Performance of RIS-Secured Short-Packet NOMA Systems With Discrete Phase-Shifter to Protect Digital Content and Copyright Against Untrusted User by Nguyen Quang Sang, Hye-Young Kim, Tan N. Nguyen, Minh Bui Vu, Phuong T. Tran, Tran Trung Duy, Byung-Seo Kim, Miroslav Voznak

“…In this strategy, untrustworthy users will be allocated higher power levels than trustworthy users, while the latter will be configured with sub-optimal phase shift criteria at RIS to maximize its cascaded channel gain. …”
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Assessing the role of genotype by environment interaction of winter wheat cultivars using envirotyping techniques in North China by Haiwang Yue, Yanbing Wang, Zhaoyang Chen, Jiashuai Zhu, Partha Pratim Behera, Pengcheng Liu, Haoxiang Yang, Jianwei Wei, Junzhou Bu, Xuwen Jiang, Xuwen Jiang, Wujun Ma

“…Feixiang and Shenzhou were identified as the most discriminative and representative locations.DiscussionThese findings provide a scientific basis for optimizing winter wheat cultivation strategies in northern regions. …”
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Associations of prognostic nutritional index with cardiovascular all-cause mortality among CVD patients with diabetes or prediabetes: evidence from the NHANES 2005–2018 by WenYi Xu, Li Zhang, Li Zhang, QianKun Yang, Ying Cao, Rui Rao, Li Lv, Qin Cen, Qiong Wei, LuLing Yang

“…We used restricted cubic spline (RCS) and maximally selected rank statistics method (MSRSM) to assess the nonlinearity of the PNI-mortality association and determine the optimal PNI cutoff for survival outcomes. Additionally, weighted multivariable Cox regression models, subgroup analyses, and interaction tests were employed to examine the relationship between PNI and all-cause and CVD mortality. …”
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Exploring the relationships between self-efficacy, self-care, and glycaemic control in primary care diabetes management by Le Ho Thi Quynh Anh, Nguyen Vu Quoc Huy, Nguyen Minh Tam, Johan Wens, Anselme Derese, Wim Peersman, Vo Ngoc Ha My, Tran Binh Thang, Nguyen Thi Phuong Anh, Tran Thi Truc Ly, Peter Pype

“…Conclusions: Our study highlights the critical role of self-efficacy in diabetes primary care. For people with optimal glycaemic control, prioritising self-efficacy in diet adherence is crucial for sustaining glycaemic outcomes and supporting other self-care behaviours. …”
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Exploring the ability of plasma pTau217, pTau181 and beta-amyloid in mirroring cerebrospinal fluid biomarker profile of Mild Cognitive Impairment by the fully automated Lumipulse®... by Marcella Catania, Claudia Battipaglia, Alberto Perego, Erika Salvi, Emanuela Maderna, Federico Angelo Cazzaniga, Paolo M. Rossini, Camillo Marra, Nicola Vanacore, Alberto Redolfi, Daniela Perani, Patrizia Spadin, Maria Cotelli, Stefano Cappa, Naike Caraglia, Pietro Tiraboschi, Fabrizio Tagliavini, Giuseppe Di Fede

“…Food and Drug Administration and the European Medicine Agency makes it necessary to optimize non-invasive and cost-effective tools for the identification of subjects at-risk of developing Alzheimer’s Disease (AD). …”
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Efficacy and Safety of Risankizumab in Patients with Psoriasis Showing Suboptimal Response to Secukinumab or Ixekizumab: Results from a Phase 3b, Open-Label, Single-Arm (aIMM) Stud... by Richard B. Warren, Lev Pavlovsky, Antonio Costanzo, Michael Bukhalo, Neil J. Korman, Yu-Huei Huang, Georgios Kokolakis, Andreas Pinter, Nadia Ibrahim, Yanbing Zheng, Leonidas Drogaris, Vassilis Stakias, Ahmed M. Soliman, Simone Rubant, Diamant Thaçi

“…Methods This 52-week, phase 3b study enrolled patients (≥ 18 years) with moderate-to-severe plaque psoriasis who had previously been treated with the recommended dose of secukinumab or ixekizumab for ≥ 6 months but did not achieve an optimal response (static Physician's Global Assessment [sPGA] 2/3; body surface are [BSA] 3– < 10%). …”
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Profile of the grain physical traits and physicochemical properties of selected Malaysian rice landraces for future use in a breeding program by Site Noorzuraini Abd Rahman, Rosimah Nulit, Faridah Qamaruz Zaman, Khairun Hisam Nasir, Mohd Hafiz Ibrahim, Mohd Ramdzan Othman, Nur Idayu Abd Rahim, Nor Sufiah Sebaweh

