Thrust Force and Delamination Analysis on Redmud-Filled Coconut Sheath Fiber Polyester Composite by Sundarakannan Rajendran, Yo-Lun Yang, Uthayakumar Marimuthu, Arumugaprabu Veerasimman, Geetha Palani, Karthick Babu, Vigneshwaran Shanmugam

“…The analysis of drilled hole surfaces reveals matrix cracks, fiber extraction, and matrix smearing, underscoring the importance of optimizing drilling parameters, selecting appropriate tools, and implementing effective cooling methods to improve the overall surface finish and quality of drilled fiber composites. …”
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The Role of Gut Microbiota in Neurodegenerative Diseases by Hanna Porwolik, Agnieszka Porwolik, Magdalena Bodera, Radosław Szydłowski, Agata Porwolik, Barbara Skrzypiec, Anna Hamerla, Anna Kaźmierska, Julia Gawron

“…Further research is essential to validate these approaches and optimize personalized treatments for AD and PD. …”
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Synthesis of uniform two-dimensional nitrogen-doped graphene films via thermal evaporation as efficient oxygen reduction catalysts by Xue-Wei Lu, Xiaoliang Zhang, Ruxuan Chen, Shuwei Wang, Zile Wang, Huajun Tian, Liying Jiao

“…The nitrogen-rich ABPBI precursor and defects, as well as the beneficial morphology and structure, endowed the optimal catalyst (2D NG-900) with a comparable ORR activity and superior stability compared with the commercial Pt/C (20 wt%) catalyst. …”
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Improving P-Doped DBRs Operation at Cryogenic Temperatures: Investigating Different Mirror Geometry by Behzad Namvar, Topi Uusitalo, Heikki Virtanen, Mircea Guina, Jukka Viheriala

“…Furthermore, we explored different mirror geometries to optimize both current flow and the growth complexity of the DBR. …”
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Molecular cloning of EZH2 oncogene in chronic myeloid leukemia and therapeutic prospects by Juliana Costa Gaspar, Lucas Santos de Santana, Camila Menezes Freire de Souza, Marcos Montani Caseiro, Rosane Rezende de Souza Giuliani, Cleide Barbieri de Souza

“…Chronic myeloid leukemia (CML) is a myeloproliferative neoplasia, caused in 95 % of the cases by a cytogenetic abnormality characterized by the reciprocal translocation between chromosomes 9 and 22 t(9; 22) (q34; q11), resulting in Philadelphia chromosome (Ph).Considering that CML cure is only possible with a successful bone marrow transplantation and that there are resistance cases to the tyrosine kinase inhibitor Imatinib Mesylate, prescribed in first line drug treatment; it is important to know in detail the genes and proteins that are possibly altered in CML, favoring effective therapeutic strategies, optimized diagnosis and minimal residual disease detection. …”
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Reaction of potato varieties to treatment with nitrogen-fixing bacteria and mycorrhizal biopreparations by Vladyslav Kovalenko, Pavlo Serdiuk, Arthur Shevych, Oleksandr Serdiuk, Viktor Zakorko

“…Therefore, elements like boron should be incorporated into planning an optimal nutrition system…”
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A model‐based approach using GSK3772847, an anti‐interleukin‐33 receptor monoclonal antibody, as a showcase to predict SC administration PK and free target dynamics based on PK and... by Jan Berkhout, Dave Fairman, Martijn vanNoort, Tamara J. vanSteeg

“…Abstract Integrated modeling of the pharmacokinetic (PK) and target binding, by means of a TMDD model, can provide valuable insights into the expected pharmacodynamic (PD) effects of monoclonal antibodies (mAbs). Optimal characterization of the human PK and target binding for mAbs requires data obtained after intravenous (IV) administration which can be combined with subcutaneous (SC) data to further this characterization. …”
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Automated orthodontic diagnosis via self-supervised learning and multi-attribute classification using lateral cephalograms by Qiao Chang, Yuxing Bai, Shaofeng Wang, Fan Wang, Shuang Liang, Xianju Xie

“…Additionally, a multi-attribute classification network is proposed, leveraging attribute correlations to optimize parameters and enhance classification performance. …”
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Study on the structure characterization and moisturizing effect of Tremella polysaccharide fermented from GCMCC5.39 by Meng Yang, Zilong Zhang, Yan He, Chengliang Li, Jinmei Wang, Xia Ma

“…FTPS-2 had a better ability to prevent moisture loss, and the optimal moisture retention period was 0–4 h. FTPS-2 could significantly increase the moisture content of the skin epidermis and showed a dose-concentration relationship. …”
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Implementation and Performance of Lightweight Authentication Encryption ASCON on IoT Devices by Gabriela Cagua, Valerie Gauthier-Umana, Carlos Lozano-Garzon

“…Using the CupCarbon simulator framework, optimized for modeling smart cities and wireless sensor networks, we evaluate its effectiveness under resource-limited conditions. …”
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Study on the impact parameters of convective heat transfer in industrial-scale Siemens reactor by Xingping Yuan, Dan Zhao, Yanqing Hou, Ni Yang, Wenhui Ma, Fengyang Chen, Gang Xie

“…This study provides a valuable tool for optimizing reactor design and operation, ultimately contributing to the reduction of silica fines formation and energy consumption during the production process.…”
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Clinical Features, Treatment, and Outcome of HIV-Associated Immune Thrombocytopenia in the HAART Era by Kimberley L. S. Ambler, Linda M. Vickars, Chantal S. Leger, Lynda M. Foltz, Julio S. G. Montaner, Marianne Harris, Viviane Dias Lima, Heather A. Leitch

