Multi-omics dissection of metabolic dysregulation associated with immune recovery in people living with HIV-1 by Lin-Yu Wan, Sin Man Lam, Hui-Huang Huang, Wen-Jing Cao, Xiang-Yi Cao, Xue-Meng Li, Li-Ping Zhang, Jia-Min Gao, Chao Zhang, Xing Fan, Yan-Mei Jiao, Guanghou Shui, Fu-Sheng Wang, Jin-Wen Song

“…Abstract Background Despite the success of antiretroviral therapy (ART) in suppressing HIV-1 replication, some people living with HIV-1 (PLWH) fail to achieve an optimal recovery of CD4 T cells, and precise metabolic regulation underlying immune recovery remained poorly understood. …”
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Association Between Fentanyl Use and Post-Intubation Mean Arterial Pressure During Rapid Sequence Intubation: Prospective Observational Study by Abdullah Bakhsh, Ahmad Bakhribah, Raghad Alshehri, Nada Alghazzawi, Jehan Alsubhi, Ebtesam Redwan, Yasmin Nour, Ahmed Nashar, Elmoiz Babekir, Mohamed Azzam

“…Medication choice for RSI may either optimize or deoptimize hemodynamic parameters, thereby impacting patient outcomes. …”
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Water-Based Supplementation Technology for Grazing Cattle in the Tropics: A Large-Scale Commercial Case Study by Eliéder Prates Romanzini, Vivienne McCollum, Sarah Mcilveen, Evandro Maia Ferreira, William Luiz de Souza, Marcelo Augusto Oliveira Castro, Priscila Arrigucci Bernardes, Ryan J. Batley, Mark G. Trotter, Diogo Fleury Azevedo Costa

“…These findings suggest that water-based supplementation can be used to optimize nutrient delivery and a methane-reducing compound without compromising cattle productivity in extensive grazing environments. …”
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Variations in the End-Use Quality of Whole Grain Flour Are Closely Related to the Metabolites in the Grains of Pigmented Wheat (<i>Triticum aestivum</i> L.) by Bin Wang, Jie Kang, Shuaiqi Wang, Fasih Ullah Haider, Yingxin Zhong, Peng Zhang

“…Overall, the pigmented wheat varieties offer superior nutritional profiles and processing advantages, necessitating further research to optimize their commercial use.…”
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Modified Endothelial Activation and Stress Index: A New Predictor for Survival Outcomes in Classical Hodgkin Lymphoma Treated with Doxorubicin-Bleomycin-Vinblastine-Dacarbazine-Bas... by Fazıl Çağrı Hunutlu, Hikmet Öztop, Vildan Gürsoy, Tuba Ersal, Ezel Elgün, Şeyma Yavuz, Selin İldemir Ekizoğlu, Azim Ali Ekizoğlu, Vildan Özkocaman, Fahir Özkalemkaş

“…ROC analysis determined an optimal mEASIX score cut-off of 17.28, categorizing patients into mEASIX^high (47%) and mEASIX^low (53%) groups. …”
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Identification of key miRNAs and target genes in extracellular vesicles derived from low-intensity pulsed ultrasound-treated stem cells by Xin Yin, Xin Yin, Jialian Yi, Fugang Mao, Qisheng Tang, Xinyu Zhang, Xiaoyu Yang, Hongqing Xie, Linping Wang, Shuifen Sun, Xin Yu, Xin Yu, Jie Liu, Lihong Jiang, Lihong Jiang

“…While further investigation is necessary to validate their roles as therapeutic targets, this study lays the groundwork for future research on optimizing SC-EV therapy with LIPUS preconditioning.…”
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Combination of the endoscopic septonasal flap technique and bioabsorbable steroid-eluting stents for repair of congenital choanal atresia in neonates and infants: a retrospective s... by Peng-peng Wang, Li-xing Tang, Jie Zhang, Xiao-jian Yang, Wei Zhang, Yang Han, Xiao Xiao, Xin Ni, Wen-tong Ge

“…However, there remains no general consensus about the optimal surgical technique. This study aimed to describe and evaluate outcomes of the endoscopic septonasal flap technique combined with bioabsorbable steroid-eluting stents for repair of congenital choanal atresia in neonates and infants. …”
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Composite Sorbents Based on Chitosan Polymer Matrix and Derivatives of 4-Amino-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide for Uranium Removal from Liquid Mineralized Media by Anna I. Matskevich, Konstantin V. Maslov, Veronika A. Prokudina, Daria D. Churakova, Oleg Yu. Slabko, Dmitry K. Patrushev, Nikita S. Markin, Eduard A. Tokar’

