UNet-Att: a self-supervised denoising and recovery model for two-photon microscopic image by Yuer Lu, Yongfa Ying, Chen Lin, Yan Wang, Jun Jin, Xiaoming Jiang, Jianwei Shuai, Xiang Li, Jinjin Zhong

“…Additionally, the model supports end-to-end training, optimizing its denoising efficacy. The UNet-Att model proves to surpass mainstream algorithms in the dual objectives of denoising and preserving the textural intricacies of original images, which is evidenced by an increase of 9.42 dB in the high Peak Signal-to-Noise Ratio (PSNR) coupled with an improvement of 0.1131 in the Structural Similarity Index Measurement (SSIM). …”
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Effect of daily alcohol consumption and age over 40 years on COVID-19 vaccination antibody titers in the Delta era among hospital workers in northern Okinawa, Japan: A retrospectiv... by Takuji Kishimoto, Daisuke Tasato, Yoshitaka Nagasawa, Akihiro Yamashiro, Hayashi Shokita

“…Conclusions: The results of this study indicate that shortening vaccination intervals for individuals over 40 years and discontinuing daily alcohol consumption are associated with the preservation of acquired antibody titers for optimizing vaccine efficacy.…”
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Impact of pubertal timing on growth progression and final height in subjects affected by RASopathies by Federica Tamburrino, Laura Mazzanti, Dino Gibertoni, Concetta Schiavariello, Annamaria Perri, Eleonora Orlandini, Cesare Rossi, Marco Tartaglia, Marcello Lanari, Emanuela Scarano

“…While most patients initiate puberty spontaneously, careful monitoring of growth and pubertal progression is crucial to optimize therapeutic interventions and improve final height outcomes.…”
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Establishing a preoperative predictive model for gallbladder adenoma and cholesterol polyps based on machine learning: a multicentre retrospective study by Yubing Wang, Chao Qu, Jiange Zeng, Yumin Jiang, Ruitao Sun, Changlei Li, Jian Li, Chengzhi Xing, Bin Tan, Kui Liu, Qing Liu, Dianpeng Zhao, Jingyu Cao, Weiyu Hu

“…Results Among the 110 combination predictive models, the Support Vector Machine + Random Forest (SVM + RF) model demonstrated the highest AUC values of 0.972 and 0.922 in the training and internal validation sets, respectively, indicating an optimal predictive performance. The model-selected features included gallbladder wall thickness, polyp size, polyp echo, and pedicle. …”
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Efficacy of first-line radiofrequency ablation combined with systemic chemotherapy plus targeted therapy for initially unresectable colorectal liver metastases by Yaqing Kong, Xiaoyu Huang, Gang Peng, Xiaojing Cao, Xiang Zhou

“…Background/Objective The optimal strategy for patients with colorectal liver metastases is still controversially discussed. …”
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Droplets Cas13a‐RPA measurement delineates potential role for plasma circWDR37 in colorectal cancer by Jingsong Xu, Li Cao, Shuang Yang, Ying Jian, Yu Liu, Zhen Shen, Qian Liu, Xiang Chen, Min Li, Shun Li, Xiaolei Zuo, Min Li, Hua Wang

“…Furthermore, our innovative µDCR method for detecting circWDR37 demonstrates impressive attributes such as streamlined operation, rapidity, and high‐throughput, making it an optimal technology platform for the noninvasive screening of CRC.…”
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Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer by Abhishek Chauhan, Hemant Joshi, Divya Kandari, Diwakar Aggarwal, Ritu Chauhan, Hardeep Singh Tuli, Arpit Mehrotra, Abhilasha Sood, Ujjawal Sharma, Darin Mansor Mathkor, Shafiul Haque, Naveen Chandra Joshi, Laurent Dufossé

“…Its derivatives and novel delivery systems offer promising avenues for overcoming drug resistance and optimizing its therapeutic efficacy. Further research, including clinical trials, is necessary to fully harness its potential as a cancer treatment alternative.…”
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Reimagining habitat suitability modeling for Pacific saury (Cololabis saira) in the Northwest Pacific Ocean through acoustic data analysis from fishing vessels by Minghua Xue, Jianfeng Tong, Wen Ma, Zhenhong Zhu, Weiqi Wang, Shuo Lyu, Xinjun Chen

“…The suitability index model determined the optimal habitat ranges for the four environmental variables. …”
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Immunomodulatory Effect of Phage Depolymerase Dep_kpv74 with Therapeutic Potential Against K2-Hypervirulent <i>Klebsiella pneumoniae</i> by Nikolay V. Volozhantsev, Maria A. Makarova, Alena S. Kartseva, Marina V. Silkina, Valentina M. Krasilnikova, Egor A. Denisenko, Alexander I. Borzilov, Victoria V. Firstova

“…<b>Results:</b> The stability tests showed that Dep_kpv74 remained active in the temperature range from 8 °C to 55 °C. The optimal pH value for maintaining the activity of Dep_kpv74 ranged from 5.0 to 9.0. …”
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Activated Human Umbilical Cord Blood Platelet-Rich Plasma Enhances the Beneficial Effects of Human Umbilical Cord Mesenchymal Stem Cells in Chemotherapy-Induced POF Rats by Jiawei Wang, Yunxiao Zhao, Fengque Zheng, Nana Ma, Rongyan Qin, Weili Qin, Bo Liu, Aiping Qin

