Medialization of shaft of humerus to provide medial buttress and prevent varus collapse in 3- and 4-part proximal humerus fractures: review of the surgical technique by Srinivas Kasha, MS(Ortho), Ranjith Kumar Yalamanchili, MS(Ortho), G.P.R.K. Rohit, MS(Ortho), Suresh Krishna Lokayah, MS(Ortho), Varun Kulkarni, MBBS

“…Hypothesis: Proximal humerus fractures present a treatment challenge due to varied fracture configurations and a lack of consensus on optimal management. Locking plate designs offer promising solutions, yet technical guidelines for successful outcomes remain elusive. …”
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Advancing Pediatric Surgery: The Use of HoloLens 2 for 3D Anatomical Reconstructions in Preoperative Planning by Marco Di Mitri, Annalisa Di Carmine, Simone D’Antonio, Benedetta Maria Capobianco, Cristian Bisanti, Edoardo Collautti, Sara Maria Cravano, Francesca Ruspi, Michele Libri, Tommaso Gargano, Mario Lima

“…Background: In pediatric surgery, a comprehensive knowledge of the child’s anatomy is crucial to optimize surgical outcomes and minimize complications. …”
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DOCK4 Is a Platinum-Chemosensitive and Prognostic-Related Biomarker in Ovarian Cancer by Qianqian Zhao, Jie Zhong, Ping Lu, Xiao Feng, Ying Han, Chenqi Ling, Wenke Guo, Weijin Zhou, Fudong Yu

“…The present study is aimed at optimizing candidate genes by integrating platinum-chemotherapy expression data and PPAR family genes with their targets. …”
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Trends and Clinical Implications of Pediatric Pulmonary Function After Hematopoietic Stem Cell Transplantation: A Systematic Review by Xiaowei Zhao, Yuqi Zhao, Guoyu Ding, Xue Li, Xiaoyue Zhang, Yanli Leng, Hongmei Wang

“…Advanced diagnostic methods, like PRM and MBW, may improve early detection and help optimize the management of pulmonary dysfunction, ultimately improving long‐term outcomes for pediatric patients.…”
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Retrieval of Land Surface Temperature From Passive Microwave Observations Using CatBoost-Based Adaptive Feature Selection by Yang Dai, Yingbao Yang, Xin Pan, Penghua Hu, Xiangjin Meng, Fanggang Li, Zhenwei Wang

“…Next, for each group, we ranked the feature sets according to their importance and employed the recursive feature elimination (RFE) method for feature selection. Finally, the optimized feature sets were used in the CatBoost algorithm to construct the PMW-LST retrieval model. …”
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Development of the Dutch translational knowledge agenda for inherited metabolic diseases by I. J. Hieltjes, J. H. van derLee, M. C. Groenendijk, G. vanHaaften, P. M. vanHasselt, R. J. Lunsing, G. J. J. vanProoijen, E. M. deRuiter, F. J. vanSpronsen, N. M. Verhoeven‐Duif, A. deVreugd, M. Wagenmakers, H. Zweers, H. Dekker, H. R. Waterham, C. D. vanKarnebeek, R. J. A. Wanders, R. A. Wevers

“…The resulting top 10 research questions cover multiple themes, i.e. prediction of disease progression, development of novel tools, mechanistic insights, improved diagnostics, therapeutic integration of multi‐omics techniques, assessment of impact on daily life, expanding treatment avenues, optimal study designs, effect of lifestyle interventions, and data utilization using FAIR principles. …”
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On the lookout for a potential antagonist against Cryptostroma corticale—an insight through in vitro dual culture studies by Rebekka Schlößer, Rebekka Schlößer, Rebekka Schlößer, Steffen Bien, Johanna Bußkamp, Gitta Jutta Langer, Ewald Johannes Langer

“…For Test 2, only fungi which showed inhibition at distance in Test 1 were chosen and tested on different media at 25°C, the optimal growing temperature of the pathogen. In Test 3, fungi showing signs of antagonism in Test 1 were tested against C. corticale in a 6:1 ratio of potential antagonist plugs to the C. corticale plug. …”
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Review of Urinary Tract Infections in Pregnancy: Risks, Complications and Management by Patrycja Kałuziak, Jakub Parys, Agnieszka Mikosińska, Martyna Kaźmierczak, Marta Jajczak, Maciej Mossakowski, Aleksandra Witek, Mateusz Litwin, Stanisław Jesionek

“…Early detection through routine screening and prompt treatment is crucial for optimal outcomes. Healthcare professionals, including obstetricians, should educate patients on preventive measures and recognizing early UTI symptoms. …”
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Existent state and removal rate of silver in lead-silver slag during the melt-vaporization process by Shen Y.-Y., Zhao X.-S., Zhang F.-J., Ma W.-X., Wang X.-F., Du X.-Y.