“…The study aimed to evaluate the grain physical traits and physicochemical properties of 30 Malaysian rice landraces to optimize the use of rice landraces in breeding programs. …”
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Prediction Models of Severity in Acute Biliary Pancreatitis by Iulia Ratiu, Renata Bende, Camelia Nica, Oana Budii, Calin Burciu, Andreea Barbulescu, Tudor Moga, Bogdan Miutescu, Roxana Sirli, Mirela Danila, Alina Popescu, Felix Bende

“…Therefore, early risk assessment is crucial for optimizing management and treatment. The aim of the present study wasto compare simple prognostic markers and identify the best predictors of severity in patients with acute pancreatitis. …”
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TP53 germline testing and hereditary cancer: how somatic events and clinical criteria affect variant detection rate by Paula Rofes, Carmen Castillo-Manzano, Mireia Menéndez, Álex Teulé, Sílvia Iglesias, Elisabet Munté, Mireia Ramos-Muntada, Carolina Gómez, Eva Tornero, Esther Darder, Eva Montes, Laura Valle, Gabriel Capellá, Marta Pineda, Joan Brunet, Lidia Feliubadaló, Jesús del Valle, Conxi Lázaro

“…As the associated cancer risks were refined over time, clinical criteria also evolved to optimize diagnostic yield. The implementation of multi-gene panel germline testing in different clinical settings has led to the identification of TP53 PV carriers outside the classic LFS-associated cancer phenotypes, leading to a broader cancer phenotypic redefinition and to the renaming of the condition as “heritable TP53-related cancer syndrome” (hTP53rc). …”
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Post-extrasystolic variation of ST segment and T wave as a mortality risk predictor after myocardial infarction by Ralf J. Dirschinger, Ralf J. Dirschinger, Alexander Müller, Petra Barthel, Alexander Steger, Michael Dommasch, Axel Bauer, Karl-Ludwig Laugwitz, Georg Schmidt, Daniel Sinnecker, Daniel Sinnecker

“…The aim of this study was to assess whether this post-extrasystolic ST segment and T wave variation (PEST) conveys prognostic information regarding the mortality risk of cardiac patients.MethodsPEST was calculated from 30-min ECGs obtained from 941 survivors of acute myocardial infarction (AMI) as mean difference between the sum of squared voltages from three orthogonal leads (XYZ) of the first (post-extrasystolic) and second (reference) beat after each VPC, in a time window between the limits ϕ1 and ϕ2. Optimal limits yielding a maximum area under the receiver-operating characteristics (ROC) curve were determined by systematic testing, covering the time window from the J point to the end of the T wave. …”
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Using Laboratory Test Results for Surveillance During a New Outbreak of Acute Hepatitis in 3-Week- to 5-Year-Old Children in the United Kingdom, the Netherlands, Ireland, and Curaç... by Maaike C Swets, Steven R Kerr, Brian MacKenna, Louis Fisher, Merel van Wijnen, Diederik Brandwagt, Paul W Schenk, Pieter Fraaij, Leonardus G Visser, Sebastian Bacon, Amir Mehrkar, Alistair Nichol, Patrick Twomey, Philippa C Matthews, Malcolm G Semple, Geert H Groeneveld, Ben Goldacre, Iain Jones, J Kenneth Baillie

