Magnetic Nanoparticle Based Nonviral MicroRNA Delivery into Freshly Isolated CD105+ hMSCs by Anna Schade, Paula Müller, Evgenya Delyagina, Natalia Voronina, Anna Skorska, Cornelia Lux, Gustav Steinhoff, Robert David

“…Thus, in this study different miR/PEI and miR/PEI/MNP complex formulations were tested in vitro for uptake efficiency and cytotoxicity with respect to the influence of an external magnetic field. Afterwards, optimized magnetic complexes were selected and compared to commercially available magnetic vectors (Magnetofectamine, CombiMag). …”
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Olfactory transport efficiency of the amorphous and crystalline manganese oxide nanoparticles by A. V. Romashchenko, D. V. Petrovskii, M. B.  Sharapova, Y. M. Moshkin, K. E. Kuper, K. N.  Morozova, E. V. Kiseleva, M. P. Moshkin

“…Data on the different intake of amorphous and crystalline nanoparticles from the nasal cavity to the brain, as well as the evidence for the key role of the mucosal layer in differentiating the penetrating power of these particles will be useful in developing approaches to assessing air pollution and optimizing the methods of inhalation therapy.…”
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Clinical analysis and risk factors associated with poor prognosis in nontuberculous mycobacterial infection by Jinjing Chai, Sujie Zhang, Chong Ma, Qimin Mei, Tao Liu, Jihai Liu, Yecheng Liu, Huadong Zhu

“…The area under the curve (AUC) values for NLR and neutrophil-to-monocyte-plus-lymphocyte-ratio (NMLR) were 0.751 and 0.763 with optimal cut-off values of 9.50 and 3.83, respectively, for prediction of mortality in patients with NTM disease.…”
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Comparison of Kolmogorov–Arnold Networks and Multi-Layer Perceptron for modelling and optimisation analysis of energy systems by Talha Ansar, Waqar Muhammad Ashraf

“…KAN models are embedded in the optimisation framework of nonlinear programming and feasible optimal solutions are estimated, maximising thermal efficiency up to 42.17 ± 0.88 % and minimising turbine heat rate to 7487 ± 129 kJ/kWh corresponding to power generation of 500 ± 14 MW for the thermal power plant. …”
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Demineralized Freeze-Dried Bovine Cortical Bone: Its Potential for Guided Bone Regeneration Membrane by David B. Kamadjaja, Achmad Harijadi, Pratiwi Soesilawati, Eny Wahyuni, Nurul Maulidah, Akhsanal Fauzi, Fika Rah Ayu, Roberto Simanjuntak, R. Soesanto, Djodi Asmara, Andra Rizqiawan, Peter Agus, Coen Pramono

“…Demineralized freeze-dried bovine cortical bone membrane showed potential for clinical application; however, it needs to be optimized in its biocompatibility to fulfill all requirements for GBR membrane.…”
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Neural Network-Based Parameter Estimation and Compensation Control for Time-Delay Servo System of Aeroengine by Hongyi Chen, Qiuhong Li, Zhifeng Ye, Shuwei Pang

“…The estimated delay was embedded into an online sequential extreme learning machine, and a nonlinear model predictive controller was designed to obtain an optimal control sequence. The compensation control loop was designed to reduce the impact of the model and delay mismatch problems of the control system. …”
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Mechanistic Insights into the Anticancer Potential of Methoxyflavones Analogs: A Review by Mohammad Aidiel, Maisarah Abdul Mutalib, Rajesh Ramasamy, Nik Nasihah Nik Ramli, Shirley Gee Hoon Tang, Siti Hajar Adam

“…Together, the analysis provides a useful strategy for the structure–activity relationship (SAR) of flavonoid analogs in distinct protein markers, suggesting optimal functional group positioning to achieve balanced lipophilicity, effective hydrogen bonding, and simultaneously minimized steric hindrance in targeting specific cancer cell types.…”
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Lane Changing Control of Autonomous Vehicle With Integrated Trajectory Planning Based on Stackelberg Game by Dongmei Wu, Zhen Li, Changqing Du, Changsheng Liu, Yang Li, Xin Xu

“…Lane changing present a significant challenge for autonomous vehicles, as they must maintain safe driving and optimize time efficiency. This process is strongly affected by traffic environment and driver characteristics. …”
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Integrating AI into Cancer Immunotherapy—A Narrative Review of Current Applications and Future Directions by David B. Olawade, Aanuoluwapo Clement David-Olawade, Temitope Adereni, Eghosasere Egbon, Jennifer Teke, Stergios Boussios

“…Results: AI has significantly contributed to identifying biomarkers that predict immunotherapy efficacy by analyzing genomic, transcriptomic, and proteomic data. It also optimizes combination therapies by predicting the most effective treatment protocols. …”
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BIPE: A Bi-Layer Predictive Ensemble Framework for Forest Fire Susceptibility Mapping in Germany by Ling Hu, Volker Hochschild, Harald Neidhardt, Michael Schultz, Pegah Khosravani, Hadi Shokati

“…Despite considerable economic advancements, firefighting strategies remain less than optimal. This paper introduces the Bi-layer Predictive Ensemble (BIPE), an innovative machine learning model designed to enhance the accuracy and generalization of forest fire susceptibility mapping. …”
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Effects of Hot Air, Vacuum, and Conductive Drying on the Fatty Acid Profile of <i>Cucurbita maxima</i> Pulp and Its Processing By-Products by Antonela Ninčević Grassino, Sven Karlović, Filip Dujmić, Suzana Rimac Brnčić, Marija Badanjak Sabolović, Mladen Brnčić

