Metabolic reprogramming and immunological changes in the microenvironment of esophageal cancer: future directions and prospects by Zhi-Xun Guo, Jia-Li Ma, Jin-Qiu Zhang, Ling-Ling Yan, Ying Zhou, Xin-li Mao, Xin-li Mao, Xin-li Mao, Shao-Wei Li, Shao-Wei Li, Shao-Wei Li, Xian-Bin Zhou, Xian-Bin Zhou, Xian-Bin Zhou

“…Immunotherapy, particularly immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 pathway, has exhibited promising results; however, a substantial proportion of patients remain unresponsive. The optimization of these immunotherapies requires further investigation. …”
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Treatment of Helicobacter pylori infection: mainstream and innovations (Review of the literature and Russian gastroenterological association Advisory council resolution, May 19, 20... by V. T. Ivashkin, I. V. Mayev, T. L. Lapina, A. A. Sheptulin, A. S. Trukhmanov, R. A. Abdulkhakov, S. A. Alekseyenko, N. N. Dekhnich, R. S. Kozlov, I. L. Klyaritskaya, S. A. Kurilovich, M. F. Osipenko, V. I. Simanenkov, I. B. Khlynov

“…To present data of clinical trials, systematic reviews and metaanalyses which allow to optimize eradication therapy of Helicobacter pylori (H. pylori) infection. …”
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Unveiling sequence-agnostic mixed-chemical modification patterns for splice-switching oligonucleotides using the NATURA platform by Tommaso Tabaglio, Taniya Agarwal, Wei Yuan Cher, Jin Rong Ow, Ah Keng Chew, Priscila Yun Qian Sun, Raja Sekhar Reddy Gurrampati, Hongfang Lu, Praveena Naidu, Hong Kai Ng, Xavier Le Guezennec, Shi Yan Ng, Manikandan Lakshmanan, Ernesto Guccione, Keng Boon Wee

“…Chemical optimization of ribose has significantly advanced nucleic acid therapeutics (NATs) by improving the stability, specificity, and safety of therapies like small interfering RNAs, CRISPR-Cas9 guide RNAs, and GAPmers. …”
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Pengukuran Kapabilitas Tata Kelola TI Sistem Informasi Tiras dan Transaksi Bahan Ajar Universitas Terbuka Menggunakan Cobit 5 by Denisha Trihapningsari, Dewi Agushinta R., Lintang Yuniar Banowosari

“…The achievement of the capability level is expected by management for the process being evaluated is the optimizing process level (level 5). It can be shown that the organization has not fully implemented some best practices for the process being evaluated, even there are already IT governance service standards but it has not been implemented optimally. …”
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Formation of forest mensuration indicators of Pseudotsuga menziesii (Mirb.) Franco in artificial plantations of the western region of Ukraine by Iurii Debryniuk, Stepan Myklush, Yuriy Myklush

“…It was not possible to establish final recommendations regarding optimising the initial planting density and the subsequent optimal proportion of Pseudotsuga menziesii within stand composition, which would ensure its maximum productivity. …”
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Remote sensing-based maize growth process parameters revel the maize yield: a comparison of field- and regional-scale by Minghan Cheng, Xiuliang Jin, Chenwei Nie, Kaihua Liu, Tianao Wu, Yuping Lv, Shuaibing Liu, Xun Yu, Yi Bai, Yadong Liu, Lin Meng, Xiao Jia, Yuan Liu, Lili Zhou, Fei Nan

“…Abstract The accurate estimation of regional crop yields holds significant importance for optimizing subsequent resource allocation and maximizing economic returns in agriculture. …”
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Advances of wearable silicone rubber-based triboelectric nanogenerators: from manufacturing to application by Dianlong Shen, Taili Du, Fangyang Dong, Hu Cai, Aziz Noor, Xiannan Du, Yongjiu Zou, Chengkuo Lee, Minyi Xu