“…For all locations combined, the rate of elevated AST or ALT measurements in the period of interest was not elevated (zP=zP ConclusionsHospital laboratories collect large amounts of data on a daily basis that can potentially be of use for disease surveillance, but these are currently not optimally used. Federated analytics using nondisclosive, summary-level laboratory data sharing was successful, safe, and efficient. …”
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Uptake and 4-week outcomes of an ‘opt-out’ smoking cessation referral strategy in a London-based lung cancer screening setting by Anthony Edey, Neal Navani, Kitty Chan, Graham Robinson, Janine Zylstra, Paul Robinson, Laura Green, Anand Devaraj, Jane Rowlands, Allan Hackshaw, Carolyn Horst, Arjun Nair, Sam M Janes, Kate Davies, Jeannie Eng, Mamta Ruparel, Samantha L Quaife, Jennifer L Dickson, Magali Taylor, Angshu Bhowmik, Hasti Robbie, Joseph Jacob, Laura Farrelly, Sophie Tisi, Tanya Patrick, Andrew Creamer, Helen Hall, Samanjit Hare, Jon Teague, Samuel M Janes, Esther Arthur-Darkwa, Thea Buchan, Stephen Ellis, Thomas Callender, Rachael Sarpong, John McCabe, Zaheer Mangera, Ethaar El-Emir, Terry O'Shaughnessy, Geoff Bellingan, Nick Screaton, Priyam Verghese, William M Ricketts, Vicky Bowyer, Kylie Gyertson, Fanta Bojang, Claire Levermore, Tania Anastasiadis, Ruth Prendecki, Amyn Bhamani, Malavika Suresh, Judy Airebamen, Alice Cotton, Kaylene Phua, Elodie Murali, Simranjit Mehta, Karen Parry-Billings, Columbus Ife, April Neville, Zahra Hanif, Helen Kiconco, Ricardo McEwen, Dominique Arancon, Nicholas Beech, Derya Ovayolu, Christine Hosein, Sylvia Patricia Enes, Qin April Neville, Aashna Samson, Urja Patel, Fahmida Hoque, Hina Pervez, Sofia Nnorom, Moksud Miah, Julian McKee, Mark Clark, Anant Patel, Sara Lock, Rajesh Banka, Ugo Ekeowa, Charlotte Cash, Tunku Aziz, Alberto Villanueva, Elena Stefan, Charlie Sayer, Navinah Nundlall, Andrew Crossingham, Tanita Limani, Kate Gowers, Andrew Perugia, James Rusius, Anne-Marie Hacker, Monica L Mullin, Evangelos Katsampouris, Chuen R Khaw, Chuen Khaw, Sheetal Karavadra, Alan Shaw, Chris Valerio, Ali Mohammed, Lynsey Gallagher, Mehran Azimbagirad, Burcu Ozaltin, Maureen Browne, Eleanor Hellier, Catherine Nestor

“…Introduction Lung cancer screening (LCS) enables the delivery of smoking cessation interventions to a population experiencing long-term tobacco dependence, but the optimal delivery method remains unclear. Here, we report uptake and short-term outcomes of an ‘opt-out’ smoking cessation referral strategy in an LCS cohort.Methods Individuals currently smoking tobacco who attended a face-to-face lung health check in the SUMMIT study (NCT03934866) were offered very brief advice on smoking cessation and where possible, an ‘opt-out’ referral to their local stop smoking service (SSS). …”
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Immune and genomic biomarkers of immunotherapy response in cancer of unknown primary by Madhu Singh, Linda Mileshkin, Penelope Schofield, Bo Gao, Gary Richardson, Andrew Pattison, Rodney J Hicks, Niko Thio, Mark Warren, Colin Wood, Stephen B Fox, Anna DeFazio, Andrew Fellowes, Christopher Steer, David Bowtell, Nicholas Wilcken, Tharani Sivakumaran, Atara Posner, Dariush Etemadmoghadam, Krista Fisher, Samantha Webb, Christos S Karapetis, Ian M Collins, Narayan Karanth, Owen W J Prall, Richard William Tothill

“…Immune checkpoint inhibitors (ICIs) can be efficacious in some patients with CUP, but the optimal predictive biomarkers are unknown. We therefore assessed immune and genomic biomarkers as well as predicted TOO in patients with CUP, including a subset treated with ICIs.Methods Patients with CUP were subject to gene-expression profiling (GEP) and DNA panel sequencing. …”
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Study protocol: type II hybrid effectiveness-implementation study of routine functional status screening in VA primary care by Francesca M. Nicosia, Kara Zamora, LauraEllen Ashcraft, Gregory Krautner, Marybeth Groot, Bruce Kinosian, Cathy C. Schubert, Sumedha Chhatre, Helene Moriarty, Orna Intrator, Andrea Wershof Schwartz, Ariela R. Orkaby, Jason Prigge, Rebecca T. Brown

