Effect of Flowering Shading on Grain Yield and Quality of Durum Wheat in a Mediterranean Environment by Giancarlo Pagnani, Alfredo Lorenzo, Nausicaa Occhipinti, Lisa Antonucci, Sara D’Egidio, Fabio Stagnari, Michele Pisante

“…These findings emphasize the interaction between light availability and nitrogen management, suggesting that optimizing these factors can improve yield and quality in durum wheat under Mediterranean conditions.…”
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A Novel Oxidative Stress Mediator in Acute Appendicitis: Thiol/Disulphide Homeostasis by Sefa Ozyazici, Faruk Karateke, Umit Turan, Adnan Kuvvetli, Huseyin Kilavuz, Burak Karakaya, Pınar Ozaltun, Murat Alısık, Ozcan Erel

“…Further studies are needed to optimize the use of this novel oxidative stress marker in AA.…”
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A single-plasmid-based, easily curable CRISPR/Cas9 system for rapid, iterative genome editing in Pseudomonas putida KT2440 by Qifeng Wen, JinJin Chen, Jin Li, Ida Putu Wiweka Dharmasiddhi, Maohua Yang, Jianmin Xing, Yilan Liu

“…We then developed an all-in-one CRISPR/Cas9 system for yqhD and ech-vdh-fcs deletions, respectively, and further optimized the editing efficiency by varying homology arm lengths and target sites. …”
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Computed tomography–guided percutaneous biopsy in diagnosis of suspected metastatic renal cell carcinoma: which location is the most suitable? by Petr Hoffmann, Michal Balik, Martina Hoffmannova, Jindrich Kopecky, Pavel Ryska, Jana Draganovicova, Petr Dvorak

“…Aim: Our aim was to evaluate an optimal location for percutaneous computed tomography-guided biopsy in a diagnosis of suspected mRCC. …”
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Management of thyroid tumors diagnosed cytologically as follicular neoplasms in a high-volume center: utility of a scoring system using serum thyroglobulin level, tumor size, ultra... by Yasuhiro Ito, Makoto Kawakami, Mitsuyoshi Hirokawa, Masashi Yamamoto, Minoru Kihara, Naoyoshi Onoda, Akihiro Miya, Akira Miyauchi, Takashi Akamizu

“…After assigning scores of 2 and 1 for cytological findings favoring malignancy and others, respectively, a receiver operating characteristic curve analysis indicated a score of 3 as the optimal cutoff for predicting malignant diagnosis; however, the area under the curve remained low, at 0.642. …”
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Safety and recommendation of voriconazole for invasive pulmonary aspergillosis in severe liver disease patients: a retrospective cohort study by Xin Zhang, Caopei Zheng, Ling Zhang, Yuqing Sun, Ying Liang, Xue Chen, Lijun Pang, Yulin Zhang

“…The aim of this study was to evaluate the efficacy and safety of voriconazole for IPA in patients with SLD and explore an optimal antifungal regimen. Methods This was a retrospective cohort study of SLD patients diagnosed with proven or probable IPA at Beijing Youan Hospital, Capital Medical University between January 1, 2012 to January 31, 2023. …”
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A positive experience in applying the biolistic approach to potato varieties Aksor and Nevskiy by N. P. Malakhova, Y. A. Skiba, G. A. Iskakova, D. A. Naizabayeva, B. K. Tezekbaeva, G. A. Ismagulova, E. R. Maltseva

“…For potato plants, the transformation efficiency is quite low at the moment and the selection of optimal conditions for biolistics is one of the pressing issues of practical biotechnology. …”
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Stable improvement in hand muscle strength in incomplete spinal cord injury patients by long-term paired associative stimulation—a case series study by Kirsi Holopainen, Aleksandra Tolmacheva, Ines Bersch, Piia Haakana, Piia Haakana, Markus Pohjonen, Erika Kirveskari, Erika Kirveskari, Jari Arokoski, Anastasia Shulga, Anastasia Shulga

“…Stable results were achieved when stimulation was delivered as long as MRC score improved progressively. The optimal duration of high-PAS treatment remains unknown.Clinical trial registrationclinicaltrials.gov, identifier NCT03045744.…”
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Evaluation of CBCT reconstructed tooth models at different thresholds and voxels and their accuracy in fusion with IOS data: an in vitro validation study by Yusong Zhang, Yixin Liu, Tianqi Liu, Jiahao Zhang, Peiying Lin, Dongxu Liu

“…Smaller voxel sizes yield higher reconstruction precision, and different voxel sizes and tooth regions correspond to distinct optimal segmentation thresholds. The validated semi-automated crown-root fusion algorithm significantly enhances overall model accuracy, offering new possibilities for clinical applications.…”
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High Glucose Level Disturbs the Resveratrol-Evoked Curtailment of CX3CL1/CX3CR1 Signaling in Human Placental Circulation by Dariusz Szukiewicz, Michal Pyzlak, Grzegorz Szewczyk, Aleksandra Stangret, Seweryn Trojanowski, Michal Bachanek, Wojciech Braksator, Jaroslaw Wejman

“…In conclusion, euglycemia assures optimal effects of resveratrol pertaining to CX3CL1/CX3CR1 signaling in the placenta. …”
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A systematic investigation on microstructure evolution, phase transformation and dynamic recrystallization mechanisms of hot isostatic pressed Ti–45Al–2Mn–2Nb–1B alloy during hot d... by Meiyi Ba, Hongkui Tang, Lianxi Hu, Yu Sun, Fei Gao

