Lower incidence of hepatocellular carcinoma with tenofovir alafenamide in chronic hepatitis B: Evidence from a large-scale cohort by Hye-Jin Yoo, Jae-Young Kim, Jeong-Ju Yoo, Hye Won Lee, Sang Gyune Kim, Young Seok Kim

“…From a practical perspective, these findings can guide physicians in prescribing more effective treatments, assist researchers in designing further studies to explore the mechanisms behind the effectiveness of TAF, and inform policymakers to craft healthcare policies that optimize patient outcomes while considering potential limitations, such as the observational nature of the study and residual confounding factors.…”
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Effect of dietary protein level and lamb breed on meat physicochemical traits, fatty acid profile and nutritional indices by H. Hajji, S. Smeti, I. Mekki, N. Atti

“…Barbarine (BB), Queue Fine de l'Ouest (QFO) and Noire de Thibar (NT), under diets with low (11 %) or high (16 %) crude protein (CP) levels, aiming to optimize feeding strategies for Tunisian sheep production. …”
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Effect of different 1-methylcyclopropene formulations and dosing on the ripening profile of Tommy Atkins mango fruits by Geoffrey Chomba, Jane Ambuko, Cecilia Onyango, John Robert Ouko

“…Overall, the findings of this study suggest that 2.0ppm of the ‘powder’ formulation and 4.0ppm of the ‘Inbox Sachet’ formulation of SmartFresh™ would offer optimal effects at 24hrs and 12hrs exposure respectively. …”
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Blinking characteristics analyzed by a deep learning model and the relationship with tear film stability in children with long-term use of orthokeratology by Yue Wu, Siyuan Wu, Yinghai Yu, Yinghai Yu, Xiaojun Hu, Ting Zhao, Yan Jiang, Bilian Ke

“…In addition, Spearman’s correlation analysis revealed a negative correlation between incomplete blinks and NIBUT (for first-NIBUT, r = −0.292, p = 0.004; for avg-NIBUT, r = −0.3512, p < 0.001) in children with long-term use of ortho-K.ConclusionThe deep learning system based on U-net and Swim-Transformer achieved optimal performance in the observation of blinking characteristics. …”
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Conocimientos, práctica y actitudes hacia la salud oral entre matronas de España by Yolanda Martínez-Beneyto, Andrea Poza Pascual, Cristina Carazo, Clara Serna-Muñoz, Amparo Pérez-Silva, Antonio José Ortiz-Ruiz

“…It is necessary to improve interprofessional education to optimize oral health during pregnancy.…”
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Tax Exemptions and R;D Expenditures in Iran Saeed Dorokhshi Moghaddam by Saeed Dorokhshi Moghaddam, Bahram Sahabi, Hassan Heydari, Sajad Barkhordari

“…Future research can explore how to optimize the use of these tools, offering valuable insights to policymakers…”
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Exploration of rituximab treatment strategies for membranous nephropathy adapted to the Chinese healthcare environment by Xiaolong Wang, Xueying Cao, Jie Wu, Shuang Liang, Jian Yang, Hong Wang

“…Abstract Purpose This study aimed to explore the specific efficacy of rituximab (RTX) in the treatment of membranous nephropathy (MN) and compare and analyze the differences in effectiveness among various treatment regimens, with the objective of identifying the optimal treatment protocol suitable for the medical environment in China. …”
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Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab by Meng Wu, Claudia A.M. Fulgenzi, Antonio D’Alessio, Alessio Cortellini, Ciro Celsa, Giulia F. Manfredi, Bernardo Stefanini, Y. Linda Wu, Yi-Hsiang Huang, Anwaar Saeed, Angelo Pirozzi, Tiziana Pressiani, Lorenza Rimassa, Martin Schoenlein, Kornelius Schulze, Johann von Felden, Yehia Mohamed, Ahmed O. Kaseb, Arndt Vogel, Natascha Roehlen, Marianna Silletta, Naoshi Nishida, Masatoshi Kudo, Caterina Vivaldi, Lorenz Balcar, Bernhard Scheiner, Matthias Pinter, Amit G. Singal, Joshua Glover, Susanna Ulahannan, Fredrich Foerster, Arndt Weinmann, Peter R. Galle, Neehar D. Parikh, Wei-Fan Hsu, Alessandro Parisi, Hong Jae Chon, David J. Pinato, Celina Ang

“…Background & Aims: Atezolizumab/bevacizumab (A/B) is now a standard first-line treatment for advanced hepatocellular carcinoma (HCC), but the optimal second-line regimen is not known. We evaluated real-world treatment patterns and outcomes to investigate factors associated with post-progression survival (PPS). …”
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Exploring in vivo human brain metabolism at 10.5 T: Initial insights from MR spectroscopic imaging by Lukas Hingerl, Bernhard Strasser, Simon Schmidt, Korbinian Eckstein, Guglielmo Genovese, Edward J. Auerbach, Andrea Grant, Matt Waks, Andrew Wright, Philipp Lazen, Alireza Sadeghi-Tarakameh, Gilbert Hangel, Fabian Niess, Yigitcan Eryaman, Gregor Adriany, Gregory Metzger, Wolfgang Bogner, Małgorzata Marjańska