“…Identifying functional impairments – defined as having difficulty or needing help performing these activities – is essential for clinicians to provide optimal care to older adults, and on a population level, understanding function can help anticipate service needs. …”
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A phase 1b clinical trial to determine the safety, tolerability and immunogenicity of simian adenovirus and poxvirus vectored vaccines against Mycobacterium avium complex subspecie... by Jeremy Sanderson, Jeremy Aboagye, Rebecca Makinson, Katerina Rapi, Samuel Provstgaard-Morys, Lisa Stockdale, Alison Lawrie, Isabelle Lanigan, Nishat Halim, Abdel Douiri, Emily Greenlay, Rayka Malek, Emma Gray, Lindsey West, Fatima El Oulidi, Paul Ian Cross, Michael Stallibrass, Sarah C. Gilbert, Adrian V.S. Hill, Katie J. Ewer

“…Further studies are required to determine the efficacy and optimal regime of the vaccines. Funding: HAV Vaccines Limited funded the trial and acted as trial sponsor. …”
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Clinical characteristics and outcomes of patients with chondroblastoma undergoing surgery with various adjuvant procedures: a retrospective study of 59 cases by Toru Hirozane, Tetsuya Sekita, Eisuke Kobayashi, Tomoaki Mori, Naofumi Asano, Toru Udaka, Takashi Tajima, Rumi Nakagawa, Kazutaka Kikuta, Akira Yoshiyama, Hideo Morioka, Itsuo Watanabe, Ukei Anazawa, Michiro Susa, Keisuke Horiuchi, Yoshihisa Suzuki, Takeshi Morii, Robert Nakayama

“…If bone grafts are necessary, materials with low biocompatibility, including artificial bone, may be optimal. Managing patients with chondroblastoma should encompass curative and functional aspects.…”
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Meta-analysis on the chronic effects of exercise on depression in older adults by Melanie Mack, Claudia Voelcker-Rehage, Pinelopi S. Stavrinou, Iuliia Pavlova, Yaël Netz, Burcu Kömürcü Akik, Antonia Kaltsatou, Sandra Haider, Christoforos D. Giannaki, Arzu Erden, Andreea Badache, Michel Audiffren

“…The results highlight the importance of individualizing exercise regimens to achieve optimal outcomes. The conclusions drawn may provide a foundation for developing evidence-based recommendations for exercise programs aimed at alleviating depression in older adults. …”
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Identification and validation of a novel autoantibody biomarker panel for differential diagnosis of pancreatic ductal adenocarcinoma by Metoboroghene O. Mowoe, Metoboroghene O. Mowoe, Hisham Allam, Joshua Nqada, Marc Bernon, Karan Gandhi, Sean Burmeister, Urda Kotze, Miriam Kahn, Christo Kloppers, Suba Dharshanan, Zafirah Azween, Pamela Maimela, Paul Townsend, Eduard Jonas, Jonathan M. Blackburn, Jonathan M. Blackburn

“…Identified AAbs were validated in silico using public immunohistochemistry datasets and experimentally using a custom PDAC protein microarray comprising the 11 optimal AAb biomarker panel. The clinical utility of the biomarker panel was tested in an independent cohort comprising 223 PDAC, PC, PRC, colorectal cancer (CRC), and HC samples. …”
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Metabolic syndrome in type 1 diabetes: higher time above range and glycemic variability revealed by continuous glucose monitoring (CGM) by Yayu Fang, Wei Liu, Xiaoling Cai, Yu Zhu, Mingxia Zhang, Siqian Gong, Xiangqing Wang, Chu Lin, Rui Zhang, Sai Yin, Juan Li, Yongran Huo, Xiaodan Hu, Xiaoqi Xie, Linong Ji

“…Personalized diabetes education including optimal meal planning and sufficient physical activity should be emphasized to improve glycemic control in T1D with metabolic syndrome.…”
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Multi-omics uncovers immune-modulatory molecules in plasma contributing to resistance exercise-ameliorated locomotor disability after incomplete spinal cord injury by Ren Zhou, Jibao Chen, Yunhan Tang, Chuijin Wei, Ping Yu, Xinmei Ding, Li’ao Zhu, Jiajia Yao, Zengqiang Ouyang, Jing Qiao, Shumin Xiong, Liaoliao Dong, Tong Yin, Haiqing Li, Ye Feng, Lin Cheng

“…Notably, resistance exercise has demonstrated significant improvements in muscle strength, coordination, and overall functional recovery. However, to optimize clinical management and mimic exercise-like effects, it is imperative to obtain a comprehensive understanding of the molecular alterations that underlie these positive effects. …”
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