Hot melt extrusion assisted additive manufacturing of mixed polymeric 3D printed metoprolol succinate extended-release tablets for controlled oral drug delivery by Shubham Ghatole, Jannu Dilip, Makka Krupali Ashokbhai, Himanshu Vishwakarma, Subham Banerjee, Santanu Kaity

“…This study introduces an innovative methodology for fabricating extended-release metoprolol succinate (MS) tablets through the integration of Soluplus® and hydroxypropyl methylcellulose acetate succinate (HPMCAS) polymers, employing hot-melt extrusion (HME) and additive manufacturing technology. A carefully optimized polymer-plasticizer combination facilitated the production of extrudable filaments, which were subsequently used in three-dimensional printing (3DP) tablets via fused deposition modeling (FDM). …”
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The Case for Telemedicine from a Sustainability Perspective by Elisa SALA, Luisa BROGONZOLI, Marco DE BENEDICTIS, Maria Franca TOMASSI, Gabriella PAOLI, Mauro GIACOMINI

“…It enables earlier and more optimal treatment of patients, improves adherence to treatment plans, and reduces hospitalisations and emergency room visits. …”
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Research progress of network-based interventions on self-care ability of patients with chronic heart failure (慢性心力衰竭患者自我护理能力网络干预的研究进展) by ZHAI Kaijing (翟凯静), ZHANG Yuqing (张雨晴), LIU Wei (刘薇), QIAO Zhihui (乔志桧), FANG Cui (方璀), FU Conghan (付聪晗)

“…The aim of this study is to ensure that these interventions meet the needs of different individuals to optimize the self-care management of chronic heart failure. …”
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Contingent Negative Variation and Working Memory Maintenance in Adolescents with Low and High Motor Competencies by Sebastian Ludyga, Christian Herrmann, Manuel Mücke, Christian Andrä, Serge Brand, Uwe Pühse, Markus Gerber

“…Thus, high performers on complex motor tasks seem to rely more on a proactive control strategy, which is optimal in tasks with high working memory demands.…”
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Numerical Simulation of Bubble Coalescence and Break-Up in Multinozzle Jet Ejector by Dhanesh Patel, Ashvinkumar Chaudhari, Arto Laari, Matti Heiliö, Jari Hämäläinen, Kishorilal Agrawal

“…Designing the jet ejector optimally is a challenging task and has a great impact on industrial applications. …”
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Maximizing E-Tailers’ Sales Volume through the Shipping-Fee Discount and Product Recommendation System by Yan Guo, Xiaonan Hu, Yu Zou, Shouwei Li, Wenchuan Cheng, Zhiyong Li

“…The proposed model first determines the optimal shipping-fee discount to attract customers and then establishes the most suitable product recommendation list to encourage customers to spend more money on other products. …”
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Islet organoids: a new hope for islet transplantation in diabetes by Xuemei Yu, Chengkong Liu, Zheng Kuang, Siyuan Song, Limin Tian, Yi Wang, Yi Wang

“…While each approach addresses specific challenges in islet transplantation, further research is needed to optimize scalability, immune compatibility, and long-term functionality. …”
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Concurrent Effects of Plyometric Interval Training Implemented in Physical Education Lessons on Adolescent Power and Endurance: An Analysis of Responder Prevalence by Dawid Koźlenia, Katarzyna Kochan-Jacheć, Jarosław Domaradzki

“…However, the effects varied across individuals and were generally small, highlighting the need to optimize the intervention to achieve more pronounced results tailored to individual characteristics.…”
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Intelligent IoT-Based Network Clustering and Camera Distribution Algorithm Using Reinforcement Learning by Islam T. Almalkawi, Rami Halloush, Mohammad F. Al-Hammouri, Alaa Alghazo, Loiy Al-Abed, Mohammad Amra, Ayooub Alsarhan, Sami Aziz Alshammari

“…Our proposed approach initially uses a geometric distributed network clustering algorithm that optimizes camera placement based on the camera Field of View (FoV). …”
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Quantitative Detection of miRNA-21 Expression in Tumor Cells and Tissues Based on Molecular Beacon by Qingxin Liu, Jialong Fan, Chuang Zhou, Liqun Wang, Bin Zhao, Haibin Zhang, Bin Liu, Chunyi Tong

“…With the tool of molecular beacons which can hybridize specifically with target miRNA-21 and generate fluorescence signal change, this paper develops a direct, simple, and rapid method for miRNA-21 detection with detection limit of 0.5 nM. Under the optimal conditions, the method was used to detect the expression of miRNA-21 in tumor cells and tissues. …”
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Changes in crop mix and the effects on agricultural carbon emissions in China by Fei Meng, Hang Chen, Yongzhong Tan, Wenying Xiong

