Effects of plant active substances in rheumatoid arthritis—a systematic review and network meta-analysis by Qiuwei Peng, Jian Wang, Kesong Li, Congming Xia, Chuanhui Yao, Qiuyan Guo, Xun Gong, Xiaopo Tang, Quan Jiang

“…Lastly, with respect to DAS28, resveratrol emerged as the optimal choice (74.3%).ConclusionAccording to the network meta-analysis (NMA), curcumin exhibited superior efficacy compared to placebo in decreasing SJC and TJC. …”
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Research on equity analysis and forecasting of nursing human resource allocation in Jiangxi Province, China by Yunyu Du, Zhiqin Xie, Zhen Yang, Wanyin Xiong, Li Zhou, Min Zhang, Suhua Zeng, Min Wang

“…These findings provide a foundation for optimizing future nursing resource allocation to ensure equitable access to healthcare services.…”
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Clinicopathologic characteristics, therapeutic modalities and survival outcomes of plasmablastic lymphoma: A real-world study by Yan-Hua Zheng, Kun Xie, Hong-Yuan Shen, Zhuo Wan, Shan Gao, Wen-Rui Sun, Guang-Xun Gao, Li Liu, Juan Feng

“…Bortezomib combined with DA-EPOCH may serve as an effective regimen for PBL. The optimal therapeutic modality necessitates further exploration.…”
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Integrative analyses of morpho-physiological, biochemical, and transcriptomic reveal the seedling growth response of Pinus yunnanensis to nitrogen and phosphorus fertilization by Junfei Xu, Junfei Xu, Xiyan Li, Shi Chen, Shi Chen, Lin Chen, Lin Chen, Junrong Tang, Junrong Tang, Peizhen Chen, Peizhen Chen, Nianhui Cai, Nianhui Cai, Yulan Xu, Yulan Xu

“…In conclusion, this study provides comprehensive information on the response of seedlings to varying proportions of N and P and may promote the growth of P. yunnanensis seedlings by optimizing the proportion of N and P in fertilizers.…”
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Status of cerebrovascular autoregulation relates to outcome in severe paediatric head injury: STARSHIP, a prospective multicentre validation studyResearch in context by Shruti Agrawal, Claudia Smith, Stefan Y. Bogli, Michal M. Placek, Manuel Cabeleira, Deborah White, Esther Daubney, Adam Young, Erta Beqiri, Riaz Kayani, Diarmuid O'Donnell, Nazima Pathan, Suzanna Watson, Anna Maw, Matthew Ganrett, Hari Krishan Kanthimathianathan, Harish Bangalore, Santosh Sundararajan, Gayathri Subramanian, Dusan Raffaj, Avishay Sarfatti, Simona Lampareillo, Anton Mayer, Oliver Ross, Marek Czosnyka, Peter J. Hutchinson, Peter Smielewski, Carly Tooke, Caroline Payne, Holly Belfield, Amisha Mistry, Collette Spencer, Claire Jennings, Lara Bunni, Laura Anderson, Emily Morgan, Melanie James, Rebecca Beckley, Tahnima Khatun, Hafiza Khatun, Olivia Nugent, Richard Aldridge, Ruth Morgan, Julie Morcombe, Martin Quinton, Catherine Postlethwaite, Jenny Pond, Jessica Cutler, Caitlin Oxford

“…The main objective was to validate and identify optimal thresholds of PRx associated with outcome (as assessed with Glasgow outcome scale extended for Pediatrics at 12 months) in children (<16 years) requiring invasive arterial blood pressure and intracranial pressure monitoring for TBI and establish a comprehensive research database. …”
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Adverse events of hepatic anti-fibrotic agents in phase 3 and above clinical trials: a descriptive analysis of the WHO-VigiAccess database by Yuwei Liu, Yuwei Liu, Xu Zhao, Xu Zhao, Xinrui Wang, Xinrui Wang, Qiang Zhou, Qiang Zhou

“…This study assessed ADRs associated with anti-fibrotic agents as reported in the World Health Organization (WHO) VigiAccess database and compared the adverse reaction characteristics of these agents for optimizing therapeutic strategies.MethodsA detailed search was conducted on ClinicalTrial.gov to identify phase 3 or 4 clinical trials involving hepatic anti-fibrotic agents. …”
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Combination of clinical factors predicts successful glucocorticoid withdrawal in systemic lupus erythematosus (SLE): results from a multicentre, retrospective cohort study by Alessandra Bortoluzzi, Marcello Govoni, Dimitrios T Boumpas, Antonis Fanouriakis, Prodromos Sidiropoulos, George Bertsias, Konstantinos Parperis, Argyro Repa, Ettore Silvagni, Myrto Nikoloudaki, Nestor Avgoustidis, Sofia Pitsigavdaki, Antonio Marangoni, Irini Flouri, Spyridon Katechis

