Olfactory impairment in Italian patients with chronic rhinosinusitis with nasal polyps: a patient-centered survey by Francesca Anastasi, Francesca Anastasi, Frank Rikki Mauritz Canevari, Frank Rikki Mauritz Canevari, Stefania Gallo, Giulia Gramellini, Enrico Heffler, Enrico Heffler, Ignazio La Mantia, Giulia Monti, Martina Ragusa, Alberto Macchi

“…Further research is warranted to explore the mechanisms of olfactory recovery and to optimize treatment protocols for CRSwNP.…”
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Repeated intravenous infusions of esketamine in inpatients with bipolar depression: A retrospective real-world study by Naima Guhad Shire, Michael Ioannou, Örjan Falk, Ane Bakken Wold, Caroline Wass, Zoltán Szabó, Steinn Steingrimsson

“…Background: Ketamine shows promise for treating bipolar depression, particularly in severe cases. However, the optimal administration route and enantiomer (esketamine, arketamine, or racemic mixture) remain unclear. …”
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A Single Electrode Organic Neuromorphic Device for Dopamine Sensing in Vivo by Federico Rondelli, Michele Di Lauro, Gioacchino Calandra Sebastianella, Anna De Salvo, Matteo Genitoni, Mauro Murgia, Pierpaolo Greco, Carolina Giulia Ferroni, Riccardo Viaro, Luciano Fadiga, Fabio Biscarini

“…The device response is investigated as a function of the driving frequency, resulting in the determination of the optimal operational configuration for minimally invasive neuromorphic devices. …”
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Molecular identification of chitinase and its function in growth of Odontobutis potamophila by Siyu Lu, Lin Du, Ting Zhang, Dan Wang, Jinjuan Wan, Guoxing Liu, Yuning Hu, Yu Xu, Zhiqiang Xu, Xuguang Li

“…Quantitative real-time PCR analyses showed that OpCht was mainly expressed in stomach, liver, intestine and increased significantly during the period of juvenile. The optimal gradient concentrations and intervals/efficiency of RNA interference (RNAi) in OpCht were established, the results demonstrated that RNAi significantly repressed the expression of OpCht and diminished the chitinase activity. …”
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Understanding the Enzymatic Synthesis of a New Biolubricant: Decane-1,10-diyl bis(2-methylpentanoate) by Salvadora Ortega-Requena, Fuensanta Máximo, María Claudia Montiel, María Gómez, María Dolores Murcia, Josefa Bastida

“…The reaction conversion is determined by an acid number determination and a gas chromatographic analysis. The most optimal result is achieved at a temperature of 80 °C, a biocatalyst concentration of 2.5% (<i>w</i>/<i>w</i>), and a non-stoichiometric substrate relation. …”
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Enhancing human ACE2 expression in mouse models to improve COVID‐19 research by Sun Jiaoyang, Cheng Shaofei, Hong Guangliang, Quan Xiongzhi, Lin Haofeng, Mao Rui, Johannes Grillari, Shi Zheng‐Li, Chen Jiekai, Liu Meiqin, Wu Haoyu, Wu Guangming

“…Our findings show that distinct β‐globin insertion within hACE2 cassette significantly influences its expression, with downstream placement enhancing transcription. Moreover, optimizing hACE2 codons (opt‐hACE2) improves translation efficiency in multiple tissues. …”
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Comparative Study on the Evolution of Airflow Temperature and Valid Ventilation Distance Under Different Cooling Strategies in High-Temperature Tunnels for Mining Thermal Energy by Fangchao Kang, Jinlong Men, Binbin Qin, Guoxi Sun, Ruzhen Chen, Weikang Zhang, Jiamei Chen, Zhenpeng Ye

“…These findings provide valuable insights for optimizing cooling strategies and engineering parameters in high-temperature tunnel environments.…”
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The effect of liquid inorganic fertilizer on the growth of seven sugarcane (Saccharum officinarum L.) clones for sugar factory in Indonesia by Wiharyanti Nur Lailiyah, Setyo Budi, Arofatuz Zumroh, Isnaini Maulidatu Nisa, Indah Nurjanah, Mochammad Jamaluddin Husain

“…Petrovita fertilizer application resulted in more optimal growth in sugarcane clone. …”
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Local Application of Semaphorin 3A Combined with Adipose-Derived Stem Cell Sheet and Anorganic Bovine Bone Granules Enhances Bone Regeneration in Type 2 Diabetes Mellitus Rats by Xiaoru Xu, Kaixiu Fang, Lifeng Wang, Xiangwei Liu, Yuchao Zhou, Yingliang Song

“…Bone tissue regeneration is considered to be the optimal solution for bone loss. However, diabetic patients have a greater risk of poor bone healing or bone grafting failure than nondiabetics. …”
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When Hysteroscopy is the only way out; a case series of endometrial osseous metaplasia by John Imaralu, Taiwo Solaja, Oluwole Ayegbusi, Olukemi Grillo, Remilekun Atunrase-Sotola, Theophilus Elejere

