Bioelectric stimulation outperforms brain derived neurotrophic factor in promoting neuronal maturation by María del Pilar Diego-Santiago, María Ujué González, Esther María Zamora Sánchez, Nuria Cortes-Carrillo, Carlos Dotti, Francesc Xavier Guix, Sahba Mobini

“…We identified accumulated charge and effective electric field time as novel criteria for determining optimal ES regimes. ES parameters were obtained using electrochemical characterisation and equivalent circuit modelling. …”
Get full text

Proximity of maxillary molar palatal roots to adjacent structures for endodontic microsurgery: a cone-beam computed tomography study by Xiaoxiang Huang, Jun Xu, Benxiang Hou, Ying Wang

“…Understanding the relationship between the roots of the maxillary molar and neighbouring anatomical structures helps surgeons evaluate potential difficulties, select optimal strategies, and reduce complications. Clinical trial number Not applicable.…”
Get full text

Effect of Ultrasonic Exposure on the Efficiency of De-Oiling Fluid Lecithins by Ekaterina V. Lisovaya, Elena P. Viktorova, Anastasia V. Sverdlichenko, Mariet R. Zhane

“…The study specified the optimal technological modes for obtaining a phospholipid isolate with a high content of phospholipids (98.6%), which can be recommended as a food additive.…”
Get full text

Fortifying plant fortresses: siderophores in defense against Cercospora leaf spot disease in Vigna radiata L. by Anushree Kamath, Abhishek Sharma, Arpit Shukla, Arpit Shukla, Arpit Shukla, Paritosh Parmar, Dhara Patel

“…Field trials are essential to validate these results under natural conditions and optimize their use in agriculture.…”
Get full text

High-Performance Photocatalytic Multifunctional Material Based on Bi₄Ti₃O₁₂-Supported Ag and Ti₃C₂T_x for Organic D... by Kexi Zhang, Bingdong Yan, Xiaohong Wang, Yang Cao, Wanjun Hao, Jinchun Tu

“…We discovered that the addition of Ag and Ti₃C₂T_x effectively optimized the visible light absorption characteristics of BTO, reduced the electron transfer resistance, and increased the carrier concentration, thus significantly improving the photocatalytic performance of composite material, thereby markedly improving the composite’s photocatalytic performance and its efficacy in photochemical sensing and photodegradation. …”
Get full text

Enhanced CyGNSS Soil Moisture Retrieval Validated by In-Situ Data in Argentina's Pampas by Javier Arellana, Francisco Grings, Mariano Franco

“…We observe that both the in-situ measurements of <inline-formula><tex-math notation="LaTeX">$\varepsilon _{1}$</tex-math></inline-formula> and the reflectivity reported by CyGNSS align with the optimal values obtained from the fit, resulting in a 73&#x0025; reduction in root mean square error when compared to the traditional approach. …”
Get full text

Participant Compliance With Ecological Momentary Assessment in Movement Behavior Research Among Adolescents and Emerging Adults: Systematic Review by Shirlene Wang, Chih-Hsiang Yang, Denver Brown, Alan Cheng, Matthew Y W Kwan

“…Findings also highlight the need for greater consistency in reporting and more specificity when explaining procedures to understand how EMA compliance could be optimized in studies examining physical activity and sedentary time among youth. …”
Get full text

Quantitative Physiologic MRI Combined with Feature Engineering for Developing Machine Learning-Based Prediction Models to Distinguish Glioblastomas from Single Brain Metastases by Seyyed Ali Hosseini, Stijn Servaes, Brandon Hall, Sourav Bhaduri, Archith Rajan, Pedro Rosa-Neto, Steven Brem, Laurie A. Loevner, Suyash Mohan, Sanjeev Chawla

“…<b>Background</b>: The accurate and early distinction of glioblastomas (GBMs) from single brain metastases (BMs) provides a window of opportunity for reframing treatment strategies enabling optimal and timely therapeutic interventions. We sought to leverage physiologically sensitive parameters derived from diffusion tensor imaging (DTI) and dynamic susceptibility contrast (DSC)–perfusion-weighted imaging (PWI) along with machine learning-based methods to distinguish GBMs from single BMs. …”
Get full text

