Development and validation of a novel risk-predicted model for early sepsis-associated acute kidney injury in critically ill patients: a retrospective cohort study by Bo Li, Kun Zhang, Cong-Cong Zhao, Zi-Han Nan, Yan-Ling Yin, Li-Xia Liu, Zhen-Jie Hu

“…The least absolute shrinkage and selection operator regression method was used to screen the risk factors, and the final screened risk factors were constructed into four machine learning models to determine an optimal model. External validation was performed using another single-centre intensive care unit (ICU) database.Setting Data for the development cohort were obtained from the MIMIC-IV 2.0 database, which is a large publicly available database that contains information on patients admitted to the ICUs of Beth Israel Deaconess Medical Center in Boston, Massachusetts, USA, from 2008 to 2019. …”
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Effects of Providing Enrichment to Broilers in an Animal Welfare Environment on Productivity, Litter Moisture, Gas Concentration (CO₂ and NH₃), Animal Welfare... by Chan-Ho Kim, Woo-Do Lee, Ji-Seon Son, Jung-Hwan Jeon, Se-Jin Lim, Su-Mi Kim

“…However, it is still necessary to explore optimal enrichment materials that can help not only the welfare level but also the broiler performance.…”
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Rapid Adaptation to Prevent Drug Use (RAPD): protocol of a pilot randomized trial to enhance the impact of an evidence-based intervention for youth by Andria B. Eisman, Christine Koffkey, Robert T. Partridge, Suzanne Brown, Bo Kim

“…We have a critical need to advance implementation strategies to optimize system responsiveness to these emerging drug issues. …”
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Comparison of new secondgeneration H1 receptor blockers with some molecules; a study involving DFT, molecular docking, ADMET, biological target and activity by Velid Unsal, Erkan Oner, Reşit Yıldız, Başak Doğru Mert

“…Melatonin had the best Caco-2 permeability PPB values of Quercetin, CAPE and Curcumin were at optimal levels. On the OATP1B1 and OATP1B3 of curcumin and CAPE, Quercetin was found to have strong inhibition effects on BCRP. …”
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Statistical analysis based on a two-staged SEM-SVM approach for environmental noise annoyance prediction and identification of influencing factors by M. Rehman, M. Kamal, S. Tiwari

“…For the community, urban planners and policymakers can use these findings to design silent areas by implementing noise barriers, optimizing traffic flow, and enforcing stricter noise regulations.…”
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A comprehensive analysis of molecular characteristics of hot and cold tumor of gastric cancer by Chenxi Lv, Tianwei Chen, Jiangtao Li, Yuqiang Shan, Hong Zhou

“…However, a detailed molecular characterization of the tumor immune microenvironment in GC is essential to further optimize these therapies and enhance their efficacy. …”
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Research on therapeutic clinical trials including immunotherapy in triple-negative breast cancer: a bibliometric analysis by Qi Xu, Xiaoyu Feng, Siyuan Qin, Yu Hong, Rui Cui, Jia Liang, Zhuya Xiao, Yuan Li

“…Clinical trial is an important tool for optimizing therapeutic strategies in the evaluation of the safety and efficacy for TNBC. …”
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Comparative efficacy of different drugs in acute heart failure with renal dysfunction: a systematic review and network meta-analysis by Qianyu Lv, Qian Wu, Yingtian Yang, Lanlan Li, Xuejiao Ye, Shihan Wang, Yanfei Lv, Manshi Wang, Yushan Li

“…Hence, HDD and levosimendan may be optimal agents in the treatment of AHF with renal dysfunction.Systematic Review RegistrationPROSPERO, identifier (CRD42023454616).…”
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Revitalizing Ukrainian Cities: The Role of Public-Private Partnerships in Smart Urban Development by Vitalii Kruhlov, Jaroslav Dvorak, Volodymyr Moroz, Dina Tereshchenko

“…The study explores key aspects of smart cities development, including the integration of digital technologies, the use of data, and innovative business models aimed at optimizing city functions. Design/Methodology/Approach: The research employs a multi-stage methodological approach, encompassing elements such as gauging urban population satisfaction with municipal services, graphical analysis using CIMI, assessing the relevance of revitalizing Ukrainian cities and the need for mobilizing business resources, sociological surveys, developing a Smart City model based on PPP project outcomes, and formulating key elements of the national Smart City development strategy. …”
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Effects of vitamin D supplementation in patients with rheumatoid arthritis: A systematic review and meta-analysis by Mahsa Ranjbar, Mehran Rahimlou, Maryam Fallah, Kurosh Djafarian, Hamed Mohammadi

“…Conclusion: To improve DAS-28, CRP, ESR, and serum vitamin D in RA patients, vitamin D supplements may be beneficial, although the optimal dosage and length of treatment are still unknown.…”
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Analysis of the IGS rRNA Region and Applicability for Leishmania (V.) braziliensis Characterization by Tayná C. de Goes, Rayana C. S. de Morais, Maria G. N. de Melo, Rômulo P. e Silva, Antônio M. Rezende, Milena de Paiva-Cavalcanti

“…In addition, a set of primers for L. braziliensis identification for qPCR was developed and optimized. Sensitivity (S), specificity (σ), and efficiency (ε) tests were applied. …”
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Accuracy of Large Language Models for Infective Endocarditis Prophylaxis in Dental Procedures by Paak Rewthamrongsris, Jirayu Burapacheep, Vorapat Trachoo, Thantrira Porntaveetus

