Correlation between serum homocysteine level and clinicopathological factors of IgA nephropathy by Cai Xiao-fan, Huang Jie-bo, Xing Yue, Cai Xiu-feng, Li Xue-ling, Zhong Yi-fei

“…The AUC of Hcy in predicting T and A was 0.751 （95%CI：0.699-0.803） and 0.625 （95%CI：0.565-0.685）， respectively， with the optimal cut-off value of 15.04 μmol/L and 13.11 μmol/L， respectively （all P<0.05）.ConclusionsHcy level at renal biopsy is significantly correlated with sex， Alb， Scr， Cys C， T and A in patients with IgAN， showing a potential ability to predict associated damages.…”
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Presenting the evaluation model of financial technology policies in National Bank of Iran by Vahid moradi, changiz mohammadi zadeh, ali farhadi mahali

“…New technologies are optimizing various aspects of banking firms' operations, and it is very important to assess whether they can accelerate green financing while supporting bank profitability. …”
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Developing and presenting a mathematical model for the purpose of organizational culture architecture based on creating alignment between the strategic reference points of organiza... by Elyas hasanzadeh Shweili, Mir Mehrdad peidaie, Ali reza Rezghi Rostami

“…It is recommended according to the strategic orientation of the studied organizations; by observing the standard principles and designing of the organizational structure of the upstream institution, as well as the results of the analysis of organizational processes using the APQC model, information systems and employee capabilities, to revise and optimize the organizational structure of the studied organization.…”
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Investigation on the situation of hospital accompanying visitors and patient satisfaction under the nursing management in orthopedic wards in the post-epidemic era (后疫情时代骨科病房护理管理下住... by CHEN Liping (陈丽萍), WANG Fengmei (王凤美), LI Nannan (李南南), LI Jing (李靖)

“…It is necessary to pay more attention to the psychology of hospitalized male patients and reduce the impact of the epidemic on the lives of inpatients, so as to continuously optimize medical services, ensure medical safety, and improve patient satisfaction. …”
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A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity by Da-yan Zhang, Zhi-hua Zhang, Wen-ting Liu, Wei-ming Zhou, Peng-fei Zhou, Juan-juan Wei, Xue-jing Dai, Xiao-li Zeng, Yu-qiong Zhou, Han-wang Li, Heng Zhang, Ao-lin Shen, Lian-sheng Cheng, Guo-dong Shen, Yi-fu He

“…In addition, the mean half-life of HK013-G1 was approximately 61 and 97 h at single doses of 3 and 30 mg/kg, respectively. Conclusion The optimal anti-MSLN×4-1BB bsAb HK013-G1 exhibited synergistic antitumour effects by inducing an ADCC effect (innate immunity) and stimulating the 4-1BB signaling pathway (adaptive immunity) upon cross-bridging with MSLN with no systemic toxicity, which may offer the promise of an improved therapeutic window relative to that of 4-1BB agonists.…”
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Bioassays for the evaluation of the attractiveness of attractive targeted sugar bait (ATSB) against Anopheles mosquitoes in controlled semi-field systems by Frank S. C. Tenywa, Ummi A. Kibondo, Julian Entwistle, Osward Dogan, Mapipi Haruna, Restuta P. Phisoo, Jason Moore, Jane J. Machange, Haji Makame, Frederic Tripet, Pie Müller, Mathias Mondy, Derric Nimmo, Jennifer C. Stevenson, Sarah J. Moore

“…Abstract Background Sugar feeding is an essential aspect of mosquito biology that may be exploited for mosquito control by adding insecticides to sugar attractants, so-called ‘attractive targeted sugar baits’ (ATSBs). To optimize their effectiveness, ATSB products need to be maximally attractive at both short and long range and induce high levels of feeding. …”
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Association between interpregnancy interval and adverse perinatal outcomes according to maternal age in the context of China’s two-child policy by SiQin Xiu, Li Tang, Chengjie Qin, Di Tian, Yuhong Chen, Lingling Gu, Liu Yang, Yuhao Sun, Xinghui Liu, Yonghong Lin, Yumei Wang

“…Medical professionals should advise women an optimal IPI to mitigate these risks. With China’s shift from a “one-child” to a “three-child” policy, future research will focus on analyzing this new fertility pattern to refine IPI recommendations.…”
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Sustainability index analysis for environmentally low-input integrated farming by E. Widjaja, B.N. Utomo, A.D. Santoso, Y.P. Erlambang, . Surono, M.A. Firmansyah, S. Handoko, E. Erythrina, M.N. Rofiq, D. Iskandar, N.A. Sasongko, T. Rochmadi, N. Abbas, M. Hanif, Y.S. Garno, F.D. Arianti, N.D. Suretno, M. Askinatin, C.O.I. Hastuti, F. Fahrodji

