Undoped ruthenium oxide as a stable catalyst for the acidic oxygen evolution reaction by Jiayi Tang, Daqin Guan, Hengyue Xu, Leqi Zhao, Ushtar Arshad, Zijun Fang, Tianjiu Zhu, Manjin Kim, Chi-Wen Pao, Zhiwei Hu, Junjie Ge, Zongping Shao

“…While considerable progress has been made in designing doped Ru oxides and composites to improve stability, the uncertainty in true failure mechanism in acidic oxygen evolution reaction inhibits their further optimization. This study reveals that proton participation capability within Ru oxides is a critical factor contributing to their instability, which can induce catalyst pulverization and the collapse of the electrode structure. …”
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A Cost-Effective and Robust Cell-Based Bioassay Method for Evaluating the Bioactivity of Trastuzumab-like Antibodies by Pooja Bharali, Subhash Chand, Harish Chander

“…<b>Results:</b> The SKBR3 cell line was found to express the HER2 receptors significantly higher in comparison to the other cell lines, and it was thereby selected for further bioassay optimization. The biological activity of trastuzumab was determined using the inhibition of proliferation (IOP) assay on the SKBR3, which was optimized based on the parameters of cell seeding density, drug dilution range, and incubation time, and it was further validated as per the compendial guidelines and found valid for the parameters of specificity, accuracy (% relative bias = 0.0067%), precision (repeatability: % GCV = 1.21%), linearity (R2 = 0.99), and range (50% to 200%). …”
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A 3D Porous Gelatin-Alginate-Based-IPN Acts as an Efficient Promoter of Chondrogenesis from Human Adipose-Derived Stem Cells by Sorina Dinescu, Bianca Galateanu, Eugen Radu, Anca Hermenean, Adriana Lungu, Izabela Cristina Stancu, Dana Jianu, Tudorita Tumbar, Marieta Costache

“…Recent CTE approaches rely on optimal cell-scaffold interactions, which require a great deal of optimization. …”
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Solving Nonlinear Energy Supply and Demand System Using Physics-Informed Neural Networks by Van Truong Vo, Samad Noeiaghdam, Denis Sidorov, Aliona Dreglea, Liguo Wang

“…The neural network model is then trained, and the parameters are identified and optimized to achieve a more accurate solution. The solutions obtained from the neural network for this problem are equivalent when we compare and evaluate them against the Runge–Kutta numerical method of order 5(4) (RK45). …”
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Clinical efficacy of various resuscitation fluids in the management of sepsis in postoperative surgical and trauma patients: a systematic review and meta‑analysis by Yongjie Wang, Kewu Chen, Xiaolu Li, Jianing Guan

“…Still, there are significant ambiguities regarding the most suitable fluid type that would ensure optimization of patient outcomes. Aim: The aim of this systematic review and meta-analysis was to assess the clinical effectiveness of different resuscitation fluids for sepsis management in critically hypotensive patients. …”
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Changes in Vowel Articulation with Subthalamic Nucleus Deep Brain Stimulation in Dysarthric Speakers with Parkinson’s Disease by Vincent Martel Sauvageau, Joël Macoir, Mélanie Langlois, Michel Prud’Homme, Léo Cantin, Johanna-Pascale Roy

“…Results suggest that STN DBS may improve articulation in dysarthric speakers with PD, in terms of range of movement. Optimization of the electrical parameters for each patient is important and may lead to improvement in speech fine motor control. …”
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Effects of Dietary Protein to Lipid Ratio and Insect Meal on Growth Performance, Feed Utilization, and the Gut Microbiome of Lake Whitefish (Coregonus clupeaformis) by Rebecca Lawson, Yubing Chen, Junyu Zhang, Marcia A. Chiasson, Jennifer Ellis, Dominique Bureau, Richard D. Moccia, David Huyben

“…However, further work on targeted breeding and genetic selection of broodstock, together with diet optimization, is needed to improve the growth performance and nutrient utilization in order to enable an effective, economical, and environmentally sustainable culture of lake whitefish.…”
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Research advances of metal fluoride for energy conversion and storage by Runlin Zhang, Zijin Xu, Zeyu Hao, Zeshuo Meng, Xiufeng Hao, Hongwei Tian

“…In this paper, we summarize the difficulties and improvement methods encountered in different types of battery applications and several typical electrode optimization strategies in the field of supercapacitors. …”
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Recent progress of artificial cells in structure design, functionality and the prospects in food biotechnology by Li Li, Xiaolin Yao, Guoliang Li, Qianqian Guo, Juan Yue, Wenguang Liu, Yapeng Fang, Adam Midgley, Mouming Zhao, Katsuyoshi Nishinari

“…They are anticipated to significantly enhance advancements in food science, particularly in cellular structure optimization, precise nutrition delivery, targeted nutrient release, and rapid detection methods. …”
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Quantum chemical study of molecular properties of small branched-chain amino acids in water by Roman Boča, Žofia Rádiková, Juraj Štofko, Beata Vranovičová, Cyril Rajnák

“…B3LYP hybrid version of DFT was used for geometry optimization and a full vibrational analysis of neutral molecules, their cations and anions in the canonical and zwitterionic forms (6 forms for each species). …”
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A Low-Cost Layered Double Hydroxide (LDH) Based Amperometric Sensor for the Detection of Isoproturon in Water Using Carbon Paste Modified Electrode by Herve Leclerc Tcheumi, Aude Peggy Kameni Wendji, Ignas Kenfack Tonle, Emmanuel Ngameni

