Efficacy of pegylated interferon alfa-2b «Algeron» in the treatment of chronic hepatitis C by M. V. Mayevskaya, O. O. Znoyko, E. A. Klimova, S. L. Maximov, S. N. Kizhlo, N. A. Petrochenkova, F. I. Nagimova, R. A. Ivanov, Yu. N. Linkova, T. V. Chernovskaya

“…The complex assessment of the efficacy and safety allowed to make the conclusion about the optimal therapeutic dose of Algeron, equal to 1.5 μg/kg/week.Conclusions. …”
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Conceptual foundations of a REFRAME-based approach to discriminate across total knee implant designs based on the positions of functional centres of rotation by Adrian Sauer, Ariana Ortigas-Vásquez, Christoph Thorwaechter, Peter E. Müller, Henning Windhagen, Allan Maas, Thomas M. Grupp, William R. Taylor, Matthias Woiczinski

“…The identification of an implant design that optimally fits to a patient’s native kinematic patterns and functional requirements could provide a basis towards subject-specific phenotyping. …”
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A machine learning model and identification of immune infiltration for chronic obstructive pulmonary disease based on disulfidptosis-related genes by Sijun Li, Qingdong Zhu, Aichun Huang, Yanqun Lan, Xiaoying Wei, Huawei He, Xiayan Meng, Weiwen Li, Yanrong Lin, Shixiong Yang

“…Conclusion Our study demonstrated the relationship between disulfidptosis and COPD and established an optimal machine-learning model to evaluate the subtypes and traits of COPD. …”
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Secondary prevention of preeclampsia by Muhammad Ilham Aldika Akbar, Muhammad Ilham Aldika Akbar, Roudhona Rosaudyn, Khanisyah Erza Gumilar, Khanisyah Erza Gumilar, Renuka Shanmugalingam, Gustaaf Dekker, Gustaaf Dekker

“…Further research is needed to determine the optimal (combination) of method(s) for the individual patient with her individual risk profile.…”
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Effects of Adipose-tissue Derived Mesenchymal Stem Cells on PBMCs in Co-culture with HeLa Cell Line by Maryam Dorfaki, mahdi ghatrehsamani, fahimeh Lavi Arab, Mona Roozbehani, Majid Khoshmirsafa, Reza Falak, Fatemeh Keshavarz, Fatemeh Faraji

“…However, further research is required to fully understand the underlying mechanisms and optimize therapeutic approaches involving PBMCs and MSCs.…”
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Effect of Cowpea and Pumpkin Powders on the Physicofunctional Properties, Total Phenolic Content, Antioxidant Activity, and Consumer Acceptability of Soup by Nyarai Mungofa, Daniso Beswa

“…Overall, the cowpea seed powder plus pumpkin fruit powder added at 10% in F2 appeared nearly optimal as a soup mix. It produced an attractive golden brown soup with increased swelling power (SP) and viscosity to assist in swallowing. …”
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Technological-Based Interventions in Cancer and Factors Associated With the Use of Mobile Digital Wellness and Health Apps Among Cancer Information Seekers: Cross-Sectional Study by Ogochukwu Juliet Ezeigwe, Kenechukwu Obumneme Samuel Nwosu, Oladipo Kunle Afolayan, Akpevwe Amanda Ojaruega, Jovita Echere, Manali Desai, Modupe Olajumoke Onigbogi, Olajumoke Ope Oladoyin, Nnenna Chioma Okoye, Pierre Fwelo

“… BackgroundMobile digital wellness and health apps play a significant role in optimizing health and aiding in cancer management and decision-making. …”
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Analysis of the effect of cutting depth under thick immediate roof on gob-side entry retaining stability by WANG Fei, WANG Xuqiang, SHI Xinyu, XU Huicong

“…As the cutting depth increased, the step distance of the mining pressure decreased, the pressure intensity reduced, and the peak value of the stress concentration and roof subsidence displacement in the roadway reduced. The optimal cutting depth was determined to be 8.5 m, at which point the peak stress concentration and maximum displacement of the roadway after completion were 13.6 MPa and 235 mm, respectively. …”
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Association Between the Albumin-Bilirubin (ALBI) Score and All-cause Mortality Risk in Intensive Care Unit Patients with Heart Failure by Jiuyi Wang, Kai Wang, Guibo Feng, Xin Tian

“…ALBI may help identify high-risk patients and optimize risk stratification in this population.…”
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A Machine Learning Approach Using Topic Modeling to Identify and Assess Experiences of Patients With Colorectal Cancer: Explorative Study by Kelly Voigt, Yingtao Sun, Ayush Patandin, Johanna Hendriks, Richard Hendrik Goossens, Cornelis Verhoef, Olga Husson, Dirk Grünhagen, Jiwon Jung

