Characterization of Bozitinib as a potential therapeutic agent for MET-amplified gastric cancer by Hang Lin, Lingzhi Qu, Hudie Wei, Ming Guo, Xiaojuan Chen, Qianmeng Lin, Huajun Zhang, Shuyan Dai, Yongheng Chen

“…Structurally, bozitinib is optimally embedded in the ATP pocket of c-Met and firmly binds via an extensive interaction network. …”
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Contributions to the Virtualization of the BNG by Jorge Proenca, Ricardo Figueiredo, Vasco Pereira, Tiago Cruz, Paulo Simoes

“…It serves as a crucial component, being responsible for various essential services that allow subscribers’ connections and help optimizing infrastructure resources, including enforcing QoS policies and implementing Access Control Lists to safeguard against unauthorized access. …”
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Chloride Ion Removal from the Wet Flue Gas Desulfurization and Denitrification Wastewater Using Friedel’s Salt Precipitation Method by Ping Fang, Zi-jun Tang, Xiong-bo Chen, Jian-hang Huang, Zhi-xiong Tang, Chao-ping Cen

“…Factors affecting the Cl− removal, such as Ca(OH)2 dosage, NaAlO2 dosage, solution’s initial pH, solution’s temperature, reaction time, stirring speed, and anions (SO42−, NO3−, and F−), were investigated, and the optimal experimental conditions for Cl− removal were determined. …”
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Psychological, psychiatric, and behavioral sciences measurement scales: best practice guidelines for their development and validation by Alberto Stefana, Stefano Damiani, Umberto Granziol, Umberto Provenzani, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Eric A. Youngstrom, Eric A. Youngstrom, Eric A. Youngstrom, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli

“…Finally, in the Finalization Phase, the optimal item sequence is decided, and a comprehensive inventory manual is prepared. …”
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Fabrication of taxifolin loaded zein-caseinate nanoparticles and its bioavailability in rat by Ying Li, Hang Su, Wenjun Wang, Zhongping Yin, Jing’en Li, En Yuan, Qingfeng Zhang

“…The formulations of TZP were optimized. With mass ratio of 1:1:2 between taxifolin, zein and sodium caseinate, the particle size and ζ-potential of TZP were (168.74 ± 0.35) nm and (−57.67 ± 0.25) mV, while the encapsulation and loading efficiency of taxifolin were (85.83 ± 0.89)% and (17.11 ± 0.88)%, respectively. …”
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Traffic light system regulation of induced seismicity under multi-well fluid injection by Miao He, Qi Li, Xiaying Li, Yao Zhang

“…Understanding the relationship between injection operations and seismic magnitude is of great significance for optimizing industrial production and reducing earthquake disasters. …”
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Operation time as a prognostic indicator on postoperative complications following percutaneous nephrolithotomy by Alireza Pakdel, Abdolreza Mohammadi, Amirreza Shamshirgaran, Ehsan Zemanati Yar, Leila Zareian Baghdadabad, Farshid Alaeddini, Roghayeh Koohi Ortakand, Leonardo Oliveira Reis, Seyed Reza Hosseini, Seyed Mohammad Kazem Aghamir

“…Objective: We aimed to find an optimal cut-off time for percutaneous nephrolithotomy to prevent complications. …”
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Development of Prevascularized Synthetic Block Graft for Maxillofacial Reconstruction by Borvornwut Buranawat, Abeer Shaalan, Devy F. Garna, Lucy Di Silvio

“…The co-culture of endothelial cells (ECs) with human alveolar osteoblasts (aHOBs) on the scaffold led to the formation of tube-like structures and intrinsic VEGF release, reaching 10,455.6 pg/mL This level approached the optimal dose for vascular formation. Conversely, the co-culture with mesenchymal stem cells did not yield similar results. …”
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The relationship between malocclusion and speech patterns: a cross-sectional study by Nada E. Tashkandi, Razan AlDosary, Hissah Zamandar, Misk Alalwan, Mohannad Alwothainani, Hissah Aljoaid, Duaa Alghazhmri, Eman Allam, Anand Marya, Samar M. Adel

“…Conclusions There was an evident pattern of partial association of PAR index scores and speech abnormalities including improper articulation. To provide optimal care for involved subjects, collaboration between orthodontists and speech therapists, in pre- and post-treatment evaluations, is crucial.…”
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Determination of Ischemia Onset Based on Automatically Generated Spectralis SD-OCT Values in Acute Central Retinal Artery Occlusion by Maria Casagrande, Robert Kromer, Daniel A. Wenzel, Sven Poli, Martin S. Spitzer, Vasyl Druchkiv, Maximilian Schultheiss, Spyridon Dimopoulos

“…In all sectors, time to OCT (TTO) and RRTI correlated positively. The optimal cutoff point to detect CRAOs ≤4.5 hours was between 18.7% nasally and 22.9% RRTI temporally. …”
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Concordance between Immunohistochemistry and Microarray Gene Expression Profiling for Estrogen Receptor, Progesterone Receptor, and HER2 Receptor Statuses in Breast Cancer Patients... by Ghina B. Fakhri, Reem S. Akel, Maya K. Khalil, Deborah A. Mukherji, Fouad I. Boulos, Arafat H. Tfayli