“…Other parameters that can affect the stripping response (preconcentration time, pH of detection medium, and LDH loading within the paste) were investigated to optimize the proposed sensor. After optimization, a linear calibration curve was obtained in the concentration range from 2 × 10−8 to 1.8 × 10−7 M, leading to a detection limit of 1 × 10−9 M (S/N = 3). …”
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Extracorporeal hyperoxygenation therapy (EHT) for CO poisoning: in vitro and in vivo feasibility of a full-scale batch system by Niklas B. Steuer, Hannah Lüken, Peter C. Schlanstein, Matthias F. Menne, Christiane Hoffmann, Cavan Lübke, Thomas Schmitz-Rode, Sebastian Victor Jansen, Ulrich Steinseifer, Rüdger Kopp

“…However, the EHT also induced oscillations in hemodynamic pressures due to changes in the animals’ circulatory volume during operation. After optimization, the EHT could be a promising option for treating CO poisoning.…”
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Propagation Laws of Blasting Seismic Waves in Weak Rock Mass: A Case Study of Muzhailing Tunnel by Lijun Chen, Jianxun Chen, Yanbin Luo, Yalong Guo, Yongjun Mu, Daochuan Zhong, Weiwei Liu, Tielun Yang, Weixiang Chen

“…In order to study the propagation laws of blasting vibration waves in weak rock tunnels, the longitudinal and circumferential blasting vibration tests in Muzhailing Tunnel were carried out, and the measured data were analyzed and studied using the methods of Sadov’s nonlinear regression, Fourier transform, and Hilbert–Huang transform (HHT) to provide a reference for the optimization of blasting design of Muzhailing Tunnel or similar weak rock tunnels. …”
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Application of the AHP and PROMETHEE II individual decision-making methods and the Condorcet group decision-making method in the Selection of a multipurpose armored wheeled combat... by Miša D. Živković, Darko I. Božanić, Milija M. Suknović, Boris V. Delibašić

“…Conclusion: Solving the problem involves taking into account the views of military experts regarding the optimization of multiple criteria to provide the best performance vehicle suitable for use in various missions. …”
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Green Analytical Method for Simultaneous Determination of Glucosamine and Calcium in Dietary Supplements by Capillary Electrophoresis with Capacitively Coupled Contactless Conducti... by Yen Nhi Do, Thi Lan Phuong Kieu, Thi Huyen My Dang, Quang Huy Nguyen, Thu Hien Dang, Cao Son Tran, Anh Phuong Vu, Thi Trang Do, Thi Ngan Nguyen, Son Luong Dinh, Thi Minh Thu Nguyen, Thi Ngoc Mai Pham, Anh Quoc Hoang, Bach Pham, Thi Anh Huong Nguyen

“…The CE analysis was performed in fused silica capillaries (50 μm inner diameter, 40 cm total length, 30 cm effective length), and the analytical time was around 5 min. After optimization, the CE conditions for selective determination of glucosamine and Ca2+ were obtained, including a 10 mM tris (hydroxymethyl) aminomethane/acetic acid (Tris/Ace) buffer of pH 5.0 as the background electrolyte; separation voltage of 20 kV; and hydrodynamic injection (siphoning) at 25 cm height for 30 s. …”
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Immunotherapy in Recurrent Ovarian Cancer by Keyao Chen, Jingjing Wang, Meng Yang, Shaoqiong Deng, Li Sun

“…Several potential biomarkers have been identified, potentially aiding in patient stratification and treatment optimization. Conclusions: Immunotherapy significantly advances recurrent ovarian cancer treatment, with various combinations potentially improving outcomes. …”
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Deep Ensemble Learning for Human Action Recognition in Still Images by Xiangchun Yu, Zhe Zhang, Lei Wu, Wei Pang, Hechang Chen, Zhezhou Yu, Bin Li

“…Subsequently, in order to further exploit the advantage of the nonsequential topology, we propose an end-to-end deep ensemble learning based on the weight optimization (DELWO) model. It contributes to fusing the deep information derived from multiple models automatically from the data. …”
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Heterologous Expression and Adaptive Evolution of ε-Poly-lysine Synthase Gene in <i>Corynebacterium glutamicum</i> by Long Pan, Yihang Chen, Aimei Liao, Yinchen Hou, Jihong Huang

“…In this experiment, a recombinant <i>C. glutamicum</i> capable of synthesizing ε-PL and exhibiting certain physiological resistance to ε-PL was obtained by amplifying <i>pls</i> and heterologous expression in <i>C. glutamicum</i> for the first time. Further optimization of the fermentation temperature, initial pH, and inoculation amount of the recombinant strain resulted in an increase in the ε-PL fermentation yield from 0.12 g/L to 0.22 g/L. …”
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A Novel Change Detection Method Based on Visual Language From High-Resolution Remote Sensing Images by Junlong Qiu, Wei Liu, Hui Zhang, Erzhu Li, Lianpeng Zhang, Xing Li

“…Specifically, on the text side, we use context optimization to align text&#x2013;image semantics. On the image side, we construct a side fusion network, which integrates universal features from the foundation model with domain-specific features from remote sensing through a bridging module. …”
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Enhancing cardiac assessments: accurate and efficient prediction of quantitative fractional flow reserve by Arshia Eskandari, Sara Malek, Alireza Jabbari, Kian Javari, Nima Rahmati, Behrad Nikbakhtian, Bahram Mohebbi, Seyed Ehsan Parhizgar, Mona Alimohammadi

“…The invasive FFR results reported by the clinic have validated the optimized model.ResultsThe computational FFR data derived from all methodologies are compared with those reported by the clinic for each case. …”
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