“…Health technologies are necessary for sustaining optimal patient journeys. To understand individuals’ daily lives during their patient journey, qualitative studies are crucial. …”
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Study of the coupling effect of CO2 and PM2.5 emissions: A case study of yangtze river delta, China by Wengin Chung, Chao Liu

“…In addition, the analysis of urban influencing factors revealed a significant correlation between several key urban factors, including land area, green space and water area, road network, technical development, and industrial structure.This study recommends that cities aiming to reduce CO2 emissions and control PM2.5 pollution consider initiatives that address the coupling effect, such as optimizing industrial land use and prioritizing spatial planning strategies. …”
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New probabilistic methods for quantitative climate reconstructions applied to palynological data from Lake Kinneret by T. Netzel, A. Miebach, T. Litt, A. Hense

“…For the models and biome distributions used, a simple feedforward neural network provides the optimal choice of the classification problem.</p> <p>Based on this, we formulate a new Bayesian hierarchical model that generates local paleoclimate reconstructions. …”
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Social media-based Health Education plus Exercise Program (SHEEP) to improve muscle function among young-old adults with possible sarcopenia in the community: A feasibility study p... by Ya Shi, Emma Stanmore, Lisa McGarrigle, Chris Todd

“…This may help researchers identify ways to optimize acceptability and efficacy of the SHEEP intervention for the targeted population.…”
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Analysis of antimicrobial resistance and clinical features of Staphylococcus aureus-infected bone and joint infections in children by Xingguang Chen, Ting Zhuang, Chengda Zou, Yao Liu, Qian Sun, Mengxia Li, Wen Zheng, Chaochen Zhao, Xiaodong Wang

“…Abstract Objective This study investigates the antimicrobial resistance and clinical features of Staphylococcus aureus (S. aureus) in bone and joint infections (BJIs) among children under 14 years old, providing insights for optimal antibiotic usage. Methods A retrospective analysis was conducted on the clinical data from children treated for BJIs at the Children’s Hospital of Soochow University between January 2019 to December 2023. …”
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Value of combining lung ultrasound score with oxygenation and functional indices in determining weaning timing for critically ill pediatric patients by Ximeng Hao, Hongnian Duan, Qiushuang Li, Dan Wang, Xin Yin, Zhiyan Di, Shanshan Du

“…An LUS score ≥ 15.5 was identified as the optimal cutoff for predicting weaning failure, with superior predictive power compared to RSBI and P/F ratios. …”
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Supporting complex skill learning with digital tools in tertiary education: educator’s perspective by Bernarda Letnar, André Klostermann, Mirko Schmidt

“…Educators were presented with a video of a student performing a sports skill in suboptimal manner to prompt a discussion on their approach to optimize student’s movement. This case specific discussion was followed by broader discussion of their overall teaching approaches. …”
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Effects of dietary Acremonium terricola culture on production performance, serum biochemical parameters, egg quality and yolk amino acid contents of Beijing You-chicken by Jianzhong Wang, Cun Liu, Xiaowei Gong, Yanhan Liu

“…Future studies should focus on optimizing ATC dosage and exploring its underlying mechanisms for enhanced poultry production.…”
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Copy number variations at the Rhg1 locus and their relationship with resistance to soybean cyst nematode (Heterodera glycines) by Dinesh Poudel, Guiping Yan, Carrie Miranda, Gustavo Fernando Kreutz, Intiaz Amin Chowdhury

“…To determine CNVs at the Rhg1, a SYBR Green-based quantitative PCR (qPCR) assay was optimized and validated using 12 soybean accessions with known copy numbers. …”
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Development and Validation of a Nomogram to Predict Type 2 Diabetes Mellitus in Overweight and Obese Adults: A Prospective Cohort Study from 82938 Adults in China by Qingqing Liu, Jie Yuan, Maerjiaen Bakeyi, Jie Li, Zilong Zhang, Xiaohong Yang, Fangming Gao

“…Using the least absolute shrinkage and selection operator (LASSO) regression model in training set, we identified optimized risk factors of T2DM, followed by the establishment of T2DM prediction nomogram. …”
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Impact of commercial gut health interventions on caecal metagenome and broiler performance by Gladys Maria Pangga, Banaz Star-Shirko, Androniki Psifidi, Dong Xia, Nicolae Corcionivoschi, Carmel Kelly, Callie Hughes, Ursula Lavery, Anne Richmond, Umer Zeeshan Ijaz, Ozan Gundogdu

“…Given the critical role of gut health in chicken performance and welfare, there is a pressing need to identify effective gut health intervention (GHI) strategies to ensure optimal outcomes in poultry farming. In this study, across three broiler production cycles, we compared the metagenomes and performance of broilers provided with ionophores (as the control group) against birds subjected to five different GHI combinations involving vaccination, probiotics, prebiotics, essential oils, and reduction of ionophore use. …”
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