Closure of Full-thickness Macular Hole after Pars Plana Vitrectomy (23G) with Cataract Phacoemulsification, Artificial Intraocular Lens Implantation, and Silicone Oil Administratio... by Maria Stec, Mikołaj Kuźniak, Sebastian Sirek

“…This case study contributes to the evolving understanding of macular hole pathogenesis and reinforces the significance of tailored surgical approaches for optimal patient outcomes.…”
Get full text

Non-stationary response of complex ecosystem service networks to urbanization: Evidence from a typical eco-fragile area in China by Zhen Shen, Yang Gao, Lei Wang, Zheyi Xia, Haowei Liu, Ting Deng

“…Understanding the complex interactions between urbanization and ecosystem services (ESs) is crucial for optimizing planning policies and achieving sustainable urban management. …”
Get full text

Study on the Electrical and Mechanical Properties of TiC Particle-Reinforced Copper Matrix Composites Regulated by Different Rare Earth Elements by Denghui Li, Changfei Sun, Zhenjie Zhai, Zhe Wang, Cong Chen, Qian Lei

“…Copper matrix composites (CMCs) synergistically reinforced with rare earth oxides (Re₂O₃) and TiC were prepared using a powder metallurgy process with vacuum hot-pressing and sintering technology, aiming to explore new ways to optimize the properties of composites. Through this innovative approach, we propose a new solution strategy and idea for the difficult problem of mutual constraints between electrical and mechanical properties faced by traditional dual-phase reinforced Cu-matrix composites. …”
Get full text

Identification of maize kernel varieties based on interpretable ensemble algorithms by Chunguang Bi, Chunguang Bi, Xinhua Bi, Jinjing Liu, Hao Xie, Shuo Zhang, He Chen, Mohan Wang, Lei Shi, Lei Shi, Shaozhong Song

“…The base learner of the Stacking integration model was selected using diversity and performance indices, with parameters optimized through a differential evolution algorithm incorporating multiple mutation strategies and dynamic adjustment of mutation factors and recombination rates. …”
Get full text

In Vitro Effects of Strontium on Proliferation and Osteoinduction of Human Preadipocytes by V. Nardone, R. Zonefrati, C. Mavilia, C. Romagnoli, S. Ciuffi, S. Fabbri, G. Palmini, G. Galli, A. Tanini, M. L. Brandi

“…In searching for all the optimal sources, adipose tissue-derived mesenchymal stem cells (hADSCs or preadipocytes) are able to differentiate into osteoblasts with analogous characteristics to bone marrow mesenchymal stem cells, producing alkaline phosphatase (ALP), collagen, osteocalcin, and calcified nodules, mainly composed of hydroxyapatite (HA). …”
Get full text

Successful Renal Transplantation after Presumed Cyanide Toxicity Treated with Hydroxocobalamin and Review of the Literature by Ryan J. Hendrix, Paulo N. Martins, Jeffrey S. Stoff, Aaron Ahearn, Adel Bozorgzadeh, Babak Movahedi

“…Furthermore, we emphasize the importance of optimal organ utilization and caution against unnecessary refusal.…”
Get full text

Multiomics-based assessment of the impact of airflow on diverse plant callus cultures by June-Sik Kim, Muneo Sato, Mikiko Kojima, Muchamad Imam Asrori, Yukiko Uehara-Yamaguchi, Yumiko Takebayashi, Thi Nhung Do, Thi Yen Do, Kieu Oanh Nguyen Thi, Hitoshi Sakakibara, Keiichi Mochida, Shinjiro Ogita, Masami Yokota Hirai

“…However, the interplay between cellular diversity and ambient conditions influences the metabolism of cultured tissues; understanding these factors in detail will inform efforts to optimize culture conditions. This study presents multiomics datasets from callus cultures of tobacco (Nicotiana tabacum), rice (Oryza sativa), and two bamboo species (Phyllostachys nigra and P. bambusoides). …”
Get full text

Efficient and Fast Differentiation of Human Neural Stem Cells from Human Embryonic Stem Cells for Cell Therapy by Xinxin Han, Liming Yu, Jie Ren, Min Wang, Zhongliang Liu, Xinyu Hu, Daiyu Hu, Yihong Chen, Li Chen, Ying Zhang, Yuehua Liu, Xiaoqing Zhang, Hua He, Zhengliang Gao

“…Aberrance neurogenesis is related with brain injury, and multipotential neural stem cells from human embryonic stem (hES) cells provide a great promise for cell replacement therapies. Optimized protocols for neural differentiation are necessary to produce functional human neural stem cells (hNSCs) for cell therapy. …”
Get full text

Unlocking the Potential of Buckwheat Hulls, Sprouts, and Extracts: Innovative Food Product Development, Bioactive Compounds, and Health Benefits – a Review by Zhibek Atambayeva, Almagul Nurgazezova, Kumarbek Amirkhanov, Zhanna Assirzhanova, Altyngul Khaimuldinova, Haykuhi Charchoghlyan, Meruyert Kaygusuz

“…The review underscores the need for further research to optimize the use of buckwheat less-utilized parts and to better understand their health impacts. …”
Get full text

