To Compare and Evaluate the Efficacy of 1% Alendronate Gel and 10% Doxycycline Gel as an Adjunct to SRP in Patients with Chronic Periodontitis: A Randomized Controlled Clinical Tri... by Laloo Phassang, Radhika Kapoor, Prashant Tyagi, Amit Wadhawan

“…Local drug delivery is a promising approach, targeting therapeutic agents to specific tissues or organs, optimizing efficacy by concentrating medications at the site of action. …”
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Varying pixel resolution significantly improves deep learning-based carotid plaque histology segmentation by Yurim Lee, Rashid Al Mukaddim, Tenzin Ngawang, Shahriar Salamat, Carol C. Mitchell, Jenna Maybock, Stephanie M. Wilbrand, Robert J. Dempsey, Tomy Varghese

“…Automating and digitizing histopathological images of these plaques into tissue specific (lipid and calcified) regions can help us compare histologic findings to in vivo imaging and thereby enable us to optimize medical treatments or interventions for patients based on the composition of plaques. …”
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Assessment of healthcare workers’ knowledge and availability of resources for sickle cell disease management in Bukavu, Democratic Republic of the Congo by Nash Mwanza Nangunia, Olivier Mukuku, Viviane Bianga Feza, Yves Mulindilwa Kyembwa, Théophile Barhwamire Kabesha, André Kabamba Mutombo, Stanislas Okitostho Wembonyama

“…It is essential to improve the training of HCWs and to strengthen HCFs in order to optimize the management of SCD patients in Bukavu.…”
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Tongue Muscle Training App for Middle-Aged and Older Adults Incorporating Flow-Based Gameplay: Design and Feasibility Pilot Study by Kuan-Chu Su, Ko-Chiu Wu, Kuei-Ru Chou, Chia-Hsu Huang

“…Following the development of a tongue training app, a feasibility trial aimed to identify physiological and psychological factors that affect user and flow experience and explored whether training specialized muscles could produce a flow experience for optimal immersion. We aimed to provide a useful tool for medical rehabilitation so that older adults could retain tongue muscle flexibility. …”
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The Promising Key Factors Mediating Secondary Neuronal Damage in the Perihematomal Region of Intracerebellar Hemorrhage of Mice by Saandeep Bhatia, Ramissh Paramasivam, Mohd Khairul Izamil Bin Zolkefley, Regunath Kandasamy, Sangu Muthuraju, Jafri Malin Abdullah

“…Identifying the time window of these vital changes could help prevent secondary damage and optimize the treatment to occur at proper time points.…”
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The effect of thioredoxin and prochymosin coexpression on the refolding of recombinant alpaca chymosin by S. V. Belenkaya, D. N. Shcherbakov, A. I. Chapoval, T. I. Esina, V. V. Elchaninov

“…Fusion of thioredoxin capable of disulfide-reductase activity to the N-terminal sequence of prochymosin provides optimal conditions for zymogen refolding and increases the yield of recombinant alpaca chymosin immediately after activation and during long-term storage by 13 and 15 %, respectively. …”
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Exploring nonlinear and interaction effects of urban campus built environments on exercise walking using crowdsourced data by Bo Lu, Bo Lu, Qingyun Liu, Hao Liu, Tianxiang Long, Tianxiang Long

“…Recommendations include optimizing the spatial configuration of sports facilities, green spaces, and water bodies to maximize their synergistic impacts on walking activity. …”
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Enhancing the photocatalytic performance and chemical durability of AZ31 magnesium alloy by incorporating two types of nanoparticles through plasma electrolytic oxidation by Mosab Kaseem, Abdullah H. Alluhayb, Talitha Tara Thanaa, Arash Fattah-alhosseini, Mohammad Alkaseem

“…This approach aims to achieve an optimal balance between efficiency and stability by finely tuning the structure-surface reactivity relationship. …”
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Futility in TAVI: A scoping review of definitions, predictive criteria, and medical predictive models. by Charlie Ferry, Jade Fiery-Fraillon, Mario Togni, Stephane Cook

“…Especially in the high-risk group, some patients fail to derive optimal or any benefits from TAVI, leading to the risk of futile interventions. …”
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How, What, and Where You Sample Environmental DNA Affects Diversity Estimates and Species Detection by Anish Kirtane, Leif Howard, Caitlin E. Beaver, Margaret E. Hunter, Gordon Luikart, Kristy Deiner

