A network analysis of depression and anxiety symptoms among Chinese elderly living alone: based on the 2017–2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS) by Ze Chang, Yunfan Zhang, Xiao Liang, Yunmeng Chen, Chunyan Guo, Xiansu Chi, Liuding Wang, Xie Wang, Hong Chen, Zixuan Zhang, Longtao Liu, Lina Miao, Yunling Zhang

“…To minimize spurious correlations, the Least Absolute Shrinkage and Selection Operator (LASSO) method was applied for regularization, and the optimal regularization parameters were selected using the Extended Bayesian Information Criterion (EBIC). …”
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The aptamer BC 007 for treatment of dilated cardiomyopathy: evaluation in Doberman  Pinschers of efficacy and outcomes by Sabine Werner, Gerd Wallukat, Niels‐Peter Becker, Katrin Wenzel, Johannes Müller, Ingolf Schimke, Gerhard Wess

“…Using a natural large animal model of DCM considered superior to small animal models of immunization‐induced cardiomyopathy, combined with a study design comparable with clinical trials, we believe that our results provide the basis for optimism that treatment with BC 007 might also be effective in human patients with DCM.…”
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The clinical prediction model to distinguish between colonization and infection by Klebsiella pneumoniae by Xiaoyu Zhang, Xifan Zhang, Deng Zhang, Jing Xu, Jingping Zhang, Xin Zhang

“…In the future, the accuracy of infection diagnosis can be further enhanced through artificial intelligence technology to optimize treatment strategies, thereby improving patient prognosis and reducing healthcare burdens.…”
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Scaling climate information services and climate smart agriculture through bundled business models by Desire M. Kagabo, Livingstone Byandaga, Patrick Gatsinzi, Patrick Mvuyibwami, Yvonne U. Munyangeri, Nasson Ntwari, Mathieu Ouedraogo

“…This study reveals a reason for optimism about the future of agriculture; it suggests that scalable bundled CIS-CSA products and services can contribute significantly to attaining climate resilience and food security.…”
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Preliminary clinical performance of a Cas13a-based lateral flow assay for detecting Neisseria gonorrhoeae in urine specimens by Lao-Tzu Allan-Blitz, Gordon Adams, Gabriela Sanders, Palak Shah, Krithik Ramesh, Jana Jarolimova, Kevin L. Ard, John A. Branda, Jeffrey D. Klausner, Pardis C. Sabeti, Jacob E. Lemieux

“…We aimed to pair that assay with point-of-care DNA extraction, assess performance in clinical urine specimens, and optimize assay kinetics. We collected urine specimens among men presenting with urethritis enrolling in a clinical trial at the Massachusetts General Hospital Sexual Health Clinic. …”
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Dietary selenium peptide supplementation for increasing the growth of African catfish Clarias gariepinus by Muhammad Agus Suprayudi, Muhammad Roikhan Amanullah, Dedi Jusadi, Hasan Nasrullah, Ahmad Yazid Latif

“…Pengelolaan kualitas air dilakukan dengan filtrasi sederhana serta penggantian air untuk memastikan kualitas air optimal untuk pertumbuhan ikan lele. Hasil penelitian menunjukkan biomassa akhir ikan lele dengan suplementasi selenium peptida pada pakan berbeda nyata (p<0,05) dibandingkan dengan kontrol dengan nilai bobot sebesar 1147,50 g dan kelangsungan hidup 96,67%. …”
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Stress Reduction in Perioperative Care: Feasibility Randomized Controlled Trial by Haridimos Kondylakis, Irene Alice Chicchi Giglioli, Dimitrios Katehakis, Hatice Aldemir, Paul Zikas, George Papagiannakis, Santiago Hors-Fraile, Pedro L González-Sanz, Konstantinos Apostolakis, Constantine Stephanidis, Francisco J Núñez-Benjumea, Rosa M Baños-Rivera, Luis Fernandez-Luque, Angelina Kouroubali

“…ConclusionsOur results provide an important first step toward a deeper understanding of optimizing DH solutions to support patients undergoing surgery and for potential applications in remote patient monitoring and communication. …”
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A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation by Vladimir Majerciak, Beatriz Alvarado-Hernandez, Yanping Ma, Shivalee Duduskar, Alexei Lobanov, Maggie Cam, Zhi-Ming Zheng

“…ABSTRACT Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes an RNA-binding protein ORF57 in lytic infection. Using an optimized CLIP-seq in this report, we identified ORF57-bound transcripts from 544 host protein-coding genes. …”
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Application of Bacillus probiotic to prevent Aeromonas hydrophilla infection in Clarias sp. by Mohammad Faizal Ulkhaq, , Widanarni, Angela Mariana Kusumastuti

“…The result showed that the optimal concentration of Bacillus to inhibit A. hydrophila on in vitro test was 104 cfu/mL. …”
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Intelligent task-oriented semantic communications:theory, technology and challenges by Chuanhong LIU, Caili GUO, Yang YANG, Jiujiu CHEN, Meiyi ZHU, Lu’nan SUN

“…However, there are challenges in how to measure semantic information and how to achieve optimal semantic codec.This paper reviews the existing works related to semantic communication,and proposes a semantic communication method and framework for intelligent tasks,paving the way for further development of semantic communication. …”
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Correlation analysis of DLG5 and PD-L1 expression in triple-negative breast cancer by Jingmin Che, Bo Chen, Xusheng Wang, Baoe Liu, Cuixiang Xu, Huxia Wang, Jingying Sun, Qing Feng, Xiangrong Zhao, Zhangjun Song

