Impact of vancomycin area under the curve in early or later phase on efficacy and nephrotoxicity in patients with enterococcal bloodstream infections: a multicenter study by Piyawadee Tangvichitrerk, Dhitiwat Changpradub, Jatapat Hemapanpairoa, Piraporn Juntanawiwat, Wichai Santimaleeworagun

“…Abstract Background The optimal pharmacokinetic and pharmacodynamic (PK/PD) parameters of vancomycin that can improve outcomes in enterococcal infections remain controversial. …”
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Adverse events associated with the delivery of telerehabilitation: A scoping review protocol. by Thomas Yau, McKyla McIntyre, Josh Chan, Damanveer Bhogal, Angie Andreoli, Mark Bayley, Carl Froilan D Leochico, Ailene Kua, Meiqi Guo, Sarah Munce

“…This will help to identify key limitations for optimizing telerehabilitation delivery by allowing for the development of key risk-mitigation measures and quality indicators. …”
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Characteristics of velopharyngeal dysfunction in 22q11.2 deletion syndrome: a retrospective case-control study by Sebastiano Failla, Peng You, Chandheeb Rajakumar, Anne Dworschak-Stokan, Philip C. Doyle, Murad Husein

“…These findings may guide further efforts directed toward understanding the dynamic velopharyngeal characteristics of this population and potentially optimize surgical management and functional outcomes.…”
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Technoeconomic Feasibility of Wind and Solar Generation for Off-Grid Hyperscale Data Centres by William Rollinson, Andrew Urquhart, Murray Thomson

“…WindPRO 4.0 software is used to find optimal configurations with wind and solar generation, backed up by battery storage and onsite gas generation. …”
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The Effect of Resistance Strength Training on Muscle Cross Education: A Meta analysis by Yuan Hao Dong, Jiong Luo

“…The main purpose of this review is to explore the impact mechanism of cross transfer phenomenon and summarize the optimal training methods and rehabilitation methods for cross transfer phenomenon. …”
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Application of Patient Version of General Practitioner Assessment of Cognition for Screening Elderly with Mild Cognitive Impairment in Community by YANG Ting, HE Jiali, SONG Linlin, LIU Wentao, GUI Chenfan, CHEN Xiao, XU Li, JIA Chengsen

“…AUC of P-GPCOG for differentiating MCI patients was 0.804 [95% <italic>CI</italic> (0.773, 0.836), <italic>P</italic>&lt;0.001], with an optimal cutoff value of 7/8 points. The sensitivity was 82.7%, the specificity was 72.6%, the positive predictive value was 57.2%, and the negative predictive value was 90.4%.ConclusionThe P-GPCOG is a good community-based cognitive screening tool for screening MCI patients in community, but its original scoring criteria needs to be refined to improve the correct screening rate.…”
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Motor Unit Sampling From Intramuscular Micro-Electrode Array Recordings by Agnese Grison, Jaime Ibanez Pereda, Dario Farina

“…Through systematic offline analyses of these recordings, we tested different electrode configurations to identify optimal setups for accurately capturing motor unit activity. …”
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Histological Ex Vivo Evaluation of the Suitability of a 976 nm Diode Laser in Oral Soft Tissue Biopsies by Gaspare Palaia, Federico Renzi, Daniele Pergolini, Alessandro Del Vecchio, Paolo Visca, Gianluca Tenore, Umberto Romeo

“…The results showed that histological readability was optimal in all the samples. The thermal damage was negligible in all groups. …”
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Evolution characteristics and driving factors of rural living space system in the Three Gorges reservoir area:A case study of Santuo Village in Chongqing Municipality by YAN Yan, YANG Qingyuan, HU Baoqing

“…[Conclusion] In the past 20 years, the rural living spaces in the Three Gorges reservoir area had been gradually optimized due to the combined influence of socioeconomic development, the willingness of rural entities, and post-project implementation support policies of the Three Gorges Project. …”
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Identification of lethality-related m7G methylation modification patterns and the regulatory features of immune microenvironment in sepsis by Dan Wang, Rujie Huo, Lu Ye

“…Results: In total, 10 differentially expressed m7G-related genes were identified between the survivors and non-survivors, and after further analysis, EIF4G3, EIF4E3, NSUN2, NUDT4, and GEMIN5 were identified as the optimal lethality-related m7G genes. A survival status diagnostic model was then constructed with a combined AUC of 0.678. …”
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Spectrum of bacterial keratitis at a tertiary eye center in Indonesia by Rifna Lutfiamida, Rien Widyasari, Kara Citra Kalandra

“…This study aims to investigate the prevalence, antibiotic susceptibility patterns, and risk factors associated with bacterial keratitis cases, providing valuable insights for clinicians to optimize management protocols and enhance the overall ocular health landscape in Indonesia or in other countries that have similar geographical conditions.…”
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İMALAT ŞİRKETLERİNDE ÇALIŞMA SERMAYESİ ETKİNLİĞİNİN FİRMA DEĞERİNE ETKİSİ NASILDIR? by H. Ali Ata, Mehmet Fatih Buğan