“…Objective Glucocorticoid (GC) tapering and withdrawal to reduce damage represents a key aspect of the European Alliance of Associations for Rheumatology (EULAR) SLE recommendations. However, optimal strategies for relapse-free GC cessation remain ill-defined. …”
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Differential Prognosis of True Bifurcation Lesions According to Left Main Versus Non–Left Main Location and Treatment Strategy by Ki Hong Choi, Chang‐Wook Nam, Francesco Bruno, Yun‐Kyeong Cho, Leonardo De Luca, Jeehoon Kang, Alessio Mattesini, Young Bin Song, Alessandra Truffa, Hyo‐Soo Kim, Wojciech Wańha, Woo Jung Chun, Sebastiano Gili, Gerard Helft, Seung Hwan Han, Bernardo Cortese, Cheol Hyun Lee, Javier Escaned, Hyuck‐Jun Yoon, Alaide Chieffo, Joo‐Yong Hahn, Guglielmo Gallone, Seung‐Hyuk Choi, Gaetano De Ferrari, Bon‐Kwon Koo, Giorgio Quadri, Seung‐Ho Hur, Fabrizio D'Ascenzo, Hyeon‐Cheol Gwon, Ovidio de Filippo

“…This study aimed to identify whether clinical outcomes of true bifurcation lesions differed between left main coronary artery (LM) and non‐LM bifurcations and to determine the optimal treatment strategy for subtypes of bifurcation lesions in the current‐generation drug‐eluting stent era. …”
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Fecal microbiota is more stable during degradation and more diverse for ex situ cheetahs in Namibia compared to the USA by Morgan A. Maly, Morgan A. Maly, Morgan A. Maly, Morgan A. Maly, Reade B. Roberts, Mia M. Keady, Anne Schmidt-Küntzel, Meagan Maxwell, Laurie Marker, Matthew Breen, Carly R. Muletz-Wolz, Adrienne E. Crosier

“…This study had two aims: 1) to determine the optimal collection time point for cheetah feces after deposit in their native environment of Namibia as a guide for wild cheetah fecal microbiome studies; and 2) to compare the fecal microbiota of two ex situ cheetah populations (Front Royal, VA, USA and Otjiwarongo, Namibia), which also consume different diets. …”
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Superior Mesenteric Artery Syndrome: Clinical, Endoscopic, and Radiological Findings by Emanuele Sinagra, Dario Raimondo, Domenico Albano, Valentina Guarnotta, Melania Blasco, Sergio Testai, Marta Marasà, Vincenzo Mastrella, Valerio Alaimo, Valentina Bova, Giovanni Albano, Dario Sorrentino, Giovanni Tomasello, Francesco Cappello, Angelo Leone, Francesca Rossi, Massimo Galia, Roberto Lagalla, Federico Midiri, Gaetano Cristian Morreale, Georgios Amvrosiadis, Guido Martorana, Marcello Giuseppe Spampinato, Vittorio Virgilio, Massimo Midiri

“…Studies to determine the optimal methods of diagnosis and treatment are required. …”
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One Health interventions and challenges under rural African smallholder farmer settings: A scoping review by Evanson R. Omuse, Honest Machekano, Bonoukpoè M. Sokame, Daniel M. Mutyambai, Thomas Dubois, Sevgan Subramanian, Frank Chidawanyika

“…Thus, this study was conducted to critically map the available evidence of OH initiatives in the lens of African smallholder settings and identify gaps and opportunities for optimally targeted interventions. An extensive article searches yielded 1479 references, with only 21 studies from 11 countries qualifying for this review. …”
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Microenvironment Influences on Human Umbilical Cord Mesenchymal Stem Cell-Based Bone Regeneration by Lingling E, Rongjian Lu, Jianwei Sun, Hongbo Li, Wen Xu, Helin Xing, Xing Wang, Tao Cheng, Shuo Zhang, Xiaocao Ma, Rong Zhang, Hongchen Liu