“…Recent advancements in immunotherapy, particularly immune checkpoint inhibitors (ICIs) that target programmed death 1/programmed death ligand 1 (PD-1/PD-L1) and cytotoxic T lymphocyte associated antigen 4 (CTLA-4), have provided renewed optimism for the treatment of patients with TNBC. Prior research has indicated that the expression level of the cell polarity protein discs large homolog 5 (DLG5) correlates with the malignant progression and prognosis of breast cancer; nevertheless, its influence on PD-L1 expression and its function in immunotherapy for TNBC require further investigation. …”
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Finite element investigation for improving chest wall reconstruction process using ceramic and polymeric implants by Yomna H. Shash

“…The null hypothesis suggests that stiff implants will provide optimal results. The results illustrate that when using alumina implants, under normal breathing, the maximum tensile and compressive stresses increased to 11.41 and 15.86 MPa on ribs, while decreasing to 0.32 and 0.324 MPa, and 0.96 and 0.56 Pa on cartilages and lung respectively, compared to titanium. …”
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Feasibility of HIV self-test implementation among Mizo youths: a field investigation from Northeast India bordering Myanmar by Amrita Rao, Henry Zodinliana Pachuau, Samiran Panda, Richard L. Chawngthu, Rita Zomuanpuii, Pranoti Hemade, Amit Nirmalkar

“…They also provided valuable insights on the optimal locations and methods for making HIVST kits accessible. …”
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Influence of substrate bias on the properties of CrAlN wear-resistant coating prepared by arc/magnetron composite technology by Xiaoyan NIU, Mingze LIU, Guoqiang DONG, Yujiang WANG, Haoliang TIAN

“…Tuning the substrate bias voltage, allowed for effectively optimizing the microstructure, mechanical properties, frictional behavior, and wear resistance of CrAlN coatings. …”
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Noninvasive Oral Hyperspectral Imaging–Driven Digital Diagnosis of Heart Failure With Preserved Ejection Fraction: Model Development and Validation Study by Xiaomeng Yang, Zeyan Li, Lei Lei, Xiaoyu Shi, Dingming Zhang, Fei Zhou, Wenjing Li, Tianyou Xu, Xinyu Liu, Songyun Wang, Quan Yuan, Jian Yang, Xinyu Wang, Yanfei Zhong, Lilei Yu

“…The model demonstrating the optimal performance in both internal and external testing groups was selected to construct the HFpEF diagnostic model. …”
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Treatment Planning Strategies for Interstitial Ultrasound Ablation of Prostate Cancer by Pragya Gupta, Tamas Heffter, Muhammad Zubair, I-Chow Hsu, E. Clif Burdette, Chris J. Diederich

“…Conclusions: Prostate-specific simulations of interstitial ultrasound applicators were used to generate a library of thermal-dose distributions to visually optimize and set applicator positioning and directivity during a priori treatment planning pre-procedure. …”
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Interactions of fertilisation and crop productivity in soil nitrogen cycle microbiome and gas emissions by L. Kuusemets, Ü. Mander, J. Escuer-Gatius, A. Astover, K. Kauer, K. Soosaar, M. Espenberg

“…The results of the study provide evidence that, for wheat, a fertilisation rate of 80 kg N ha<span class="inline-formula">⁻¹</span> is closest to the optimal rate for balancing biomass yield and N<span class="inline-formula">₂</span>O emissions and achieving a high NUE. …”
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Associations of meteorological factors and ambient air pollutants with mumps incidence in Ningxia Hui Autonomous Region: boosted regression tree model analysis by Xianglong LIU, Linlin CHEN, Jiayu YU, Rui GONG, Yaogeng CHEN, Yu ZHAO

“…A boosted regression tree (BRT) model was used to determine the optimal lag of meteorological factors and air pollutants that best explained mumps cases and to evaluate the associations of meteorological factors and air pollutants with the daily number of mumps cases in the region. …”
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Correlation between social support, self-efficacy and quality of life in primary trigeminal neuralgia patients (原发性三叉神经痛患者社会支持、自我效能感与生活质量的相关性研究)... by SUN Xiuxiu (孙秀秀), JIA Jianhua (贾建华), LI Yeyuan (李业园)

“…Objective To explore the correlation between social support, self-efficacy and quality of life of patients with primary trigeminal neuralgia, and to provide reference basis for optimizing the quality of life. Methods Totally 220 primary trigeminal neuralgia patients who were 18 years old or older were conveniently selected from a tertiary hospital in Jinan City, and were surveyed with self-designed general information questionnaires, social support scales, chronic pain self-efficacy scales, and trigeminal neuralgia patients' quality of life questionnaires. …”
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Development and application of intelligent auxiliary diagnosis system in the Traditional Chinese Medicine nursing clinic (智能辅诊系统在中医护理门诊中的开发与应用)... by ZHANG Jing (张敬), TANG Ling (唐玲)

“…TCM nursing informationization can assist nurses to carry out differential nursing and provide more optimized TCM nursing programs for patients, thereby improving the operation efficiency of TCM nursing practice. …”
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