“…Firma değerinin maksimize edilmesi için karlılık, likidite ve risk unsurları arasında optimal bir denge kurulması gerektiği için çalışma sermayesi yönetiminin firma değeri üzerinde önemli bir etkisinin olduğu kabul edilmektedir. …”
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Temperature Adaptability Analysis of Closed Cycle Using CO2-Based Mixed Working Fluid for Underwater Platforms by Jiaqi FENG, Junpeng WANG, Zhentao CHEN, Zhengyuan LUO, Bofeng BAI

“…This paper proposed the plan to use CO2-based mixed working fluid to improve cycle temperature adaptability and further optimize cycle performance. A simple recuperative closed cycle thermodynamic model was established, and the changes in critical parameters of CO2-based mixed working fluid with the type and mass fraction of added gas were analyzed. …”
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Development and in vitro evaluation of biomimetic injectable hydrogels from decellularized human nerves for central nervous system regeneration by Gopal Agarwal, Kennedy Moes, Christine E. Schmidt

“…Two delipidation solvents, dichloromethane: ethanol (2:1 v/v) and n-hexane: isopropanol (3:1 v/v), were evaluated, with the former achieving optimal lipid removal and better digestion. The resulting solution was crosslinked with genipin, forming an injectable hydrogel (iHPN) that gelled within 12 min at 37 °C and exhibited mechanical stiffness of approximately 400 Pa. …”
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Anti-Tumor Necrosis Factor-α Use in Pediatric Inflammatory Bowel Disease—Reports from a Romanian Center by Roxana Matran, Andra-Mihaela Diaconu, Andreea Maria Iordache, Irina Dijmărescu, Alexandra Coroleucă, Daniela Păcurar, Cristina Becheanu

“…This study aims to evaluate and document these AEs to facilitate optimal patient selection and monitoring strategies of patients undergoing these therapies. …”
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Prognostic factors and survival outcomes in patients with salivary duct carcinoma: a retrospective cohort study by Fei Chen, Liangbo Li, Jingqiao Tao, Nenghao Jin, Liwei Wang, Liang Zhu, Bo Qiao, Lejun Xing, Bo Wei, Jingqiu Bu, Haizhong Zhang

“…These findings underscore the potential significance of incorporating hematological parameters and metastatic status into clinical decision-making to optimize risk stratification and personalized treatment strategies.…”
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Spondylolisthesis and Scoliosis Progression and Associated Revision Rates Following Bilateral Lumbar Spine Microscopic Decompression by Walter-Soon-Yaw Wong, Ashton Kai Shun Tan, Kenneth Zhi Kuan Loi, Dhivakaran Gengatharan, Craigven Hao Sheng Sim, Hao Bin Chen, Yilun Huang

“…Lumbar spine microscopic decompression (LSMD) is a common surgical procedure for decompressing neural elements. Although the optimal extent of decompression remains a critical consideration, limited evidence-based guidelines define the threshold for instrumented fusion to maintain biomechanical stability. …”
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A Review of the Therapeutic Potential of Ginseng and Its Bioactive Components in Nonalcoholic Fatty Liver Disease by Hao L, Li S, Li C, Zhang Z, Hu X, Yan H

“…Moreover, the pharmacokinetic properties of different ginsenosides, optimal therapeutic dosages, and the safety of long-term use require further investigation. …”
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Preparation and Physicochemical Properties of High-purity Isomaltooligosaccharides by Sequential Simulated Moving Bed Chromatography by Shenghui RUAN, Xiqun ZHENG, Xiaolan LIU, Liangyu LI

“…Further the separation conditions were optimized and the best technical parameters were as follows: feed refraction was 60% and column temperature was 65 ℃. …”
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Performance evaluation of nine reference centers and comparison of DNA extraction protocols for effective surveillance of Leishmania-infected Phlebotomine sand flies: Basis for tec... by Jorian Prudhomme, Aymeric Delabarre, Bulent Alten, Umut Berberoglu, Eduardo Berriatua, Gioia Bongiorno, José Manuel Cristovao, Maya Davidovich-Cohen, Trentina Di Muccio, Ozge Erisoz Kasap, Eleonora Fiorentino, Oscar D Kirstein, Edwin Kniha, Carla Maia, Mesut Mungan, Clara Muñoz-Hernández, Muhammed Nalçaci, Gizem Oguz Kaskan, Yusuf Ozbel, Seray Ozensoy Toz, Ricardo Parreira, Katharina Platzgummer, Ceylan Polat, José Risueño, Liora Studentsky, Gamze Varol, Julia Walochnik, Kardelen Yetişmiş, Florence Robert-Gangneux

“…This study aimed to compare different DNA extraction protocols and conduct a qPCR-based External Quality Assessment (EQA) through a multicenter study involving nine reference laboratories, with a focus on optimizing Leishmania DNA detection in sand fly.<h4>Methodology/principal findings</h4>EQA samples consisted of Leishmania infantum and L. major species, at concentrations ranging from 101 to 104 parasites/mL. …”
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