“…Given that the manufacturing method of SR-TENGs largely determines its output performance and sensitivity, this paper introduces the design of SR-TENGs, including material selection, process modulation, and structure optimization. Additionally, this article discusses the current challenges in the SR-TENG fabrication technology and potential future directions, aiming to promote the effective development of SR-TENGs in biomechanical energy harvesting and self-powered sensing applications.…”
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Prediksi Kesiapan Sekolah Menggunakan Machine Learning Berbasis Kombinasi Adam dan Nesterov Momentum by Indah Mustika Rahayu, Ahmad Yusuf, Mujib Ridwan

“…The research used Artificial Neural Network algorithms with a combination of Adam and Nesterov Momentum optimization method. Model testing used a 5-fold cross validation scenario. …”
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Evidence-based clinical standard for the diagnosis and treatment of candidemia in critically ill patients in the intensive care unit by Jorge Alberto Cortés, Martha Carolina Valderrama-Rios, Paula M. Peçanha-Pietrobom, Moacyr Silva Júnior, Cándida Diaz-Brochero, Rafael Ricardo Robles-Torres, Carmelo José Espinosa-Almanza, Laura Cristina Nocua-Báez, Marcio Nucci, Carlos Arturo Álvarez-Moreno, Flavio Queiroz-Telles, Ricardo Rabagliati, Rita Rojas-Fermín, Jorge L. Finquelievich, Fernando Riera, Patricia Cornejo-Juárez, Dora E. Corzo-León, Luis E. Cuéllar, Jeannete Zurita, Augusto Raúl Hernández, Arnaldo Lopes Colombo

“…These guidelines are part of the efforts to implement antifungal optimization programs in the region to obtain better clinical outcomes and promote rational antifungal use. …”
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New era towards autonomous additive manufacturing: a review of recent trends and future perspectives by Haolin Fan, Chenshu Liu, Shijie Bian, Changyu Ma, Junlin Huang, Xuan Liu, Marshall Doyle, Thomas Lu, Edward Chow, Lianyi Chen, Jerry Ying Hsi Fuh, Wen Feng Lu, Bingbing Li

“…Additionally, this paper discusses the role of AI in self-optimization and lifelong learning, positing that the future of AM will be characterized by a symbiotic relationship between human expertise and advanced autonomy, fostering a more adaptive, resilient manufacturing ecosystem.…”
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Fracture-seepage characteristic zones of the overburden of extra-thick coal seams: Evolutionary patterns and their engineering applications by Xiangguo KONG, Tianshuo ZHAO, Haifei LIN, Pengxiang ZHAO, Xu WANG, Yuchu CAI, Pengfei JI, Di HE, Ke LI, Chuanyu XU

“…The results of this study will provide some theoretical guidance for the optimization of borehole parameters for gas extraction and the gas control of coal seams.…”
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Coronary Heart Disease Risk Prediction Model Based on Machine Learning by YUE Haitao, HE Chanchan, CHENG Yuyou, ZHANG Sencheng, WU You, MA Jing

“…Among them, the XGBoost model exhibited superior performance and can be referenced for future optimization of CHD prediction models. Additionally, considering the excellent performance of the XGBoost model and the convenience and interpretability of stepwise logistic regression, a combined use of these approaches after data balancing is recommended in CHD risk prediction models.…”
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Evaluasi TKTI Puri Saron Hotel Seminyak dengan Framework Cobit 5 by Norsa Yudhi Arso, Made Wisnu Antara Kesiman, Dewa Gede Hendra Divayana

“…Abstract   The Puri Saron Hotel Seminyak evaluates Information Technology (IT) governance to address issues such as the efficiency and effectiveness of IT management, optimization of facilities and infrastructure, and human resource management in order to provide an overview of current conditions, mapping by domain, and recommendations for improve the quality of IT governance. …”
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The Impact of Bacterial Leaf Blight Disease (<i>Pantoea agglomerans</i>) on Grain Yield and Nutritional Quality of Oat by Ruochen Zhang, Jianjun Wang, Longhai Xue, Malik Kamran, Yue Wang, Xuekai Wei, Guiqin Zhao, Chunjie Li

