Supplemental oxygen strategies in infants with bronchopulmonary dysplasia after the neonatal intensive care unit period: study protocol for a randomised controlled trial (SOS BPD s... by Anton H van Kaam, Wes Onland, Irwin K M Reiss, Peter H Dijk, Arend F Bos, Eleni-Rosalina Andrinopoulou, E Villamor, LGM van Rooij, M de Jong, JS von Lindern, Lucas Goossens, Stephanie Balink, Elianne J L E Vrijlandt, Anthon R Hulsmann, Debbie H Nuytemans, Arwen J Sprij, André A Kroon, Marielle Pijnenburg, MGA Baartmans, GJ Blok, WP de Boode, HD Buiter, CE Counsilman, CA Dalen Meurs, ACM Dassel, AM de Grauw, MEN van den Heuvel, JLAM van Hillegersberg, JCR van Hoften, JHL van Hoorn, CH ten Hove, A Kamerbeek, AAMW van Kempen, LH van der Meer, RMJ Moonen, EEM Mulder, HJ Niemarkt, MAG van Scherpenzeel-de Vries, IAM Schiering, RNGB Tan

“…However, it is unknown what oxygen saturation levels are optimal to improve outcomes in infants with established BPD from 36 weeks postmenstrual age (PMA) onwards. …”
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A Hierarchical Graph-Enhanced Transformer Network for Remote Sensing Scene Classification by Ziwei Li, Weiming Xu, Shiyu Yang, Juan Wang, Hua Su, Zhanchao Huang, Sheng Wu

“…HGTNet achieves classification accuracies of 98.47%, 95.75%, and 96.33% on the aerial image, NWPU-RESISC45, and OPTIMAL-31 datasets, respectively, demonstrating superior performance compared to other state-of-the-art models. …”
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Evaluating the accuracy of earth rotation parameters based on the BDS observations by Chenxiang Wang, Pengfei Zhang, Tengxu Zhang, Ziyu Shen, Jizhang Sang, Wenbin Shen

“…When selecting a specific satellite type, it is necessary to choose an appropriate observation arc length based on different numbers of reference stations while maximizing the volume of the formed polyhedron to achieve optimal efficiency and accuracy in parameter estimation. …”
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Water quality characteristics of municipal wastewater treatment plants and the prospect of reclaimed water utilization in lower-middle income and water-scarce areas: A case study o... by Yutong Duan, Hongbo Xi, Zhikai Qin, Ruili Guo, Fang Wang, Yue Yuan

“…Influent water quality analysis showed high concentrations of COD, NH₃-N, TN, and TP, and nutrient ratios that often exceeded the optimal level for biological nutrient removal. Effluent water quality generally met the discharge standards, though TN removal efficiency was unsatisfactory in some cases. …”
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Cystic Fibrosis and Reproductive Outcomes: The Latest Insights into Fertility and Pregnancy by Weronika Małagocka, Karol Zagórski, Mateusz Kozik, Nina Skalska-Dziobek, Karolina Chybowska, Maria Naruszewicz, Przemysław Cetnarowski

“…Planning the pregnancy gives time to prepare the mother, optimize her nutrition status and make sure medications she takes are safe for the fetus. …”
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Definitions matter: Multicenter investigation of incidence and outcome of poor graft function after hematopoietic cell transplantation by Konradin F. Müskens, Winny N. R. Collot‐d'Escury, Rana Dandis, Saskia Haitjema, Jürgen Kuball, Moniek A. deWitte, Marc Bierings, Caroline A. Lindemans, Stefan Nierkens, Mirjam E. Belderbos

“…Future studies, using standardized, quantitative thresholds for PGF, are required to determine optimal treatment strategies for both mild and severe forms of PGF.…”
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Experimental investigation on the anti-detonation performance of composite structure containing foam geopolymer backfill material by Hang Zhou, Hujun Li, Zhen Wang, Dongming Yan, Wenxin Wang, Guokai Zhang, Zirui Cheng, Song Sun, Mingyang Wang

“…The results of this study provide a scientific basis for optimizing underground composite structure interlayer parameters.…”
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Effect of Flaxseed Gum and Konjac Gum on the 3D Printing Properties of Pea Protein Isolate Emulsion Gels by Congjin BAI, Jingjing GUO, Yifan WANG, Zhenrong LI, Bo JIAO, Lei DAI

“…At a concentration of 1.1%, the emulsion gel exhibited the smallest particle size, the highest G' and G'' values, and optimal viscoelasticity. Furthermore, the printed structures displayed the most distinct textures, stable frameworks, and superior printing adaptability. …”
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Quantifying Joystick Interactions and Movement Patterns of Toddlers With Disabilities Using Powered Mobility With an Instrumented Explorer Mini by Kimberly A. Ingraham, Nicole L. Zaino, Claire Feddema, Mia E. Hoffman, Liesbeth Gijbels, Alexis Sinclair, Andrew N. Meltzoff, Patricia K. Kuhl, Heather A. Feldner, Katherine M. Steele

“…However, many open questions persist regarding how joystick-based mobility technologies should be designed to optimally suit the developmental needs of toddlers. …”
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Tumour heterogeneity and personalized treatment screening based on single-cell transcriptomics by Xinying Zhang, Jiajie Xie, Zixin Yang, Carisa Kwok Wai Yu, Yaohua Hu, Jing Qin