“…These results indicated that the integration of organic fertilizer, corn, and layer hen farming in the area had successfully optimized the available resources, created a sustainable farming model, and had the potential for adoption in various locations and future periods. …”
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Does pregabalin offer potential as a first-line therapy for generalized anxiety disorder? A meta-analysis of efficacy, safety, and cost-effectiveness by Narcis Cardoner, Narcis Cardoner, Narcis Cardoner, Narcis Cardoner, Luis Gutiérrez-Rojas, Luis Gutiérrez-Rojas, Pilar Saiz, Pilar Saiz, Pilar Saiz, Pilar Saiz, Pilar Saiz, Guillermo Lahera, Guillermo Lahera, Guillermo Lahera, Guillermo Lahera, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Pino Alonso Ortega, Pino Alonso Ortega, Pino Alonso Ortega, Pino Alonso Ortega, María Pérez-Páramo

“…This study aimed to assess the efficacy, safety, and optimal pregabalin dosage for the treatment of GAD.MethodsThis meta-analysis followed PRISMA guidelines. …”
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Coal mining-induced composite damage to geological bodies and geological guarantee against damage reduction by Shuangming WANG, Qiang SUN, Xin HU, Jishi GENG, Enke HOU, Shengquan WANG, Shutao ZHOU, Qingmin SHI, Shihao YUAN, Kai CHEN, Shijie SONG

“…The purpose is to achieve transparent geological structure conditions, effective evaluation models and methods, optimized coal development models, advanced prediction of risk dynamics, and scientific strategies for geological security. …”
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Utilization of patient-reported outcomes to assess adherence to relugolix when combined with stereotactic body radiation therapy for intermediate to high-risk prostate cancer by Kelly Gaudian, Min Jung Koh, Min Ji Koh, Ryan R. Collins, Shaine Eden, Zoya Zwart, Malika Danner, Alan Zwart, Mark Fallick, Deepak Kumar, Paul Leger, Nancy A. Dawson, Simeng Suy, Sean P. Collins

“…Future studies should focus on how to optimally incorporate this questionnaire into patient management.…”
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Local and distant response to intratumoral immunotherapy assessed by immunoPET in mice by Aurélien Marabelle, Louis Meyblum, Lambros Tselikas, Thierry de Baere, Sandrine Susini, Fréderic Deschamps, Baptiste Bonnet, Céline Chevaleyre, Benoit Jego, Dimitri Kereselidze, Vincent Lebon, Charles Truillet

“…However, a comprehensive understanding of the local and systemic distribution of ICBs following intratumoral administration, as well as their impact on distant tumors, remains crucial for optimizing their therapeutic potential.To comprehensively investigate the distribution patterns following the intratumoral and intravenous administration of radiolabeled anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and to assess its corresponding efficacy in both injected and non-injected tumors, we conducted an immunoPET imaging study.Methods CT26 and MC38 syngeneic colorectal tumor cells were implanted subcutaneously on both flanks of Balb/c and C57Bl/6 mice, respectively. …”
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Liver Elastography for Liver Fibrosis Stratification: A Comparison of Three Techniques in a Biopsy-Controlled MASLD Cohort by Antonio Liguori, Giorgio Esposto, Maria Elena Ainora, Irene Mignini, Raffaele Borriello, Linda Galasso, Mattia Paratore, Maria Cristina Giustiniani, Laura Riccardi, Matteo Garcovich, Antonio Gasbarrini, Luca Miele, Maria Assunta Zocco

“…The fibrosis diagnostic accuracy of both S-Shearwave Imaging and 2D-SWE was good to optimal with AUROCs of 0.81 and 0.70 for significant fibrosis (≥F2), 0.94 and 0.91 for severe fibrosis (≥F3), respectively. …”
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Efficacy of PARPi re-maintenance therapy for recurrent ovarian cancer by Yulin Wang, Yunjie Yang, Binghong Guo, Binghong Guo, Xiaoyan Li, Renakezi Tuersun, Ye Cao, Jundong Li, Jihong Liu, Su Li, Tao Liu, Yongwen Huang

