Comparing the cost-benefit of breast cancer screening programs in rural and urban areas across four economic zones in China: a Markov modeling analysis by Dachuang Zhou, Kejia Zhou, Wenjuan Wang, Hanqiao Shao, Hongliu Zhang, Wenxi Tang

“…These findings highlight the necessity of universal screening and the importance of optimizing strategies based on regional economic development and epidemiological characteristics. …”
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Impact of hospital formulary intervention on carbapenem use: a segmented time-series analysis of consumption and a propensity score-matched non-inferiority study of treatment effic... by Nakaba Okamura, Ayano Katagiri, Tomoya Komori, Kei Kawanabe, Hirofumi Koike, Yukiko Sahashi, Rie Kubota

“…These findings suggest that formulary management can be a valuable strategy for optimizing antibiotic use while maintaining clinical outcomes and contributing to improved antimicrobial stewardship in healthcare settings. …”
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Enhancing Older Adults’ Lives Through Positive Aging Perception, Quality-of-Life Enhancement, and Social Support to Drive Acceptance and Readiness Toward Indoor Assistive Technolog... by Ka Po Wong, Pei-Lee Teh, Weng Marc Lim, Shaun Wen Huey Lee

“…Among demographic variables, educational level significantly impacted gerontechnology confidence (P=.004) while ethnicity influenced optimism (P=.003). ConclusionsThis study sheds light on key factors affecting older adults’ acceptance and readiness to adopt indoor assistive technologies. …”
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The usage of personalized scheme of fentanyl administration during coronary artery stenting by D.О. Dziuba

“…Its usage is safe (due to the optimal parameters of gas exchange and hemodynamics and fewer side effects, such as nausea and residual sedation) and effective (due to the lower level of stress markers and less frequent complaints of pain of various origins) than when the routine technique was used.…”
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Preliminary evaluation of the FastCAP for users of the Nurotron cochlear implant by Xue-Ying Yang, Sui Huang, Qian-Jie Fu, John Galvin, Bing Chen, Ji-Sheng Liu, Duo-Duo Tao

“…The FastCAP paradigm maintained the accuracy and reliability the ECAP measurements while offering a significant reduction in time requirements.ConclusionThis preliminary evaluation suggests that the FastCAP could be an effective clinical tool to optimize CI processor settings (e.g., threshold stimulation levels) in users of the Nurotron CI device.…”
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“I’m living in a ‘no’ world now…”- A qualitative study of the widespread impact of living with chronic breathlessness, and experiences of identification and assessment of this symp... by Helene L. Elliott-Button, Miriam J. Johnson, Ann Hutchinson, David C. Currow, Joseph Clark

“…Breathlessness adversely impacts physical and psychological wellbeing. (2) Barriers to optimal health-seeking and identification of chronic breathlessness. …”
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An In Vitro Model of Diabetic Retinal Vascular Endothelial Dysfunction and Neuroretinal Degeneration by Qiyun Wang, Xinyuan Zhang, Kaiyue Wang, Ling Zhu, Bingjie Qiu, Xiaosi Chen, Xiao Lin, Yao Nie

“…Conclusions. We have optimized glucose concentrations to model diabetic retinal endothelial (25-50 mM) or neuronal (50-100 mM) dysfunction in vitro, which have a wide range of downstream applications.…”
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The role of highly dispersed silica nanoparticles in the realization of the effects of granulosa on the maturation and fertilization competence of <i>Sus scrofa domesticus</i> oocy... by T. I. Kuzmina, I. V. Chistyakova, A. O. Prituzhalova, D. N. Tatarskaya

“…The positive effects of a joint addition of GCs and HDSn to the maturation system have made it possible to increase the indicators of the meiotic maturation and fertilization of oocytes. Optimal results of developmental competence of oocytes were achieved with the joint use of GCs and HDSn in the maturation system (the proportion of matured cells reached 89 %, the level of oocytes with chromosome degeneration was 12 %, 39 % of embryos reached the final stage of preimplantation development). …”
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Investigating the characteristics and needs of frequently admitting hospital patients: a cross-sectional study in the UK by John Chang, Anuj Sharma, Reem Kayyali, Gill Funnell, Bassel Odeh, Yannis Katsaros, Shereen Nabhani-Gebara, Barbara Pierscionek, Joshua Sterling Wells

“…Objectives This study forms the user requirements phase of the OPTIMAL project, which, through a predictive model and supportive intervention, aims to decrease early hospital readmissions. …”
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Specificity of psychological readiness for changes and personality’s maturity of the employees of the state criminal and executive service by O. V. Mitroshkina

