Isomeric Differentiation of Four Triterpene Acids Using Full Collision Energy Ramp-MS2 Analysis by Li-juan WU, Rui-ru NAN, Qian WANG, Xin CHEN, Wen-jing LIU, Yue-lin SONG

“…The parameters, such as collision energy at the half survival rate (CE50) of precursor ions, the optimal collision energy (OCE) of primary fragment ion species and the maximal relative ion intensity (RIImax) were calculated from those regressive equations, and subsequently were applied for isomers differentiation. …”
Get full text

Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors by Laetitia Fend, Eric Quemeneur, Monika Semmrich, Jean-Baptiste Marchand, Matilda Rehn, Nathalie Silvestre, Linda Mårtensson, Johann Foloppe, Ingrid Teige, Björn Frendeus, Petra Holmkvist, Carolin Svensson, Christelle Remy, Patricia Kleinpeter, Jules Deforges, Fred Junghus, Kirstie L Cleary, Mimoza Bodén

“…Remarkably, in a clinically relevant mouse model resistant to systemic ICB, intratumoral VVGM-αCTLA-4 synergized with αPD-1 to reject cold tumors.Conclusion Our findings demonstrate in vivo proof of concept for spatial restriction of Treg depletion-optimized immune checkpoint blocking, vectorized αCTLA-4 as a highly effective and safe strategy to target CTLA-4. …”
Get full text

Assessing Mental Illness Referral Request Acceptance: A Nationwide E-Referral Data From Saudi Arabia by Alharbi AA, Aljerian NA, Alghamdi HA, Binhotan MS, Alsultan AK, Arafat MS, Aldhabib A, Aloqayli AI, Alwahbi EB, Horner RD

“…External referrals were half as likely to be accepted as internal ones (aOR = 0.51; 95% CI = 0.42– 0.64).Conclusion: SMARC demonstrates effectiveness in optimizing mental healthcare access through strategic matching of patient needs with available resources. …”
Get full text

Relationship between pregnant women's combined exposure to heavy metals and their offspring's congenital heart defects in Lanzhou, China by Lulu Chen, Lulu Chen, Yaqin Zhao, Yaqin Zhao, Jianhao Sun, Jianhao Sun, Xinjuan Jiao, Zhenzhen Wu, Zhenzhen Wu, Jian Wang, Jie Qiu, Baohong Mao, Baohong Mao, Qing Liu, Qing Liu

“…The research identified a significant correlation between the concentrations of Ni, Pb, and Ti in the blood of pregnant women and the risk of CHDs (P < 0.05). The optimal cut-off for heavy metals in pregnant women's blood was determined using the ROC curve. …”
Get full text

SIMULASI PENCAHAYAAN ALAMI SIANG HARI TERHADAP DESAIN FASAD (STUDI KASUS: GEDUNG LABORATORIUM TEKNIK ELEKTRO UNIVERSITAS MALIKUSSALEH) by Leo Sani Muslim Pinem, Atthaillah Atthaillah, Effan Fahrizal, Eri Saputra, Badriana Badriana

“…Therefore, it is required to optimize the façade design of the building by altering the façade of the laboratorium building for better daylight performance inside the spaces. …”
Get full text

Perfusion mode as a factor of appearance of cognitive dysfunction in patients after on-pump coronary artery bypass grafting by S.M. Sudakevych, О.А. Loskutov, І.P. Shlapak, V.V. Babenko, B.М. Todurov

“…Conclusions. The support of optimal parameters of perfusion pressure during artificial blood circulation in patients undergoing coronary artery bypass grafting, namely maintaining it at a level above 60 mm Hg, is an extremely important criterion and it can reduce the incidence of postoperative cognitive dysfunction in the early postoperative period and 3 months after surgery. …”
Get full text

Treatment of mine water containing ammonia nitrogen by sodium hexametaphosphate modified zeolite by Liping ZHANG, Xiang HU, Weiwei WANG, Wenbo LEI, Huitong LI, Huaran SUN, Yongqi ZHAN, Zeyu LIAN

“…The adsorption of NH4+—N by SHMP−NZ was optimal under weakly acidic or neutral conditions. …”
Get full text

Growth performance and survival of snakehead Channa striata juvenile with different stocking density reared in recirculation system by Adang Saputra, Tatag Budiardi, Reza Samsudin, Naufal Dwi Rahmadya

“…This study was conducted to determine the best stocking density on snakehead juvenile rearing to achieve optimal production. The treatments used in this study were stocking density of 1 juvenile/L, 2 juveniles/L, and 3 juveniles/L. …”
Get full text

Reproduction performance of climbing perch Anabas testudineus F1 and F2 broodstock with different dietary supplementation by Helmizuryani, Helmizuryani, Boby Muslimin, Khusnul Khotimah

“…This species is potential to create the sustainability production in the future because they offer a promising price, so it needs a further study for optimizing the quality of broodstock and its offsprings. …”
Get full text

Investigation on nursing needs of patients in the Traditional Chinese Medicine Famous-Doctor clinic and countermeasures (中医名医堂门诊患者护理需求调查及对策分析)... by MI Wei (米薇), SHU Baozhen (舒宝珍), TANG Ling (唐玲), WANG Huaxin (王华新), ZHANG Yongli (张永丽)

