Fractionated robotic radiosurgery for unfavorable nonfunctioning pituitary macroadenoma: 5-year outcomes from a single institution protocol by Akrita Bhatnagar, Monica Pernia Marin, Jonathan W. Lischalk, Min Ji Koh, Siviero Agazzi, Simeng Suy, Brent T. Harris, Susmeeta T. Sharma, Edward Aulisi, Amjad Anaizi, Mohamed H. Khattab, Walter C. Jean, Walter C. Jean, Sean P. Collins, Brian T. Collins

“…However, tumors with GTVs greater than 20 cc may still require conventionally fractionated treatment with a margin to optimize local control.…”
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Influence of cervical muscle strength and pain severity on functional balance and limits of stability in elderly individuals with chronic nonspecific neck pain: a cross-sectional s... by Shaker Hassan S. Alshehri, Ravi Shankar Reddy, Mohammad A. ALMohiza, Mastour Saeed Alshahrani, Batool Abdulelah Alkhamis, Hani Hassan Alnakhli, Ghada Mohammed Koura, Ajay Prashad Gautam, Debjani Mukherjee, Raee S. Alqhtani, Saeed Y. Al Adal, Abdullah Mohammed Alyami, Faisal M. Alyazedi

“…Pain severity moderates the relationship between cervical muscle strength and balance outcomes, emphasizing the importance of integrating muscle strengthening and pain management in rehabilitation programs for elderly individuals with CNSNP to optimize postural control and minimize fall risk.…”
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Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

“…BackgroundDespite durable responses achieved with Immune Checkpoint Inhibitors (ICIs), data about optimal duration of treatment, especially in the context of adverse events, remain scarce.ObjectiveTo systematically review the evidence concerning the impact of treatment discontinuation with ICIs for reasons other than progressive disease (PD) on relapse rates and survival of melanoma patients.MethodsA systematic literature search was conducted in three electronic databases until July 2024. …”
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Feasibility study of Omaha System in the construction of health education program for elderly patients with chronic obstructive pulmonary disease (奥马哈系统在老年慢性阻塞性肺疾病健康教育方案构建中的可行性研究)... by YANG Yuanqin (杨元琴), YIN Cuihong (尹翠红), SHEN Xiaohong (申晓红), WU Sichao (吴思超), WANG Anxiu (王安秀)

“…Therefore, the Omaha system can be used as a guide to build health education programs for elderly COPD inpatients, improve the quality of medical and health education, and optimize the management of elderly COPD patients. …”
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3D-QSAR, design, molecular docking and dynamics simulation studies of novel 6-hydroxybenzothiazole-2-carboxamides as potentially potent and selective monoamine oxidase B inhibitors by Dong Xie, Dong Xie, Yongzheng Tian, Li Cao, Penghang Guo, Penghang Guo, Zhibiao Cai, Jie Zhou

“…Background6-hydroxybenzothiazole-2-carboxamide is a novel, potent and specific inhibitor of monoamine oxidase B (MAO-B), which can be used to study the molecular structure and develop new neuroprotective strategies.ObjectiveThe aim of this study was to create an effective predictive model from 6-hydroxybenzothiazole-2-carboxamide derivatives to provide a reliable predictive basis for the development of neuroprotective MAO-B inhibitors for the treatment of neurodegenerative diseases.MethodsFirst, the compounds were constructed and optimized using ChemDraw and Sybyl-X software. Subsequently, QSAR modeling was performed using the COMSIA method in Sybyl-X to predict the IC50 values of a set of novel 6-hydroxybenzothiazole-2-carboxamide derivatives. …”
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Soil Organic Carbon Estimation and Transfer Framework in Agricultural Areas Based on Spatiotemporal Constraint Strategy Combined with Active and Passive Remote Sensing by Jiaxin Qian, Jie Yang, Weidong Sun, Lingli Zhao, Lei Shi, Hongtao Shi, Lu Liao, Chaoya Dang, Qi Dou

“…The spatial interpolation accuracy of each MLR algorithm is satisfactory, with the Gaussian process regression (GPR) model demonstrating optimal modeling performance. When SAR, MS, or TB data are used individually in modeling, the estimation errors (RMSE) for SOC are 0.637 g/kg, 0.492 g/kg, and 0.229 g/kg for the SMAPVEX12 sampling campaign, and 0.706 g/kg, 0.454 g/kg, and 0.474 g/kg for the SMAPVEX16-MB sampling campaign, respectively. …”
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Endo 180 participates in collagen remodeling of the periodontal ligament during orthodontic tooth movement by Liyuan Chen, Danqing He, Zixin Li, Shengjie Cui, Min Yu, Zimo Zhao, Yuetong Chen, Jiayi Song, Nan Jiang, Huajie Yu, Yan Liu

