Research on the Spatial Network Connection Characteristics and Influencing Factors of Chengdu–Chongqing Urban Agglomeration from the Perspective of Flow Space by Yangguang Hao, Zhongwei Shen, Jiexi Ma, Jiawei Li, Mengqian Yang

“…The findings of this study can provide a scientific basis for the construction and optimization of the spatial connectivity pattern of the CCUA.…”
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Fruit Leather Melon Formulation with Supplementation of Pineapple Puree, Carrageenan and Sorbitol by Aini Nur, Nurfadilah Azzahra Salma, Setyawati Retno, Sustriawan Budi, Eko Kusuma Kurniawan Ruly, Sabila Arsyistawa Hadana, Putri Roro Arianti Embun

“…The research stages carried out included preliminary research, formulation optimization, data analysis, verification and validation, and characterization of the optimum product. …”
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Exploring molecular determinants and pharmacokinetic properties of IgG1-scFv bispecific antibodies by Kristina M.J. Aertker, Minu Ravindra Pilvankar, Tobias M. Prass, Michaela Blech, Fabian Higel, Srinath Kasturirangan

“…For numerous mAb therapeutics, optimization of neonatal Fc receptor (FcRn) interactions and elimination of unfavorable molecular properties have led to improved PK properties. …”
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An indoor positioning method based on bluetooth array/PDR fusion using the SVD-EKF by Chenhui Li, Jie Zhen, Jianxin Wu

“…The dynamic test results in the room show that after SVD-EKF algorithm optimization, the positioning error is reduced by 0.05m, which is equivalent to the EKF algorithm. …”
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Development of Hydrogenated Microcrystalline Silicon-Germanium Alloys for Improving Long-Wavelength Absorption in Si-Based Thin-Film Solar Cells by Yen-Tang Huang, Hung-Jung Hsu, Shin-Wei Liang, Cheng-Hang Hsu, Chuang-Chuang Tsai

“…However, the bias-dependent EQE measurement revealed that too much Ge incorporation in absorber deteriorated carrier collection and cell performance. With the optimization of RH2 and RGeH4, the single-junction μc-Si1-xGex:H cell achieved an efficiency of 5.48%, corresponding to the crystalline volume fraction of 50.5% and Ge content of 13.2 at.%. …”
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Experimental Study on Enhanced Condensate Recovery by Gas Injection in Yaha Condensate Gas Reservoir by Yiming Wu, Kun Yao, Yan Liu, Xiangyun Li, Mimi Wu, Ronghong Cheng, Bo Wang

“…To improve the recovery efficiency of condensate oil in the middle and late stages of production of a condensate gas reservoir, a gas injection parameter optimization test study was carried out, taking the Yaha gas condensate reservoir in China as an example. …”
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Data-driven prediction of critical diameter for deterministic lateral displacement devices: an integrated DPD-ML approach by Shuai Liu, Peng Zhang, Anbin Wang, Keke Tang, Shuo Chen, Chensen Lin

“…The high performance of DLD devices in various tasks relies on optimal design. However, current DLD design lacks clear guidance and heavily depends on expert experience, requiring extensive repetitive microfluidic experiments and numerical simulations. …”
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Large language models improve the identification of emergency department visits for symptomatic kidney stones by Cosmin A. Bejan, Amy M. Reed, Matthew Mikula, Siwei Zhang, Yaomin Xu, Daniel Fabbri, Peter J. Embí, Ryan S. Hsi

“…Leveraging a dataset of manually annotated ED reports, we developed strategies to enhance LLMs including prompt optimization, zero- and few-shot prompting, fine-tuning, and prompt augmentation. …”
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Chlorella’s transport inhibition: A powerful defense against high ammonium stress by Lihe Xu, Li Chen, Longxing Jiang, Jingni Zhang, Peike Wu, Wenguo Wang

“…This research enriches our understanding of microalgal molecular responses to high NH₄⁺ stress, paving the way for the development of engineered optimization strategies for microalgal bioremediation systems treating NH₄⁺-rich wastewater.…”
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Modified CD15/CD16-CLL1 inhibitory CAR-T cells for mitigating granulocytopenia toxicities in the treatment of acute myeloid leukemia by Rui Zhang, Yifan Zhao, Xiao Chai, Yingshuai Wang, Mohan Zhao, Shujing Guo, Yu Zhang, Mingfeng Zhao

“…Through extensive screening of structural optimization, we have successfully identified CD16-CLL1 iCAR-T cells that combine PD1 and 2B4 blockade, as well as a single VHH fragment replacing the entire CD16 scFv recognition domain. …”
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Designing EV Charging Energy Hubs to Meet Flexibility Requirements in Smart Grids by Walied Alfraidi, Fahad Alaql, Khalid AlMuhanna, Hassan M. Hussein Farh, Abdullrahman A. Al-Shamma’a

