Development and validation of an explainable machine learning model for mortality prediction among patients with infected pancreatic necrosisResearch in context by Caihong Ning, Hui Ouyang, Jie Xiao, Di Wu, Zefang Sun, Baiqi Liu, Dingcheng Shen, Xiaoyue Hong, Chiayan Lin, Jiarong Li, Lu Chen, Shuai Zhu, Xinying Li, Fada Xia, Gengwen Huang

“…The final model constructed with optimal feature subset was deployed as an interactive web-based Shiny app. …”
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Metabolomic profiles of <i>Ribes nigrum</i> L. and <i>Lonicera caerulea</i> L. from the collection of the N.I. Vavilov Institute in the setting of Northwest Russia by T. V. Shelenga, V. S. Popov, A. V. Konarev, N. G. Tikhonova, O. A. Tikhonova, Y. A. Kerv, A. E. Smolenskaya, L. L. Malyshev

“…The investigation of L. caerulea and R. nigrum fruit’s accessions from the VIR collection using gas-liquid chromatography with mass spectrometry allows us to obtain new information about the biochemical characteristics of fruits, to identify L. caerulea and R. nigrum varieties with optimal economically valuable characteristics, to determine the specificity of L. caerulea and R. nigrum metabolomic spectra in the setting of Northwest Russia. …”
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Angel or devil: the dual roles of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside in the development of liver injury based on integrating pharmacological techniques: a system... by Jiajie Jiang, Jiajie Jiang, Qixiu Wang, Qiang Wu, Bobin Deng, Cui Guo, Jie Chen, Jinhao Zeng, Yaoguang Guo, Xiao Ma

“…The histological analysis of liver tissue confirmed the regulatory effects of TSG, and a comprehensive analysis revealed the optimal protective dosage range was 27.27–38.81 mg/kg/d and the optimal toxic dosage range was 51.93–76.07 mg/kg/d. …”
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Deficit Irrigation and an IoT-Based System for Improving Yield and Water Use Efficiency of Winter Wheat Grown Under Semi-Arid Conditions by Salah Belkher, Basma Latrech, Wifak Bekri, Felix Markwordt, Mohamed Abdur Rahim, Corentin Dupont, Mohamed Ali Ben Abdallah, Hedi Daghari, Mourad Rezig

“…The adoption of deficit irrigation at 75% ETc based on smart tensiometers can be used as an effective strategy to optimize water use in winter wheat without compromising yield.…”
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Polycaprolactone for Hard Tissue Regeneration: Scaffold Design and In Vivo Implications by Fernanda Ramírez-Ruiz, Israel Núñez-Tapia, María Cristina Piña-Barba, Marco Antonio Alvarez-Pérez, Vincenzo Guarino, Janeth Serrano-Bello

“…Different techniques can be used to manufacture 3D scaffolds for bone tissue regeneration based on optimizing reproducible scaffolds with a controlled hierarchical porous structure like the extracellular matrix of bone. …”
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Evaluation of Expanded Clay and Tuff as Lightweight Agents in Concrete Stabilized with Nopal Mucilage and Aloe Vera by Daniel Mendoza-Goden, Rocio Rafaela Gallegos-Villela, Pedro Flores-Becerra, Josue Francisco Perez-Sanchez, Edgardo Jonathan Suarez-Dominguez, Arturo Palacio-Perez

“…The findings provide valuable insights into optimizing eco-friendly concrete mixtures with improved thermal retention, workability, and mechanical properties, offering a sustainable alternative for modern construction.…”
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Prognostic correlation analysis of multiple myeloma based on HALP score of peripheral blood before chemotherapy by CHEN Min, AN Liying, LIN Xiaojing, ZHAO Pan, ZOU Xingli, WEI Jin, NI Xun

“…The HALP score was calculated, and the optimal cutoff value for HALP was determined using X-tile software. …”
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Impact of the Number of Administered Systemic Treatment Lines on Local Response to Radiation Therapy for Multiple Myeloma by Andrea Emanuele Guerini, MD, Eneida Mataj, MD, Paolo Borghetti, MD, Luca Triggiani, Ludovica Pegurri, MD, Stefania Nici, Stefano Riga, Alessandra Tucci, MD, Angelo Belotti, MD, Marco Lorenzo Bonù, MD, Giorgio Facheris, MD, Stefano Maria Magrini, Luigi Spiazzi, Michela Buglione

“…The toxicity profile was optimal, as grade > 2 events during RT were reported only in 0.9% of cases. …”
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Ganciclovir Resistance-Linked Mutations in the HCMV <i>UL97</i> Gene: Sanger Sequencing Analysis in Samples from Transplant Recipients at a Tertiary Hospital in Southern Brazil by Anna Caroline Avila da Rocha, Grazielle Motta Rodrigues, Alessandra Helena da Silva Hellwig, Dariane Castro Pereira, Fabiana Caroline Zempulski Volpato, Afonso Luís Barth, Fernanda de-Paris

“…<b>Conclusions:</b> The optimized Sanger sequencing protocol provides a cost-effective solution for detecting GCV resistance mutations in HCMV <i>UL97</i> among transplant recipients. …”
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Salinity Tolerance of Artificially Restored Vegetation Under Different Irrigation Strategies in Arid, Abandoned Mining Areas by Aishajiang Aili, Yuguang Zhang, Tao Lin, Hailiang Xu, Abdul Waheed, Wanyu Zhao, Jia Wang, Chuhan Wang