“…The characteristics of HIV-associated ITP were documented prior to the HAART era, and the optimal treatment beyond HAART is unknown. We performed a review of patients with HIV-associated ITP and at least one platelet count <20 × 109/L since January 1996. …”
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Repurposing brucine as a chemopreventive agent in mammary gland carcinoma: Regulating lactate transport through MCT-4 by Asma Khatoon Zaidi, Anurag Kumar, Rohit Kumar, Jyoti Singh, Sneha Yadav, Archana Bharti Sonkar, Dharmendra Kumar, Neeraj Kumar Shrivastava, Mohd Nazam Ansari, Abdulaziz S. Saeedan, Gaurav Kaithwas

“…After in-depth analysis, 900 molecules were shortlisted based on Lipinski's rule, optimal molecular weight, binding energy, hydrogen bonding, and ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties that render them viable MCT-4 inhibitors. …”
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Efficient, Compact Mid-Infrared Sources: A Systematic Study of Intracavity Difference-Frequency Generation by Saeed Salimian Rizi, Liam G. K. Flannigan, Alex Chiasson, Tyler Kashak, Daniel Poitras, Chang-Qing Xu

“…This study presents a compact intracavity difference-frequency generation (DFG) source designed for mid-infrared (mid-IR) applications. By optimizing overlap between the pump and signal beams, we obtained a black-box efficiency (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>η</mi></mrow><mrow><mi>B</mi><mi>B</mi></mrow></msub></mrow></semantics></math></inline-formula>) of 3.4% W⁻¹ and a maximum DFG output power of 63 mW at a wavelength of 3437 nm for a 50 mm long periodically poled lithium niobate (PPLN) crystal. …”
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Prognosis of urgent initiation of peritoneal dialysis: a systematic review and meta-analysis by Ji He, BaoQiao Wu, Yue Zhang, Limiao Dai, Juan Ji, Yueming Liu, Qiang He

“…Objectives Currently, there is no consensus on the optimal timing for the initiation of peritoneal dialysis (PD) after catheter placement.Design Systematic review and meta-analysis.Exact date of data collection From inception till July 31, 2023.Main outcome measures To assess the outcomes and safety of unplanned PD initiation (<14/7 days after catheter insertion) in cohort studies.Results Fifteen studies involving 3054 participants were included. (1) The risk of unplanned initiation of leakage and Obstruction was no difference in both the break-in period (BI) <14 and BI < 7 groups. (2) Catheter displacement was more likely to occur in the emergency initiation group with BI < 7. (3) No significant differences were observed between the two groups regarding infectious complications. (4) There was no difference in transition to HD between patients with BI < 7 and BI < 14 d.Conclusion Infectious complications of unplanned initiation of peritoneal dialysis did not differ from planned initiation. …”
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Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pres... by Ignacio Farro, Daniel Bia, Yanina Zócalo, Juan Torrado, Federico Farro, Lucía Florio, Alicia Olascoaga, Walter Alallón, Ricardo Lluberas, Ricardo L. Armentano

“…All subjects represented the “reference population”; the group of subjects with optimal/normal blood pressures levels at study time represented the “normal population.” …”
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Evaluating suitability of regression models in small data regimes using concrete with recycled copper tailings as a case study by Ahed Habib, Samer Barakat, Samir Dirar, Salah Al-Toubat, Zaid A. Al-Sadoon

“…Through rigorous evaluation involving a 10-fold cross-validation process to verify accuracy, the research demonstrates that selecting the optimal regression model and data preprocessing technique selection substantially improves prediction outcomes, even with limited data. …”

Development of a Novel, Sensitive, Selective, and Fast Methodology to Determine Malondialdehyde in Leaves of Melon Plants by Ultra-High-Performance Liquid Chromatography-Tandem Mas... by Melisa E. Yonny, Ariel Rodríguez Torressi, Mónica A. Nazareno, Soledad Cerutti

“…The precision intraday and interday values were 2.7% and 3.8%, respectively. The optimized methodology was applied to monitoring of changes in MDA levels between control and exposed to thermal stress conditions melon leaves samples. …”
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Constraining Solar Emission Radius at 42 MHz During the 2024 Total Solar Eclipse Using a Student-commissioned Radio Telescope by Olivia R. Young, Timothy E. Dolch, Joseph F. Helmboldt, Christopher Mentrek, Louis P. Dartez, Michael T. Lam, Sophia V. Sosa Fiscella, Evan Bretl, Colin Joyce, Johannes Loock, Grace Meyer, Annabel Peltzer, Joseph Petullo, Parker Reed, Emerson Sigtryggsson, Benjamin Bassett, Andrew B. Hawken, Alejandro Z. Heredia, Paige Lettow, Whit Lewis, Mikayla Manna, Nicholas Mirochnikoff, Michael Zemcov

“…The Deployable Low-Band Ionosphere and Transient Experiment (DLITE) is a low-frequency radio array comprised of four dipole antennas, optimized to observe at 35–45 MHz, and capable of resolving the brightest radio sources in the sky. …”
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Nanoformulation of Spirooxindole and Methods for Treating Hepatocellular Carcinoma by Assem Barakat, Fardous F. El-Senduny, Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Yaseen A. M. M. Elshaier, Eman A. Mazyed, Farid A. Badria

“…The proniosomes, loaded with the compound, exhibited high entrapment efficiency and prolonged drug release rates of up to 12 h in vitro. The optimized formula demonstrated superior drug release percentages and stability compared to conventional niosomes. …”
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