“…The structural domains of BRCA mutations with different sensitivity to PARPi might serve as a promising biomarker for optimizing treatment. Re-treatment with PARPi was well-tolerated.…”
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The Influence of Edaphic and Climatic Factors on the Morphophysiological Behavior of Young Argan Plants Cultivated in Orchards: A Comparative Analysis of Three Regions in Southwest... by Fatima Ezzahra Tiouidji, Assma Oumasst, Salma Tabi, Naima Chabbi, Abdelaziz Mimouni, Meriyem Koufan, Naima Ait Aabd, Abdelghani Tahiri, Youssef Karra, Jamal Hallam, Redouan Qessaoui, Rachid Bouharroud, Fouad Elame, Nadya Wahid, Ahmed Wifaya

“…The Tamjloujt site, characterized by protective vegetation cover, showed optimal growth conditions with the highest leaf and branch water content (46.89 ± 4.06% and 37.76 ± 3.51%, respectively), maximum height growth (91.33 ± 28.68 mm), trunk diameter (24.85 ± 3.78 mm), and leaf surface area (69.33 ± 19.28 mm²) during Summer 2022. …”
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Micro-nano aerated subsurface drip irrigation and biochar promote photosynthesis, dry matter accumulation and yield of cucumbers in greenhouse by Zan Ouyang, Jie Zhang, Xueli Liang, Hui Wang, Zhenfeng Yang, Rong Tang, Qihua Yu, Yong Zhang

“…The ''oxidation-porous'' qualities of micro-nano bubble water and biochar combined to enhance clay soil aeration, promote cucumber development, accelerate photosynthetic rate and dry matter buildup, and enhance yield and quality.O3B3 (O3 14–15 mg/L, B3 60 t/hm2) was the optimal treatment when factors like yield and quality were taken into consideration. …”
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Efficacy and safety of SHR8554 on postoperative pain in subjects with moderate to severe acute pain following orthopedic surgery: A multicenter, randomized, double-blind, dose-expl... by Yanhua Zhao, Zhisheng Lu, Xuesong Song, Haihui Xie, Xungang Xiao, Guonian Wang, Qi Zhou, Qingmei Zhang, Liang Liu, Zhijian Lan, Ning Bai, Haiyan Wang, Zhihao Pan, Liang Dong, Xianzhong Lin, Gang Chen, Qinghui Wang, Jiangtao Dong, Jia Deng, Yongshan Nan, Jiaqiang Zhang, Xiaohua Zhou, Yanjuan Huang, Yongquan Chen, Huanzhong He, Ye Yang, Dengpan Yao, Jintai Jia, Shuan Jin, Yafeng Zhang, Zhonghui Luo, Jiangang Li, Linzhong Zhang, Fang Wang, Juehua Jing, Jiang Zhu, Lin Li, Guangda Wang, Huajing Guo, Qiang Wang, Diansan Su, Weifeng Yu, Xiyao Gu

“…This multicenter Phase II/III trial evaluated the optimal dosage, efficacy, and safety of SHR8554, a biased MOR agonist, for postoperative pain management following orthopedic surgery. …”
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Enhanced fibrotic potential of COL1A1hiNR4A1low fibroblasts in ischemic heart revealed by transcriptional dynamics heterogeneity analysis at both bulk and single-cell levels by Cheng Luo, Cheng Luo, Cheng Luo, Baoping Tan, Luoxiang Chu, Liqiang Chen, Xinglong Zhong, Yangyang Jiang, Yuluan Yan, Fanrui Mo, Hong Wang, Fan Yang, Fan Yang

“…Multiple machine learning models were employed to identify the optimal gene panel for diagnosing ischemic heart disease (IHD) based on the intersected DEGs. …”
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Dose-dependent serological profiling of AdCLD-CoV19-1 vaccine in adults by Jung Hyuk Lee, Yuna Shin, Kwang-Soo Shin, Ju Yeon Park, Mi Sun Kim, Young-Shin Park, Wuhyun Kim, Joon Young Song, Ji Yun Noh, Hee Jin Cheong, Chang-Yuil Kang, Sang Hwan Seo, Jae-Ouk Kim, Deok Ryun Kim, Nathaniel S. Hwang, Jae Seung Yang, Jerome H. Kim, Byoung-Shik Shim, Manki Song

“…These findings underscore the importance of considering diverse humoral immune responses when evaluating vaccine efficacy and provide insights for optimizing adenovirus vector-based SARS-CoV-2 vaccine doses.IMPORTANCEOptimization of vaccine dose is crucial for eliciting effective immune responses. …”
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Innovación en sueño by Laura Vigil, Toni Zapata, Andrea Grau, Marta Bonet, Montserrat Montaña, María Piñar

“…In addition, techniques such as cluster analysis are used to identify symptomatic patterns and phenotypes, which improves understanding of OSA pathophysiology and optimizes CPAP treatment.However, implementation of AI in hospitals faces technological, ethical, and legal barriers. …”
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