“…By providing unprecedented spatial and spectral resolution, this technology could offer a unique view into the metabolic intricacies of the human brain, but further technical developments will be necessary to optimize data quality and fully leverage the capabilities of 10.5 T MRSI.…”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Internal validation was conducted to assess optimism of the performance statistics using the bootstrapping procedure. …”
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Impact de l’évaluation de la sédation sur la durée de ventilation mécanique en réanimation pédiatrique [Impact of sedation assessment on duration of mechanical ventilation in pedia... by Zakaria Zoheir Addou, Nabil Tabet Aoul, Abdessamad DALI ALI Dali-Ali

“…English Abstract: Introduction-Sedation and analgesia should optimize the comfort and safety of children hospitalized In the intensive care unit (ICU).The objective of this study is to evaluate the effects of the implementation of an adaptive sedation algorithm on the duration of mechanical ventilation. …”
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A Comparative Study of Health Efficacy Indicators in Subjects with T2DM Applying Power Cycling to 12 Weeks of Low-Volume High-Intensity Interval Training and Moderate-Intensity Con... by Jun Li, Wei Cheng, Haifeng Ma

“…The effect of power cycling on FI has the advantages of both aerobic and resistance exercise, which may optimize the type, intensity, and time of exercise prescription according to the individual or the type of exercise program. …”
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Normative Database of Spatiotemporal Gait Metrics Across Age Groups: An Observational Case–Control Study by Lianne Mobbs, Vinuja Fernando, R. Dineth Fonseka, Pragadesh Natarajan, Monish Maharaj, Ralph J. Mobbs

“…The IMU was placed at the sternal angle of each participant to ensure optimal data capture during a 50 m walk along a flat, unobstructed pathway. …”
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超高效液相色谱-三重四极杆串联质谱法同时 测定植物油中4种维生素E异构体Simultaneous determination of four vitamin E isomers in vegetable oil by ultra-high performance liquid chromatography- triple quadrupole... by 李彩玲1，张见1,2，刘元法1,3，王晓超1，梅东旭1 LI Cailing1, ZHANG Jian1,2, LIU Yuanfa1,3, WANG Xiaochao1, MEI Dongxu1

“…The conditions of mass spectrometry, chromatography, and sample pretreatment were optimized, and the method established was examined. …”
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Life Cycle Assessment (LCA) of Carbon Emission of Garden Pavement by Peiyong WANG, Ruixing LU

“…Therefore, in order to assess the carbon emissions of garden pavements with different types of surface layers in pavement projects over the life cycle of such pavements, and to provide theoretical basis for the research on low-carbon emission reduction in landscape engineering, this research takes the life cycle of garden pavement projects as the theoretical basis, adopts the carbon emission factor method, constructs a calculation model for carbon emissions of garden pavements, and then calculates and screens out the optimal “carbon-friendly” materials most suitable material for garden pavements in the context of the “carbon peaking and carbon neutrality” strategy, so as to provide the theoretical basis for the low-carbon emission reduction target of landscape architecture. …”
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Response of Agronomic Characteristics and Yield of Garlic Plant (Allium sativum L.) to Different Levels of Planting Density and Nutrition by Hadi khavari, Masoud Rafiee

“…The highest mean of garlic grain yield as a provisioning service was obtained from 42 Plants per m-2 in nutrition with totalize fertilizer 20-20-20 (25756 kg. ha-1), and the lowest garlic grain yield was obtained in control treatment with non-fertilizer application and 32 plants per m-2 (14314 kg.ha-1). Therefore, with the optimal use of this fertilizer (Humic acid and total fertilizer), the effects of growth and yield on plants are somewhat enhanced, and it is recommended for use in a similar climate.…”
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Bridge Employment Model of Qualified Employees in Iran's Public Organizations by Seyedeh Sanaz Sadafi Mousavi, Mir ali Syed nagavi, Seyed Mehdi Alvani, Alireza Koushki Jahromi

“…Just as research is conducted to optimize a person’s working life, it is essential to think and research about the stage after his working life so that the retirement stage is not considered an abnormal stage and does not cause a loss of balance in the individual’s life. …”
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Integrated Framework and Technical Path for Multi-level Nested Assessment of Landscape Character by Yuncai WANG, Qizhen DONG

“…The integration of the two can help optimize the landscape character assessment system in both theory and practice. …”
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Comparative Analysis of Prediction Models for Trawling Grounds of the Argentine Shortfin Squid <i>Illex argentinus</i> in the Southwest Atlantic High Seas Based on Vessel Position... by Delong Xiang, Yuyan Sun, Hanji Zhu, Jianhua Wang, Sisi Huang, Shengmao Zhang, Famou Zhang, Heng Zhang

“…Additionally, such models support quota management in global fisheries by optimizing resource use, reducing fishing time, and consequently lowering carbon emissions and environmental impact, while promoting marine environmental protection in the Southwest Atlantic high seas.…”
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Impact de l’évaluation de la sédation sur la durée de ventilation mécanique en réanimation pédiatrique [Impact of sedation assessment on duration of mechanical ventilation in pedia... by Zakaria Zoheir Addou, Nabil Tabet Aoul, Abdessamad DALI ALI Dali-Ali

“…English Abstract: Introduction-Sedation and analgesia should optimize the comfort and safety of children hospitalized In the intensive care unit (ICU).The objective of this study is to evaluate the effects of the implementation of an adaptive sedation algorithm on the duration of mechanical ventilation. …”
Get full text