“…Hysteroscopy is the gold standard in the diagnosis of endometrial pathologies and offers optimal treatment for osseous metaplasia. Case presentation: Five new cases of EOM were diagnosed within four years, giving an annual incidence of 5/101 (1.24%) of hysteroscopies and 5/583 (0.21%) of gynaecological surgeries. …”
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A cGAMP‐Containing Hydrogel for Prolonged SARS‐CoV‐2 Receptor‐Binding Domain Subunit Vaccine Exposure Induces a Broad and Potent Humoral Response by Volker Böhnert, Emily C. Gale, Lauren J. Lahey, Jerry Yan, Abigail E. Powell, Ben S. Ou, Jacqueline A. Carozza, Lingyin Li, Eric A. Appel

“…It is hypothesized that this limitation can be overcome by sustained coadministration with a more potent and optimized adjuvant than standard adjuvants. One such candidate adjuvant, cGAMP, exhibits promising potency via activation of the antiviral STING pathway. …”
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A Readout Scheme for PCM-Based Analog In-Memory Computing With Drift Compensation Through Reference Conductance Tracking by Alessio Antolini, Andrea Lico, Francesco Zavalloni, Eleonora Franchi Scarselli, Antonio Gnudi, Mattia Luigi Torres, Roberto Canegallo, Marco Pasotti

“…Accuracy drop due to circuits mismatch and variability involved in the computational chain are minimized with an optimized iterative program-and-verify algorithm applied to the phase-change memory (PCM) devices. …”
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On-Demand Energy Provisioning Scheme in Large-Scale WRSNs: Survey, Opportunities, and Challenges by Gerald K. Ijemaru, Kenneth Li-Minn Ang, Jasmine Kah Phooi Seng, Augustine O. Nwajana, Phee Lep Yeoh, Emmanuel U. Oleka

“…Furthermore, we investigate energy management techniques that adaptively balance energy consumption and harvesting, optimizing the overall network performance. In addition to providing a thorough overview of existing solutions, this paper identifies opportunities and challenges in the field of on-demand energy provisioning for large-scale WRSNs. …”
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Numerical analysis of evaporation reduction in floating photovoltaic power plants: influence of design parameters by Berlioux Baptiste, Amiot Baptiste, Ferrand Martin, Le Berre Rémi, Rhazi Oume-Lgheit, Vidal Javier, Pabiou Hervé, Knikker Ronnie

“…Other parameters have only a moderate impact, allowing the fine-tuning of evaporation reduction. The optimal configuration would involve covering the entire water body with a single large water footprint island positioned downwind of the prevailing transversal winds. …”
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An exploratory qualitative assessment of patient and clinician perspectives on patient-reported outcome measures and disease-modifying therapies in adults with spinal muscular atro... by Jeremy Slayter, Lauren Casey, Shane McCullum, Dorothy Drost, Allison Banks, Colleen O'Connell

“…Conclusion: After considering patient goals, functional status, and preferences, patient-reported outcome measures represent a valuable adjunct to standard clinical and research tools. Optimal selection of patient-reported outcome measures requires careful consideration of multiple patient factors. …”
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Management of Coppices in Central Dinnarides in the European Concept of Coppice Management – A Case Study of Lika by Martina Đodan, Darko Smerdel, Valeriu Norocel-Nicolescu, Sanja Perić

“…For example, research excluded coppices in Lika region as the ones with the longest rotations out of all European countries, low intensities of silvicultural efforts and conversion of European beech coppice which could be significantly optimized.…”
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Higher performance enhancement of direct torque control by using Space Vector Modulation for doubly fed induction machine by Gouaamar Radouan, El Fadl Adiba, Bri Seddik, Mekrini Zineb

“…This study discusses the pros and cons of all mentioned methods, which helps in better understanding for optimal speed control selection to improve DFIM performance at different operating conditions. …”
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Continuous photo-oxidation of methane to methanol at an atomically tailored reticular gas-solid interface by Yuchen Hao, Liwei Chen, Haodong Liu, Wenfeng Nie, Xiangjie Ge, Jiani Li, Hui-Zi Huang, Chao Sun, Cuncai Lv, Shangbo Ning, Linjie Gao, Yaguang Li, Shufang Wang, An-Xiang Yin, Bo Wang, Jinhua Ye

“…Meanwhile, the “breathable” MOF membrane, optimized by solar-driven interfacial water management, provides high-flux channels to facilitate efficient gas diffusion and rapid methanol desorption and transfer. …”
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Prediction of Europium Retention in Perovskite: Potential Candidates for an Engineering Barrier in the Disposal of Radioactive Waste by Huemantzin B. Ortiz-Oliveros, Rosa Ma. Flores Espinosa, Pedro Ávila-Pérez, Daniel Cruz-Gonzalez, Noureddine Ouerfelli

“…The evidence obtained suggests that π is a physical parameter that relates pH to an optimal value and could explain the equilibrium between the surface complexes that tausonite forms with europium. …”
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On Control of Reaching Movements for Musculo-Skeletal Redundant Arm Model by Kenji Tahara, Suguru Arimoto, Masahiro Sekimoto, Zhi-Wei Luo

“…The results suggest that the reaching movements can be achieved using only a simple task-space feedback scheme together with the internal force effect that comes from non-linear properties of skeletal muscles without any complex mathematical computation such as an inverse dynamics or optimal trajectory derivation. In addition, the dynamic damping ellipsoid for evaluating how the internal forces can be determined is introduced. …”
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