“…The formation of the Se derivative of amidoxime during its attachment to the polymer matrix (Se-chit) contributes to the creation of a more chemically stable and highly effective adsorbent, compared to the direct binding of 4-amino-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide with chitosan (43AF-chit). The optimal parameters for the synthesis of materials were established. …”
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Whole genome sequencing of a novel carrageenan-degrading bacterium Photobacterium rosenbergii and oligosaccharide preparation by Jing Chen, Jing Chen, Runmin Chen, Kit-Leong Cheong, Zhuo Wang, Rui Li, Xuejing Jia, Qiaoli Zhao, Xiaofei Liu, Bingbing Song, Saiyi Zhong, Saiyi Zhong

“…GDSX-4 exhibited remarkable carrageenan-degrading activity, with a specific enzyme activity of 46.94 U/mg. Optimal hydrolysis conditions were determined to be 40°C and pH 7.0, with the enzyme retaining 80% of its activity below 30°C and across a pH range of 4.0–10.0. …”
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Role of stability analysis and waste discharge concentration of ternary hybrid nanofluid in a non-Newtonian model with slip boundary conditions by Nurhana Mohamad, Shuguang Li, Umair Khan, Anuar Ishak, Ali Elrashidi, Mohammed Zakarya

“…This research provides insights into optimizing nanofluids in pollutant-laden environments, with potential applications in industrial processes involving heat exchangers and pollution control. …”
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Negative valuation of ambiguous feedback may predict near-term risk for suicide attempt in Veterans at high risk for suicide by Catherine E. Myers, Catherine E. Myers, Rokas Perskaudas, Rokas Perskaudas, Vibha Reddy, Chintan V. Dave, Chintan V. Dave, John G. Keilp, Arlene King, Kailyn Rodriguez, Kailyn Rodriguez, Lauren St. Hill, Rachael Miller, Alejandro Interian, Alejandro Interian

“…Computational modeling was used to estimate latent cognitive variables including learning rates from positive and negative outcomes, and the subjective value of ambiguous feedback.ResultsOptimal responding on the reward-based trials was positively associated with upcoming ASA, and remained predictive even after controlling for other standard clinical variables such as current suicidal ideation severity and prior suicide attempts. …”
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Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with Concurrent <i>Clostridioides difficile</i> Infection: A Comparative Cohort Analysis by Flavia Ignuta, Adrian Vlad, Teodor Cerbulescu, Stana Loredana, Felix Bratosin, Ovidiu Rosca, Lavinia Stelea, Daciana Nistor

“…Future studies should expand on these findings to optimize care and guide therapeutic strategies.…”
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The prognostic value of systemic immune-inflammation index in patients with unresectable hepatocellular carcinoma treated with immune-based therapy by Tian He, Bin Xu, Lu-Na Wang, Zi-Yi Wang, Huan-Chen Shi, Cheng-Jie Zhong, Xiao-Dong Zhu, Ying-Hao Shen, Jian Zhou, Jia Fan, Hui-Chuan Sun, Bo Hu, Cheng Huang

“…The predictive accuracy of SII was evaluated using receiver operating characteristic (ROC) curves. Results An optimal SII cutoff of 752*109 stratified patients into high and low SII groups. …”
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Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trialsResearch in context by Sabri Soussi, Tuukka Tarvasmäki, Antoine Kimmoun, Mojtaba Ahmadiankalati, Feriel Azibani, Claudia C. dos Santos, Kevin Duarte, Etienne Gayat, Jacob C. Jentzer, Veli-Pekka Harjola, Benjamin Hibbert, Christian Jung, Lassus Johan, Bruno Levy, Zihang Lu, Patrick R. Lawler, John C. Marshall, Janine Pöss, Malha Sadoune, Alexis Nguyen, Alexandre Raynor, Katell Peoc'h, Holger Thiele, Rebecca Mathew, Alexandre Mebazaa

