A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria by Yildiz Tutuncu, Ilhan Satman, Selda Celik, Nevin Dinccag, Kubilay Karsidag, Aysegul Telci, Sema Genc, Halim Issever, Jaakko Tuomilehto, Beyhan Omer

“…We aimed to identify optimal cut-off points of high sensitive C-reactive protein (hs-CRP) in new-onset DM people based on FPG, 2-hPG, or HbA1c methods. …”
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Infectious outcomes of a standardized subcutaneous immunoglobulin dose reduction strategy in primary immune deficiencies amid global shortage by Pedro Moral Moral, Pedro Moral Moral, Marta Dafne Cabanero-Navalon, Marta Dafne Cabanero-Navalon, Paula Teresa López-León, Paula Teresa López-León, Héctor Balastegui-Martín, Héctor Balastegui-Martín, Sandra Martínez Mercader, Sandra Martínez Mercader, Amparo Mir, Victor Garcia-Bustos, Victor Garcia-Bustos, Victor Garcia-Bustos

“…The dose reduction saved an average of 5,550 euros per patient annually, totaling 172,050 euros annually for our cohort.DiscussionOptimizing SCIg doses in selected well-controlled humoral PIDs is feasible without increasing infection rates, conserving this plasma-derived product during shortages. …”
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Classification of management tools in small business organizations for developing a sales funnel by E. R. Tolstova, L. V. Silakova

“…The classification of programs and services that will automate the company’s sales funnel, taking into account the price of the product and its functionality, the combination of which will be optimal for small businesses, is proposed. …”
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Real-world clinical outcome of unresectable locally advanced & de-novo metastatic pancreatic ductal adenocarcinoma: a multicentre retrospective study by Mohamed Aseafan, Ali H. Alfakeeh, Emad Tashkandi, Mervat Mahrous, Mohammed Alghamdi, Bader Alshamsan, Marwan Al-Hajeili, Safwan Bakhsh, Kanan Alshammari, Fahad A. Almugbel, Abdulhameed H. Alfagih, Ahmed Allehebi, Mohamed Montaser, Mohamed Hamdy Elsafty, Khaled Abd Elaziz Elnaghi, Ibrahim Issa, Eesa Bakshi, Sadeem AlSubaie, Bandar AlMutairi, Hoda Mokhtar, Mohamed Aboelatta, Nedal Bukhari, Ali M. Alzahrani, Tusneem Elhassan, Ali Alqahtani, Shouki Bazarbashi

“…Further research is warranted to optimize treatment selection and improve survival outcomes in this population.…”
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The effect of low donor-to-recipient body weight ratio on graft survival after dual kidney transplantation from pediatric deceased donors by Mingchuan Huang, Shenghui Wu, Pengfei Gao, Li Zhou, Qian Fu, Chenglin Wu, Huanxi Zhang, Yitao Zheng, Xiaojun Su, Wenrui Wu, Jinghong Tan, Qiang Zhang, Pei Xia, Zhe Xu, Longshan Liu, Jun Li, Changxi Wang

“…Efforts to minimize extreme weight mismatch are recommended to optimize outcomes.…”
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Experimental Investigation on Temperature-Resistant CO₂ Foam Flooding in a Heterogenous Reservoir by Mei Tian, Yi Wu, Yuhua Shi, Guohua Cao, Yu Sun, Maozhu Li, Wei Wang, Li Gao, Zhipeng Wang, Yiqiang Li

“…The profile control performance of the optimized foaming agent was investigated via dual-core gas flooding experiments. (1) The results show that QPJ-c featured good foaming stability, which made it present the largest foam comprehensive index, although its foaming volume was slightly lower than that of QPJ-b. …”
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INTERPROFESSIONAL COLLABORATION AND HEALTHCARE ORGANIZATION: an exploratory investigation into the challenges and opportunities for rehabilitation professionals. by Simone Sottana, Andrea Vianello, Matteo Tognin, Deborah Mazzarotto, Marco Ceccato, Daria Visintin, Riccardo Martignon, Francesca Magaton Rizzi, Noemi Pasquon, Lucia Savietto