“…Accurate evaluation of estrogen and progesterone receptors and HER2 is critical when diagnosing invasive breast cancer for optimal treatment. The current evaluation method is via immunohistochemistry (IHC). …”
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Three-periodic 1D photonic crystals based on dielectric oxides SiO2, Al2O3, TiO2, ZrO2: an emerging class of structures with wide possibilities for applied photonics by I.S. Panyaev, D.G. Sannikov, Yu.S. Dadoenkova, N.N. Dadoenkova

“…Using the transfer matrix method, frequency-angle spectra and energy characteristics of the PC structures are studied and optimal combinations of layers (and contrast) are found, enabling obtaining controllable photonic band gaps (PBGs). …”
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Effects of limited introgressions from Triticum timopheevii Tausch. into the genome of bread wheat (Triticum aestivum L.) on physiological and biochemical traits under normal water... by T. A. Pshenichnikova, A. V. Permyakov, S. V. Osipova, M. D. Permyakova, E. G. Rudikovskaya, V. V. Verchoturov

“…In flag leaves of 821 line, an increased transpiration rate and stomatal conductance (1.6 times the value in optimal watering and 1.2 times the value under water deficit) and, correspondingly, reduced water use efficiency were found compared to the initial cultivar. …”
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Fermentation of Musa paradisiaca Peels to Produce Citric Acid by Mariel Monrroy, Lineth Rueda, Anaís L. Aparicio, José Renán García

“…As a result, M. paradisiaca peels are concluded to be a suitable substrate for CA biosynthesis via fermentation with A. niger under optimal nutritional conditions.…”
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Behavior and Mechanisms of Antimony Precipitation from Wastewater by Sulfate-Reducing Bacteria <i>Desulfovibrio desulfuricans</i> by Fan Zhuang, Xiaowu Xiang, Jin Hu, Jing Xiong, Teng Zhang, Lei Zhou, Guoping Jiang, Min Zhang, Zhenghua Liu, Huaqun Yin, Ling Xia, Ibrahim Ahmed Ibrahim Mahmoud, Delong Meng

“…The precipitation of heavy metals by microorganisms involves complex mechanisms that require further investigation to optimize bioremediation technologies. In this study, we employed a sulfate-reducing bacteria (SRB) strain <i>Desulfovibrio desulfuricans</i> CSU_dl to treat the antimony (Sb)-containing wastewater; the behavior of Sb and mechanisms underlying precipitation were investigated by characterizing the precipitates. …”
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Evaluating the antagonist effect of naltrexone implant via opioid challenge tests with escalating doses of hydromorphone injection in former heroin dependent patients by Wei Qu, Xuyi Wang, Chongyang Dong, Tao Zhang, Shugui Yin, Zhijun Sun, Shiqiang Wang, Anni Guo, Wei Hao

“…This study (trial registration number: CTR20181954) aimed to evaluate the effect, safety, and pharmacokinetics of NTX-IMP in agonist effects via hydromorphone challenge test, and to determine optimal dosages for future research. Thirty-one former opioid-dependent individuals were randomized to the 0.9g or the 1.5g NTX-IMP group. …”
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Sorption isotherms and kinetics of Crystal Violet dye uptake from aqueous solution by using polyaniline nanocomposite as adsorbent by Piyush Gupta, Amrita Kaushik, Garima Nagpal, Markus Diantoro, Firdaus Mohamad Hamzah, Faisal Islam Chowdhury, Pramod K. Singh

“…The analysis of the adsorption isotherm corroborated the applicability of the Langmuir model, indicative of a monolayer adsorption mechanism. Under optimal conditions (pH 9, 0.5 g of adsorbent in 50 ml of solution, and a 60-minute contact time), the ZnFe₂O₄-PANi nanocomposite exhibited endothermic and spontaneous adsorption characteristics. …”
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Neonatal Intensive Care and Child Psychiatry Inpatient Care: Do Different Working Conditions Influence Stress Levels? by Evalotte Mörelius, Per A. Gustafsson, Kerstin Ekberg, Nina Nelson

“…Healthcare managers need to acknowledge the less healthy work situation CAP nurses experience in order to provide optimal support and promote good health.…”
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Benefits and Harms of Extending the Duration of Dual Antiplatelet Therapy after Percutaneous Coronary Intervention with Drug-Eluting Stents: A Meta-Analysis by Chun Shing Kwok, Heerajnarain Bulluck, Alisdair D. Ryding, Yoon K. Loke

“…Background. The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) is unclear. …”
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Thermosensitive In Situ Ophthalmic Gel for Effective Local Delivery and Antifungal Activity of Ketoconazole Nanoparticles by Chutima Chaiwut, Sarin Tadtong, Puriputt Akachaipaibul, Jutamas Jiaranaikulwanitch, Sudarshan Singh, Siriporn Okonogi, Dwi Marlina Syukri, Chuda Chittasupho

“…The NPs exhibited sustained zero-order release kinetics. The optimized NPs were incorporated into a poloxamer-based in situ gel, demonstrating a gelation temperature of 34.67 ± 0.58 °C and the shortest gelation time. …”
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