The road ahead: emerging therapies for primary IgA nephropathy by Edward J. Filippone, Rakesh Gulati, John L. Farber

“…Our current approach for those requiring immunosuppression involves combining the reduction of Gd-IgA1 (nefecon) with suppressing the effects of inflammation (iptacopan). The optimal duration of such therapy is uncertain. Clearly, there is more to be learned with many trials underway.…”
Get full text

Analytical determination of the stress-strain state of soil mass during tunnelling by A. Z. Ter-Martirosyan, V. V. Rud

“…This approach is justified by the fact that actual displacements can be close to predicted ones when the optimal face-support pressure is selected and there is no face loss of soil, which could lead to unforeseen deformations. …”
Get full text

Leveraging mRNA technology for antigen based immuno-oncology therapies by Wei Zheng, Michele Ceccarelli, Charalampos S Floudas, Siranush Sarkizova

“…This comprehensive overview highlights the therapeutic potential of mRNA-based cancer vaccines and underscores ongoing research efforts aimed at optimizing these therapies for improved clinical outcomes.…”
Get full text

Development of Tracer Gas Method to Improve Indoor Air Quality: A Study on Ventilation Performance in Apartment Buildings in South Korea by Soo Man Lee, Sang Yoon Lee, Gil Tae Kim, Byung Chang Kwag

“…However, the suggested tracer gas method and indicators can be used to discover the optimal locations of vents for better indoor air quality or to drive a better building design to achieve better indoor ventilation performance. …”
Get full text

Laser Beam Welding of AA5052, AA5083, and AA6061 Aluminum Alloys by A. El-Batahgy, M. Kutsuna

“…Porosity was prevented by accurate cleaning of the base metal prior to welding and optimizing the flow rate of argon shielding gas. Solidification cracking was avoided through two different approaches. …”
Get full text

Real-Time Heterogeneous Collaborative Perception in Edge-Enabled Vehicular Environments by Samuel Thornton, Nithin Santhanam, Rajeev Chhajer, Sujit Dey

“…Additionally, we propose an Adaptive Perception Frequency (APF) model to determine the optimal end-to-end latency requirement according to the current state of the environment. …”
Get full text

Profiling endogenous airway proteases and antiproteases and modeling proteolytic activation of Influenza HA using in vitro and ex vivo human airway surface liquid samples. by Stephanie A Brocke, Boris Reidel, Camille Ehre, Meghan E Rebuli, Carole Robinette, Kevin D Schichlein, Christian A Brooks, Ilona Jaspers

“…Secondly, we present an optimized method for probing the proteolytic environment of airway surface liquid samples (in vitro and ex vivo) using fluorogenic peptides modeling the cleavage sites of respiratory viruses. …”
Get full text

Assessment of Ecosystem Vulnerability in the Tropic of Cancer (Yunnan Section) by Hui Ye, Die Bai, Jinliang Wang, Shucheng Tan, Shiyin Liu

“…By proposing targeted policy recommendations—such as enhancing ecological protection and restoration, optimizing land use planning, and increasing public environmental awareness—this study provides actionable strategies to reduce ecological vulnerability. …”
Get full text

Hyperthermia and cisplatin combination therapy promotes caspase-8 accumulation and activation to enhance apoptosis and pyroptosis in cancer cells by Guanghui Zi, Jin Chen, Yatu Peng, Yue Wang, Baowei Peng

“…The present study aimed to investigate the possible interactions between caspase 8 activation, apoptosis, and pyroptosis in combination therapy.Methods Cells were treated with CDDP (15 µg/ml), followed by hyperthermia at optimized temperature (42.5 °C) in water-bath. After combination therapy, cell viability was analyzed by CCK-8, and cell death was analyzed by Annexin-V-FITC/PI and caspases activation. …”
Get full text

Experimental Study on Mechanical Properties of Polypropylene: Steel Fiber Concrete and Loading Characteristics of Shaft Lining by Bendong Qin, Shuo Li, Jiaqi Guo, Shaofeng Liu, Xiliang Liu, Yongbiao Lai, Hailiang Li

“…The SPHFRC with various mix proportions was prepared by optimizing the fiber content. The mechanical properties of SPHFRC were tested and compared with the reference concrete (PHSC). …”
Get full text

