Functional Connectivity and MRI Radiomics Biomarkers of Cognitive and Brain Reserve in Post-Stroke Cognitive Impairment Prediction—A Study Protocol by Hanna Maria Dragoș, Adina Stan, Livia Livinț Popa, Roxana Pintican, Diana Feier, Nicu Cătălin Drăghici, Dragoș-Cătălin Jianu, Diana Chira, Ștefan Strilciuc, Dafin F. Mureșanu

“…Cognitive reserve involves the brain’s ability to optimize performance and use alternative networks to maintain function. …”
Get full text

The Neutrophil-to-Monocyte Ratio and Platelet-to-White Blood Cell Ratio Represent Novel Prognostic Markers in Patients with Pancreatic Cancer by Feng Tang, Penghui Dai, Qiongqiong Wei, Ke Gan, Zijie Wang, Huan Chen, Ting Li, Muhan Lv, Mingming Deng, Gang Luo

“…Kaplan-Meier curves and the Cox proportional hazard model were employed to analyze the relationships among NMR, PWR, and overall survival (OS). Results. The optimal cutoff values of NMR and PWR were 48 and 6, respectively. …”
Get full text

Newcastle Disease Virus Displaying an Ectodomain of Middle East Respiratory Syndrome Coronavirus Spike Protein Elicited Robust Humoral and Cellular Immunity in Mice by Jaturawitt Prasopsiri, Kanjana Srisutthisamphan, Benjamas Liwnaree, Juggragarn Jengarn, Jarin Kramyu, Payuda Hansoongnern, Papon Muangsanit, Nathiphat Tanwattana, Challika Kaewborisuth, Suttipun Sungsuwan, Anan Jongkaewwattana, Nanchaya Wanasen

“…With recent advancements in stabilizing coronavirus spike proteins to enhance their antigenicity, this study aimed to determine whether modifications to the MERS-CoV spike protein could improve its presentation on NDV particles, allowing the resulting virus to be used as an inactivated vaccine. Methods: We codon-optimized the gene encoding the ectodomain of the MERS-CoV spike protein and incorporated modifications at the S1/S2 and S2’ cleavage sites, along with a proline substitution at residues V1060-L1061. …”
Get full text

Tracing the Origin of Oxide Inclusions in Vacuum Arc Remelted Steel Ingots Using Trace Element Profiles and Strontium Isotope Ratios by Christoph Walkner, Gulnaz Mukhametzianova, Stefan Wagner, Jörg C. Korp, Andreas Graf, Johanna Irrgeher, Thomas C. Meisel, Thomas Prohaska

“…This is particularly evident in the case of macroscopic inclusions (>100 µm), which are rarely observed in steel castings produced using state-of-the-art technologies, whereby casting parameters are optimized towards steel cleanliness, and post-treatment steps such as vacuum arc remelting (VAR) are used, but frequently result in the rejection of the affected product. …”
Get full text

Patient perspectives on acromegaly disease burden: insights from a community meeting by Shruti N. Shah, Kevin C. J. Yuen, Vivien Bonert, Wenyu Huang, Jill Sisco, Chrystal Palaty, Kristen Dancel-Manning, Nidhi Agrawal

“…ObjectiveA profound mismatch between biological and symptom control in acromegaly creates a high disease burden despite achieving optimal biological control. There is a great need to learn more about the perspectives of patients living with acromegaly.MethodsAcromegaly Community hosted a virtual meeting in January 2021 and prepared a detailed report capturing participants’ input on acromegaly symptoms and current and future treatment approaches. …”
Get full text

Deep Joint Demosaicking and Super-Resolution for Spectral Filter Array Images by Abdelhamid N. Fsian, Jean-Baptiste Thomas, Jon Y. Hardeberg, Pierre Gouton

“…This holistic approach ensures a more coherent and optimized restoration process, mitigating the risk of error accumulation and preserving image quality throughout the reconstruction pipeline. …”
Get full text

Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort study by John Kinuthia, R Scott McClelland, Barbra A Richardson, Elizabeth Maleche-Obimbo, Brent R Collett, Sarah Benki-Nugent, Faridah H Were, Anne M Riederer, Michael Gatari, CJ Karr, Edmund YW Seto, Beatrice C Mutai, Susan Wamithi, Priscilla Wanini Edemba, Timothy V Larson, Julian D Marshall

“…Longitudinal pregnancy cohort studies are optimal for individual exposure assessment during critical windows of brain development and examination of neurodevelopment. …”
Get full text

Co-Cultivations of <i>Beauveria bassiana</i>, <i>Metarhizium anisopliae</i>, and <i>Trichoderma harzianum</i> to Produce Bioactive Compounds for Application in Agriculture by Pauline Flores da Silva, Maicon Sérgio Nascimento dos Santos, Beatriz de Andrade Araújo, Bruno Douglas Kerber, Heloisa Alves Pinto de Oliveira, Jerson Vanderlei Carús Guedes, Marcio Antonio Mazutti, Marcus Vinícius Tres, Giovani Leone Zabot

“…As a way forward, this product demonstrated integrated bioactivities as insecticide and fungicide and can be optimized to substitute chemical pesticides that have negative impacts on the environment.…”
Get full text

Revealing intra- and inter-container fruit quality heterogeneity within overseas refrigerated container shipments using a physics-based digital twin by Celine Verreydt, Tarl Berry, Leo Lukasse, Deniz Turan, Paul Cronje, Thijs Defraeye

“…The air temperature and relative humidity inside refrigerated containers should be kept at optimal conditions to prevent fruit losses. However, each shipment evolves differently in terms of shipping duration and temperature. …”
Get full text

Integration of ground-based and remote sensing data with deep learning algorithms for mapping habitats in Natura 2000 protected oak forests by Lucia Čahojová, Ivan Jarolímek, Barbora Klímová, Michal Kollár, Michaela Michalková, Karol Mikula, Aneta A. Ožvat, Denisa Slabejová, Mária Šibíková

“…The study also seeks to evaluate the accuracy of this approach, specifically in oak-dominated forests, as well as identify the optimal time period within a year for effective habitat identification.Using the specialised software NaturaSat, automated segmentations were performed based on the coordinates of phytosociological relevés and forest strands defined in database. …”
Get full text

Rational design of a triple-type HPV53/56/66 vaccine with one preferable base particle incorporating two identified immunodominant sites by Ciying Qian, Jie Chen, Yurou Yang, Yihan Lu, Tianyu Ren, Yanan Jiang, Yang Huang, Xin Chi, Shuyue Zhang, Chengzong Zhang, Kewei Li, Jingjia Shen, Sibo Zhang, Daning Wang, Lizhi Zhou, Tingting Li, Qingbing Zheng, Hai Yu, Ying Gu, Ningshao Xia, Shaowei Li

“…Comprehensive evaluations identified unique dominant immunogenic loops for each type: the FG loop for HPV53, the HI loop for HPV56, and the DE loop for HPV66, with HPV66 emerging as the optimal chimeric backbone virus-like particle (VLP). …”
Get full text

Advances in Nucleic Acid Drugs and Gene Therapies based on Animal Models of Duchenne Muscular Dystrophy by LIU Siyu, LAI Yuezhao, GUO Wenting, CHEN Xuejin

“…Future studies must optimize existing therapeutic strategies, improve their efficacy and applicability, and explore innovative approaches to deliver more effective and sustainable treatments for DMD patients.…”
Get full text

Coloration and functionalization of organic cotton fabric using Chinese fringe leaf extraction: A greener approach by Md Shazzat Hossain, Mohammad Ullah, Rony Mia, Mohammed A. Assiri, Yahui Zhou, Haroon A.M. Saeed, Sakil Mahmud

“…Spectroscopic analyses, including UV−visible (UV−vis) spectroscopy and Fourier transform infrared spectroscopy (FTIR), confirmed the presence of flavonoid compounds as the key bio−colorants in the dye solution. Optimal dyeing conditions were established with a 10 % Al2(SO4)3 mordant, resulting in dyed OCF exhibiting a significant color strength (K/S) of 5.90 and excellent fastness including rubbing, washing and light. …”
Get full text

