Cultivatable Bacteriota of Chronic Wound of Patients with Diabetic Foot Syndrome with Critical Limb Ischemia Based on Wound Biopsy in Peri-Revascularization Period by Syedah Sarah Hussaini, Fran Dominic Grubesa, Mateusz Gajda, Martyna Schönborn, Katarzyna Bogucka, Mikołaj Maga, Paweł Maga, Jadwiga Wójkowska-Mach

“…Pathogen distribution at follow-up resembled baseline findings. Optimizing clinical environments (enhancing blood flow and controlling inflammation) in general over focusing singularly on microbiota composition or revascularization seems to be crucial and arguably outweighed the impact of microbial change alone; in particular, reperfusion may increase the conditions to bacterial growth at the first stage.…”
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Predicting the risk of heart failure after acute myocardial infarction using an interpretable machine learning model by Qingqing Lin, Qingqing Lin, Wenxiang Zhao, Wenxiang Zhao, Hailin Zhang, Hailin Zhang, Wenhao Chen, Sheng Lian, Qinyun Ruan, Qinyun Ruan, Zhaoyang Qu, Zhaoyang Qu, Yimin Lin, Yimin Lin, Dajun Chai, Dajun Chai, Dajun Chai, Dajun Chai, Xiaoyan Lin, Xiaoyan Lin, Xiaoyan Lin, Xiaoyan Lin

“…In addition, we used the Shapley Additive Explanations (SHAP) value to determine the importance of the selected features and interpret the optimal model.ResultsA total of 1220 AMI patients were included and 244 (20%) patients developed HF during follow-up. …”
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Prognostic significance of albumin corrected anion gap in patients with acute pancreatitis: a novel perspective by Jianjun Wang, Pei Yang, Xintao Zeng, Sirui Chen, Xi Chen, Lan Deng, Ruizi Shi, Chuan Qin, Huiwen Luo, Jianping Gong, Hua Luo, Decai Wang

“…R statistical software was used to identify the optimal thresholds for ACAG. Kaplan-Meier survival curves and multivariate Cox proportional hazards regression models were employed to assess the association between ACAG and short- and long-term ACM of AP. …”
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Unlocking barriers and strategies of halal certification for micro and small enterprises in Indonesia: Analytic network process approach by Muhammad Anwar Fathoni, Prima Dwi Priyatno, Faizi, Fadhli Suko Wiryanto, Widarto Rachbini, Suryani

“…This analysis contributes to the broader discourse on enhancing MSE participation in the halal market, offering implications for both local and international stakeholders seeking to optimize the halal certification process. Acknowledgment The authors would like to express their sincere gratitude to the Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia (Kemendikbudristek RI) for providing financial support for this investigation. …”
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Development and external validation of a dynamic nomogram for predicting the risk of functional outcome after 90 days in patients with acute intracerebral hemorrhage by Shaojie Li, Hongjian Li, Jiani Chen, Baofang Wu, Jiayin Wang, Chaocan Hong, Changhu Yan, Weizhi Qiu, Yasong Li, Hongzhi Gao

“…Background and purposeIntracerebral hemorrhage remains a significant cause of death and disability worldwide, highlighting the urgent need for accurate prognostic assessments to optimize patient management. This study aimed to develop a practical nomogram for risk prediction of poor prognosis after 90 days in patients with intracerebral hemorrhage.MethodsA retrospective study was conducted on 638 patients with intracerebral hemorrhage in the Second Hospital of Fujian Medical University, China, who were divided into a training set (n = 446) and a test set (n = 192) by random splitting. …”
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Impact of Nasal Anatomical Variation Subtype on Surgical Outcomes for Rhinogenic Contact Point Headache by Salvatore Lavalle, Annalisa Pace, Giuseppe Magliulo, Mario Lentini, Jerome Rene Lechien, Christian Calvo-Henriquez, Federica Maria Parisi, Giannicola Iannella, Antonino Maniaci, Daniela Messineo

“…Larger studies should validate these findings to optimize RCPH management.…”
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Hydrocarbon generation, expulsion, and retention characteristics of the Permian Fengcheng shale and Lucaogou shale in the Junggar Basin: implications for the exploration of lacustr... by Wenjun He, Zhiming Li, Zhiming Li, Zhiming Li, Changrong Li, Changrong Li, Jinyi He, Jinyi He, Jinyi He, Junying Leng, Junying Leng, Junying Leng, Zhongliang Sun, Zhongliang Sun, Zhongliang Sun, Deguang Liu, Sen Yang

“…Mesopore volume and its connectivity were critical factors affecting the hydrocarbon expulsion ratio, whereas oil mobility and macropore volume have relatively limited effects. The optimal maturity interval for shale oil exploration as Ro = 1.0%–1.1% for the Fengcheng shale and Ro = 0.9%–1.1% for the Lucaogou shale. …”
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Association between prostate-specific antigen density and prostate cancer prediction among Nigerian men by Abudu EK, Okuku CN, Akaiso OE, Fabian UA, Udoh EA, Ukpong AE, Kudamnya IJ, Ajayi OO, Uduma FU, Abudu OO, Ekpo BO

