Exploring cardiovascular implications in systemic lupus erythematosus: A holistic analysis of complications, diagnostic criteria, and therapeutic modalities, encompassing pharmacol... by Dawi John, Affa Scarlet, Misakyan Yura, Fardeheb Sabrina, Kades Samuel, Kiriaki Anthony, Mohan Aishvaryaa Shree, Norris Brandon, Yoon Sonyeol, Venketaraman Vishwanath

“…Ongoing research is essential to refine these strategies and optimize individualized treatment plans for improved patient outcomes.…”
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A prediction model for guiding tumor microwave ablation surgery based on simulation by Lu Qian, Yamin Yang, Pan Chen, Jia Liu, Xiaofei Jin, Zhiyu Qian, Chunxiao Chen

“…Methods: An MWA process was first simulated by incorporating electromagnetic radiation equations, thermal equations, and optimized biological tissue parameters (dynamic dielectric and thermophysical parameters). …”
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Deep Brain Stimulation in the treatment of disorders of consciousness by Joanna Olszak, Karolina Zalewa, Lidia Bartoszek, Dominika Orłowska, Wojciech Kapłan, Mikołaj Poleszczuk, Karol Poleszczuk, Alicja Milewska, Anna Czuba, Marta Kaus

“…While the results are promising, more controlled and larger-scale clinical trials areneeded to better understand the long-term efficacy, optimal timing, and appropriate patient selection.  …”
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Vision-based manipulation of transparent plastic bags in industrial setups by F. Adetunji, F. Adetunji, A. Karukayil, A. Karukayil, P. Samant, P. Samant, S. Shabana, S. Shabana, F. Varghese, F. Varghese, U. Upadhyay, U. Upadhyay, R. A. Yadav, R. A. Yadav, A. Partridge, E. Pendleton, R. Plant, Y. R. Petillot, Y. R. Petillot, M. Koskinopoulou, M. Koskinopoulou

“…The system incorporates vacuum gripping technology with compliance control for optimal grasping and manipulation points, using a Franka Emika robot arm.ResultsThe system successfully demonstrates its capability to automate the unpacking and cutting of transparent plastic bags for an 8-stack bulk-loader. …”
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Nitrogen-rich covalent organic polymers for efficient solid phase extraction of nonsteroidal anti-inflammatory drugs from water samples by Yuqi Cheng, Jia Li, Xiaochen Xiu, Xinghua Teng, Wen Zhang, Lei Ji, Leilei Wang

“…Then, utilizing nitrogen-rich covalent organic polymer as adsorbent for solid phase extraction cartridges, the pretreatment method was combined with high-performance liquid chromatography-diode array detection to quantify five representative NSAIDs (ketoprofen, carprofen, flurbiprofen, diclofenac and mefenamic acid) in environmental water samples. Under the optimal extraction conditions (adsorbent amount: 40 mg; NaCl concentration: 0%; pH 6; extraction time: 20min; eluent solvent: 4 mL of formic acid/acetonitrile (5%, v/v)), the proposed method provided low detection limits (0.06–0.2 μg L-1), wide linear ranges (0.2–100 μg L-1) with correlation coefficients (0.9991–0.9997) and acceptable precision (RSDs, 6.6–8.5% for intra-day, 7.2–9.5% for inter-day). …”
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Enhanced intestinal epithelial co-culture model with orbital mechanical stimulation: a proof-of-concept application in food nanotoxicology by Mattia Santoni, Giovanni Piccinini, Giovanni Piccinini, Giovanni Liguori, Maria Roberta Randi, Massimo Baroncini, Liliana Milani, Francesca Danesi

“…Mechanical stimulation selectively promoted goblet cell differentiation without affecting general epithelial markers. The optimized model successfully detected concentration-dependent oxidative stress responses to TiO₂ exposure, revealing cellular dysfunction preceding membrane damage.DiscussionThis improved co-culture system provides a better physiological platform for nanotoxicology studies. …”
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Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel by Kate Halsby, Gerhard Dobler, Ava Easton, Guntis Karelis, Lenka Krbková, Jan Kyncl, Johann Sellner, Franc Strle, Malin Veje, Joanna Zajkowska, Dace Zavadska, Frederick J. Angulo, Andreas Pilz, Wilhelm Erber, Meghan Gabriel, Jon Russo, Mark Price, Harish Madhava, Uta Katharina Meyding-Lamadé

