A novel imatinib analogue inhibitor of chronic myeloid leukaemia: design, synthesis and characterization—explanation of its folded conformation by Rodolfo Moreno-Fuquen, Juan F. Avellaneda-Tamayo, Kevin Arango-Daraviña, Javier Ellena, Alan R. Kennedy

“…These findings suggest that PAPP could be a promising scaffold for future CML drug design, offering a potential alternative to existing TKIs, and PAPP1 is a promising lead susceptible to optimization.…”
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Pathogenetic Substantiation of the Therapeutic Impact on Microbiota in Irritable Bowel Syndrome by Yu. O. Shulpekova, G. H. Babaeva, V. Yu. Rusyaev

“…For the pathogenetic treatment of irritable bowel syndrome, the use of non-drug treatment is justified, such as diet optimization and prescription of plant fibres and probiotic bacterial strains. …”
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Extrapolation of cavitation and hydrodynamic pressure in lubricated contacts: a physics-informed neural network approach by Faras Brumand-Poor, Freddy Kokou Azanledji, Nils Plückhahn, Florian Barlog, Lukas Boden, Katharina Schmitz

“…By integrating physical laws into the parameter optimization of the neural network (NN), PINNs provide accurate and fast solutions. …”
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Structure of Spatial Correlation Network and Influencing Factors of Urban-Rural Integration in China by Wang Kai, Liu Meilun, Tan Jiaxin, Gan Chang

“…Accordingly, this study proposes countermeasures to optimize the spatial correlation network of urban-rural integration in China. …”
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Computational Modeling and Experimental Investigation of CO₂-Hydrocarbon System Within Cross-Scale Porous Media by Feiyu Chen, Linghui Sun, Bowen Li, Xiuxiu Pan, Boyu Jiang, Xu Huo, Zhirong Zhang, Chun Feng

“…The proposed model offers a more precise framework for evaluating phase transitions in unconventional reservoirs, aiding in the optimization of CO₂-based enhanced oil recovery strategies.…”
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Treatment of inoperable pancreatic adenocarcinoma with focused ultrasound and microbubbles in patients receiving chemotherapy by Margrete Haram, Rune Hansen, Ola Finneng Myhre, Stian Solberg, Naseh Amini, Bjørn Atle Angelsen, Catharina de Lange Davies, Eva Hofsli

“…Reducing the time between chemotherapy and injection of MB and FUS and optimization of ultrasound parameters may improve the treatment effect. …”
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Study on the Noise Reduction of Vehicle Exhaust NOX Spectra Based on Adaptive EEMD Algorithm by Kai Zhang, Yujun Zhang, Kun You, Ying He, Qiankun Gao, Guohua Liu, Chungui He, Yibing Lu, Boqiang Fan, Qixing Tang, Wenqing Liu

“…In this paper, an adaptive ensemble empirical mode decomposition (EEMD) denoising model based on a special normalized index optimization is proposed and used in the spectral noise reduction of vehicle exhaust NOX. …”
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EDEM-based study on the adjustable feeding parameters of square bale maize straw bale-breaking device. by Tiejun Wang, Tinghe Zhang, Shuai Yu, Hongguang Cui, Ruili Wang

“…In the interaction of factors, x1x2 and x2x3 had an extremely significant impact, and x1x3 had a significant impact on Y1; x1x2, x1x3 and x2x3 had a significant impact on Y2. The optimal structure and working parameters combination were determined to be 1448 rpm for x1, 268 mm for x2, and 14 pieces for x3. …”
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Towards faster plan adaptation for proton arc therapy using initial treatment plan information by Benjamin Roberfroid, Margerie Huet-Dastarac, Elena Borderías-Villarroel, Rodin Koffeing, John A. Lee, Ana M. Barragán-Montero, Edmond Sterpin

“…Materials and Methods: The proposed workflow transfers spots from initial computed tomography (CT) to the CT of the day, updates energy layers considering the initial pattern, and re-optimizes selected transferred spots based on their initial weights and impact on the objective function.A retrospective study was conducted on five head and neck patients who underwent plan adaptation on a repeated CT. …”
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SHASI-ML: a machine learning-based approach for immunogenicity prediction in Salmonella vaccine development by Ottavia Spiga, Ottavia Spiga, Ottavia Spiga, Anna Visibelli, Francesco Pettini, Bianca Roncaglia, Annalisa Santucci, Annalisa Santucci, Annalisa Santucci

“…The methodology can be applied to guide and optimize both research and industrial-scale production of Salmonella vaccines, potentially accelerating the development of more effective immunization strategies.…”
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Graph Neural Network-Based Approach for Detecting False Data Injection Attacks on Voltage Stability by Shahriar Rahman Fahim, Rachad Atat, Cihat Kececi, Abdulrahman Takiddin, Muhammad Ismail, Katherine R. Davis, Erchin Serpedin