“…The Area Under the Curve (AUC) and optimal cut-off point for the PSAD was 0.9 (95% CI: 0.83–0.97) and 0.052 respectively, indicating strong diagnostic performance for predicting prostate cancer. …”
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Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells by Christian Sávio-Silva, Stephany Beyerstedt, Poliana E. Soinski-Sousa, Expedito B. Casaro, Maria Theresa A. Balby-Rocha, Antônio Simplício-Filho, Jamille Alves-Silva, Érika B. Rangel

“…Therefore, randomized and controlled trials considering the source, optimal cell number, and route of delivery in DM patients are further required to advance MSC-based therapy. …”
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Response of alcohol fermentation strains, mixed fermentation and extremozymes interactions on wine flavor by Ling-Zhi Zhao, Ling-Zhi Zhao, Jing Chen, Jing Chen, Jing Chen, Xiang-Ying Wei, Xiang-Ying Wei, Xiang-Ying Wei, Bo Lin, Feng-Jin Zheng, Krishan K. Verma, Gan-Lin Chen, Gan-Lin Chen, Gan-Lin Chen

“…However, the physicochemical and sensory properties of alcohol are important to the quality of end-use products. Therefore, when optimizing fermentation conditions, selecting a right combination of microorganisms is the key to derive better physicochemical and sensory properties. …”
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Development and predictors of bipolar disorder in children and adolescents with depressive disorders: a systematic review, meta-analysis, and meta-regression by Gonzalo Salazar de Pablo, Violeta Perez-Rodriguez, Javier de Otazu Olivares, Javier Camacho-Rubio, Aditya Sharma, Ana Catalán, Josefien Breedvelt, Claudia Aymerich, Mihai Pop, Carmen Moreno, Ian Kelleher, Jane Anderson, Paolo Fusar-Poli, Christoph U Correll, Allan H. Young

“…Abstract Background Estimating the risk of developing bipolar disorder (BD) in children and adolescents (C&A) with depressive disorders is important to optimize prevention and early intervention efforts. …”
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Characterization and Analysis of 2-(2-Phenylethyl)chromone Derivatives and Sesquiterpenoids from Agarwood of Four “Qi-Nan” Clones (<i>Aquilaria sinensis</i>) with Different Inducti... by Ming Li, Zhou Hong, Shengjie Wang, Daping Xu, Zinong Yang, Zhihui Li, Houzhen Hu, Suxin Li

“…The study underscores that optimizing induction time and selecting suitable “Qi-Nan” clones can significantly enhance agarwood yield, quality, and production efficiency.…”
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The Global RAdical Cystectomy Evaluation and Management (GRACEM) pathway: single‐centre prospective observational cohort study protocol by Bruno Bernardini, Federico Piccioni, Manuele Pastore, Paolo Casale, NicolòMaria Buffi, Giovanni Lughezzani, Massimo Lazzeri, Alberto Saita, Maria Vittoria Fantacci, Stefano Mancon, Filipo Dagnino, Roberto Contieri, Pietro Brin, Stefano Mancin, Andrea Gobbo, Maria Rosaria Martucci, Giovanna Cerina, Sara Ghirmai, Ezio Lanza, Giulia Goretti, Giorgio Ferruccio Guazzoni, Rodolfoi Hurle

“…New insights will be gained into how to optimize the physical and mental status and quality of life of patients before and after surgery, up to 1 year later. …”
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Predictors of Recurrence After Curative Surgery for Stage I Colon Cancer: Retrospective Cohort Analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collab... by Giulia Turri, MD, Luigi Martinelli, MD, Daniela Rega, MD, Nicolò Tamini, MD, Lucia Paiano, MD, Simona Deidda, MD, QuocRiccardo Bao, MD, Laura Lorenzon, MD, PhD, Raffaele De Luca, MD, Caterina Foppa, MD, PhD, Valentina Mari, MD, Giovanni Taffurelli, MD, Arcangelo Picciariello, MD, PhD, Patrizia Marsanic, MD, Leandro Siragusa, MD, Francesco Bagolini, MD, Riccardo Nascimbeni, MD, Gianluca Rizzo, MD, PhD, Sara Vertaldi, MD, Michele Zuolo, MD, Giorgio Bianchi, MD, Lisa Marie Rorato, MD, Rossella Reddavid, MD, PhD, Gaetano Gallo, MD, PhD, Lorenzo Crepaz, MD, Alberto Di Leo, MD, Mario Trompetto, MD, Enrico Potenza, MD, Mauro Santarelli, MD, Nicola de’Angelis, MD, PhD, Francesco Ciarleglio, MD, Marco Milone, MD, PhD, Claudio Coco, MD, Guido Alberto Tiberio, MD, Gabriele Anania, MD, Giuseppe S. Sica, MD, PhD, Andrea Muratore, MD, Donato Francesco Altomare, MD, Isacco Montroni, MD, PhD, Maurizio De Luca, MD, Antonino Spinelli, MD, PhD, Michele Simone, MD, Roberto Persiani, MD, Gaya Spolverato, MD, Angelo Restivo, MD, Nicolò de Manzini, MD, Marco Braga, MD, Paolo Delrio, MD, Giuseppe Verlato, MD, PhD, Corrado Pedrazzani, MD, Adriana Gioia, Cristina Vacca, Dario Parini, Giovanni Tomasicchio, Marcello Calabrò, Bruno Sensi, Filomena Misuriello, Carlo Alberto Schena, Silvia Picotto