“…This collagen reorganization facilitates efficient tooth movement, highlighting Endo180 as a potential therapeutic target to optimize orthodontic treatment outcomes.…”
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Identifying subgroup of severe community-acquired pneumonia based on clinical metagenomics, a multicenter retrospective cohort study by Mingqiang Wang, Mingqiang Wang, Yue Jin, Yue Jin, Wenxiao Zhang, Wenxiao Zhang, Ling Ye, Ling Ye, Huanzhang Shao, Huanzhang Shao

“…Latent class analysis (LCA) was applied to routine clinical parameters such as gender, age, white blood cell (WBC), lymphocytes, C-reactive protein (CRP), and Procalcitonin (PCT), identifying two optimally fitting models.ResultsA total of 569 patients were enrolled. …”
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Rainfall intensity profile induced changes in surface‒subsurface flow and soil loss as influenced by surface cover type: A long-term in situ field study by Jian Duan, Haijin Zheng, Lingyun Wang, Yaojun Liu, Minghao Mo, Jie Yang

“…This study highlights the crucial importance of rain intensity profiles on water erosion and provides a basis for optimizing measures to effectively control soil and water loss under climate change.…”
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Study on the correlation between microstructural evolution and hydrogen storage properties in hyper-eutectic Mg-xNi (x = 15, 20, 25) alloys by So Jin Jung, Seok Su Sohn, Da Hye Lee, Won-Seok Ko, Tae Jun Ha, Ryun-Ho Kwak, Byeong-Chan Suh, Young Min Kim, Hyung-Ki Park

“…Therefore, it is essential to derive an optimal Mg–Ni alloy composition that balances both reaction kinetics and hydrogen storage capacity.…”
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Nitrogen dynamic and precise management to predict corn yield in tropical upland acid soils by A. Kasno, A.A. Rivaie, C. Tafakresnanto, E. Pratiwi, E. Karmawati, A.F. Siregar, M. Hatta, M.T. Sutriadi

“…There is a strong correlation between leaf chlorophyll meter readings and corn yield, suggesting the chlorophyll meter can serve as a reliable tool in the study site in determining optimal fertilizer rates.…”
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The effect of the relative dose intensity of chemoradiotherapy on the effectiveness of therapy of locally advanced unresectable non-small cell lung cancer by A. E. Glukhareva, G. V. Afonin, I. V. Kolobaev, L. Yu. Grivtsova, S. A. Ivanov, A.  D.  Kaprin

“…To estimate the number of patients with the preservation of relative dose intensity (RDI) ≥ 80 % of first-line antitumor therapy in patients with unresectable non-small cell lung cancer (NSCLC), and to compare the effectiveness of therapy in groups with optimal and lower RDI.Patients and methods. The study included 30 patients (25 men and 5 women) with locally advanced unresectable NSCLC. …”
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Rat models of postintracerebral hemorrhage pneumonia induced by nasal inoculation with Klebsiella pneumoniae or intratracheal inoculation with LPS by Ruihua Wang, Changlian Gan, Rui Mao, Yang Chen, Ru Yan, Geng Li, Tianqin Xiong, Jianwen Guo

“…Using an LPS-induced ALI complicating ICH model, we also characterized SAP-induced brain, lung and gut histopathology injuries; peripheral immune disorders and intense pulmonary inflammatory responses.ConclusionsThese two models may be highly useful for investigating the pathogenesis and screening and optimizing potential treatments for SAP. Moreover, the differential genera and sphingolipid or Trp metabolites identified above seem to be promising therapeutic targets.…”
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Is the freezing index a valid outcome to assess freezing of gait during turning in Parkinson’s disease? by Maaike Goris, Pieter Ginis, Clint Hansen, Christian Schlenstedt, Christian Schlenstedt, Jeffrey M. Hausdorff, Jeffrey M. Hausdorff, Jeffrey M. Hausdorff, Nicholas D’Cruz, Wim Vandenberghe, Wim Vandenberghe, Walter Maetzler, Alice Nieuwboer, Moran Gilat