“…This comprehensive analysis offers novel insights into DRX mechanisms, providing valuable guidance for optimizing the hot working process of Ti–45Al–2Mn–2Nb–1B (at%) alloy.…”
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Study of the Interplay Among Melt Morphology, Rheology and 3D Printability of Poly(Lactic Acid)/Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Blends by Marco Costantini, Flavio Cognini, Roberta Angelini, Sara Alfano, Marianna Villano, Andrea Martinelli, David Bolzonella, Marco Rossi, Andrea Barbetta

“…Through thoroughly screening printing parameters such as deposition speed, nozzle diameter, flow percentage and deposition platform temperature, we determined the optimal printing conditions for the two PLA/PHBV blends. …”
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Opinions on hypertension care and therapy adherence at the healthcare provider and healthcare system level: a qualitative study in the Hague, Netherlands by Mattijs E Numans, Michiel L Bots, Sytske van Bruggen, Hedwig M M Vos, Rimke C Vos, Guy Rutten, Saskia E van Grondelle, Judith Meijer, Erik van Duin

“…Data were analysed using the theoretical domains framework (TDF) and the behaviour change wheel.Setting and participants Participants were from a highly urbanised city environment (the Hague, Netherlands), and included nine primary care physicians, six practice nurses and five secondary care physicians involved in hypertension care.Results Nine domains on the TDF were found to be relevant at the healthcare provider level (‘knowledge’, ‘physical, cognitive and interpersonal skills’, ‘memory, attention and decision processes’, ‘professional, social role and identity’, ‘optimism’, ‘beliefs about consequences’, ‘intention’, ‘emotion’ and ‘social influences’) and two domains (‘resources’ and ‘goals’) were found to be relevant at the system level. …”
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Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy by Stewart D. Ramsay, Stewart D. Ramsay, Stewart D. Ramsay, Marni A. Nenke, Marni A. Nenke, Emily J. Meyer, Emily J. Meyer, David J. Torpy, David J. Torpy, Richard L. Young, Richard L. Young, Richard L. Young, Richard L. Young

“…Circadian rhythms are critical to coordinating body processes to external environmental cues, such as light and feeding, to ensure efficiency and maintain optimal health. These rhythms are controlled by ‘clock’ transcription factors, such as Clock, Bmal1, Per1/2, Cry1/2, and Rev-erbs, which are present in almost every tissue. …”
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Association of calf circumference with osteoporosis and hip fracture in middle-aged and older adults: a secondary analysis by Mumin Cao, Yuanwei Zhang, Mengze Tong, Xiangxu Chen, Ziang Xu, Renwang Sheng, Liu Shi, Cheng Zhang, Wenbin Fan, Tian Xie, Yingjuan Li, Jinyu Wang, Wei Gao, Yunfeng Rui

“…The receiver operating characteristic (ROC) curve was utilized to determine the optimal cut-off value for CC. Finally, logistic regression model analysis was applied to test the predictive efficacy of CC. …”
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Impact of Organic Agriculture on the Quality of Grapes (Syrah and Tempranillo) Harvested in Guanajuato, Mexico: Relationship Between Soil Elemental Profile and Grape Bioactive Prop... by Fabio Macías-Gallardo, Tannia Alexandra Quiñones-Muñoz, Raúl Miranda-Avilés, Luis Felipe Ramírez-Santoyo, Gabriela Ana Zanor, César Ozuna

“…Finally, the edaphic conditions of the ORG vineyard allowed for one to obtain optimal grapes for winemaking due to their higher phenol content.…”
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Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory by Jeyanthan Charles James, Hannah Schulze, Nadine Siems, Christian Prehn, Daniel R. Quast, Nadine Trampe, Ralf Gold, Simon Faissner

“…The present results should be considered to optimize treatment algorithms for therapy and rehabilitation programs of PCS patients with neurologic symptoms.…”
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Joint Group and Multi Institutional Position Opinion: Cirrhotic Cardiomyopathy—From Fundamentals to Applied Tactics by Ivan Rankovic, Ivana Babic, Jelena Martinov Nestorov, Jelena Bogdanovic, Maja Stojanovic, Jovanka Trifunovic, Nikola Panic, Mihailo Bezmarevic, Jelena Jevtovic, Dusan Micic, Vladimir Dedovic, Nemanja Djuricic, Filip Pilipovic, Elena Curakova Ristovska, Tijana Glisic, Sanja Kostic, Nemanja Stojkovic, Nata Joksimovic, Mileva Bascarevic, Aleksandra Bozovic, Lewis Elvin, Ajibola Onifade, Keith Siau, Elizaveta Koriakovskaia, Vladimir Milivojevic

“…However, our group still advocates them as essential tools in optimizing the neurohumoral pathologic axis that perpetuates CCM. …”
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Sequential Docetaxel in ≥7 Cycles Followed by Cabazitaxel Improves Oncological Outcomes in Patients with Metastatic Castration-Resistant Prostate Cancer by Seiichi Kato, Manabu Takai, Koji Iinuma, Shota Fujimoto, Masahiro Nakano, Takashi Ishida, Masahiro Uno, Masayoshi Tamaki, Mitsuhiro Taniguchi, Hisao Komeda, Yoshito Takahashi, Takuya Koie

“…However, it is unclear whether switching to second-line chemotherapy or optimal sequencing of cabazitaxel (CBZ) ensures better clinical outcomes. …”
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Standardization in the management of gram-negative bloodstream infections after implementation of a clinical care guideline at a large academic, safety-net institution: a quasi-exp... by Michael A. Deaney, Katherine C. Shihadeh, Alexandra Craig, Margaret M. Cooper, Paul D. Paratore, Timothy C. Jenkins

“…These findings support the effectiveness of institutional guidelines in standardizing care, optimizing resource utilization, and promoting evidence-based practices in infectious disease management. …”
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