Lidocaine could promote the cuproptosis through up-regulating the long noncoding RNA DNMBP-AS1 in Hep-2 cells by Wei Liu, Yi Yu, Yi He, Meihong Lv

“…The results of this study offered initial optimism that lidocaine could be used in an adjuvant or neoadjuvant fashion in cancer treatment.…”
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Machine learning models for predicting interaction affinity energy between human serum proteins and hemodialysis membrane materials by Simin Nazari, Amira Abdelrasoul

“…These models, by enabling early interventions in hemodialysis membranes, could enhance patient safety and optimize the care of hemodialysis patients.…”
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Identification of Novel GCK and HNF4α Gene Variants in Japanese Pediatric Patients with Onset of Diabetes before 17 Years of Age by Rumi Katashima, Mari Matsumoto, Yuka Watanabe, Maki Moritani, Ichiro Yokota

“…A precise molecular diagnosis is essential for the optimal treatment of patients and allows for early diagnosis of their asymptomatic family members. …”
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Methodical approaches in experimental modelling of non-alcoholic fatty liver disease by N. V. Bivalkevich, Yu. K. Denisenko, T. P. Novgorodtseva

“…It is necessary to choose the optimal way of NAFLD modelling, allowing to reveal certain part of pathologic mechanisms of disease and to determine strategy of hepatotropic treatment according to determined task.…”
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Evaluation of University’s Place in the Adult Education Ecosystem by G. Z. Efimova, M. Yu. Semenov

“…Universities, having a high level of public trust and being mainly responsible for fundamental professional education, are interested in accumulating the advantages of other participants of the educational ecosystem. It is optimal to present the university as a central hub of educational practices for the population, accumulating the advantages of other actors of the adult education ecosystem. …”
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Weight method for determination of soluble β-glucans in barley grain by V. S. Popov, A. V. Konarev, O. N. Kovaleva, N. G. Konkova, V. I. Khoreva

“…Based on the conducted research, optimal conditions for the isolation and quantitative determination of β-glucans from barley grain were selected: centrifugation modes, temperature and extraction ratio, concentration of compounds, precipitation and drying procedures. …”
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Ciliary peristalsis flow of hydromagnetic Sutterby nanofluid through symmetric channel: Viscous dissipation in case of variable electrical conductivity by Sameh A. Hussein, Sameh E. Ahmed, Anas A.M. Arafa

“…Additionally, when the metachronal waves variable gets bigger, the peristaltic ciliary motility has a more optimal axial velocity than peristaltic flow along the walls within the entire area [±0.5,±1]. …”
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Analysis of a novel method for finding solutions of interval game problems via fuzzy approaches by Monika Bisht, Shivam Rawat, Junaid Ahmed

“…According to the literature, various methodologies exist to identify the optimal strategies and game value for IVMGs. However, many of these methods possess some shortcomings dis-cussed in the paper, highlighting the requirement for a novel approach. …”
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Analisis Tingkat Efektivitas Media Dakwah Melalui Lisan dan Tulisan pada Mahasiswa di Era 4.0 by Hae Ruli Rusdi, Nur Aisyah

“…Perbandingan antara media dakwah lisan dan tulisan di kalangan mahasiswa juga masih perlu diuraikan lebih rinci, membatasi pemahaman mengenai strategi yang optimal. Pendekatan penelitian ini mengusung metode deskriptif kualitatif dengan analisis literatur untuk menyelidiki efektivitas media dakwah lisan dan tulisan di era 4.0. …”
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Circadian rhythm related genes signature in glioma for drug resistance prediction: a comprehensive analysis integrating transcriptomics and machine learning by Junbo Liao, Yingxing Duan, Xiangwang Xu, Yaxue Liu, Chaohong Zhan, Gelei Xiao

“…Based on the CRRS model, an optimal comprehensive nomogram was created, exhibiting a favorable potential for predicting drug resistance in samples. …”
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FusionScan: accurate prediction of fusion genes from RNA-Seq data by Pora Kim, Ye Eun Jang, Sanghyuk Lee

“…Here, we present FusionScan, a highly optimized tool for predicting fusion transcripts from RNA-Seq data. …”
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A system approach to the modeling of fungal infections of the wheat leaf by S. V. Nikolaev, U. S. Zubairova, E. S. Skolotneva, E. A. Orlova, D. A. Afonnikov

