Characterization of Bozitinib as a potential therapeutic agent for MET-amplified gastric cancer by Hang Lin, Lingzhi Qu, Hudie Wei, Ming Guo, Xiaojuan Chen, Qianmeng Lin, Huajun Zhang, Shuyan Dai, Yongheng Chen

“…Structurally, bozitinib is optimally embedded in the ATP pocket of c-Met and firmly binds via an extensive interaction network. …”
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Bacterial Composition of Dairy Base during Fermentation by Mariya V. Gryaznova, Inna Yu. Burakova, Yuliya D. Smirnova, Ekaterina Yu. Nesterova, Natalia S. Rodionova, Evgeniy S. Popov, Mikhail Yu. Syromyatnikov, Vasily N. Popov

“…Eventually, Lactobacillus replaced all other genera, including Bifidobacterium, probably, as a result of pH going down during fermentation. The optimal values for the proliferation of Lactobacillus (pH = 4.2–4.4), which were registered after 18 h, turned out to be too low for the productive growth of Bifidobacterium. …”
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Modeling and correction of protein conformational disease in iPSC-derived neurons through personalized base editing by Colin T. Konishi, Nancy Mulaiese, Tanvi Butola, Qinkun Zhang, Dana Kagan, Qiaoyan Yang, Mariel Pressler, Brooke G. Dirvin, Orrin Devinsky, Jayeeta Basu, Chengzu Long

“…To address several challenges for clinical applications of gene correction, we developed a neuron-specific engineered virus-like particle to optimize neuronal ABE delivery, resulting in higher correction efficiency. …”
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Contributions to the Virtualization of the BNG by Jorge Proenca, Ricardo Figueiredo, Vasco Pereira, Tiago Cruz, Paulo Simoes

“…It serves as a crucial component, being responsible for various essential services that allow subscribers’ connections and help optimizing infrastructure resources, including enforcing QoS policies and implementing Access Control Lists to safeguard against unauthorized access. …”
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Chloride Ion Removal from the Wet Flue Gas Desulfurization and Denitrification Wastewater Using Friedel’s Salt Precipitation Method by Ping Fang, Zi-jun Tang, Xiong-bo Chen, Jian-hang Huang, Zhi-xiong Tang, Chao-ping Cen

“…Factors affecting the Cl− removal, such as Ca(OH)2 dosage, NaAlO2 dosage, solution’s initial pH, solution’s temperature, reaction time, stirring speed, and anions (SO42−, NO3−, and F−), were investigated, and the optimal experimental conditions for Cl− removal were determined. …”
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Psychological, psychiatric, and behavioral sciences measurement scales: best practice guidelines for their development and validation by Alberto Stefana, Stefano Damiani, Umberto Granziol, Umberto Provenzani, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Eric A. Youngstrom, Eric A. Youngstrom, Eric A. Youngstrom, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli

“…Finally, in the Finalization Phase, the optimal item sequence is decided, and a comprehensive inventory manual is prepared. …”
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Fabrication of taxifolin loaded zein-caseinate nanoparticles and its bioavailability in rat by Ying Li, Hang Su, Wenjun Wang, Zhongping Yin, Jing’en Li, En Yuan, Qingfeng Zhang

“…The formulations of TZP were optimized. With mass ratio of 1:1:2 between taxifolin, zein and sodium caseinate, the particle size and ζ-potential of TZP were (168.74 ± 0.35) nm and (−57.67 ± 0.25) mV, while the encapsulation and loading efficiency of taxifolin were (85.83 ± 0.89)% and (17.11 ± 0.88)%, respectively. …”
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Native Microbiota of Rapeseed Cake as Potential Source of Industrial Producers by Olga P. Sverdlova, Elizaveta V. Podshivalova, Natalya Yu. Sharova, Daria D. Belova

“…Further research will identify the microbial species, their useful properties, and optimal cultivation conditions.…”
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Impact of haemostasis methods during ovarian cystectomy on ovarian reserve: a pairwise and network meta-analysis by Qin Xie, Yue Xie, Ying Shi, Xiaozhen Quan, Xuezhou Yang

“…The comprehensive ranking results revealed that suture treatment was, with the highest probability, beneficial to the protection of the ovarian reserve.Conclusions There was insufficient research to detect the optimal haemostasis method for ovarian reserve preservation in ovarian cystectomy. …”
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Traffic light system regulation of induced seismicity under multi-well fluid injection by Miao He, Qi Li, Xiaying Li, Yao Zhang

“…Understanding the relationship between injection operations and seismic magnitude is of great significance for optimizing industrial production and reducing earthquake disasters. …”
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Operation time as a prognostic indicator on postoperative complications following percutaneous nephrolithotomy by Alireza Pakdel, Abdolreza Mohammadi, Amirreza Shamshirgaran, Ehsan Zemanati Yar, Leila Zareian Baghdadabad, Farshid Alaeddini, Roghayeh Koohi Ortakand, Leonardo Oliveira Reis, Seyed Reza Hosseini, Seyed Mohammad Kazem Aghamir