“…Additionally, the growth of maize and vegetables ratios played a significant role in the CI increases in most provinces. To optimize crop cultivation and mitigate carbon emissions, possible strategies including rational crop production layout, land transfer, and clean production technologies were proposed.…”
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Convolutional Neural Decoder for Surface Codes by Hyunwoo Jung, Inayat Ali, Jeongseok Ha

“…In addition, we introduce how to optimize the hyperparameters in the CNN, according to the lattice structure of a given surface code. …”
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Clinical impact of direct rotational atherectomy in patients with complex coronary artery lesions by Kyusup Lee, Ji-hoon Jung, Woojin Kwon, Dae-Won Kim, Mahn-Won Park, Ik Jun Choi, Jae-Hwan Lee, Yong Hoon Yoon, Jang Hoon Lee, Sang Rok Lee, Pil Hyung Lee, Seung-Whan Lee, Ki Dong Yoo, Kyeong Ho Yun, Hyun-Jong Lee, Sung-Ho Her

“…Abstract Owing to limited data on the optimal timing of rotational atherectomy (RA), we sought to evaluate the clinical impact of the early application of the RA strategy. …”
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Source Design of Vertical III–V Nanowire Tunnel Field-Effect Transistors by Gautham Rangasamy, Zhongyunshen Zhu, Lars-Erik Wernersson

“…The performance of devices were improved further by optimizing the doping levels which led to record subthermal current of <inline-formula> <tex-math notation="LaTeX">$1.2 ~\mu \text{A}/\mu \text{m}$ </tex-math></inline-formula> and transconductance of <inline-formula> <tex-math notation="LaTeX">$205 ~\mu \text{S}/\mu \text{m}$ </tex-math></inline-formula> at <inline-formula> <tex-math notation="LaTeX">$V_{\text {DS}}$ </tex-math></inline-formula> of 500 mV.…”
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Non-melanoma skin cancer treated with hypofractionated 192—Ir contact brachitherapy: a single institution series by Elisa Ciurlia, Bianca Santo, Maria Cristina Barba, Elisa Cavalera, Paola De Franco, Sara De Matteis, Giuseppe Di Paola, Angela Leone, Antonella Papaleo, Dino Rubini, Donatella Russo, Giuseppe Rubini, Angela Sardaro

“…Finally, the study emphasizes the importance of personalization of treatment and careful evaluation of individual cases to optimize the treatment approach in NMSC.…”
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Standardization of Micropropagation for Four Hybrids of <i>Coffea arabica</i> Through Direct Somatic Embryogenesis by Marileydi Zuta-Puscan, Jegnes Benjamín Meléndez-Mori, Eyner Huaman-Huaman, Yoiner Kalin Lapiz-Culqui, Reyna Stefani Mego-Pérez, Manuel Oliva-Cruz

“…In addition, the germination and conversion of embryos into plantlets are more efficient in the woody plant medium (WPM), while rooting is optimized using indole-3-butyric acid (IBA) concentrations between 1 mg L⁻¹ and 3 mg L⁻¹, regardless of the hybrid. …”
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Experimental Study and Application of LASC Foamed Concrete to Create Airtight Walls in Coal Mines by Duo Zhang, Weifeng Wang, Jun Deng, Hu Wen, Xiaowei Zhai

“…In the LASC filling materials, the optimal volume ratio of foam dosage to gel slurry is 2. …”
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Two Approaches to Cognitive Evaluation: Assessing the Strengths and Limitations of GPCOG and ACE-III by Magdalena Mąka, Dominik Sikora, Piotr Oleksy, Adam Zając, Karol Zieliński, Łukasz Papież, Ewa Góralczyk, Jakub Kamiński, Bartosz Buczkowski, Dagmara Wochnik

“…Conclusions : ACE-III is optimal for detailed evaluations in specialized settings, while GPCOG excels in rapid primary care screening. …”
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The effect of auditory rhythm on the temporal allocation of visual attention in aging by Zhihan Xu, Juan Huang, Yuxuan Shen, Yanna Ren, Yulin Gao, Ting Guo

“…IntroductionIsochronous rhythm has been shown to induce temporal expectation, allocated attention to specific points in time to optimize behavioral performance, both within a single modality and across different modalities, in younger adults. …”
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Enhancing Environmental Control in Broiler Production: Retrieval-Augmented Generation for Improved Decision-Making with Large Language Models by Marcus Vinicius Leite, Jair Minoro Abe, Marcos Leandro Hoffmann Souza, Irenilza de Alencar Nääs

“…Among the promising advances in artificial intelligence (AI), large language models (LLMs) hold potential to enhance decision-making in broiler production by supporting environmental control through the interpretation of climatic data, the generation of reports to optimize conditions, guidance on ventilation adjustments, recommendations for thermal management, assistance in air quality monitoring, and the translation of simulation results into actionable suggestions to improve bird welfare. …”
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