“…Pre-prompts offer a potential solution, and domain-specific training is essential for optimizing LLM performance in healthcare, especially with the emergence of models with increased token limits.…”
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Screening and prognostic roles of renal volumetry and scintigraphy in the assessment of living kidney transplant donors, considering the early recovery of the residual renal functi... by Shunta Hori, Mitsuru Tomizawa, Kuniaki Inoue, Tatsuo Yoneda, Kenta Onishi, Yosuke Morizawa, Daisuke Gotoh, Yasushi Nakai, Makito Miyake, Kazumasa Torimoto, Nobumichi Tanaka, Kiyohide Fujimoto

“…Conclusions CTV may be used as a reliable prognostic screening tool to select LKDs and assess their split renal functions before DN, and renal scintigraphy may help select the optimal LKD.…”
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Enhancing the strength and toughness of WTaTiVN+Taμm heterogeneous alloys via nano Ti–V–N precipitation phase adjustment by Yifei Hu, Ang Xu, Jilong Liu, Ruoqi Wang, Jinping Suo

“…In this study, a WTaTiVN system was developed with optimal nitrogen content. By combining nano-sized WTaTiVN powder, micro-sized WTaTiVN powder, and large-grained Ta powder, a high-entropy heterogeneous alloy was obtained with a three-phase structure (WTaTiVN+Taμm) through high-energy ball milling (HEBM) and spark plasma sintering (SPS). …”
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Superior persistence of ustekinumab compared to anti-TNF in vedolizumab-experienced inflammatory bowel diseases patients: a real-world cohort study by Horng-Yih Chiu, Chia-Jung Kuo, Ming-Wei Lai, Ren-Chin Wu, Chien-Ming Chen, Cheng-Tang Chiu, Yu-Bin Pan, Cheng-Hsun Chiu, Puo-Hsien Le

“…Abstract Background/Aims The increasing use of biologic therapies for moderate to severe inflammatory bowel disease (IBD) highlights the importance of optimal treatment sequencing, particularly after vedolizumab (VDZ) exposure. …”
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Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis by Li-wei Huang, Hua-min Li, Bei He, Xiao-bo Wang, Qi-zhi Zhang, Wen-xing Peng

“…However, there remains a limited amount of research on the cardiovascular manifestations of PACS, which may delay the development of optimal treatment strategies for affected patients. …”
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Machine learning prediction models for mortality risk in sepsis-associated acute kidney injury: evaluating early versus late CRRT initiation by Chuanren Zhuang, Ruomeng Hu, Ke Li, Zhengshuang Liu, Songjie Bai, Sheng Zhang, Xuehuan Wen

“…BackgroundSepsis-associated acute kidney injury (S-AKI) has a significant impact on patient survival, with continuous renal replacement therapy (CRRT) being a crucial intervention. However, the optimal timing for CRRT initiation remains controversial.MethodsUsing the MIMIC-IV database for model development and the eICU database for external validation, we analyzed patients with S-AKI to compare survival rates between early and late CRRT initiation groups. …”
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Results of biochemical and histological studies after restoration of bone defects using cellular technologies in dental patients by А.V. Bambuliak, N.B. Kuzniak, L.Y. Lopushniak, І.І. Dronyk, О.О. Myhal

“…Having analyzed the results of biochemical and histological studies it was established that application of an osteoplastic composition based on the multipotent mesenchymal stromal cells of the adipose tissue, bone tissue substitute with hydroxyapatite and platelet-rich plasma allows restoration of bone defects of the alveolar processes and an alveolar part of the appropriate jaw in shorter terms. The method is an optimal alternative to traditional osteoplastic materials to be used in modern dental practice and dental implantation.…”
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Analysis of the interaction mechanism between straw soil rotary tillage blade during rotary tillage process by Zhaojie Wang, Xiangyu Li, Junwei Li, Yuntao Qiu, Tianlong Gu, Hailong Wang

“…Conducted a three-factor, three-level quadratic regression orthogonal test with the bionic rotary tillage blade (B-RTB) bending angle, tine spacing, and cutter roller rotational speed as the test factors, and with the rotary tillage torque and the number of straw contact bond breaks as the response indexes to determine the optimal parameter combinations of the rotary tillage torque and the number of straw contact bond breaks. …”
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Understanding ICU Nursing Knowledge, Perceived Barriers, and Facilitators of Sepsis Recognition and Management: A Cross-Sectional Study by Katherine A. Kissel, MN, RN, Karla D. Krewulak, PhD, Thérèse G. Poulin, BSc, Ken Kuljit S. Parhar, MD, MSc, Daniel J. Niven, MD, PhD, Vanessa M. Doiron, MScHQ, RN, Kirsten M. Fiest, PhD

“…Most nurses agreed early sepsis detection saves lives (n = 98, 97%, TDF domain Beliefs About Consequences) and that nursing care can improve patient outcomes (n = 97, 96%, TDF domain Optimism). Fewer nurses agreed it was easy to identify priority sepsis interventions based on order urgency (n = 53, 53%, TDF domain Memory, Attention, and Decision Processes). …”
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