“…<i>C. mongolicum</i>, however, displayed optimal vertical growth under border irrigation, although drip irrigation promoted a denser, more compact crown structure. …”
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Residency training programs to support residents working in First Nations, Inuit, and Métis communities by Marghalara Rashid, Julie Nguyen, Wayne Clark, Jessica L. Foulds, Ida John, Ming-Ka Chan, Molly Whalen-Browne, Pamela Roach, Melanie Morris, Sarah Forgie

“…We present educational recommendations for residency programs to optimize First Nations, Inuit and/or Métis health educational experiences and provide residents with skills to provide effective and culturally safe care.…”
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Determination of Puberulic Acid in Monascus-Fermented Red Yeast Rice by LC-MS/MS Combined with Precolumn Derivatization by Hui-Qin Pan, Rui Feng, Yan-Nan Tan, Xiao-Ya Qin, Yi-Min Cao, Xiu-Hong Mao, Qing Hu, Heng Zhou

“…The methylating derivatization with trimethylsilyldiazomethane (TMSCHN₂) was performed to enhance its analytical performance. To achieve optimal detection sensitivity, the amount of solvent and TMSCHN₂ for the derivatization reaction, along with the reaction time, were individually optimized. …”
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Innovative determination of phytohormones in Aloe vera by Muhammad K. Hakeem, Meera Maraqa, Sampath K. Elangovan, Sampath K. Elangovan, Esam Eldin Saeed, Ajay Kumar Mishra, Khaled M. Hazzouri, Iltaf Shah, Iltaf Shah, Khaled M. A. Amiri

“…The sample extraction process and mobile phase composition were optimized to enhance chromatographic separation and mass spectrometry sensitivity. …”
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Extracellular Lipase from Pseudomonas aeruginosa SB-37: Production by Solid State Fermentation, Immobilization, and Characterization by Titin Haryati, Norman Yoshi Haryono, Dian Nugraheni, Fenti Fatmawati, Alfina Kusuma Dewi, Muhammad Zahran Edlian Syach

“…To obtain high lipase production using SSF methods, we optimized the type of agro-wastes substrates, fermentation time, oil induction percentage and volume of preculture percentage. …”
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Incorporating insulin into alginate-chitosan 3D-printed scaffolds: A comprehensive study on structure, mechanics, and biocompatibility for cartilage tissue engineering by Afsaneh Jahani, Mohammad Sadegh Nourbakhsh, Ali Moradi, Marzieh Mohammadi, Lobat Tayebi

“…This research aims to develop to yield mechanically optimized, bioactive 3D-printed scaffolds for regulated delivery of Insulin to promote cartilage regeneration.…”
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Advancements in lamb wave high-frequency devices using diamond-like carbon (DLC) coatings by Jatinder Pal Singh, Ajay Kumar Sao, Babita Sharma, Satyam Garg, Anjali Sharma, Reema Gupta, Lokesh Rana, Mallika Verma, Akhilesh Pandey, Archibald Theodore Nimal, Upendra Mittal, Amit Kumar Vishwakarma, Monika Tomar, Arijit Chowdhuri

“…The outcomes of this research underscore the potential of DLC coatings to optimize the Lamb wave device functionalities, promising enhanced performance and broader applications. …”
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Impact of prior CAR T-cell therapy on mosunetuzumab efficacy in patients with relapsed or refractory B-cell lymphomas by Elise A. Chong, Elicia Penuel, Ellen B. Napier, Rachel K. Lundberg, Lihua E. Budde, Mazyar Shadman, Matthew J. Matasar, Nancy L. Bartlett, Ian W. Flinn, Francesc Bosch, Keith Fay, Andre Goy, Anita Kumar, Loretta J. Nastoupil, Michael C. Wei, Mei Wu, Shen Yin, Joseph A. Fraietta, Emeline R. Chong, Stephen J. Schuster

“…Abstract: Mosunetuzumab and other CD20/CD3 bispecific antibodies (BsAbs) have efficacy in B-cell lymphomas relapsing after or refractory to CD19-directed chimeric antigen receptor (CAR)–modified T cells (CAR-T). The optimal timing of BsAbs and biomarkers of BsAb response after CAR-T are unknown. …”
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Isolation of competent actinomycetes strains from soil planted with three species of mint irrigated with olive mill wastewater by Oumaima Beroigui, Lahsen El Ghadraoui, Faouzi Errachidi

“…The application of 5 L of OMWW per m² is optimal for maximum hydrolytic enzyme production by actinomycetes. …”
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Comparative and synergistic impacts of lime and biochar on soil properties, nitrogen transformation, and microbial function in acidic soils under tobacco cropping by Bianhong Zhang, Lina Tang, Zhicheng Chen, Xiaoyan Chen, Lindong You, Ruixin Pan, Ting Chen, Yifei Liu, Wenxiong Lin, Wenxiong Lin, Jinwen Huang

“…This study offers valuable insights into the synergistic use of lime and biochar for mitigating soil acidification and optimizing nitrogen management in agricultural systems.…”
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Online Determination of Sm, Eu and Yb in Environmental Samples by Inductively Coupled Plasma – Optical Emission Spectrometry by J. Dilip Kumar, P. Reddy Prasad, B. Krishna Priya, P. Subrahmanyam S. Ramanaiah, P. Chiranjeevi

“…The sorbed element was subsequently eluted with 0.4 M HNO3 and the acid eluates were analyzed by ICP-OES. Under the optimal conditions, Sm, Eu and Yb in aqueous samples were concentrated 100-fold. …”
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