“…Additionally, we investigated the FOG-index’s optimal cutoff values to differentiate between PwPD with and without FOG.Methods164 PwPD self-reported the presence of FOG on the New Freezing of Gait Questionnaire (NFOGQ) and performed the DT 360 turn in the ON medication state while being videoed and wearing five wearable sensors. …”
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Food choice motivations and perceptions of healthy eating: a cross-sectional study among consumers in the UAE by Leila Cheikh Ismail, Tareq M. Osaili, Reyad Shaker Obaid, Mona Hashim, Marya Ahmed, Fatma Al-Fayadh, Aisha Farah, Hanin Sad, Humood Alghanem, Maysm N. Mohamad, Sheima T. Saleh, Rameez Al Daour, Emad Masuadi, Lily Stojanovska, Habiba I. Ali, Ayesha S. Al Dhaheri

“…Hierarchical Cluster Analysis (HCA) and K-means cluster analysis were used to identify and determine the optimal number of clusters. Differences between clusters were evaluated using an Independent sample t-test, One-Way ANOVA test, and Chi-square analysis. …”
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A patient-derived HCC spheroid system to model the tumor microenvironment and treatment response by Emilie Crouchet, Nuno Almeida, Sarah C. Durand, Marie Parnot, Marine A. Oudot, Fabio Giannone, Cloé Gadenne, Natascha Roehlen, Antonio Saviano, Emanuele Felli, Patrick Pessaux, Hong Tuan Duong, Hideki Ohdan, Hiroshi Aikata, Kazuaki Chayama, Thomas F. Baumert, Catherine Schuster

“…Cells were grown in 3D in optimized medium in the presence of patient serum. …”
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Machine learning using random forest to model heavy metals removal efficiency using a zeolite-embedded sheet in water by N.D. Takarina, N. Matsue, E. Johan, A. Adiwibowo, M.F.N.K. Rahmawati, S.A. Pramudyawardhani, T. Wukirsari

“…The random forest model is very useful to provide information and determine the threshold of heavy metal contents, water potential of hydrogen and temperature to optimize the heavy metal removal efficiency using a zeolite-embedded sheet and reducing pollutants in the environment.…”
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Immunotherapy combined with chemotherapy without locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: two case reports and a literature review by Yingna Gao, Xiaoqiong Shi, Jianqiao He, Hui Yao, Guoning Yu, Lin Zhao, Yi Ma, Yi Ma, Hongliang Zheng, Minhui Zhu, Caiyun Zhang

“…BackgroundThere is no consensus regarding the optimal regimen for de novo metastatic nasopharyngeal carcinoma (dmNPC). …”
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Comparative Study on Growth Characteristics and Early Selection Efficiency of Hybrid Offspring of <i>Populus deltoides</i> ‘DD-109’ and <i>P. maximowiczii</i> in Liaoning, China... by Wei Liu, Chenggong Liu, Yan Zhang, Jinhua Li, Jiabao Ji, Xiaorui Qin, Fenfen Liu, Chengcheng Gao, Nairui Wang, Xueli Zhang, Ning Liu, Rusheng Peng, Qinjun Huang

“…Using DBH as a reference, correlation and early selection efficiency analysis showed a strong relationship between growth characteristics at planting years 4–5 and later-stage performance, indicating this as the optimal period for early selection. These findings contribute to evaluating the production potential of <i>P. deltoides</i> ‘DD-109’ and <i>P. maximowiczii</i> germplasm in northern China and provide valuable guidance for selecting poplar clones suitable for local cultivation, accelerating breeding processes, and informing management planning for poplar plantations.…”
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Microwave ablation vs. single-needle radiofrequency ablation for the treatment of HCC up to 4 cm: A randomized-controlled trial by Katsutoshi Sugimoto, Kento Imajo, Hidekatsu Kuroda, Go Murohisa, Kazue Shiozawa, Kentaro Sakamaki, Takuya Wada, Hirohito Takeuchi, Kei Endo, Tamami Abe, Takashi Matsui, Takahiro Murakami, Masato Yoneda, Atsushi Nakajima, Shigehiro Kokubu, Takao Itoi

“…Given that an RCT differs slightly from daily clinical situations, practical and anatomical criteria for selecting the optimal technique on a lesion-by-lesion basis are required.…”
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