“…In this study, the effects of hot air drying (HAD), vacuum drying (VAD), and conductive drying (CD) at 50, 60, and 70 °C on fatty acid profiles were investigated to determine optimal drying conditions that preserve fatty acid (FA) quality and associated nutritional benefits. …”
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Discovery of a novel highly specific, fully human PSCA antibody and its application as an antibody-drug conjugate in prostate cancer by Xiaojie Chu, Seungmin Shin, Du-San Baek, Liyong Zhang, Alex Conard, Megan Shi, Ye-Jin Kim, Cynthia Adams, Maggie Hines, Xianglei Liu, Chuan Chen, Zehua Sun, Dontcho V. Jelev, John W. Mellors, Dimiter S. Dimitrov, Wei Li

“…This is a first reported ADC based on a fully human PSCA antibody and MMAE that is characterized in a xenograft murine model, which warrants further optimizations and investigations in additional preclinical tumor models, including prostate and other solid tumors.…”
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Effect of ecological restoration on physicochemical properties, bacterial and fungal communities of red sand soil in Longquan Mountain forest park by Yan Wang, Yu-Long Zhang, Rui Zhang, Cai-Xia Li, Xian-Jun Lai, Xin-Rong Ma

“…Ecological restoration significantly optimized the community structure and diversity of bacteria, but with minor shifts in the composition and structure of fungi. …”
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Enhanced Ciprofloxacin Ozonation Degradation by an Aqueous Zn-Cu-Ni Composite Silicate: Degradation Performance and Surface Mechanism by Yue Liu, Rong Guo, Jie Li, Yizhen Cheng, Congmin Wang, Weiqiang Wang, Huifan Zheng

“…The CIP and total organic carbon (TOC) removal rates were increased by 51.09% and 18.72%, respectively, under optimal conditions, compared with ozonation alone. …”
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Self-Assembly Strategy for Synthesis of WO₃@TCN Heterojunction: Efficient for Photocatalytic Degradation and Hydrogen Production via Water Splitting by Li Zhou, Wenjie Zhang, Zezhao Huang, Feng Hu, Peng Li, Xiaoquan Yao

“…After modulation, the optimal 3%WO₃@TCN exhibited a maximal degradation rate constant that was twofold higher than that of TCN alone and showed continuous H₂ generation in the photocatalytic hydrogen evolution. …”
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Employing the concept of stacking ensemble learning to generate deep dream images using multiple CNN variants by Lafta Alkhazraji, Ayad R. Abbas, Abeer S. Jamil, Zahraa Saddi Kadhim, Wissam Alkhazraji, Sabah Abdulazeez Jebur, Bassam Noori Shaker, Mohammed Abdallazez Mohammed, Mohanad A. Mohammed, Basim Mohammed Al-Araji, Abdulkareem Z. Mohmmed, Wasiq Khan, Bilal Khan, Abir Jaafar Hussain

“…For model development, a series of five pre-trained Convolutional Neural Network (CNN) architectures—VGG-19, Inception v3, VGG-16, Inception-ResNet-V2, and Xception were stacked in an ensemble learning approach to create Deep Dream images whereby the upper hidden layers of the architectures were activated, and the models were trained via the Adam optimizer. Performance of the proposed model was evaluated across three octaves to amplify the maximum possible patterns and features of the base image. …”
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Synthesis and structural insights of bis(2-methoxy-6-{[(2-methylpropyl)imino]methyl}phenolato) nickel (II) complex through DFT and docking investigations by K. Jayachandiran, Sv. Esha, M. Savitha Lakshmi, S. Mahalakshmi, S. Arockiasamy

“…The TG analysis revealed its thermal durability pre and post-melting up to 225 oC with a weight loss of only 2%. The optimized molecular structure, energy gap between HOMO and LUMO, and intermolecular interactions were studied by computational methods. …”
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Evaluation of the Nutrition Heart Program Through the Four Elements of Community Empowerment Approach by Rika Satyadewi, Galuh Mega Kurnia, Arina Mufida Ersanti, Corie Indria Prasasti

“…Efforts should be made to establish or involve local organizations in program implementation of the program, as well as efforts to optimize the implementation of the other three empowerment elements.…”
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The Impact of Grape Maceration on Quality and Biogenic Amine Formation in Slovak Tokaj Wines: Examination of Microbial, Chemical and Sensory Properties by Boris Semjon, Martin Bartkovský, Peter Očenáš, Ivana Regecová, Zuzana Megyesy Eftimová, Jana Výrostková, Lýdia Mesarčová, Mariana Kováčová, Matúš Várady, Lucia Šuľáková, Slavomír Marcinčák

“…Future research should aim to optimize maceration time in order to enhance the sensory quality of macerated wines without increasing the BA concentration, especially that of histamine.…”
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Identification of New Rat Bone Marrow-Derived Population of Very Small Stem Cell with Oct-4A and Nanog Expression by Flow Cytometric Platforms by Anna Labedz-Maslowska, Elzbieta Kamycka, Sylwia Bobis-Wozowicz, Zbigniew Madeja, Ewa K. Zuba-Surma

“…Based on our experience in both murine and human VSEL isolation procedures by fluorescence-activated cell sorting (FACS), we also optimized sorting protocol for separation of CD45−/Lin−/CD106+ rat BM-derived VSELs from wild type and eGFP-expressing rats, which are often used as donor animals for cell transplantations in regenerative studies in vivo. …”
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