“…Results: The results highlight the critical importance of interprofessional collaboration and teamwork, showing the need to improve communication and knowledge sharing in order to optimize patient care. Emerging priorities include collaboration-centered education and organizational adaptation in order to handle complexities and limited resources, suggesting the expansion of collaboration models and the reorganization of rehabilitations environments. …”
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Association between the levels of urinary cell cycle biomarkers and non-recovery of renal function among critically ill geriatric patients with acute kidney injury by Li Cheng, Hui-Miao Jia, Xi Zheng, Yi-Jia Jiang, Xin Xin, Wen-Xiong Li

“…The regression model incorporating [TIMP-2]*[IGFBP7] demonstrated a fair predictive value (AUC 0.774, p < 0.001), with the optimal threshold set at 0.81 (ng/mL)2/1000. When [TIMP-2]*[IGFBP7] was combined with AKI severity and the APACHE score, the AUC increased to 0.851. …”
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Relationship between the latent profiles of health information-seeking behaviour and glycated haemoglobin levels in patients with type 2 diabetes: a cross-sectional survey in rural... by Xin Zhang, Lin Zeng, Yan-Ping Zhang, Jing-Feng Chen, Chao-Qun Bai, Xiao-Xue Lei, Gui-Fen Fu

“…We recommend that clinical medical professionals develop personalised health management education based on the various latent profile characteristics of patients to promote HISB and thereby achieve optimal glycaemic control.…”
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Deep-Learning-Based Land Cover Mapping in Franciacorta Wine Growing Area by Girma Tariku, Isabella Ghiglieno, Andres Sanchez Morchio, Luca Facciano, Celine Birolleau, Anna Simonetto, Ivan Serina, Gianni Gilioli

“…However, significant challenges remain in managing large, complex satellite imagery datasets, acquiring specialized datasets due to high costs and labor intensity, including a lack of comparative studies for the selection of optimal deep learning models. No less important is the scarcity of aerial datasets specifically tailored for agricultural areas. …”
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Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma by Deana Haralampieva, Souzan Salemi, Thomas Betzel, Ivana Dinulovic, Stefanie D. Krämer, Roger Schibli, Tullio Sulser, Christoph Handschin, Simon M. Ametamey, Daniel Eberli

“…Therefore, the first goal of our project was to optimize the functional regenerative potential of hMPC by genetic modification to overexpress human peroxisome proliferator-activated receptor gamma coactivator 1-alpha (hPGC-1α), key regulator of exercise-mediated adaptation. …”
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Long‐term survival outcome with tyrosine kinase inhibitors and surgical intervention in patients with metastatic or recurrent gastrointestinal stromal tumors: A 14‐year, single‐cen... by Jwa Hoon Kim, Min‐Hee Ryu, Changhoon Yoo, Heejung Chae, Hana Na, Moyoul Beck, Beom Su Kim, Moon‐Won Yoo, Jeong Hwan Yook, Byung Sik Kim, Ki‐Hun Kim, Chan Wook Kim, Yoon‐Koo Kang

“…Patients with advanced GIST showed better prognosis with the optimal use of imatinib, along with active surgical intervention and more common use of subsequent TKIs in period 2.…”
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A Shared Path: Co-occurrence and Clinical Implications of Celiac Disease and Type 1 Diabetes Mellitus by Wojciech Florczak, Joanna Śnieżna, Jakub Dziewic, Karol Dzwonnik, Wiktoria Domino, Urszula Zelik, Gabriela Trestka, Maria Przygoda, Jagienka Włodyka, Kamila Stępień, Sabina Adamczyk