“…Despite advancements in anticancer drugs and optimised chemotherapy regimens that have improved cure rates for malignant tumours, the presence of tumour heterogeneity has resulted in substantial variations among patients in terms of disease progression, clinical response, sensitivity to therapy, and prognosis, posing significant challenges in attaining optimal therapeutic outcomes for each patient. Here, we collected five single-cell transcriptome datasets from patients with lung, breast, colorectal, gastric, and liver cancers and constructed multiple cancer blueprints of tumour cell heterogeneity. …”
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Transcranial brain atlas based on photon measurement density function in a triple-parameter standard channel space by Lijiang Wei, Yang Zhao, Farui Liu, Yuanyuan Chen, Yilong Xu, Zheng Li, Chaozhe Zhu

“…Therefore, in the absence of individual sMRI data, PMDF-TBA can optimize optode montage design, enhance channel sensitivity in target brain regions, and assist in source localization for fNIRS data, thereby facilitating the application of fNIRS in neuroscience research.…”
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Influence of human peripheral blood samples preprocessing on the quality of Hi-C libraries by M. M. Gridina, E. Vesna, M. E. Minzhenkova, N. V. Shilova, O. P. Ryzhkova, L. P. Nazarenko, E. O. Belyaeva, I. N. Lebedev, V. S. Fishman

“…The purpose of this study was to determine the optimal storage conditions of blood samples for subsequent Hi-C analysis. …”
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Impact of Varying Amplitudes of Upward and Downward Motion on the Torque/Force Generation, Canal-Centering Ability, and Cyclic Fatigue Resistance of Nickel–Titanium Reciprocating I... by Keiko Hirano, Shunsuke Kimura, Keiichiro Maki, Satoshi Omori, Arata Ebihara, Takashi Okiji

“…The optimal amplitude of pecking motion during nickel–titanium rotary root canal instrumentation remains unclear. …”
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Machine learning algorithm for predict the in-hospital mortality in critically ill patients with congestive heart failure combined with chronic kidney disease by Xunliang Li, Zhijuan Wang, Wenman Zhao, Rui Shi, Yuyu Zhu, Haifeng Pan, Deguang Wang

“…The selection of the optimal model was based on the area under the curve (AUC). …”
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Numerical Simulation of Channelization Near the Wellbore due to Seepage Erosion in Unconsolidated Sands during Fluid Injection by Jin Sun, Shiguo Wu, Jingen Deng, Qingping Li, Qi Fan, Linwei Ma, Yanrui Liu

“…The study can provide a theoretical reference for the optimal design of high-pressure water injection or frac-packing operation in the unconsolidated sands reservoir.…”
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Intensity of Oestrus Signalling Is the Most Relevant Indicator for Animal Well-Being in High-Producing Dairy Cows by Emanuel Garcia, Jan Hultgren, Pontus Fällman, Johanna Geust, Bo Algers, George Stilwell, Stefan Gunnarsson, Heriberto Rodriguez-Martinez

“…Intensity of oestrus signalling relates to animal well-being, reflected in pregnancy-to-term being a good indicator for optimal welfare in high-producing dairy cattle.…”
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Spatially ordered recruitment of fast muscles in accordance with movement strengths in larval zebrafish by Sayaka Shimizu, Taisei Katayama, Nozomi Nishiumi, Masashi Tanimoto, Yukiko Kimura, Shin-ichi Higashijima

“…These findings provide significant insights into the organization and function of fast muscles in larval zebrafish, illustrating how spatial recruitment and fiber size interact to optimize movement performance.…”
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Prognostic value of [18F]FDG PET/CT in patients with idiopathic pulmonary fibrosis by Wonseok Whi, Hwanhee Lee, Young Seok Cho, Hyunjong Lee, Hongseok Yoo, Man Pyo Chung, Joon Young Choi

“…Pulmonary FDG uptake [target to background ratio (TBR)] was binarized by optimal cut-off value based on survival analysis. …”
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Mixed radiation with different doses induces CCL17 to recruit CD8+T cell to exert anti-tumor effects in non-small cell lung cancer by Liuying Huang, Duo Wang, Muchen Xu, Danqi Qian, Yulin Cao, Xiaohan Wu, Liang Ming, Junhui Tang, Zhaohui Huang, Yuan Yin, Leyuan Zhou, Leyuan Zhou, Leyuan Zhou

“…This study sought to elucidate the influence of combining different doses of RT with immune checkpoint inhibitors (ICIs) on the infiltration of CD8+T cells within tumors, thereby augmenting the anti-tumor response.MethodsConstructing a mouse model featuring bilateral lung cancer tumors subjected to high and low dose irradiation, the analysis of RNA transcriptome sequencing data and immunohistochemical validation for tumors exposed to various dosages guided the selection of the optimal low-dose irradiation scheme. Subsequently, upon the integration of immune checkpoint inhibitors (ICIs) therapy, the infiltration of immune cells within the tumor was ascertained via immunohistochemistry (IHC) and flow cytometry (FCM). …”
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Analysis of mechanical properties and energy evolution mechanism of frozen calcareous clay under multi-factor interaction by Jihao Feng, Hao Shi, Chuanxin Rong, Lei Song, Wei Long, Jianpeng Liu, Di Wei, Gangjian An

“…Abstract Research investigating the complex mechanical properties and energy evolution mechanisms of frozen calcareous clay under the influence of multiple factors is crucial for optimizing the artificial ground freezing method in shaft sinking, thereby enhancing construction quality and safety. …”
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