“…This study introduces a novel mathematical optimization model designed to maximize the operational flexibility of EV charging stations by transforming them into fully functional energy hubs. …”
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Modeling the digital transformation of industrial holdings by A. E. Miller, N. S. Rudenko

“…The proposed model allows you to: optimize the configuration of manufactured products and processes of its life cycle in terms of optimizing the added value of an industrial holding; integrate systems and processes, as well as the value chain of an industrial holding, the components of which are: optimization of production, environmental safety, cost reduction, asset productivity, productivity improvement, profitability growth and increase in the value of the holding.…”
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LUneXt: Simple and Efficient U-shaped Network Design for Medical Image Segmentation with Nonlinear Activation by Guanghong Deng, Bing Yu, Wenlong Jing, Yong Li, Xiaodan Zhao

“…Both normalized activations for the original negative input image activation have good optimization capabilities for the tokenization module parameters proposed in the original UneXt model. …”
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Weather resilience of the future Swiss electricity system with very high shares of variable renewable energy sources by Collin Killenberger, Nik Zielonka, Jan-Phillipp Sasse, Evelina Trutnevyte

“…To design weather-resilient electricity systems that rely on variable renewable energy sources (VRES), spatially-explicit modeling with several decades of historical weather data is necessary to avoid over-optimization to a single weather year. Here, we apply the electricity system model EXPANSE for Switzerland to search for resilient cost-optimal and near-optimal system designs in 2035 under various policy scenarios, using data from 25 historical weather years (1995–2019) for electricity demand, solar photovoltaics (PV), wind power, hydropower dams and run-of-river hydropower. …”
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A Framework for Privacy-Preserving in IoV Using Federated Learning With Differential Privacy by Muhammad Adnan, Madiha Haider Syed, Adeel Anjum, Semeen Rehman

“…Group Leader is used as an optimization of the overall framework including efficiency and implementation of the scheme. …”
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Journey across extrinsic tactics for power improvements of triboelectric energy harvesting beyond intrinsic materials and device structures: A concise review by Ahmed Mahfuz Tamim, Yebin Lee, Jung Hwan Park, Geon-Tae Hwang, Chang Kyu Jeong

“…The most promising approaches involve the optimization of material selection, surface modification, and chemical modification techniques to increase the triboelectric effect. …”
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Chemometric Methods—A Valuable Tool for Investigating the Interactions Between Antifungal Drugs (Including Antifungal Antibiotics) and Food by Agnieszka Wiesner-Kiełczewska, Paweł Zagrodzki, Alicja Gawalska, Paweł Paśko

“…Background/Objectives: Developing antifungal drugs with lower potential for interactions with food may help to optimize treatment and reduce the risk of antimicrobial resistance. …”
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High-level biosynthesis and purification of the antimicrobial peptide Kiadin based on non-chromatographic purification and acid cleavage methods by Liangjun Zheng, Fengyi Yang, Chen Wang, Muhammad Zafir, Zishuo Gao, Pilong Liu, Fatma A. El-Gohary, Xin Zhao, Huping Xue

“…The instability of the D–P peptide bond under acidic conditions, combined with the thermal and saline stability of DAMP4, enabled efficient separation of Kiadin through acid cleavage and isoelectric precipitation, yielding Kiadin with 96% purity and a production yield of 29.3 mg/L. Our optimization of acid cleavage temperature, duration, and isoelectric precipitation conditions proved critical for maximizing the purification efficiency and expression levels of Kiadin. …”
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Towards quantifying exfiltration from in situ sanitary sewer pipes by John F. Griffith, Joshua A. Steele, Adriana Gonzalez-Fernández, Kenneth C. Schiff

“…Future applications of this methodology should focus on method optimization, measurements at additional locations, and expanding measurements to collect data from additional types of pipe to better understand the geographic portability of the method and the relationship between exfiltration rates, pipe material, and pipe age.…”
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Molecular Mechanisms and Therapeutic Prospects of Immunotherapy and Targeted Therapy in Primary Central Nervous System Lymphoma by Lin Zhong MM, Anqing Lu MB, Xiyue Lu MM, Xiaoyin Liu MD, Lujia Cao MM, Shihong Zhu MM, SiJun Diao MM, Xu Cheng MM, Hongwei Wu MB, Jing Chen MD

“…Investigating the mechanisms, specific targets, and signaling pathways, as well as interactions with the tumor microenvironment (TME), can provide a solid foundation for further exploration and potentially enhance the optimization of treatment approaches for PCNSL. This review seeks to explore the characteristics of the TME in PCNSL, elucidate the molecular mechanisms of various immunotherapies and targeted therapies, examine their interactions with the TME, and summarize the advancements in the research of PCNSL immunotherapy and targeted therapy.…”
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