the previous research and what has been discovered so far, the variety of clinical conditions considered, the methodologies adopted, and the relevant issues to be addressed by future investigations.…”
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Endoscopic Epidurolysis for the Management of Chronic Spinal Pain: A Delphi-Based Italian Experts Consensus by Matteo Luigi Giuseppe Leoni, Felice Occhigrossi, Michael Tenti, William Raffaeli, ISAL Research Study Group

“…Despite its growing recognition, the literature lacks comprehensive guidelines on its optimal use. This study utilized a modified Delphi approach to gather expert consensus on best practices for EE in the Italian pain therapy network. …”
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The Impact of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Epithelial Ovarian Cancer by Samet Kirat, Utku Akgor

“…RESULTS: The difference was observed concerning optimal and suboptimal debulking in platelet-to-lymphocyte ratio ratios (p=0.04). …”
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Adolescent Psychological Assistance Treatment Strategy Integrating Home-School Coordination and Network Information by Yaling Li

“…Based on this, this paper will focus on optimizing the home-school cooperation strategy, further clarify the main responsibilities of the school, teachers, and parents in the home-school cooperation education in the strategy, establish and improve the home-school cooperation mechanism based on this, and focus on the cultivation of parents’ mental health education and teachers’ mental health guidance professional skills in this process. …”
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Effect of annealing on the structural, morphological, optical, magnetic, and dielectric properties of nickel-doped cobalt nanoferrites for electronic applications by Md Shihabun Sakib, Md Naimur Rahman, Md Alamgir Hossain, Md Rashedur Rahman

“…The experimental results align with reported values, showing that higher annealing temperatures provide optimal structural, morphological, and magnetic properties, while lower temperatures favor optical and dielectric properties in CNSF nanoparticles.…”
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Evaluating Trends in Interior Design Strategies and Their Impact on the Emotional Experience of Older Adults by Lintong Li, Suhua Wang, Noranita Mansor, Athira Azmi, Jialing Xiang

“…Traditional interior architectural design primarily focuses on optimizing physical functionality; however, this approach is no longer sufficient to meet the increasingly complex emotional needs of the elderly. …”
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Impact Assessment of Grid-Connected Solar Photovoltaic Systems on Power Distribution Grid: A Case Study on a Highly Loaded Feeder in Ulaanbaatar Ger District by Turmandakh Bat-Orgil, Battuvshin Bayarkhuu, Bayasgalan Dugarjav, Insu Paek

“…The results show that the power loss of the feeder can be greatly reduced when the total installed capacity of the solar PV systems is selected optimally, and the location of the connection is at the end of the power distribution grid.…”
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