Sustainability assessment of animal feed production from by-products of Sago palm smallholder industry by Allaily ., A.D. Santoso, M.N. Rofiq, N.A. Sasongko, H. Daulay, E.I. Wiloso, E. Widjaja, B.N. Utomo, A.I. Yanuar, S. Suryani, Y.P. Erlambang, U.N. Thiyas, D. Iskandar, A. Anhar, M. Rahmawati, T. Simamora, Y. Yusriani, G. Maghfirah, M. Ammar

“…However, the use of solid and liquid wastes had not been optimally used.CONCLUSION: In the economic dimension, an improvement in production factors such as the cultivation of Sago plant is important because it only relies on plant that live naturally. …”
Get full text

Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

“…Results The Catalan Government healthcare model of XUECs for the comprehensive care for RDs is currently valid and adapted to the needs of PLWRD and their families since its strategic optimal and operational framework, and it is aligned with the European Reference Networks (ERNs) thematic areas. …”
Get full text

Adaptive responses of large-seeded lentils across diverse Indian climates by Ashok Kumar Parihar, Kali Krishna Hazra, Amrit Lamichaney, Debjyoti Sen Gupta, Jitendra Kumar, Anil Kumar Singh, Sankar Prasad Das, Muniyandi Samuel Jeberson, Parvez Ahmad Sofi, Ajaz Ahmad Lone, Jai Dev, Ashok Kumar, Ravindra Kumar Panwar, Sarvjeet Singh, Harsh Kumar Dikshit, Murlidhar Aski, Bimal Singh Jamwal, Ved Prakash, Sumer Singh Punia, Khajan Singh, Sunil Kumar Nair, Mangala Parikh, Smita Tiwari, Ashok Kumar Saxena, Sudhakar Prasad Mishra, Kamaluddin, Hitesh Kumar, Umesh Kumar, Deepak Singh, Sanjeev Gupta, Shailesh Tripathi, Girish Prasad Dixit

“…Grain yield exhibited a quadratic response to 100-seed weight, with the highest yields achieved at an optimal seed weight of 3.12 g. The GGE biplot ''Which Won Where'' analysis identified two distinct mega-environments, with Durgapura (NWPZ), Sagar (CZ), Pantnagar (NWPZ), and Gurdaspur (NWPZ) emerged as ‘ideal’ testing sites with high representativeness and discriminatory scaling. …”
Get full text

N-acetylcysteine increased the growth performance of Leuciscus waleckii by improving mitochondrial function, enhancing antioxidant and anti-inflammatory, and inhibiting apoptosis i... by Deng Lai Li, Rui Zhu, Si Tong Meng, Yin Tao Wang, Si Ying Liu, Zhi Yong Yang, Li Fang Wu

“…The results revealed that 3 g/kg-6 g/kg NAC increased FW, WGR, SGR, PER, and FER and improved growth performance and feed utilization in Leuciscus waleckii. 4.50 g/kg-6.00 g/kg NAC increased the intestinal and hepatopancreatic digestive enzyme activities, enhancing digestive function. 3.00 g/kg-4.50 g/kg NAC increased serum ACP and AKP activities, decreased IL-1β and TNF-α levels, and optimized serum biochemical indices in Leuciscus waleckii. …”
Get full text

Food-related behaviors of rural (Asaase Kooko) and peri-urban (Kaadjanor) households in Ghana by Prince Kwabena Osei, Megan A. McCrory, Matilda Steiner-Asiedu, Edward Sazonov, Mingui Sun, Wenyan Jia, Tom Baranowski, Gary Frost, Benny Lo, Alex Kojo Anderson

“…Our findings suggest the need for nutrition education for mothers to provide adequate and nutrient-rich foods to support optimal child growth and development.…”
Get full text

Population Dynamics of the Crocodile Shark, <i>Pseudocarcharias kamoharai</i>, in the Tropical Equatorial Pacific Ocean, Ecuador by Marcos Douglas Calle-Morán, Eugenio Alberto Aragón-Noriega, Ana Rosa Hernández-Téllez, Emigdio Marín-Enríquez, Javier Tovar-Ávila, Juan Francisco Arzola-González, Jorge Payán-Alejo

“…The obtained BRPs were <i>F_opt</i> = 0.10 and 0.12 and <i>F_lim</i> = 0.16, which showed that the optimal fishing levels (best possible capture) to achieve long-term sustainable exploitation of the stock encompass 10 to 16% of the fishing effort applied for this species. …”
Get full text