“…This evidence could be used to optimize postoperative follow-up.…”
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Invited review: Improved control of Johne's disease in dairy cattle through advancements in diagnostics, testing, and management of young stock by Larissa Martins, Karin Orsel, Razieh Eshraghisamani, Jose Miguel Hernández-Agudelo, A. Caroline Pereira, Waseem Shaukat, Ad P. Koets, John P. Bannantine, Caroline Ritter, David F. Kelton, Richard J. Whittington, Maarten F. Weber, Antonio Facciuolo, Navneet K. Dhand, Karsten Donat, Susanne Eisenberg, Miguel A. Salgado, John P. Kastelic, Jeroen De Buck, Herman W. Barkema

“…Studies on IGRA and ELISA have focused on evaluation of new antigens and optimal age of testing. New diagnostics have been developed, including phage-based tests to detect viable MAP, as well as gene expression patterns and metabolomics to detect MAP-infected young stock. …”
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Outcomes of percutaneous endoscopic gastrostomy (PEG) in HIV patients by Nikhitha Mantri, Haozhe Sun, Sameer Datta Kandhi, Nishant Allena, Muhammad Yasir Anwar, Vibha Hayagreev, Shalini Penikilapate, Ahmed Alemam, Hassan A Muntazir, Trishna Acherjee, Harish Patel, Jasbir Makker

“…Further research is warranted to elucidate the underlying factors contributing to these outcomes, facilitating the development of targeted interventions to optimize the care of HIV patients undergoing PEG placement.…”
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Real-world prognostic factors in autotransplanted multiple myeloma patients with severe renal impairment: study of the Polish Myeloma Study Group by Anna Waszczuk-Gajda, David H. Vesole, Jolanta Małyszko, Artur Jurczyszyn, Tomasz Wróbel, Joanna Drozd-Sokołowska, Piotr Boguradzki, Krzysztof Mądry, Agnieszka Tomaszewska, Jarosław Biliński, Maria Król, Longin Niemczyk, Magdalena Olszewska-Szopa, Wieslaw W. Jedrzejczak, Grzegorz W. Basak

“…The median overall survival (OS) was 3.6 years, there was no difference in median OS between the groups (4.0 vs. 3.5 years, respectively). Conclusions Optimal patient selection including good performance status and higher albumin concentration (with every increase of 1 g/dl), chemotherapy-responsive disease pre-ASCT, melphalan dose adjusted to CKD, and intensive post-transplant supportive care are crucial to achieve acceptable results of treatment of MM patients with CKD.…”
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The Role of 3D Virtual Anatomy and Scanning Environmental Electron Microscopy in Understanding Morphology and Pathology of Ancient Bodies by Sara Salucci, Mirko Traversari, Laura Valentini, Ilaria Versari, Luca Ventura, Emanuela Giampalma, Elena Righi, Enrico Petrella, Pietro Gobbi, Gianandrea Pasquinelli, Irene Faenza

“…For this reason, computed tomography, a well-established approach that achieves optimal image contrast and three-dimensional reconstruction, has been introduced. …”
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Regional-scale precision mapping of cotton suitability using UAV and satellite data in arid environments by Jianqiang He, Yonglin Jia, Yi Li, Asim Biswas, Hao Feng, Qiang Yu, Shufang Wu, Guang Yang, Kadambot.H.M. Siddique

“…It introduces an innovative framework for assessing regional cotton crop suitability by integrating ground-measured soil water and salt data with UAV multispectral and Sentinel-2A satellite imagery from the 2022 cotton growing season. An optimized set of vegetation indices was identified through multicollinearity analysis and full subset selection. …”
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Integrating retrieval-augmented generation for enhanced personalized physician recommendations in web-based medical services: model development study by Yingbin Zheng, Yiwei Yan, Sai Chen, Yunping Cai, Kun Ren, Yishan Liu, Jiaying Zhuang, Min Zhao

“…Among these, SBERT and Mistral are identified as the optimal choices due to their balanced performance, cost effectiveness, and ease of implementation.ConclusionThe RAGPR model can significantly improve the accuracy and personalization of web-based medical services, providing a scalable solution for improving patient-physician matching.…”
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