Respiratory Virus Vaccines: Pathways to Recommendations and Enhanced Coverage for At-Risk Populations by Stefania Maggi, Odile Launay, Rachel Dawson

“…Additionally, logistical issues related to vaccine supply, access, and costs present further challenges in achieving optimal coverage. Potential strategies to overcome these barriers and improve uptake include strengthening and harmonizing immunization guidelines and improving respiratory disease surveillance systems to appropriately identify needs and direct resources. …”
Get full text

Body Composition in Preterm Infants: Current Insights and Emerging Perspectives by Sreekanth Viswanathan, Melissa Thoene, Zaineh Alja’nini, Pradeep Alur, Kera McNelis

“…This comprehensive approach is designed to optimize health outcomes for preterm newborns by focusing on their body composition from an early stage.…”
Get full text

Model of forecasting of material resources and estimated cost at early stages of life cycle of construction objects by M. V. Gureev, A. N. Makarov

“…Thus, the accuracy of forecasts of the total estimated cost is significantly increased, and it also becomes possible to predict with a given accuracy the volumes of materials and equipment at the early stages of the life cycle of the construction object in order to optimize the entire construction process.…”
Get full text

Divergent modulation of activated protein C pleiotropic functions by antibodies that differ by a single amino acid by Derek S. Sim, Meenal Shukla, Cornell R. Mallari, José A. Fernández, Xiao Xu, Doug Schneider, Maxine Bauzon, Terry W. Hermiston, Laurent O. Mosnier

“…TPP-26870 is an antibody that targets a nonactive site of APC for the selective modulation of APC activities. To optimize the potency of TPP-26870, variants with single amino acid mutation in the complementarity-determining regions (CDRs) were screened, and 21 variants with improved affinity constant were identified. …”
Get full text

Chaotic spiral based reconfiguration scheme for the mitigation of power loss in solar photovoltaic (PV) systems by Karthick. B, M. Sudhakaran

“…As the global shift towards renewable energy intensities, optimizing solar energy utilization has become a pressing concern. …”
Get full text

Revisiting Weimar Film Reviewers’ Sentiments: Integrating Lexicon-Based Sentiment Analysis with Large Language Models by Isadora Campregher Paiva, Josephine Diecke

“…Applying it to historical film reviews seemed logical and promising to us. Some of our early optimism was misplaced: while LLMs, and in particular ChatGPT, proved indeed to be much more adept at dealing with nuanced language, they are also difficult to control and implement in a consistent and reproducible way -- two things that lexicon-based sentiment analysis excels at. …”
Get full text

New-insight UVB Treatment for Psoriasis Vulgaris in Vietnamese Patients by Phuong Pham Thi Minh, Trang Trinh Minh, Phuong Hoang Thi, Giang Quach Thi Ha, Tra Bui Thi, Michael Tirant, Doanh Le Huu

“…Objectives: This study aimed to establish an optimal NBUVB therapy for the treatment of psoriasis in Vietnamese patients. …”
Get full text

Design of generic vedic ALU using reversible logic by Kanchan S. Tiwari

“…The proposed ALU architecture is optimized to perform fundamental arithmetic operations: addition, subtraction, multiplication, and division; as well as bitwise logical operations: AND, OR, and XOR. …”
Get full text

Comparison of the strength of resistance spot-welded, bonded, and hybrid single lap joints: A numerical investigation by Murat Demiral, Ali Mamedov

“…The study examined three adhesives (SikaPower 423 L1, Araldite AV138, Araldite 2015), three spot-welding diameters, and three adherend thicknesses to provide detailed insights for optimizing joint designs, enhancing reliability and durability in complex engineering applications. …”
Get full text

Single-Photon Emission Computed Tomographic Imaging of the Early Time Course of Therapy-Induced Cell Death Using Technetium 99m Tricarbonyl His-Annexin A5 in a Colorectal Cancer Xe... by Christel Vangestel, Christophe Van de Wiele, Gilles Mees, Koen Mertens, Steven Staelens, Chris Reutelingsperger, Patrick Pauwels, Nancy Van Damme, Marc Peeters

“…For 5-FU- and panitumumabtreated mice, the correlation coefficients were r = .7 ( p = .18) and r = .7 ( p = .19), respectively. Optimal timing of annexin A5 imaging after the start of different treatments in the Colo205 model was determined.…”
Get full text