Efficacy and safety of SHR8554 on postoperative pain in subjects with moderate to severe acute pain following orthopedic surgery: A multicenter, randomized, double-blind, dose-expl... by Yanhua Zhao, Zhisheng Lu, Xuesong Song, Haihui Xie, Xungang Xiao, Guonian Wang, Qi Zhou, Qingmei Zhang, Liang Liu, Zhijian Lan, Ning Bai, Haiyan Wang, Zhihao Pan, Liang Dong, Xianzhong Lin, Gang Chen, Qinghui Wang, Jiangtao Dong, Jia Deng, Yongshan Nan, Jiaqiang Zhang, Xiaohua Zhou, Yanjuan Huang, Yongquan Chen, Huanzhong He, Ye Yang, Dengpan Yao, Jintai Jia, Shuan Jin, Yafeng Zhang, Zhonghui Luo, Jiangang Li, Linzhong Zhang, Fang Wang, Juehua Jing, Jiang Zhu, Lin Li, Guangda Wang, Huajing Guo, Qiang Wang, Diansan Su, Weifeng Yu, Xiyao Gu

“…This multicenter Phase II/III trial evaluated the optimal dosage, efficacy, and safety of SHR8554, a biased MOR agonist, for postoperative pain management following orthopedic surgery. …”
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Dose-dependent serological profiling of AdCLD-CoV19-1 vaccine in adults by Jung Hyuk Lee, Yuna Shin, Kwang-Soo Shin, Ju Yeon Park, Mi Sun Kim, Young-Shin Park, Wuhyun Kim, Joon Young Song, Ji Yun Noh, Hee Jin Cheong, Chang-Yuil Kang, Sang Hwan Seo, Jae-Ouk Kim, Deok Ryun Kim, Nathaniel S. Hwang, Jae Seung Yang, Jerome H. Kim, Byoung-Shik Shim, Manki Song

“…These findings underscore the importance of considering diverse humoral immune responses when evaluating vaccine efficacy and provide insights for optimizing adenovirus vector-based SARS-CoV-2 vaccine doses.IMPORTANCEOptimization of vaccine dose is crucial for eliciting effective immune responses. …”
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Innovación en sueño by Laura Vigil, Toni Zapata, Andrea Grau, Marta Bonet, Montserrat Montaña, María Piñar

“…In addition, techniques such as cluster analysis are used to identify symptomatic patterns and phenotypes, which improves understanding of OSA pathophysiology and optimizes CPAP treatment.However, implementation of AI in hospitals faces technological, ethical, and legal barriers. …”
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Dietary ambon lumut banana stem extract Musa cavendishii var. dwarf Paxton as an immunostimulant for white spot disease prevention in Pacific white shrimp Litopenaeus vannamei by Afriani Ramadhan, Sri Nuryati, Nur Bambang Priyoutomo, Alimuddin Alimuddin

“…Keywords: Pacific white shrimp, white spot disease, immune response, Ambon banana stem extract     ABSTRAK   Penelitian ini bertujuan untuk menguji dosis optimal ekstrak batang pisang ambon melalui pakan dalam meningkatkan respon imun, pertumbuhan dan kelangsungan hidup udang putih terhadap penyakit white spot. …”
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Recent advances in systemic therapy for advanced biliary tract cancer: A systematic review and meta-analysis using reconstructed RCT survival data by Zhihao Li, Daniel Aliseda, Owen Jones, Luckshi Rajendran, Christian Magyar, Robert Grant, Grainne M. O’Kane, Anna Saborowski, Gonzalo Sapisochin, Arndt Vogel

“…Further improvements in treatment efficacy may require biomarker identification to optimize combinational therapies for better patient selection. …”
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Reducing dietary crude protein levels while meeting metabolizable protein requirements: Performance of dairy cows over a full lactation period by A. Lavery, A. Craig, A.W. Gordon, A. White, N. Barkley, C.P. Ferris

“…These results indicate that a dietary CP content of 160 g CP/kg DM, which met the MP requirement of cows, may be optimal to support performance over a whole lactation, improve NUE, and reduce N excretion, thus contributing to a more sustainable approach to dairy cow production.…”
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Health economic evaluation of different colorectal cancer screening strategies in Hubei province: a Markov simulation analysis based on local cancer registration and domestic study... by Jie JI, Yuying WANG, Duan ZHUO, Yuhan LIU, Jiaxi PENG, Ruijingfang JIANG, Hao WU, Song LIU, Lijian ZHAO, Jian WANG, Bing MAO, Shida ZHU, Hongbing TAO

“…ObjectiveTo construct a Markov decision model for colorectal cancer screening, evaluate the long-term cost-effectiveness of different screening strategies, determine the optimal screening strategy, and provide a theoretical reference for improving colorectal cancer screening programs. …”
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Research Progress in and Planning Strategies for Multi-scale Measurement of the Efficiency of Urban Blue-Green Infrastructure in Carbon Sink Enhancement and Emission Reduction by Song LIU, Zhaocheng BAI, Dizi LIU, Peiyu SHEN

“…How to balance UBGI’s carbon sink enhancement and emission reduction with other functions to achieve the optimal layout for comprehensive benefits? How to achieve urban “carbon justice” through UBGI? …”
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Modeling Seed Longevity and Percentile Prediction: A Sigmoidal Function Approach in Soybean, Maize, and Tomato by Felipe Souza Carvalho, Brunna Rithielly Rezende, Amanda Rithieli Pereira dos Santos, Maria Márcia Pereira Sartori

“…These findings emphasize the importance of using viability percentiles to optimize storage practices, minimize economic losses, and prevent genetic erosion in conservation programs. …”
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The generation and evaluation of TKO/hCD55/hTM/hEPCR gene-modified pigs for clinical organ xenotransplantation by Guoli Huai, Yong Wang, Jiaxiang Du, Zhenhui Cheng, Yuxuan Xie, Jia Zhou, