CLN-978, a novel half-life extended CD19/CD3/HSA-specific T cell-engaging antibody construct with potent activity against B-cell malignancies with low CD19 expression by Agapitos Patakas, Bochong Li, Naveen K Mehta, Kristan Meetze, Patrick A Baeuerle, Jennifer S Michaelson, Hannah M Findlay, Timothy B London

“…Background Despite significant progress in the development of T cell-engaging therapies for various B-cell malignancies, a high medical need remains for the refractory disease setting, often characterized by suboptimal target levels.Methods To address this issue, we have developed a 65-kDa multispecific antibody construct, CLN-978, with affinities tuned to optimize the killing of low-CD19 expressing tumor cells. …”
Get full text

Analysis of panel physician inquiries to U.S. TB Centers of Excellence, 2018–2022 by E. Leithead IV, S. Subramanian, K. Pimenta, N.D. Goswami, A. Patrawalla, A. Lardizabal, C. Haley, L. Chen, L. Armitige, B. Seaworth, B. Sylvester, R. Bhavaraju

“…Treatment tailoring inquiries involved optimizing the initial regimen (n = 89, 41.4%) or modifying existing regimens (n = 26, 12.1%). …”
Get full text

Pityriasis versicolor: insight into current knowledge and treatment possibilities by Jakub Parys, Agnieszka Mikosińska, Martyna Kaźmierczak, Patrycja Kałuziak, Maciej Mossakowski, Marta Jajczak, Aleksandra Witek, Stanisław Jesionek, Mateusz Litwin

“…Future efforts should aim to optimize treatment efficacy, reduce relapse rates, and minimize adverse effects. …”
Get full text

MECHANISMS AND CLINICAL PERSPECTIVES OF ALLERGEN-SPECIFIC IMMUNOTHERAPY by Leila Akhvlediani, Marina Izmailovich, Meruyert Gazaliyeva, Anna Skvortsova, Kanan Tanriverdiev

“…This highlights the importance of personalized treatment strategies combining ASIT with vitamin D supplementation for optimal outcomes. …”
Get full text

Legislative framework of career guidance and counselling in Serbia by Miljković Jovan, Čairović-Pavlović Neda, Robertson Kristina

“…For career guidance and counselling to be managed adequately and to optimize its expected outcomes, it is necessary to have a consistent, carefully designed legislative framework in place. …”
Get full text

Association of abstinence time with semen quality in men who undergoing fertility evaluation: a cross-sectional study from 3052 participants by Guanying Yao, Qinglin Qi, Xianchao Dou, Wen Zhou, Shun Bai, Xi Zhang, Xi Zhang

“…Additionally, short abstinence periods may be recommended to maintain optimal sperm DNA integrity.…”
Get full text

AI-Based Holistic Framework for Cyber Threat Intelligence Management by Arnolnt Spyros, Ilias Koritsas, Angelos Papoutsis, Panos Panagiotou, Despoina Chatzakou, Dimitrios Kavallieros, Theodora Tsikrika, Stefanos Vrochidis, Ioannis Kompatsiaris

“…However, in order to obtain optimal results, organisations should be able to utilise all capabilities of CTI. …”
Get full text

Effects of wire diameter on mechanical and microstructural properties of Inconel 625 fabricated by wire arc additive manufacturing by Fakada Dabalo Gurmesa, Hirpa G. Lemu, Wakshum Mekkonen Tucho, Adugna Deressa Akessa

“…The results contribute to optimizing the WAAM products with wire diameters for producing high-performance IN625 components with variations of wire diameter.…”
Get full text

Exploring the role of artificial intelligence in chemotherapy development, cancer diagnosis, and treatment: present achievements and future outlook by Bassam Abdul Rasool Hassan, Ali Haider Mohammed, Souheil Hallit, Souheil Hallit, Souheil Hallit, Diana Malaeb, Hassan Hosseini, Hassan Hosseini

“…Evidence from recent studies highlights AI’s potential to reduce cancer-related mortality by optimizing diagnostic accuracy, personalizing treatment plans, and improving therapeutic outcomes. …”
Get full text

A detoxified TLR4 agonist inhibits tumour growth and lung metastasis of osteosarcoma by promoting CD8+ cytotoxic lymphocyte infiltration by Ryunosuke Oyama, Akira Nabeshima, Makoto Endo, Alexey Novikov, Toshifumi Fujiwara, Capucine Phelip, Nobuhiko Yokoyama, Yoshinao Oda, Martine Caroff, Yoshihiro Matsumoto, Jerome Kerzerho, Yasuharu Nakashima

“…Lipo-MP-LPS exhibited an optimal safety and solubility profile for systemic administration at an effective dose. …”
Get full text

A hybrid setup for rodent hyperpolarized metabolic imaging using a clinical magnetic resonance scanner by Ditte Bentsen Christensen, Ingeborg Sæten Skre, Jan Henrik Ardenkjær-Larsen, Mor Mishkovsky, Mathilde H Lerche