The effect of resizing on the natural appearance of scintigraphic images: an image similarity analysis by Siraj Ghassel, Amir Jabbarpour, Jochen Lang, Eric Moulton, Eric Moulton, Ran Klein, Ran Klein, Ran Klein, Ran Klein

“…These image quality metrics were subsequently compared to those of two independent count-matched images at the target grid size (representing variance due to natural noise permutations) as a reference to establish an optimal resizing method.ResultsOnly upsampled images with the Poisson resampling correction after linear interpolation produced images that were similar to those acquired at the target grid size. …”
Get full text

Increased Intra-Abdominal Pressure as One of the Links in the Pathogenesis of Secondary Diffuse Purulent Peritonitis by D. V. Cherdantsev, O. V. Ovchinnikova, Yu. G. Trofimovich, I. G. Noskov, O. V. Pervova, A. A. Kovalenko

“…According to reference values, the optimal level of intra-abdominal pressure does not exceed 5 mmHg. …”
Get full text

Contemporary Management of Patent Foramen Ovale: A Multinational Survey on Cardiologists’ Perspective by Maciej Dębski, Amr Abdelrahman, Halia Alshehri, Marloe Prince, Andrew Wiper, Shajil Chalil, Dariusz Dudek, Christopher J. White, David Hildick-Smith, David H. Roberts

“…The study shows a vast spectrum of opinions on the optimal approach to PFO closure with significant differences between the US, UK, and Gulf countries. …”
Get full text

Ferroptosis genes and ST-segment elevation myocardial infarction outcomes: A predictive signature by Xing-jie Wang, Lei Huang, Min Hou, Jie Guo, Xi-ming Li

“…We performed functional enrichment analysis to explore their biological functions. We built an optimal model with least absolute shrinkage and selection operator (LASSO) penalized Cox proportional hazards regression. …”
Get full text

Non-classical pulmonary exacerbation in cystic fibrosis revealing ALK-Translocated lung cancer: A case report by Mohamad Hadhud, Johnathan Arnon, Anat Hershko-Moshe, Adi Hollander, Noa Hurvitz-Lehmann, Assaf Potruch, Henny Azmanov, Rottem Kuint, Nurith Hiller, Elie Picard, Naama Sebbag-Sznajder, Shira Leebhoff, Michael Wilschanski, Myriam Grunewald, Liron Birimberg-Schwartz, Malena Cohen-Cymberknoh

“…Care for pwCF with lung cancer requires a unique multi-disciplinary approach to optimize their complex multifactorial treatment.…”
Get full text

Integrating Analytical Procedures in Routine Practices of Centralized Antiblastic Compounding Units for Valorization of Residual Compounded Drugs by Rita Patrizia Aquino, Giovanni Falcone, Paola Russo, Fabrizio Dal Piaz, Giulia Auriemma, Ferdinando Maria de Francesco, Stefania Cascone, Eduardo Nava, Pasquale Del Gaudio

“…In relation to their different physicochemical properties, two analytical approaches were optimized and involved in the stability investigation: HPLC-DAD for small molecules and a combined approach of LC-MS/MS with size exclusion chromatography for monoclonal antibodies analysis. …”
Get full text

Protective Efficacy of Decreasing Antigen Doses of a <i>Chlamydia abortus</i> Subcellular Vaccine Against Ovine Enzootic Abortion in a Pregnant Sheep Challenge Model by Morag Livingstone, Kevin Aitchison, Javier Palarea-Albaladejo, Francesco Ciampi, Clare Underwood, Antonia Paladino, Francesca Chianini, Gary Entrican, Sean Ranjan Wattegedera, David Longbottom

“…Conclusions: The results show that a dose of 10 µg antigen in the vaccine will be optimal in terms of maximising efficacy, reducing shedding at parturition, and ensuring it is cost-effective to produce for commercial manufacture.…”
Get full text