“…The results indicated that the combination of in vitro hUC-MSCs+nHAC/PLA+OMD+rhBMP-7 microenvironment and in vivo orthotopic microenvironment provided a more optimized niche for bone regeneration of hUC-MSCs. …”
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Development and validation of a nomogram model for prolonged length of stay in spinal fusion patients: a retrospective analysis by Linghong Wu, Xiaozhong Peng, Yao Lu, Cuiping Fu, Liujun She, Guangwei Zhu, Xianglong Zhuo, Wei Hu, Xiangtao Xie

“…Results Model 1 was identified as the optimal model. The risk factors for prolonged LOS comprised blood transfusion, operation type, use of tranexamic acid (TXA), diabetes, electrolyte disturbance, body mass index (BMI), surgical procedure performed, the number of preoperative diagnoses and operative time. …”
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KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors by Linyan Tian, Chengming Liu, Sufei Zheng, Huiyang Shi, Fang Wei, Wenxin Jiang, Yucheng Dong, Haiyan Xu, Enzhi Yin, Nan Sun, Jie He, Yan Wang

“…Abstract Background KRAS-G12C inhibitors mark a notable advancement in targeted cancer therapies, yet identifying predictive biomarkers for treatment efficacy and resistance remains essential for optimizing clinical outcomes. Methods This systematic meta-analysis synthesized studies available through September 2024 across PubMed, Cochrane Library, SpringerLink, and Embase. …”
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Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise by Huiying Zhu, Huiying Zhu, Jianchao Pan, Jianxuan Wen, Jianxuan Wen, Xiaojing Dang, Xiaojing Dang, Xiankun Chen, Xiankun Chen, Yunxiang Fan, Yunxiang Fan, Weihui Lu, Weihui Lu, Wei Jiang, Wei Jiang

“…Thus, it could be useful to develop exercises of appropriate intensity to optimize physical and metabolic health.…”
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Impact of Ecobiol plus ® feed additive on growth performance, physiological response, oxidative status and immunological status of Nile tilapia (Oreochromis niloticus) fingerlings... by Amira A. Omar, Doaa H. Assar, Mustafa Shukry, Aya Abo El-Ezz, Foad A. Farrag, Wesam E. Abd El-Aziz, Eman M. Moustafa

“…These results suggest that Ecobiol plus® can be a natural, antibiotic-free additive to strengthen growth and disease resistance in Nile tilapia. The optimal inclusion level of Ecobiol plus® is 0.4 g/kg for maximum benefit.…”
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Parameter Study on Ultraviolet Rayleigh–Brillouin Doppler Lidar with Dual-Pass Dual Fabry–Perot Interferometer for Accurately Measuring Near-Surface to Lower Stratospheric Wind Fie... by Fahua Shen, Zhifeng Shu, Jihui Dong, Guohua Jin, Liangliang Yang, Zhou Hui, Hua Xu

“…Combining the wind speed measurement error and measurement bias on both sides, the parameters of the dual-pass dual-FPI are optimized. The free spectral range (FSR) of the dual-pass dual-FPI is selected as 12 GHz, the bandwidth as 1.8 GHz, and the peak-to-peak spacing as 6 GHz. …”
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Remote Monitoring of Chemotherapy-Induced Peripheral Neuropathy by the NeuroDetect iOS App: Observational Cohort Study of Patients With Cancer by Ciao-Sin Chen, Michael P Dorsch, Sarah Alsomairy, Jennifer J Griggs, Reshma Jagsi, Michael Sabel, Amro Stino, Brian Callaghan, Daniel L Hertz

“…The Combined Model numerically, though not statistically, outperformed either assessment strategy individually, indicating that the combination of functional and patient-reported assessment within a smartphone may be optimal to CIPN detection. ConclusionsOur findings demonstrate the feasibility of integrating subjective and objective CIPN assessment into a smartphone app for remote, longitudinal CIPN monitoring. …”
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Effect of Planting Systems on the Physicochemical Properties and Bioactivities of Strawberry Polysaccharides by Qiuqiu Zhang, Renshuai Huang, Guangjing Chen, Fen Guo, Yan Hu

“…It is therefore recommended that suitable planting systems be selected to optimize the functionality of plant-derived polysaccharides for potential applications in the food and pharmaceutical industries.…”
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Hypothermia during Surgical Treatment of Type A Aortic Dissection: A 16 Years’ Experience by Francesco Macrina, Maria Cristina Acconcia, Luigi Tritapepe, Mizar D’abramo, Wael Saade, Alessandra Capelli, Fabio Miraldi

“…However, there is still no definitive consensus concerning the optimal range of temperature to be used during circulatory arrest. …”
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