“…Conclusion In view of the existing problems, targeted countermeasures were formulated to improve the comprehensive quality of nurses, assist patients in registration and payment, and optimize the drug taking process. (目的 对中医名医堂门诊患者的护理需求进行调查, 分析存在的问题并提出改进措施, 提高中医门诊护理服务质量。…”
Get full text

Machine learning for predicting neoadjuvant chemotherapy effectiveness using ultrasound radiomics features and routine clinical data of patients with breast cancer by Pu Zhou, Pu Zhou, Hongyan Qian, Pengfei Zhu, Jiangyuan Ben, Jiangyuan Ben, Guifang Chen, Qiuyi Chen, Lingli Chen, Jia Chen, Ying He, Ying He

“…Subsequently, construction of clinical predictive models and Rad score joint clinical predictive models using ML algorithms for optimal diagnostic performance. The diagnostic process of the ML model was visualized and analyzed using SHapley Additive exPlanation (SHAP).ResultsOut of 231 participants with BC, 98 (42.42%) achieved pCR, and 133 (57.58%) did not. …”
Get full text

Optimasi Algoritma Naive Bayes dengan Diskritisasi K-Means pada Diagnosis Penyakit Jantung by Nafa Fajriati, Budi Prasetiyo

“…This shows that K-means discretization plays a role in optimizing the performance of the Naïve Bayes algorithm to produce better accuracy. …”
Get full text

Effect of modified Traditional Chinese Medicine hot compress technique in the treatment of osteoarthritis of the knee (改良式中药热敷技术治疗膝骨关节炎效果观察) by CUI Yangfang (崔杨芳), LIU Ai (刘爱), ZHANG Xuejian (张雪键), ZHAO Yue (赵月), QI Mengying (齐梦颖)

“…The control group received conventional TCM hot compress technique, and the observation group received the modified hot compress technique by optimizing the size of Chinese herbal medicine package, regulating duration of treatment, and monitoring the temperature with electric temperature controller. …”
Get full text

Whole lung radiomic features are associated with overall survival in patients with locally advanced non-small cell lung cancer treated with definitive radiotherapy by Meng Yan, Zhen Zhang, Jia Tian, Jiaqi Yu, Andre Dekker, Dirk de Ruysscher, Leonard Wee, Lujun Zhao

“…The combination of tumor- and lung-based radiomic features can achieve optimal performance.…”
Get full text

A review of literature of a functional, congenital intrathoracic kidney by Sahil Sabharwal, Brandyn Young, Sarat Sabharwal, Kristen Brandon, Sarah Assem

“…Further research and documentation is essential not only to provide optimal care in this patient, but to better understand the pathophysiology and management of renal ectopia for future patients.…”
Get full text

THE PUBLIC DEBT OF UKRAINE: A NEW DIMENSION OF DYNAMICS AND ARCHITECTURE OF THE MODEL FRAMEWORK OF THE MANAGEMENT SYSTEM by Serhii Petrukha, Nina Petrukha, Roman Miakota

“…The conclusions emphasise the necessity to approximate the optimal practices of fiscal consolidation and to implement measures, including those envisaged by the National Revenue Strategy until 2030, in order to increase the revenues of the state budget of Ukraine. …”
Get full text

Enhancing deep learning methods for brain metastasis detection through cross-technique annotations on SPACE MRI by Tassilo Wald, Benjamin Hamm, Julius C. Holzschuh, Rami El Shafie, Andreas Kudak, Balint Kovacs, Irada Pflüger, Bastian von Nettelbladt, Constantin Ulrich, Michael Anton Baumgartner, Philipp Vollmuth, Jürgen Debus, Klaus H. Maier-Hein, Thomas Welzel

“…Abstract Background Gadolinium-enhanced “sampling perfection with application-optimized contrasts using different flip angle evolution” (SPACE) sequence allows better visualization of brain metastases (BMs) compared to “magnetization-prepared rapid acquisition gradient echo” (MPRAGE). …”
Get full text

Caracterización de la piscicultura amazónica ecuatoriana, un panorama de su desarrollo y perspectivas by Ricardo Ernesto Burgos-Morán, Cristina Altamirano-Cantos

“…These actions seek to optimize its sustainability and efficiency.…”
Get full text

Effect of seed priming and foliar application of organic liquid manure on germination, growth, yield and quality of late-sown wheat by Okram Ricky Devi, Omvati Verma, Bibek Laishram, S. Anbarasan, Abhijit Debnath, Narinder Panotra, Priyanka Elumle, Sunita T. Pandey, R. Ajaykumar, Samreen

“…The sub-optimal temperature during sowing results in delayed germination, poor crop establishment, and constrained vegetative development, which results in forced maturity, low yield, and wheat with poorer quality grains in north India. …”
Get full text

Distribution of Airway Findings in ANCA-Associated Vasculitis: A 20-Year Observational Analysis by Megan M. Sullivan, Maximiliano Diaz Menindez, Hassan Baig, Anushka Irani, Ronald Butendieck, Benjamin Wang, Florentina Berianu, Carolyn Mead-Harvey, Andy Abril, Vikas Majithia

“…LCA identified a three-class model as optimal: tracheal predominant (<i>n</i> = 94), tracheobronchial (n = 12), and bronchial predominant (n = 5). …”
Get full text