Incidence and contributing factors of dementia among people living with HIV in British Columbia, Canada, from 2002 to 2016: a retrospective cohort study by Rolando Barrios, Julio S G Montaner, Silvia Guillemi, Ni Gusti Ayu Nanditha, Viviane D Lima, Thomas L Patterson, Fidel Vila-Rodriguez, William G Honer, Jason Trigg, Hasan Nathani, Sara Shayegi-Nik, Weijia Yin, Alejandra Fonseca, Bronhilda T Takeh

“…We estimated the incidence and prevalence of dementia and identified its key risk factors in a cohort of PLWH in British Columbia, Canada.Methods This retrospective cohort study used data from the Seek and Treat for Optimal Prevention of HIV/AIDS study. Eligible individuals were diagnosed with HIV, ≥40 years of age, naïve to antiretroviral therapy (ART), had no dementia at the index date and were followed for ≥1 year during 2002–2016. …”
Get full text

Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma by Yunxi Chen, Eva Jin, Mohamed Abdouh, Éric Bonneil, Daniel Alexander Jimenez Cruz, Thupten Tsering, Qianqian Zhou, Aurélie Fuentes-Rodriguez, Alexandra Bartolomucci, Alicia Goyeneche, Solange Landreville, Miguel N. Burnier, Julia V. Burnier

“…., supplementation with serum and 12-O-tetradecanoylphorbol-13-acetate) to determine optimized protocols. Particularly, Matrigel™ coating induced spheroid growth under certain coating thickness and cell seeding density but did not improve NCM metabolic activity. …”
Get full text

Maternal exposure to dim light at night induces behavioral alterations in the adolescent and adult offspring Wistar rat by Shellye González-González, Mariana Gutiérrez-Pérez, Mara A. Guzmán-Ruiz, Estefania Espitia-Bautista, Rosa María Pavón, Karla P. Estrada-Rodríguez, Alejandro Díaz-Infante R., Cecilia G. Guadarrama Gándara, Carolina Escobar, Natalí N. Guerrero-Vargas

“…During the gestational period, physiological adaptations occur to ensure a successful pregnancy and optimal fetal development. Environmental maternal conditions, such as disruptions of maternal circadian rhythms, could negatively affect offspring health. …”
Get full text

Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy by James Dooley, Bart Neyns, Elizabeth Allen, Frank Tacke, Louis Boon, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter

“…These Nbs were formulated as tetravalent Nb-Fc fusion proteins for optimal CCR8 binding and blocking, containing either an antibody-dependent cell-mediated cytotoxicity (ADCC)-deficient or an ADCC-prone Fc region. …”
Get full text

Oxygenation targets for endovascular therapy in acute ischemic stroke patients (Oxy-TARGET): protocol for a single-centre, open-label randomised controlled trial by Anxin Wang, Zhengfang Hu, Ruquan Han, Fa Liang, Youxuan Wu, Minyu Jian, Xinyan Wang, Yunzhen Wang, Haiyang Liu, Xuan Hou, Kangda Zhang, Zihui Zhang

“…Introduction Preclinical studies have shown that oxygen therapy can improve ischaemic brain tissue oxygen tension, reduce reperfusion injury after revascularisation, promote neuroregeneration and inhibit inflammatory responses potentially exerting a beneficial effect after endovascular treatment (EVT) in patients with acute ischaemic stroke (AIS). However, the optimal fraction of inspired oxygen (FiO2) during EVT under general anaesthesia is currently unknown. …”
Get full text

HESS Opinions: Towards a common vision for the future of hydrological observatories by P. Nasta, G. Blöschl, G. Blöschl, H. R. Bogena, S. Zacharias, R. Baatz, G. De Lannoy, K. H. Jensen, S. Manfreda, L. Pfister, L. Pfister, A. M. Tarquis, I. van Meerveld, M. Voltz, Y. Zeng, W. Kustas, X. Li, H. Vereecken, N. Romano

“…</p> <p>A discussion on the relative merits and limitations of these two visions regarding HOs is presented to build consensus on the optimal path for the hydrological community to address the UPH in the coming decades. …”
Get full text

Peculiarities of ambulatory blood pressure monitoring in patients who have suffered from COVID-19 by V.O. Zbitnieva, O.B. Voloshyna, I.V. Balashova, E.A. Zubok, O.R. Dukova, L.I. Kovalchuk