“…., outcome) phases of TBEV infection and optimally reflects both clinical presentation and severity. …”
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Advances in physiological and clinical relevance of hiPSC-derived brain models for precision medicine pipelines by Negin Imani Farahani, Negin Imani Farahani, Negin Imani Farahani, Lisa Lin, Lisa Lin, Lisa Lin, Shama Nazir, Shama Nazir, Shama Nazir, Alireza Naderi, Alireza Naderi, Alireza Naderi, Leanne Rokos, Leanne Rokos, Leanne Rokos, Anthony Randal McIntosh, Anthony Randal McIntosh, Lisa M. Julian, Lisa M. Julian, Lisa M. Julian, Lisa M. Julian

“…Precision, or personalized, medicine aims to stratify patients based on variable pathogenic signatures to optimize the effectiveness of disease prevention and treatment. …”
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Dual-sided centripetal microgrooved poly (D,L-lactide-co-caprolactone) disk encased in immune-regulating hydrogels for enhanced bone regeneration by You Wu, Xiaokun Yue, Ying Zhang, Ning Yu, Chengyan Ge, Rui Liu, Zhongying Duan, Lilong Gao, Xinlong Zang, Xin Sun, Deteng Zhang

“…Well-designed artificial scaffolds are urgently needed due to the limited self-repair capacity of bone, which hampers effective regeneration in critical defects. Optimal scaffolds must provide physical guidance to recruit cells and immune regulation to improve the regenerative microenvironment. …”
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CT-based intratumoral and peritumoral radiomics nomogram to predict spread through air spaces in lung adenocarcinoma with diameter ≤ 3 cm: A multicenter study by Yangfan Su, Junli Tao, Xiaosong Lan, Changyu Liang, Xuemei Huang, Jiuquan Zhang, Kai Li, Lihua Chen

“…A nomogram based on prediction probability value of the optimal radiomics model and clinical independent risk factors was developed to predict STAS status. …”
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REVOLUTIONIZING LUXURY: THE ROLE OF AI AND MACHINE LEARNING IN ENHANCING MARKETING STRATEGIES WITHIN THE TOURISM AND HOSPITALITY LUXURY SECTORS by Maria Nascimento CUNHA, Manuel PEREIRA, António CARDOSO, Jorge FIGUEIREDO, Isabel OLIVEIRA

“…Through a detailed quantitative examination of 2,048 survey responses, this study investigates how AI and ML technologies are employed to optimize digital marketing strategies, focusing particularly on the effectiveness of remarketing and retargeting tactics and their influence on consumer purchasing decisions. …”
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Biotechnology of Lactulose Production: Progress, Challenges, and Prospects by Svetlana A. Ryabtseva, Andrey G. Khramtsov, Maria A. Shpak, Alexey D. Lodygin, Georgy S. Anisimov, Serafima N. Sazanova, Yulia A. Tabakova

“…The yield can reach 30% if the processing conditions are optimal. Fructose remains the main problem in the production process. …”
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Rapid assessment of main agronomic indicators in the grain of winter and spring forms of triticale using infrared spectroscopy by V. S. Popov, N. G. Konkova, T. V. Shelenga, V. I. Khoreva, I. A. Kibkalo, M. Kh. Gadjimagomedova, L. G. Suvaryan

“…These calibration models will enable users to find the most optimal utilization trends for individual triticale accessions. …”
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Enhanced Photocatalytic Degradation of Methylene Blue Dye Using Co3O4 Nanoparticles from the Fruit Extracts of Diplocyclos palmatus (L) C. Jeffrey for Wastewater Remediation by Parethe Gurusamy Thangam, Rajesh Pattulingam, Velmani Vellaiyan, Balaji Murugaesan, Kavica Sathasivam