“…Personalized treatment approaches seem to be essential for simultaneously managing and optimizing CeD and T1DM. However, the lower compliance to GFD among T1DM patients suggests the need for further research to provide support for long-term management of both T1DM and CeD. …”
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Comparative effectiveness of buprenorphine-naloxone versus methadone for treatment of opioid use disorder: a population-based observational study protocol in British Columbia, Cana... by Lawrence C McCandless, Malcolm Maclure, M Eugenia Socías, Evan Wood, Paul Gustafson, Robert W Platt, Bohdan Nosyk, Sander Greenland, Micah Piske, Trevor Thomson, Emanuel Krebs, Natt Hongdilokkul, Julie Bruneau, M Ehsan Karim, Judith I Tsui

“…We will determine the effectiveness of buprenorphine/naloxone vs methadone using intention-to-treat and per-protocol analyses—the former emulating flexible-dose trials and the latter focusing on the comparison of the two medication regimens offered at the optimal dose. Sensitivity analyses will be used to assess the robustness of results to heterogeneity in the patient population and threats to internal validity.Ethics and dissemination The protocol, cohort creation and analysis plan have been approved and classified as a quality improvement initiative exempt from ethical review (Providence Health Care Research Institute and the Simon Fraser University Office of Research Ethics). …”
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Diagnostic Accuracy of Shear Wave Elastography in Predicting Malignant Origins of Pleural Effusions in Emergency Departments by Rune Wiig Nielsen, Casper Falster, Stefan Posth, Niels Jacobsen, August Emil Licht, Rahul Bhatnagar, Christian Borbjerg Laursen

“…The objective of this study was to appraise the diagnostic accuracy of ultrasonographic findings associated with thoracic malignancy as well as to calculate the optimal cutoff values for SWE in this regard. <b>Methods</b>: Patients with a unilateral pleural effusion of unknown origin were included in the ED and subjected to a thoracic ultrasound (TUS) scan during their first 48 h after admittance. …”
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Savolitinib Induced Pathological Complete Response in Non-small Cell Lung Cancer with MET Amplification: A Case Report by Meng LU, Ran ZHANG, Baiwei LI, Haidi XU, Yongkuan GUO, Jian YOU, Bingsheng SUN

“…For advanced NSCLC with secondary METamp, EGFR-TKIs combined with MET-TKIs are usually used in clinical treatment, while the optimal treatment strategy for advanced NSCLC with primary METamp has not yet been determined. …”
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Sustainability index analysis of microalgae cultivated in biorefinery palm oil mill effluent by A. Santoso, T. Handayani, D. Pinardi, K. Kusrestuwardani, N. Widyastuti, I. Djarot, J. Haryanti, A. Sitomurni, H. Apriyanto

“…It is still necessary to do further research for the utilization of microalgae biomass into value-added products with an optimal, technically, economically, environmentally and socially sustainable system. …”
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Efforts to strengthen anatomic pathology diagnostic services for cancer in sub-Saharan Africa: a scoping review protocol by Katherine Van Loon, Elia John Mmbaga, Marcia Edelweiss, Dianna L. Ng, Asteria Herman Kimambo, Edda Vuhahula, Beatrice Paul Mushi, Omolade Adegoke, Johanna Goldberg, Pendo M. Ibrahim, Zainab Illonga, Julia Jackman, Luisa Jamisse

“…Although pathology services are essential to providing optimal oncological care, diagnostic capacity in sub-Saharan Africa is insufficient for the cancer burden. …”
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Comprehensive Evaluation of Quality Characteristics and Processing Suitability of Different Varieties of Large-fruited Sea Buckthorn Juice from Xinjiang Using Multivariate Analysis... by Rong HAN, Yan MA, Yu AO, Ting ZHANG, Xintao MENG, Mingqiang XU, Yan PAN

“…Overall, this study serves as an important reference for the selection of sea buckthorn varieties optimized for the production of large-fruited sea buckthorn juice.…”
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Generating and monitoring mild hyperthermia using a ring array ultrasound transducer by David Bustamante, Yan Yan, Trevor Mitcham, Rehman Ali, Brian Marples, Kimberly R. Gergelis, Peter Littrup, Nebojsa Duric, Mohammad Mehrmohammadi

“…The closed geometry of the transducer is optimal for acoustic focusing and UST-guidance allows for improved aberration correction in a heterogenous medium. …”
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