“…Models of fungal infections development on the wheat leaf (for example, brown rust) are used to monitor, predict and control the state of crops in order to optimize the growing process. Mathematical models allow computational experiments to make predictions about the risk dynamics of infections in different scenarios of global weather changes. …”
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Penerapan Algoritma Pillar Untuk Inisialisasi Titik Pusat K-Means Klaster Dinamis by Ketut Agus Seputra, I Nyoman Saputra Wahyu Wijaya

“…Sehingga jika dilihat dari nilai validitas SSE, algoritma pillar k-means klaster dinamis masih kurang bekerja optimal dibandingkan dengan algoritma k-means klaster dinamis. …”
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The role of Beringia in human adaptation to Arctic conditions based on results of genomic studies of modern and ancient populations by B. A. Malyarchuk

“…Meanwhile, the analysis of the existing hypotheses about the selection of some genetic variants in the Beringian ancestors of the Amerindians in connection with adaptation to the Arctic conditions (for example, in the FADS, ACTN3, EDAR genes) shows the ambiguity of the testing results, which may be due to the loss of some traces of the “Beringian” adaptation in the gene pools of modern Native Americans. The most optimal strategy for further research seems to be the search for adaptive variants using the analysis of paleogenomic data from the territory of Beringia, but such genetic data are still very scarce.…”
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An Unusual Case of Radicular Pain Caused by Bilateral Lumbar Synovial Cyst: A Case Report and Review of the Literature by David Ruiz-Picazo, José Ramírez-Villaescusa, Ana Verdejo-González

“…After reviewing the literature, the optimal management for patients with symptomatic lumbar synovial cyst must be very individualized, which is essential to achieve a favorable outcome.…”
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Comprehensive Methodology to Evaluate Parasitic Energy Consumption for Different Types of Dual-Axis Sun Tracking Systems by Ming-Hui Tan, Tze-Koon Wang, Chee-Woon Wong, Kok-Keong Chong, Boon-Han Lim, Tiong-Keat Yew, Woei-Chong Tan, An-Chow Lai

“…However, there is no significant study yet to optimize the net performance of the photovoltaic (PV) or concentrator photovoltaic (CPV) system equipped with a dual-axis sun tracking system. …”
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Evaluation of the Cost of Intelligent Upgrades of Transportation Infrastructure for Intelligent Connected Vehicles by Zongwei Liu, Haokun Song, Hong Tan, Han Hao, Fuquan Zhao

“…Then, the cost evaluation model for intelligent upgrade of transportation infrastructures was established, based on which, the cost evaluation of different intelligent upgrade routes of transportation infrastructure was carried out in closed highway and open urban road scenarios to determine the optimal route. Besides, the key elements affecting the cost of transportation infrastructure upgrades were identified, and their impact degrees on transportation infrastructure upgraded were analyzed by scenario analysis. …”
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A Miniaturized Loaded Open-Boundary Quad-Ridge Horn with a Stable Phase Center for Interferometric Direction-Finding Systems by Zibin Weng, Chen Liang, Kaibin Xue, Ziming Lv, Xing Zhang

“…First, to stabilize the phase center of the antenna, the design builds on the foundation of a quad-ridge horn antenna, where measures such as optimizing the ridge structure and introducing resistive loading were implemented to achieve size reduction. …”
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Garba Dance Is Effective in Parkinson’s Disease Patients: A Pilot Study by Anish Mehta, Pooja Dugani, Rohan Mahale, null Nandakumar, Krishna Haskar Dhanyamraju, R. Pradeep, Mahendra Javali, Purushottam Acharya, R. Srinivasa

“…Underscoring a cautious optimism, results of the current study indicate that Garba dance may be an effective, safe, and well-tolerated intervention for Indian patients with mild-to-moderate PD (H&Y stage 1 to 2.5).…”
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Abstractive Summarization of Historical Documents: A New Dataset and Novel Method Using a Domain-Specific Pretrained Model by Keerthana Murugaraj, Salima Lamsiyah, Christoph Schommer

“…To address the mismatch between the pre-trained encoder and the non-pre-trained decoder, we employ a novel fine-tuning schedule that uses different optimizers for each component. Experimental results on our constructed dataset demonstrate that our HistBERTSum-Abs method outperforms recent state-of-the-art deep learning-based methods and achieves results comparable to state-of-the-art LLMs in zero-shot settings in terms of ROUGE-1, ROUGE-2, and ROUGE-L F1 scores. …”
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