“…In this present study, Cobalt oxide (Co3O4) nanoparticles, have been synthesized by Co-precipitation technique and assessed as optimized catalyst for photocatalytic dye degradation under sunlight irradiation. …”
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Multifunctional Plumeria rubra nanoparticles: Antimicrobial, antiviral, antiparasitic and anti-inflammatory activities by Bassma H. Elwakil, Mohab H. Elsabrouty, Areej Eskandrani, Keshav Raj Paudel, Esraa Abdelhamid Moneer

“…The optimum conditions for Plumeria rubra nanoparticle synthesis were 30 min stirring time and a 1:1 PVA/Plumeria rubra ratio. The optimized nanoparticles showed antimicrobial activity reached 7.8 μg/mL with entrapment and loading efficiencies %, zeta size, zeta potential, and PDI were 89.0 %, 40.0 %, 18.5 nm, −1.65 mV, and 0.29, respectively. …”
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Effects of Intercropping and Mowing Frequency on Biological Nitrogen Fixation Capacity, Nutritive Value, and Yield in Alfalfa (<i>Medicago sativa</i> L. cv. Vernal) by Yao Wang, Jinsong Zhang, Chunxia He, Ping Meng, Jie Wang, Jun Gao, Pan Xue

“…Our study suggests that intercropping with walnut can improve biological nitrogen fixation in alfalfa, and that adopting a mowing-thrice regime can optimize yield and nutritive value.…”
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Antioxidant therapy for infertile couples: a comprehensive review of the current status and consideration of future prospects by Ramadan Saleh, Ramadan Saleh, Hassan Sallam, Hassan Sallam, Mohamad AlaaEldein Elsuity, Mohamad AlaaEldein Elsuity, Sulagna Dutta, Sulagna Dutta, Pallav Sengupta, Ahmed Nasr

“…Despite several findings suggesting improvements in fertility potential with AOX therapy, the data remains inconclusive regarding optimal dosage and combination, duration of treatment, and the specific patient populations most likely to benefit. …”
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Flow Cytometry of the Side Population: Tips & Tricks by Irene Sales-Pardo, Ariadna Avendaño, Vanessa Martinez-Muñoz, Marta García-Escarp, Raquel Celis, Phil Whittle, Jordi Barquinero, Joan Carles Domingo, Pedro Marin, Jordi Petriz

“…Results: The Ho342 concentration and the staining procedure are critical for the optimal resolution of the SP cells. Although UV laser alignment is very important to resolve the dim tail that outlines the SP, the problem with Ho342 excitation is not the Hoechst Blue emission, but rather the Hoechst Red's (because of the weak emission). …”
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Harnessing the potential of chloroplast-derived expression elements for enhanced production of cellulases in Escherichia coli by Ayesha Siddiqui, Muhammad Mudassar Iqbal, Asad Ali, Iqra Fatima, Hazrat Ali, Aamir Shehzad, Sameer H. Qari, Ghulam Raza, Muhammad Aamer Mehmood, Peter J. Nixon, Niaz Ahmad

“…The genes encoding the cellulases were sourced from a thermophilic bacterium Thermotoga maritima to exploit their industrially needed thermotolerance potential. The codon-optimized gene sequences were synthesized and placed under a tobacco chloroplast 16S rRNA promoter (Prrn), along with the 5′ UTR (untranslated region) from gene 10 of phage T7 (T7g10). …”
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Traceability simulation of drainage in irrigation areas along the south bank of the Yellow River based on the SWAT model by Zheng Hexiang, Han Yujing, Han Yujing, Bao Rongxuan, Wang Biyu, Wu Jiabin, Tian Delong, Yan Haofang, Yan Haofang, Hao Beibei

“…Moreover, the model parameters were optimized using SWAT-CUP software to obtain the R2, NSE, Re, and RMSE values of 0.65, 0.60, −8.54%, and 384.65 × 104 m3, respectively, for the model calibration period, and the corresponding values were 0.63, 0.56, −7.82%, and 389.65 × 104 m3, respectively, for the validation period. …”
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