Evolving racial/ethnic disparities in AML survival in the novel therapy era by Xin Wang, Phyllis A. Gimotty, Andrew H. Matthews, Ronac Mamtani, Selina M. Luger, Elizabeth O. Hexner, Daria V. Babushok, Shannon R. McCurdy, Noelle V. Frey, Ximena Jordan Bruno, Saar Gill, Mary Ellen Martin, Vikram R. Paralkar, Ivan Maillard, David L. Porter, Alison W. Loren, Alexander E. Perl, Keith W. Pratz, Kelly D. Getz, Catherine Lai

“…Additional studies are needed to elucidate factors contributing to these observed survival differences and to inform strategies to optimize outcomes for all patients with AML.…”
Get full text

Critical care services in Bagmati province of Nepal: A cross sectional survey [version 4; peer review: 4 approved, 2 approved with reservations] by Subekshya Luitel, Sushila Paudel, Diptesh Aryal, Janaki Pandey, Hem Raj Paneru, Roshni Shakya, Prashant Acharya, Isha Amatya, Rashan Haniffa, Suman Pant, Abi Beane, Pradip Gyanwali

“…This study suggests conducting a nationwide mapping of ICU resources, prioritizing infrastructure development, optimizing resource allocation, and establishing national protocols.…”
Get full text

Verifying the Usefulness of Pulmonary Blood Flow Studies in the Correction of Pulmonary Atresia and Ventricular Septal Defect with Major Aortopulmonary Collateral Arteries by Zirou Huang, Fan Cao, Rongjun Zou, Minghui Zou, Weidan Chen, Wenlei Li, Guodong Huang, Li Ma, Xinxin Chen

“…The maximum Youden’s index was 0.713, which corresponded to an optimal mean pulmonary artery pressure cutoff value of 24.5 mmHg. …”
Get full text

Integrated response of crop yields and greenhouse gas emissions to cropland management practices and natural factors: a global meta-analysis by Jiahui Dong, Shikun Sun, Guolong Zhan, Jingxin Sun, Yihe Tang, Yubao Wang

“…The effect of intermittent irrigation (I-IRR) on the yield of C _4 crop was 25.7% higher than that of C _3 crop. The optimal nitrogen utilization rates for wheat and corn were 253.20 kg·N·hm ^−2 and 239.84 kg·N·hm ^−2 , respectively, and N fertilizer was more effective in reducing GHG of C _3 crops. …”
Get full text

Image-based robotic (ROSA® knee system) total knee arthroplasty with inverse kinematic alignment compared to conventional total knee arthroplasty by Henriëtte M. Eijking, Isobel M. Dorling, Emil H. van Haaren, Roel Hendrickx, Thijs Nijenhuis, Martijn G.M. Schotanus, Lee Bouwman, Jasper Most, Bert Boonen

“…Relatively high rates of dissatisfactory results after total knee arthroplasty (TKA), as reported by approximately 20% of patients, may be caused by sub-optimal knee alignment and balancing. While mechanical alignment has traditionally been the goal, patient-specific alignment strategies are gaining interest. …”
Get full text

Pt@ZnCo₂O₄ Microspheres as Peroxidase Mimics: Enhanced Catalytic Activity and Application for L-Cysteine Detection by Shuqi Liao, Weisen Deng, Feng Yang, Jutao Zhou, Ling Wu, Donghong Yu, Zhong Cao

“…Using fluorescent probes and electrochemical methods, the peroxidase-like catalytic mechanism has been explored that Pt@ZnCo₂O₄ microspheres can accelerate the electron transfer between H₂O₂ and 3,3′,5,5′-tetramethylbenzidine (TMB). Based on the optimal loading ratio of 12.5% of Pt@ZnCo₂O₄, a colorimetric sensor for visual detection of L-cysteine (L-Cys) was constructed, exhibiting a wide linear range of 0.1~50 µM and a low detection limit of 0.0163 µM. …”
Get full text