“…ABSTRACT Environmental DNA (eDNA) is a complex mixture of DNA, varying in particle sizes and distributed heterogeneously in aquatic systems. Optimizing eDNA sampling is crucial for maximizing species detection, particularly in high‐risk scenarios like invasive species management. …”
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Medical thoracoscopy combined with intrapleural injection of urokinase for treatment of pleural infection-a multicenter, prospective, randomized controlled study: study protocol by Kaige Wang, Linhui Yang, Panwen Tian, Fen Tan, Dan Liu, Weimin Li

“…It is recommended that the diameter of the chest tube be 12–14 F, with three daily flushes of 30 ml normal saline to ensure optimal drainage. Subsequently, comprehensive statistical analyses will be conducted to compare treatment effects and complications across all groups, ultimately leading to conclusive findings. …”
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Transparent memory tests with even repeating addresses for storage devices by V. N. Yarmolik, I. M. Mrozek, V. A. Levantsevich, D. V. Demenkovets

“…The properties of new characteristics of the pA sequences are investigated and their applicability is evaluated for choosing the optimal test pA sequences that ensure the high efficiency of new transparent tests. …”
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MONETARY POLICY RULES AS THE FOUNDATION OF THE MODERN PARADIGM OF CENTRAL BANK INDEPENDENCE by Inna O. Shkolnyk, Yurii M. Ohorilko

“…Taylor, whose rule served as a guideline for establishing the optimal interest rate to combat high inflation and ensure economic growth, pointed out that the deviation of central banks from rule-like behavior led to the crisis of 2008, and emphasized the need to return to using monetary rules for macroeconomic stabilization. …”
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2D Fast Vessel Visualization Using a Vessel Wall Mask Guiding Fine Vessel Detection by Sotirios Raptis, Dimitris Koutsouris

“…These are easily computed as Gaussian-like 2D forms that use a limited range sub-optimal parameters adjusted to the dominant vessel characteristics obtained by Spatial Grey Level Difference statistics limiting the range of search into vessel widths of 16, 32, and 64 pixels. …”
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Enabling analytical precision in microplastic analysis: innovative solutions for precise method validation, evaluation and quality control by Jovan Badzoka, Christoph Kappacher, Jakob Lauß, Lisa Obwaller, Anna Pavun, Christian W. Huck

“…Leveraging Fourier Transform Infrared (FT-IR) and Quantum-cascade laser (QCL) imaging, we introduce a method that utilizes potassium bromide (KBr) pellets embedded with microplastics (MPs), facilitating exact particle number determination for method validation and quality control (QC) using FT-IR imaging of formed potassium bromide (KBr) pellets. KBr exhibits optimal properties as a matrix for MP-immobilization due to its excellent water solubility and infrared transparency. …”
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HDNLS: Hybrid Deep-Learning and Non-Linear Least Squares-Based Method for Fast Multi-Component T1ρ Mapping in the Knee Joint by Dilbag Singh, Ravinder R. Regatte, Marcelo V. W. Zibetti

“…Among these, HDNLS emerges as the optimal trade-off between performance and fitting time. …”
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Spatiotemporal air quality prediction using stochastic advection–diffusion model for multimodal data fusion by Byeongseong Choi, Michelle A Hummel

“…However, data fusion approaches face multiple challenges, including incompatible measurement units, varying data resolutions, and differing levels of uncertainty. As a result, the optimal method for data fusion remains an open question. …”
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INNOVATIVE MECHANISMS FOR IMPLEMENTING STATE ECONOMIC POLICY FOR POST-WAR RECONSTRUCTION OF UKRAINE: QUANTUM TRANSFORMATIONS AS A DRIVER OF DEVELOPMENT by Oleksiy Shkuratov, Liudmila Antonova, Roman Dzyuba

“…The second quantum revolution involves the introduction of quantum computers, quantum cryptography and quantum communication, capable of accelerating the development of new materials, optimizing logistics chains and increasing the level of data security. …”
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Study of Fluid Flow Characteristics and Mechanical Properties of Aviation Fuel-Welded Pipelines via the Fluid–Solid Coupling Method by Changhong Guo, Mengran Di, Hanwen Gong, Jin Zhang, Shibo Sun, Kehua Ye, Bin Li, Lingxiao Quan

“…This study enhances our comprehension of the mechanical properties of aircraft fuel lines with fluid–solid coupling and provides a foundation and guidance for the optimal design of fuel-welded lines.…”
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Evaluasi implementasi program pendidikan gratis di kota Padang Sidimpuan by Freddy Sanda P.H, Nurhizrah Gistituati

“…Efisiensi, jumlah dana atau anggaran pendidikan gratis sudah cukup optimal untuk mendukung pelaksanaan pendidikan di sekolah. …”
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