“…A graph autoencoder-based detector that is able to identify cyberattacks targeting voltage regulation is proposed. A bi-level optimization approach is put forward to concurrently optimize the objectives of both attackers and defenders in the context of voltage regulation. …”
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Production, Purification, and Characterization of Thermostable α-Amylase Produced by Bacillus licheniformis Isolate AI20 by Yasser R. Abdel-Fattah, Nadia A. Soliman, Nabil M. El-Toukhy, Hamada El-Gendi, Rania S. Ahmed

“…An optimization strategy, based on statistical experimental design, is employed to enhance the production of thermostable α-amylase by a thermotolerant B. licheniformis AI20 isolate. …”
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Performance Improvements of Selective Emitters by Laser Openings on Large-Area Multicrystalline Si Solar Cells by Sheng-Shih Wang, Jyh-Jier Ho, Jia-Jhe Liou, Jia-Show Ho, Wei-Chih Hsu, Wen-Haw Lu, Song-Yeu Tsai, Hsien-Seng Hung, Kang L. Wang

“…Laser fluences can vary in range of 2–5 J/cm2. The optimal conversion efficiency of 15.95% is obtained with the SE3 (2 J/cm2 fluence) after laser opening with optimization of heavy and light dopant, which yields a gain of 0.48%abs compared with that of a reference cell (without fluence). …”
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Extraction of Saponins from Xanthoceras sorbifolium Bunge Leaves Using Deep Eutectic Solvents and Their Inhibitory Activity against Postharvest Pathogenic Fungi by Xue LI, Xinyu CHU, Erzheng SU, Jiahong WANG

“…Among these, choline chloride:lactic acid (1:1) exhibited the highest yield was therefore chosen as the extraction solvent. Optimization of the extraction procedure was carried out through one-way and Box-Behnken experiments. …”
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Sensitivity to Initial Data Errors in Interpreting Temperature Logging of an Isolated Injection Well Segment by K. A. Potashev, D. R. Salimyanova, A. B. Mazo, A. A. Davletshin, A. V. Kosterin

“…An algorithm to automatically scale one of the method’s parameters (step length) was developed, and the optimal value of the second parameter (inertial step) was calculated. …”
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A Comprehensive Review of Artificial Intelligence (AI) Applications in Pulmonary Hypertension (PH) by Sogol Attaripour Esfahani, Nima Baba Ali, Juan M. Farina, Isabel G. Scalia, Milagros Pereyra, Mohammed Tiseer Abbas, Niloofar Javadi, Nadera N. Bismee, Fatmaelzahraa E. Abdelfattah, Kamal Awad, Omar H. Ibrahim, Hesham Sheashaa, Timothy Barry, Robert L. Scott, Chadi Ayoub, Reza Arsanjani

“…Furthermore, we explore the potential of AI in risk stratification, leading to treatment optimization for PH. <i>Conclusions:</i> While acknowledging the existing challenges and limitations and the need for continued exploration and refinement of AI-driven tools, this review highlights the significant promise of AI in revolutionizing PH management to improve patient outcomes.…”
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Investigation of Mechanical and Tribological Characteristics of Medical Grade Ti6al4v Titanium Alloy in Addition with Corrosion Study for Wire EDM Process by S. Prakash, C. S. Abdul Favas, I. Ameeth Basha, R. Venkatesh, M. Prabhahar, V. P. Durairaj, K. Gomathi, Haiter Lenin

“…By comparing the Modified Differential Evolution (MDE) approach to the basic differential evolution (DE) optimization strategy, the effectiveness of the MDE approach has been established. …”
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I. Ivkovic-Kihic, M. Read, Sh. Rane, A. Kovacevic. «Compressors and their systems». Post conference report / trans. from Engl. M. A. Fedorova by M. A. Fedorova

“…At this prestigious scientific and educational forum, within the framework of the plenary session, world experts made reports in the field of compressor technology and de-carbonization, as well as presentations at several technical and panel sessions on such topics as screw, scroll, vane and piston compressors; compressor systems and their diagnostic and control systems; turbo-machines; mathematical modeling and optimization of compressors, expanders and their systems. …”
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Rapid Detection of microRNA-122 in Serum and Finger Blood Using a Lateral Flow Nucleic Acid Biosensor by Min Zhang, Meijing Ma, Jiahui Wang, Yurui Zhou, Xueji Zhang, Guodong Liu

“…The principle of detecting miR-122 is based on dual DNA-miRNA hybridization reactions on the LFNAB to form sandwich-type AuNP-Det-DNA-miR-122-Cap-DNA complexes, which are captured on the test area of LFNAB for visualization and quantification. After systematic optimization of conditions of experiment, the response of LFNAB was highly linear within the scope of 0 pM-100 pM miR-122, and the detection limit in 15 min was 3.90 pM. …”
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Application of 2D polymerase chain reaction for single-tube detection of high-risk human papillomaviruses by Weifeng Wang, Min Jiang, Ying Liu, Xuan Wu, Yan Chen, Xiaoyun Zhang, Weiwei Liu

“…The 2D PCR system underwent optimization, with its detection performance assessed in terms of specificity and sensitivity. …”
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