“…At present, human umbilical cord mesenchymal stem cells (HucMSCs) have been used in the treatment of POF, but the effect is still not optimal. The purpose of this study was to determine whether human umbilical cord blood platelet-rich plasma (ucPRP) enhances the beneficial effects of HucMSCs in the treatment of POF. …”
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Efficacy and safety of once-weekly semaglutide monotherapy in a young subject with Prader-Willi syndrome, obesity, and type 2 diabetes: a case report by Elisa Dinoi, Giuseppe Daniele, Giuseppe Daniele, Angela Michelucci, Fulvia Baldinotti, Fabrizio Campi, Piero Marchetti, Stefano Del Prato, Angela Dardano, Angela Dardano

“…At 24-month follow-up, glycemic control remained optimal (HbA1c 38 mmol/mol) with further BW reduction (71 kg). …”
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Advancing Pediatric Surgery: The Use of HoloLens 2 for 3D Anatomical Reconstructions in Preoperative Planning by Marco Di Mitri, Annalisa Di Carmine, Simone D’Antonio, Benedetta Maria Capobianco, Cristian Bisanti, Edoardo Collautti, Sara Maria Cravano, Francesca Ruspi, Michele Libri, Tommaso Gargano, Mario Lima

“…Background: In pediatric surgery, a comprehensive knowledge of the child’s anatomy is crucial to optimize surgical outcomes and minimize complications. …”
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DOCK4 Is a Platinum-Chemosensitive and Prognostic-Related Biomarker in Ovarian Cancer by Qianqian Zhao, Jie Zhong, Ping Lu, Xiao Feng, Ying Han, Chenqi Ling, Wenke Guo, Weijin Zhou, Fudong Yu

“…The present study is aimed at optimizing candidate genes by integrating platinum-chemotherapy expression data and PPAR family genes with their targets. …”
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Trends and Clinical Implications of Pediatric Pulmonary Function After Hematopoietic Stem Cell Transplantation: A Systematic Review by Xiaowei Zhao, Yuqi Zhao, Guoyu Ding, Xue Li, Xiaoyue Zhang, Yanli Leng, Hongmei Wang

“…Advanced diagnostic methods, like PRM and MBW, may improve early detection and help optimize the management of pulmonary dysfunction, ultimately improving long‐term outcomes for pediatric patients.…”
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Retrieval of Land Surface Temperature From Passive Microwave Observations Using CatBoost-Based Adaptive Feature Selection by Yang Dai, Yingbao Yang, Xin Pan, Penghua Hu, Xiangjin Meng, Fanggang Li, Zhenwei Wang

“…Next, for each group, we ranked the feature sets according to their importance and employed the recursive feature elimination (RFE) method for feature selection. Finally, the optimized feature sets were used in the CatBoost algorithm to construct the PMW-LST retrieval model. …”
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Development of the Dutch translational knowledge agenda for inherited metabolic diseases by I. J. Hieltjes, J. H. van derLee, M. C. Groenendijk, G. vanHaaften, P. M. vanHasselt, R. J. Lunsing, G. J. J. vanProoijen, E. M. deRuiter, F. J. vanSpronsen, N. M. Verhoeven‐Duif, A. deVreugd, M. Wagenmakers, H. Zweers, H. Dekker, H. R. Waterham, C. D. vanKarnebeek, R. J. A. Wanders, R. A. Wevers

“…The resulting top 10 research questions cover multiple themes, i.e. prediction of disease progression, development of novel tools, mechanistic insights, improved diagnostics, therapeutic integration of multi‐omics techniques, assessment of impact on daily life, expanding treatment avenues, optimal study designs, effect of lifestyle interventions, and data utilization using FAIR principles. …”
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Existent state and removal rate of silver in lead-silver slag during the melt-vaporization process by Shen Y.-Y., Zhao X.-S., Zhang F.-J., Ma W.-X., Wang X.-F., Du X.-Y.

“…The existing Ag state in the soot was analyzed, the influence of the reaction temperature, the carbon ratio, and the reaction time on the removal rate of the silver was investigated, and the process conditions were optimized using reaction surface methodology. Silver chloride, silver metal, silver sulfide, silver oxide, and silver sulfate are the main silver phases in lead-silver slag, of which silver chloride and silver sulfide are the main phases. …”
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Shift in the profile and prognostic implications in invasive fungal rhinosinusitis: experience of 10 years in a tertiary center by Raúl Mellidez-Acosta, Lidia Torres-García, Miguel Saro-Buendía, Natalia Jaramillo-Ángel, Javier Cabrera-Guijo, Catalina Bancalari-Díaz, Noelia Muñoz-Fernández, Lucas Fito-Martorell, Miguel Armengot-Carceller, Alfonso García-Piñero

“…Abstract Background Despite appropriate treatment, mortality of acute invasive fungal rhinosinusitis remains exceedingly high, surpassing 50%. Evidence on how to optimize its management is still limited. We present a case series from our institution aiming to fill the knowledge gap. …”
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Advanced perspective on heavily phosphorus-doped diamond layers via optical emission spectroscopy by Kil-dong Sung, Stefan Andrei Irimiciuc, Michal Novotný, Zdeněk Weiss, Pavel Hubík, Jaromír Kopeček, Martin Vondráček, Vincent Mortet

“…This novel growth approach offers valuable insights for optimizing PDD synthesis, enabling more efficient phosphorus incorporation for electronic, electrochemical, and quantum applications.…”
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Sensitivity and specificity of the Patient Health Questionnaire (PHQ-9, PHQ-8, PHQ-2) and General Anxiety Disorder scale (GAD-7, GAD-2) for depression and anxiety diagnosis: a cros... by David Villarreal-Zegarra, Juan Carlos Bazo-Alvarez, Juan Barrera-Begazo, Sharlyn Otazú-Alfaro, Nikol Mayo-Puchoc, Jeff Huarcaya-Victoria

“…For a similar contrast against the gold standard, the other optimal cut-off points were: ≥7 for the PHQ-8 and ≥2 for the PHQ-2. …”
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