“…Less distinct manifestation of a number of components of psychological readiness for changes and a certain deficiency of its interaction with personality maturity can hinder both the successful professional activity of low-level group and their optimal functioning in the personality’s sense. The results obtained in the study can be used to develop programs for psychological support of the professional activities of the staff of the Criminal and Executive Service at the stage of its reformation.…”
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Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Are Correlated with Complicated Diverticulitis and Hinchey Classification: A Simple Tool to Assess Disease Severity in th... by Amir Mari, Tawfik Khoury, Ahmad Lubany, Mohammad Safadi, Moaad Farraj, Amir Farah, Anas Kadah, Wisam Sbeit, Mahmud Mahamid

“…This simple available laboratory tool can be implemented into clinical practice to optimize patient management.…”
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Digitalisation of Professional Education: Prospects and Invisible Barriers by L. M. Andryukhina, N. O. Sadovnikova, S. N. Utkina, A. M. Mirzaahmedov

“…The materials of the undertaken research have significant implications for further development of perceptions of the essence and content of digital didactics; justification and formation of optimal conditions for digitalisation of vocational education, including psychological and pedagogical adjustment of the system of training and retraining of pedagogical and managerial personnel for the digital economy.…”
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Determination of unbound-bound moisture interface of faecal sludges from different on-site sanitation systems by Arun Kumar Rayavellore Suryakumar, Edwina Mercer, Jonathan Pocock, Santiago Septien

“…For the effective operation of NSS, it is important to ensure optimal treatment of the collected faecal sludge (FS) in on-site sanitation systems. …”
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Modeling and Analysis of Rice Root Water Uptake under the Dual Stresses of Drought and Waterlogging by Jie Huang, Wei Dong, Luguang Liu, Tiesong Hu, Shaobin Pan, Xiaowei Yang, Jianan Qin

“…The development of an accurate root water-uptake model is pivotal for evaluating crop evapotranspiration; understanding the combined effect of drought and waterlogging stresses; and optimizing water use efficiency, namely, crop yield [kg/ha] per unit of ET [mm]. …”
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Enhancing cotton irrigation with distributional actor–critic reinforcement learning by Yi Chen, Meiwei Lin, Zhuo Yu, Weihong Sun, Weiguo Fu, Liang He

“…This study introduces a novel intelligent irrigation approach based on distributional reinforcement learning, ensuring that the algorithm simultaneously considers weather, soil, and crop conditions to make optimal irrigation decisions for long-term benefits. …”
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Navigating Treatment Dilemmas: Exploration of Strategies in Managing Unfavorably Positioned Maxillary Impacted Canines with Contraindication to Traction - Unmasking Orthodontic Per... by Gargi Singh, Purva Joneja, Tanveer Akhtar, Oshin Pawar, Mahathi Gurijala, Rani Mehrotra

“…Conclusion: By carefully assessing the anatomical position, angulation and considering patient-related factors, as well as through a comprehensive understanding of potential risks and benefits of each option dental professionals can make informed decisions regarding most appropriate treatment modality and can guide patients toward optimal esthetic and functional outcomes, restoring harmony and function to their smiles.…”
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Effects of Different Levels of <i>Lycium barbarum</i> Flavonoids on Growth Performance, Immunity, Intestinal Barrier and Antioxidant Capacity of Meat Ducks by Minhang Tu, Gentan Cai, Longfei Ma, Leyan Yan, Tian Wang, Zhendan Shi, Chao Wang, Zhe Chen

“…<b>Conclusions:</b> The addition of LBFs to the diet improved the growth performance, intestinal barrier function, immune response, and antioxidant capacity of the ducks, which may be closely associated with the activation of the Nrf2 signaling pathway and the inhibition of the NF-κB signaling pathway. The optimal dietary inclusion level of LBFs in ducks was 500 mg/kg.…”
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Toward Robust Lung Cancer Diagnosis: Integrating Multiple CT Datasets, Curriculum Learning, and Explainable AI by Amira Bouamrane, Makhlouf Derdour, Akram Bennour, Taiseer Abdalla Elfadil Eisa, Abdel-Hamid M. Emara, Mohammed Al-Sarem, Neesrin Ali Kurdi

“…The proposed approach achieved optimal results of 100% in all metrics, with 00% false positive and false negative rates. …”
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Oral delivery of the non-β-blocking R-carvedilol enantiomer for skin cancer chemoprevention in SKH-1 mice by Pabitra K. Sardar, Steven Yeung, Ruby Tow, Jacqueline Luga, Matthew Huang, Ayaz Shahid, Bradley T. Andresen, Ying Huang

“…Further studies determining the optimal doses and timing of drug treatment are warranted.…”
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Navigating barriers and embracing facilitators of connection: insights from peer recovery specialists working with individuals with substance use disorder and criminal justice invo... by Rebecca Sutter-Barrett, Nancy R.B. Spencer, Nora Elnahas, Rebecca Hurd, Margaret Delaney, Aman Bivens

“…Findings emphasize the need for collaborative efforts between justice and recovery partners to optimize the impact of peer-based support services.…”
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