“…Objective: We aimed to find an optimal cut-off time for percutaneous nephrolithotomy to prevent complications. …”
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Development of Prevascularized Synthetic Block Graft for Maxillofacial Reconstruction by Borvornwut Buranawat, Abeer Shaalan, Devy F. Garna, Lucy Di Silvio

“…The co-culture of endothelial cells (ECs) with human alveolar osteoblasts (aHOBs) on the scaffold led to the formation of tube-like structures and intrinsic VEGF release, reaching 10,455.6 pg/mL This level approached the optimal dose for vascular formation. Conversely, the co-culture with mesenchymal stem cells did not yield similar results. …”
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Axial Compression Behavior of Novel Latticed Columns with CFST Tubes and Corrugated Steel Plates for Industrial Structures by Xuan Zhao, Ningning Zhang, Zhaohui Hu, Xian Li, Ying Nie, Jun Liu

“…Therefore, diagonal lacing tubes should be considered for the optimal axial compression behavior of latticed columns. …”
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The relationship between malocclusion and speech patterns: a cross-sectional study by Nada E. Tashkandi, Razan AlDosary, Hissah Zamandar, Misk Alalwan, Mohannad Alwothainani, Hissah Aljoaid, Duaa Alghazhmri, Eman Allam, Anand Marya, Samar M. Adel

“…Conclusions There was an evident pattern of partial association of PAR index scores and speech abnormalities including improper articulation. To provide optimal care for involved subjects, collaboration between orthodontists and speech therapists, in pre- and post-treatment evaluations, is crucial.…”
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Improving reproductive outcomes in frozen embryo transfer over fresh embryo transfer in women with endometrioma: A historical cohort study by Parisa Pirooznia, Mehri Mashayekhi, Firouzeh Ghaffari, Nadia Jahangiri, Zahra Zolfaghari, Firoozeh Ahmadi, Fateme Hasani, Nima Narimani

“…In vitro fertilization and embryo transfer (ET) are key therapeutic strategies for infertility associated with endometriosis. However, the optimal type of ET (frozen or fresh) and its impact on pregnancy success rates remain debated, with limited studies available. …”
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Determination of Ischemia Onset Based on Automatically Generated Spectralis SD-OCT Values in Acute Central Retinal Artery Occlusion by Maria Casagrande, Robert Kromer, Daniel A. Wenzel, Sven Poli, Martin S. Spitzer, Vasyl Druchkiv, Maximilian Schultheiss, Spyridon Dimopoulos

“…In all sectors, time to OCT (TTO) and RRTI correlated positively. The optimal cutoff point to detect CRAOs ≤4.5 hours was between 18.7% nasally and 22.9% RRTI temporally. …”
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Concordance between Immunohistochemistry and Microarray Gene Expression Profiling for Estrogen Receptor, Progesterone Receptor, and HER2 Receptor Statuses in Breast Cancer Patients... by Ghina B. Fakhri, Reem S. Akel, Maya K. Khalil, Deborah A. Mukherji, Fouad I. Boulos, Arafat H. Tfayli

“…Accurate evaluation of estrogen and progesterone receptors and HER2 is critical when diagnosing invasive breast cancer for optimal treatment. The current evaluation method is via immunohistochemistry (IHC). …”
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Three-periodic 1D photonic crystals based on dielectric oxides SiO2, Al2O3, TiO2, ZrO2: an emerging class of structures with wide possibilities for applied photonics by I.S. Panyaev, D.G. Sannikov, Yu.S. Dadoenkova, N.N. Dadoenkova

“…Using the transfer matrix method, frequency-angle spectra and energy characteristics of the PC structures are studied and optimal combinations of layers (and contrast) are found, enabling obtaining controllable photonic band gaps (PBGs). …”
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Learning to build low-field MRIs for remote northern communities by Gordon E. Sarty, Logi Vidarsson, Christopher Hansen, Christopher Hansen, Keifer Corrigal, Lionel Sutherland, Millie Jamieson, Micheal Hogue, Haile Kassahun, William Greyeyes, David Teixeira, Lawrence Goertzen, Jonathan McEvoy, Mark Pollard

“…The prototype built was a radio frequency (RF) encoding MRI, whose design was optimized for eventual use in space, but the techniques and procedures developed are applicable to other MRI designs. …”
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Effects of limited introgressions from Triticum timopheevii Tausch. into the genome of bread wheat (Triticum aestivum L.) on physiological and biochemical traits under normal water... by T. A. Pshenichnikova, A. V. Permyakov, S. V. Osipova, M. D. Permyakova, E. G. Rudikovskaya, V. V. Verchoturov

“…In flag leaves of 821 line, an increased transpiration rate and stomatal conductance (1.6 times the value in optimal watering and 1.2 times the value under water deficit) and, correspondingly, reduced water use efficiency were found compared to the initial cultivar. …”
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