“…Further study of the features of blood pressure (BP) fluctuations in this category of patients will allow to diagnose arterial hypertension (AH) on time, to identify the uncontrolled course of AH and to select the optimal tactics of patients’ management. It was suggested to determine the characteristics of BP fluctuations in patients who have suffered from COVID-19 more than 12 weeks ago, based on the results of ambulatory (daily) blood pressure monitoring. 98 patients (51 men – 52.0%, 47 women – 47.9%) who have had COVID-19 infection more than 12 weeks ago were examined. …”
Get full text

The biomechanical effects of treating double-segment lumbar degenerative diseases with unilateral fixation through interlaminar fenestration interbody fusion surgery: a three-dimen... by Kai-Kai Feng, Xiao-Bing Xiang, Cheng-Peng Li, Kai-Yin Gao, Wei-Wei Zhang, Zhen-Yu Nie, Wen-Xin Liao, Dong Zhao, Guang-Ru Cao

“…Abstract Background Transforaminal lumbar interbody fusion (TLIF) surgery has become increasingly popular in the surgical treatment of lumbar degenerative diseases. The optimal structure for stable double-segment fixation remains unclear. …”
Get full text

Artemisinin supplementation in concentrated cottonseed protein basal diets enhances growth, antioxidant capacity, intestinal immunity and microbiota in hybrid grouper (Epinephelus... by Ling Pan, Qi Wang, Weikang Li, Xiaohui Dong, Shiwei Xie, Beiping Tan, Hongyu Liu, Yan Wang

“…Broken-line regression analysis based on the WGR indicated that the optimal dietary artemisinin level was estimated to be 0.40 %.…”
Get full text

Quality of Life and Related Factors in Discharged Patients with COVID-19 by Jinzhuo HU, Wenhuan WU, Jinwen SUN, Wei ZHANG, Shu CHENG, Zicheng GAO, Jinghua QIAN

“…Objective:To determine the factors associated with quality of life of discharged patients with coronavirus disease 2019(COVID-19), so as to provide a basis for optimizing early intervention programs, preventing community from life restriction, and formulating appropriate community rehabilitation measures.Methods:A total of 57 discharged patients with COVID-19 who were cured from Wuhan China resources&amp; Wisco general hospital from March to April 2020. …”
Get full text

Narratives of swiss football players about talent - and positive youth development: The role of social agents and agency. by Philipp Koch, Bryan Charbonnet, Noora Ronkainen

“…These insights aim to inform practical strategies for coaches, parents, and policymakers seeking to optimize talent development pathways in youth soccer. …”
Get full text

Cesarean section in Suriname using robson classification: a two-year nationwide cross-sectional study on rates, risk factors and perinatal outcomes of cesarean section by Zita D. Prüst, Josephine A. I. Dupont, Safir Liesdek, Kitty W. M. Bloemenkamp, Thomas van den Akker, Kim J. C. Verschueren, Lachmi R. Kodan

“…Abstract Background Optimizing CS performance is a global health priority, given the maternal and perinatal morbidity and mortality associated with both underuse and overuse. …”
Get full text

Differential impact of TyG and TyG-BMI indices on short- and long-term mortality in critically ill ischemic stroke patients by Yufan Pu, Na Xing, Ying Wang, Huihuang Wang, Jiang Xu, Xuejing Li

“…This approach could enhance the precision of mortality risk stratification and optimize patient management strategies.…”
Get full text

An Easy and Quick Risk-Stratified Early Forewarning Model for Septic Shock in the Intensive Care Unit: Development, Validation, and Interpretation Study by Guanghao Liu, Shixiang Zheng, Jun He, Zi-Mei Zhang, Ruoqiong Wu, Yingying Yu, Hao Fu, Li Han, Haibo Zhu, Yichang Xu, Huaguo Shao, Haidan Yan, Ting Chen, Xiaopei Shen

“…ResultsUsing only vital signs and rapid arterial blood gas test features according to feature importance, we constructed the Septic Shock Risk Predictor (SORP), with an area under the curve (AUC) of 0.9458 in the test set, which is only slightly lower than that of the optimal multi-feature complex model (0.9651). A median forewarning time of 13 hours was calculated for SS patients. 4 distinct risk groups (high, medium, low, and ultralow) were identified by the SORP 6 hours before onset, and the incidence rates of SS in the 4 risk groups in the postonset interval were 88.6% (433/489), 34.5% (262/760), 2.5% (67/2707), and 0.3% (4/1301), respectively. …”
Get full text