Examining internet use for health information seeking and influencing factors among undergraduate health science students in Southwest Ethiopia by Alex Ayenew Chereka, Fikadu Wake Butta, Addisalem Workie Demsash, Sisay Yitayh Kassie, Adamu Ambachew Shibabaw, Abiy Tasew Dubale, Geleta Nenko Dube, Mekonnen Kenate Hunde, Wubalem Dilie Limeneh, Amare Dagnew Fentahun, Milkias Dugassa Emanu, Mekashaw Tareke Abebe, Gemeda Wakgari Kitil

“…Understanding these factors is vital for optimizing internet resources for health information dissemination.…”
Get full text

Normalization of tumor vasculature by imiquimod: proposal for a new anticancer therapeutic indication for a TLR7 agonist by Jarosz-Biej Magdalena, Czapla Justyna, Ciepła Joanna, Smolarczyk Ryszard, Drzyzga Alina, Sprus-Lipka Dorota, Pilny Ewelina, Matuszczak Sybilla, Cichoń Tomasz

“…This knowledge may help to optimize the combination of the selected IMQ dose with e.g. chemotherapy or radiotherapy to elicit synergistic effect in cancer treatment. …”
Get full text

Evolution of Treatment Outcomes and Prognostic Factors in Esophageal Cancer Surgery: A Retrospective Analysis of 1500 Consecutive Esophagostomies by Yasue Kimura, MD, PhD, Eiji Oki, MD, PhD, Tomonori Nakanoko, MD, PhD, Qingjiang Hu, MD, PhD, Keita Natsugoe, MD, Sho Nanbara, MD, PhD, Ryota Nakanishi, MD, PhD, Yuichiro Nakashima, MD, PhD, Mitsuhiko Ota, MD, PhD, Tomoharu Yoshizumi, MD, PhD

“…These findings will help optimize esophageal cancer management and improve patient outcomes.…”
Get full text

Drp1–associated genes implicated in sepsis survival by Marissa D. Pokharel, Marissa D. Pokharel, Anlin Feng, Anlin Feng, Ying Liang, Ying Liang, Wenli Ma, Wenli Ma, Saurabh Aggarwal, Hoshang Unwalla, Stephen M. Black, Stephen M. Black, Stephen M. Black, Ting Wang, Ting Wang, Ting Wang

“…This biomarker holds the potential for improving the early identification of high-risk sepsis patients and optimizing personalized treatment strategies to reduce sepsis mortality.…”
Get full text

Study of interfacial bonding properties and shrinkage deformation of cement-alkali activated gradient-structured composite in complex environments with temperature-humidity changes by Xinzhe Li, Ganyou Jiang, Naishuang Wang, Yisong Wei, Zheng Chen, Zheng Chen, Jing Li, Jing Li, Ben Chen, Ben Chen, Jiamin Yu, Jiamin Yu

“…This study provides some references for the optimal design of the early shrinkage-deformation properties and mechanical properties of gradient-structured composites under extreme environments as well as the assessment of service life.…”
Get full text

Research priorities for autosomal dominant polycystic kidney disease: a UK priority setting partnership by Tess Harris, Albert Ong, Paul J D Winyard, Richard N Sandford, Maryrose Tarpey, Hannah R Bridges, Wendy D Brown, Natasha L O’Brien, Ann C Daly, Bharat K Jindal, Gillian S Mundy, Albert J Power, John Sayer, Roslyn J Simms, Patricia D Wilson

“…The top three questions prioritised by patients, carers and healthcare professionals centred around slowing disease progression, identifying persons for early treatment and organising care to improve outcomes.Conclusions Our shortlist reflects the varied physical, psychological and practical challenges of living with and treating ADPKD, and perceived gaps in knowledge that impair optimal care. We propose that future ADPKD research funding takes these priorities into account to focus on the most important areas and to maximise improvements in ADPKD outcomes.…”
Get full text