“…Methods: We used unsupervised clustering to integrate plasma biomarker data from two prospective cohorts of CS patients: CardShock (N = 205 [2010–2012, NCT01374867]) and the French and European Outcome reGistry in Intensive Care Units (FROG-ICU) (N = 228 [2011–2013, NCT01367093]) to determine the optimal number of classes. Thereafter, a simplified classifier (Euclidean distances) was used to assign the identified CS subphenotypes in three completed randomized controlled trials (RCTs) (OptimaCC, N = 57 [2011–2016, NCT01367743]; DOREMI, N = 192 [2017–2020, NCT03207165]; and CULPRIT-SHOCK, N = 434 [2013–2017, NCT01927549]) and explore heterogeneity of treatment effect with respect to 28-day mortality (primary outcome). …”
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Strong-lensing Analysis of SPT-CL J2325−4111 and SPT-CL J0049−2440, Two Powerful Cosmic Telescopes (RE > 40″) from the SPT Clusters Sample by Guillaume Mahler, Keren Sharon, Matthew Bayliss, Lindsey. E. Bleem, Mark Brodwin, Benjamin Floyd, Raven Gassis, Michael D. Gladders, Gourav Khullar, Juan D. Remolina González, Arnab Sarkar

“…The lens models of SPT-CL J2325−4111 and SPT-CL J0049−2440 were optimized using nine and eight secure multiply imaged systems with a final image-plane rms of 0 $\mathop{.}…”
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Processing tomato (Lycopersicon esculentum Miller) yield and quality in arid regions through micro-nano aerated drip irrigation coupled with humic acid application by Jiaying Ma, Rui Chen, Yue Wen, Jinzhu Zhang, Feihu Yin, Tehseen Javed, Jiliang Zheng, Zhenhua Wang

“…Multiple regression and spatial analysis of yield, water use efficiency, and lycopene content indicated that, under micro-nano aeration, irrigation volumes between 445.700–446.833 mm, combined with 0.492–0.498 % HA, represent optimal irrigation strategies. These conditions ensured that yield (278.03–281.21 t ha–1), WUE (0.57–0.58 t ha–1 mm–1), lycopene content (56.28–56.76 mg kg–1), and Vc content (56.06–56.19 mg 100 g–1) remained above 95 % of their maximum values.…”
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Cost-effectiveness analysis of three surgical approaches for parathyroidectomy in secondary hyperparathyroidism patients by Qila Sa, Qila Sa, Yinghui Zhou, Guangming Cheng, Boyuan Nan, Yingnan Feng, Yingnan Feng, Ningyuan Zhang, Ningyuan Zhang, Wantao Xie, Wantao Xie, Wei Zhang

“…However, a debate regarding which of these surgical methods is optimal has been ongoing. Aim of this study is to compare medical costs and final outcomes associated with the three surgical approaches for the entire treatment duration, aiming to identify the most cost-effective surgical method.MethodsBased on previous research data from domestic and international studies, as well as data from on-site surveys, TreeAge Pro 2022 software was used to construct a Markov model for the surgical treatment of SHPT patients. …”
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Ovarian Reserve: A Critical Indicator of Female Reproductive Health by Julia Ufnal, Anna Wolff, Maria Morawska, Dominika Lewandowska, Dominika Rosińska-Lewandoska, Marcelina Szewczyk, Klaudia Kożuchowska, Dawid Pilarz, Kinga Jarosz, Szymon Gruszka

“…Conclusions: Assessing ovarian reserve is crucial for predicting pregnancy outcomes, optimizing ART protocols, and guiding reproductive decisions. …”
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Efficacy of Early Endoscopic Ultrasound-Guided Transluminal Drainage for Postoperative Pancreatic Fistula by Nao Fujimori, Takashi Osoegawa, Akira Aso, Soichi Itaba, Yosuke Minoda, Masatoshi Murakami, Kazuhide Matsumoto, Katsuhito Teramatsu, Yu Takamatsu, Takehiro Takaoka, Takamasa Oono, Eikichi Ihara, Tomoharu Yoshizumi, Takao Ohtsuka, Masafumi Nakamura, Yoshihiro Ogawa

“…Endoscopic ultrasound-guided transluminal drainage (EUS-TD) is generally performed 4 weeks after disease onset for evacuating pancreatic fluid collections. However, the optimal timing for conducting the procedure in those diagnosed with postoperative pancreatic fistula (POPF) has not been established. …”
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Utilizing multidisciplinary mobile outreach clinics to provide comprehensive diabetic foot care to patients experiencing homelessness by Kris M. Boelitz, MD, Jaeyoung Lee, BS, Michael D. Pepin, BS, Yiming Zhang, MS, Mallory Gibbons, MSN, NP, Frances J. Lagana, DPM, Shahida Balaparya, EdD, MBA, RVT, Lindsey Carr, Jessin Varghese, BS, NP, Caitlin Sorensen, MD, Jessica P. Simons, MD, MPH, Douglas Jones, MS, MD, Andres Schanzer, MD, Tammy T. Nguyen, MD, PhD

“…This study reflects the valuable lessons we learned in optimizing MMC events for maximum community benefit.…”
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