“…The hybrid system includes (1) a customizable, 3D-printable animal cradle setup and (2) optimized imaging strategies, including coil configurations, metabolic contrast agent administration, and proton imaging acquisition. …”
Get full text

Effects of sodium tripolyphosphate on the rheological properties of concrete: Mechanical, microstructural and carbon footprint by André Pico-Molineros, Natividad García-Troncoso, Jorge Flores-Rada, Dan V. Bompa

“…These findings highlight that incorporating STPP at optimized dosages (<5 %) improves the sustainability and performance of HES cement concrete, offering a viable alternative to conventional chemical additives in alignment with sustainable construction practices.…”
Get full text

Luffa–Ni/Al layered double hydroxide bio-nanocomposite for efficient ibuprofen removal from aqueous solution: Kinetic, equilibrium, thermodynamic studies and GEP modeling by Soheil Tavassoli, Afsaneh Mollahosseini, Saeed Damiri, Mehrshad Samadi

“…Techniques like FE-SEM, EDX, FTIR, and XRD confirmed the modification. To optimize adsorption efficiency, factors such as contact time (Ctime), adsorbent dosage (Ad), drug concentration (Dc), temperature (θ), stirring rate (Sr), and pH were carefully fine-tuned to maximize efficiency. …”
Get full text

Design of Integrated Hybrid Configuration of Modular Multilevel Converter and Marx Generator to Generate Complex Waveforms for Dielectric Testing of Grid Assets by Dhanashree Ashok Ganeshpure, Thiago Batista Soeiro, Mohamad Ghaffarian Niasar, Nitish Milind Kulkarni, Pavol Bauer, Peter Vaessen

“…Similar to the conventional superimposed circuit of the ac transformer or dc rectifier circuit with the Marx generator, three hybrid circuits of MMC and the Marx generator are introduced, where the most optimal choice is made considering the practical aspects of testing, such as the size, cost, and preparation time. …”
Get full text

Organic positioning strategies and digital consumer behavior: A study in Peru’s real estate sector by Socrates Deza-De-Souza-Ferreyra, Maria Jeanett Ramos-Cavero, Franklin Cordova-Buiza

“…In conclusion, the study demonstrates that well-executed organic positioning strategies can significantly improve digital consumer behavior, offering valuable insights for real estate companies seeking to optimize their digital marketing efforts. This highlights the importance of incorporating targeted SEO techniques to strengthen brand presence and drive consumer engagement in an increasingly competitive market.…”
Get full text

Bouveret’s Syndrome as a Rare Life-Threatening Complication of Gallstone Disease—A Surgical Problem: Two Case Reports by Nebojsa S. Ignjatovic, Ilija D. Golubovic, Miodrag N. Djordjevic, Marko M. Stojanovic, Daniela A. Benedeto Stojanov, Jelena S. Ignjatovic, Jelena D. Zivadinovic, Sonja Golubovic

“…Early recognition and prompt surgical intervention are essential for obtaining optimal patient outcomes.…”
Get full text

Intrusion detection using synaptic intelligent convolutional neural networks for dynamic Internet of Things environments by Hui Chen, Zhendong Wang, Shuxin Yang, Xiao Luo, Daojing He, Sammy Chan

“…The SICNN model leverages the synaptic intelligence (SI) algorithm to optimize the synaptic structure of the convolutional neural network (CNN), significantly mitigating the forgetfulness of the CNN for past detection tasks and simplifying model training. …”
Get full text

Effects of hormone concentrations on anther cultures and the acquisition of regenerated plants of five awnless triticale genotypes by Jun Ma, Fangyuan Zhao, Yinxia Zhang, Xinhui Tian, Wenhua Du

“…Conclusion The anther culture technology of triticale was optimized in this paper, which made it possible to rapidly breed homozygous varieties of awnless triticale.…”
Get full text

Definition of Triangular Norms and Triangular Conorms on Subfamilies of Type-2 Fuzzy Sets by Pablo Hernández-Varela, Francisco Javier Talavera, Susana Cubillo, Carmen Torres-Blanc, Jorge Elorza

“…Furthermore, the existence of a range of these operators allows for the selection of the t-norm or t-conorm that offers the optimal performance, in accordance with the specific context of the system. …”
Get full text

Chronic non-communicable diseases in patients and families with retinitis pigmentosa by Raisa Hernández Baguer, Raisa Ivis Beltràn Saìnz, Asunciòn Fortunata Rodrìguez Morris, Dagmara Magdalena Cordero Ruiz, Loida Mevis Savòn George, Bàrbara Cid Vàzquez

“…<br /><strong>Conclusions:</strong> the identification of chronic non-communicable diseases was useful to deploy holistic and interdisciplinary medical care that facilitates the prevention of diseases and complications, preserves vision, optimizes visual rehabilitation and quality of life. …”
Get full text