The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment by Prince Dadson, Peter Ngum, Luis Eduardo Juarez-Orozco, Michael Ntodie, Piotr Loba

“…Understanding the role of orbital fat and its contribution to inflammatory orbital diseases is essential for optimizing diagnostic and treatment strategies.…”
Get full text

Think4SCND: Reinforcement Learning With Thinking Model for Dynamic Supply Chain Network Design by Pan Li, Shaochen Ren, Qun Zhang, Xuran Wang, Yang Liu

“…Extensive experiments on both synthetic and real-world datasets show that Think4SCND significantly outperforms state-of-the-art baselines, achieving near-optimal solutions with a fraction of the computational cost. …”
Get full text

Using Internet of things technology to construct an integrated intelligent sensing environment for long-term care service by Lun-Ping Hung, Nan-Chen Hsieh, Li-Ju Lin, Zong-Jie Wu

“…This study uses a medical-grade Internet of Things module that can calculate the environmental values with edge computing to generate different levels of alarms by combining the index-weighted moving average method to dynamically calculate the optimal threshold value for the environment. It takes 2 months to collect data from care institutions. …”
Get full text

Manufacture of Green-Composite Sandwich Structures with Basalt Fiber and Bioepoxy Resin by J. P. Torres, R. Hoto, J. Andrés, J. A. García-Manrique

“…Numerical simulations of the mould filling stage allowed the determination of an optimal mould filling strategy. Finally, the load-bearing capacity of the board was studied by means of FEM simulations, and the presented design proved to be acceptable for service.…”
Get full text

Correlation of Macular Focal Electroretinogram with Ellipsoid Zone Extension in Stargardt Disease by Edoardo Abed, Giorgio Placidi, Luigi Calandriello, Marco Piccardi, Francesca Campagna, Matteo Bertelli, Angelo Maria Minnella, Maria Cristina Savastano, Benedetto Falsini

“…A precise assessment of macular cone function by FERG recording may be useful to monitor the progression of STGD1 and to select the optimal candidates to include in future clinical trials to treat this disease.…”
Get full text

Adaptive Model Predictive Vibration Control of a Cantilever Beam with Real-Time Parameter Estimation by Gergely Takács, Tomáš Polóni, Boris Rohal’-Ilkiv

“…The resulting cost function is then minimized using quadratic programming to find the sequence of optimal but constrained control inputs. The proposed active vibration control system is implemented and evaluated experimentally to investigate the viability of the control method.…”
Get full text

New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite by Eman M. Ragab, Doaa M. El Gamal, Fares F. El-najjar, Hager A. Elkomy, Mahmoud A. Ragab, Mariam A. Elantary, Omar M. Basyouni, Sherif M. Moustafa, Shimaa A. EL-Naggar, Abeer S. Elsherbiny

“…This review aims to explore innovative strategies for targeted therapy and optimized drug delivery in pancreatic CSCs by manipulating the Notch pathway and leveraging PLA-based drug delivery systems. …”
Get full text

Cost-effective whole-cell biosynthesis of ursodeoxycholic acid using engineered Escherichia coli with a multienzyme cascade by Xue Zhang, Xue Zhang, Jiagang Xin, Mengyu Liu, Mengyu Liu, Yue Zhang, Yue Zhang, Haoni Luan, Haoni Luan, Wei Feng, Wei Feng, Fei Wang, Fei Wang, Wei Xu, Wei Xu, Peng Song, Peng Song

“…This study systematically optimized the reaction parameters, including temperature, pH, and the addition of organic solvents and surfactants, for the whole-cell catalytic synthesis of UDCA by UCA23, and at the 2 L level, a UDCA conversion rate of 99% was achieved with 100 mM CDCA in 2 h, which is the highest level of conversion of a high-concentration CDCA substrate reported to date.…”
Get full text

Advanced Data Framework for Sleep Medicine Applications: Machine Learning-Based Detection of Sleep Apnea Events by Kristina Zovko, Yann Sadowski, Toni Perković, Petar Šolić, Ivana Pavlinac Dodig, Renata Pecotić, Zoran Đogaš

“…Through extensive feature engineering and preprocessing, the framework optimizes data representation by normalizing, scaling, and encoding input features to enhance computational efficiency and model performance. …”
Get full text

RFMVDA: An Enhanced Deep Learning Approach for Customer Behavior Classification in E-Commerce Environments by Kwanhee Kim, Mingyu Jo, Ilkyeun Ra, Sangoh Park

“…With the global expansion of the e-commerce market, research on customer analysis and classification optimized for the e-commerce environment has been actively conducted. …”
Get full text

Retention of locally injected human iPS cell-derived cardiomyocytes into the myocardium using hydrolyzed gelatin by Jun Iida, Kazuki Kotani, Kozue Murata, Keisuke Hakamada, Wusiman Maihemuti, Yoshinobu Mandai, Yosuke Hiraoka, Kenji Minatoya, Hidetoshi Masumoto

“…These findings suggest that optimizing HG concentration is crucial for enhancing the retention and therapeutic efficacy of hiPSC-CM transplants in treating heart disease.…”
Get full text