“…The existing Ag state in the soot was analyzed, the influence of the reaction temperature, the carbon ratio, and the reaction time on the removal rate of the silver was investigated, and the process conditions were optimized using reaction surface methodology. Silver chloride, silver metal, silver sulfide, silver oxide, and silver sulfate are the main silver phases in lead-silver slag, of which silver chloride and silver sulfide are the main phases. …”
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The clinical impact of conventional therapies for adults and adolescents suffering from eosinophilic esophagitis, a type 2 inflammatory chronic disease, and their economic conseque... by Giorgio Walter Canonica, MD, Gherardo Mazziotti, MD, PhD, Alessandro Repici, MD, Massimiliano Povero, PhD, Luca Castello, MSc, Lorenzo Pradelli, MD, Miryana Dobreva, MSc, Francesca Fanelli, MSc, Jean Pierre Saab, MD, Edoardo Vincenzo Savarino, MD, PhD

“…Despite advances in understanding and management, optimal therapeutic strategies remain unclear, with conflicting guidelines. …”
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Shift in the profile and prognostic implications in invasive fungal rhinosinusitis: experience of 10 years in a tertiary center by Raúl Mellidez-Acosta, Lidia Torres-García, Miguel Saro-Buendía, Natalia Jaramillo-Ángel, Javier Cabrera-Guijo, Catalina Bancalari-Díaz, Noelia Muñoz-Fernández, Lucas Fito-Martorell, Miguel Armengot-Carceller, Alfonso García-Piñero

“…Abstract Background Despite appropriate treatment, mortality of acute invasive fungal rhinosinusitis remains exceedingly high, surpassing 50%. Evidence on how to optimize its management is still limited. We present a case series from our institution aiming to fill the knowledge gap. …”
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Advanced perspective on heavily phosphorus-doped diamond layers via optical emission spectroscopy by Kil-dong Sung, Stefan Andrei Irimiciuc, Michal Novotný, Zdeněk Weiss, Pavel Hubík, Jaromír Kopeček, Martin Vondráček, Vincent Mortet

“…This novel growth approach offers valuable insights for optimizing PDD synthesis, enabling more efficient phosphorus incorporation for electronic, electrochemical, and quantum applications.…”
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Sensitivity and specificity of the Patient Health Questionnaire (PHQ-9, PHQ-8, PHQ-2) and General Anxiety Disorder scale (GAD-7, GAD-2) for depression and anxiety diagnosis: a cros... by David Villarreal-Zegarra, Juan Carlos Bazo-Alvarez, Juan Barrera-Begazo, Sharlyn Otazú-Alfaro, Nikol Mayo-Puchoc, Jeff Huarcaya-Victoria

“…For a similar contrast against the gold standard, the other optimal cut-off points were: ≥7 for the PHQ-8 and ≥2 for the PHQ-2. …”
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Clinical characteristics and usage of statins in patients with stable ischemic heart disease referred for angiography or coronary artery bypass grafting by I.V. Shklianka, O.J. Zharinov, К.O. Mikhaliev, O.A. Epanchintseva

“…Therefore, there is a great need to determine the optimal dosage, the timing of the appointment and suspension of treatment with statins in patients with stable ischemic heart disease being prepared for coronary artery bypass grafting surgery.…”
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Design and Implementation of a Software System for Full-Process Animal Experiment Ethical Review by XU Xiao, WU Jiemin, LIANG Yi, YE Mingxia, ZHOU Shunchang

“…At the pre-approval stage, the system optimizes the process for designated members involved in the project review, ensuring that all projects comply with ethical standards and legal regulations. …”
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The line Rico is the earliest maturing accession in the VIR collection of spring bread wheat by B. V. Rigin, E. V. Zuev, A. S. Andreeva, Z. S. Pyzhenkova, I. I. Matvienko

“…Background. To optimize the process of bread wheat breeding for earliness and environmental adaptability, searching for new source material is a crucial task. …”
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Maternal and Perinatal Outcome of Triplet Pregnancies in a Tertiary Care Hospital in North India: A Prospective Observational Study by Sabreen Wani, Fiza Amin, Shagufta Yasmeen Rather

“…Thus, early diagnosis, adequate antenatal care, counselling, and perinatal care and support can help to ensure optimal outcomes. …”
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Exploring the risk factors of blood transfusion in patients with isolated traumatic brain injury based on machine learning prediction models by LIU Wei, XIONG Ziqing, WU Chenggao, LE Aiping

“…Furthermore, the SHAP framework was used to explain and visualize the optimal model CatBoost, showing that surgical treatment, lower GCS, higher INR, lower Hct, lower K, lower Ca, age ≥60 years, skull fractures and hemorrhagic shock increase the risk of blood transfusion in patients. …”
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Multiple Comorbidities, Psychiatric Disorders, Healthcare Resource Utilization and Costs Among Adults with Essential Tremor: A Retrospective Observational Study in a Large US Comme... by Dingwei Dai, Ali Samiian, Joaquim Fernandes, Henriette Coetzer

“…**Discussion:** Highly prevalent multiple comorbidities and psychiatric disorders should be considered in the context of clinical decision-making to optimize ET management. **Conclusions:** This study represents the largest observational study to report ET disease and economic burdens in a real-world setting. …”
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Outcome of dual implantation in distal end femur fractures among patients attending a tertiary care hospital in Karnataka by Kumar SVA, Vishnuprasad SH, Vittal V, Diwakar P, Zai SAK

“…Conclusion: For distal femur fractures, particularly Muller's type-C2 and C3, Dual implants, such as dual plates or plate with nail, offer favorable clinical outcomes, acceptable knee motion, high union rates, and optimal supra patella area reconstruction, and thus can be recommended as a standard procedure for managing complex distal femur injuries. …”
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