“…However, leaf diseases have become a crucial factor limiting the increase in oat grain yield and the optimization of its nutritional quality. Among these, the bacterial leaf blight disease (LBD) caused by <i>Pantoea agglomerans</i> has been an emerging and prevalent oat disease in Northwest China in recent years and has become a major challenge for oat cultivation in this region. …”
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Investigation on Circadian Regulation of Four-Primary LED Display Differed in People by GA by Wenhui Li, Junying Li, Yating Feng, Yi Lin, Haoyang Liu, Ruoping Lian, Qinzhen Lin, Jingyi Cui, Zixin Huang, Yaling Chai, Ziquan Guo, Lili Zheng, Zhong Chen

“…Then, the genetic algorithm is adopted for performing the spectral optimization of four-primary LED display while many constraint conditions are set, such as CCT values (2700 K and 6500 K), CCT tolerance, and color distance (<italic>D</italic>_uv &lt; 0.01) in the CIE 1960 UCS color space. …”
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Sistem Monitoring Trafo Distribusi PT.PLN (Persero) berbasis IoT by Budi Eko Prasetyo, Widhy Hayuhardhika Nugraha Putra, Dahnial Syauqy, Adhitya Bhawiyuga, Sigi Syah Wibowo, Ferdian Ronilaya, Indrazno Siradjuddin, Supriatna Adhisuwignjo

“…After getting the data, DTMS will do the calculation to get recommendation of transformer optimization such as balancing, maintenance or power uprating. …”
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Innovations and Challenges in Intermediate Respiratory Care Units: Toward Effective Integration into the Hospital System by Beatriz Jara Chinarro, Laura Pazos Rodriguez, Miguel Cuchí Alfaro, Ainhoa Izquierdo Pérez, Silvia Aguado Ibañez, María Churruca Arrospide, Marta Soler Vigil, Cristina Moral, Carlos Almonacid

“…They reduce ICU admission rates, resulting in substantial cost savings for hospitals.Our analysis indicates that while IRCUs contribute positively to patient outcomes and resource optimization in Spain, there are significant challenges related to heterogeneity in unit structures, staffing, and resource allocation. …”
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Potentially commercializable nerve guidance conduits for peripheral nerve injury: Past, present, and future by Chundi Liu, Mouyuan Sun, Lining Lin, Yaxian Luo, Lianjie Peng, Jingyu Zhang, Tao Qiu, Zhichao Liu, Jun Yin, Mengfei Yu

“…The clinical conduit materials and prospective optimal materials are thoroughly discussed. The add-on strategies, together with their distinct obstacles and potentials are deeply analyzed. …”
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The use of antimicrobials in Italian buffalo farms by Gabriele Di Vuolo, Federico Scali, Claudia Romeo, Valentina Lorenzi, Chiara D. Ambra, Maria Serrapica, Giovanna Cappelli, Francesca Fusi, Esterina De Carlo, Giovanni Loris Alborali, Luigi Bertocchi, Domenico Vecchio

“…Therefore, there is growing institutional attention to implementing actions for the optimization of AMU. In particular, the World Health Organization’s Global Plan of Action on Antimicrobial Resistance recommends a close intersectoral collaboration between public health and animal health (One Health). …”
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Gas drainage and utilization in coal mines in China: History, technological advances, and prospects by Guofu LI, Chao LI, Bichuan ZHANG, Yun XU, Zheng WANG, Xianjun ZHOU

“…Prospects Gas drainage and utilization technologies for coal mines will focus on the development of the advanced gas pre-drainage technology system for ten-year planning areas, the expansion of the simultaneous extraction of coal and gas mode, the optimization of gas utilization processes from the source, the improvement in the intelligent level of gas drainage pipeline networks, and the implementation of gas utilization projects via government-industry-university-institute collaborations. …”
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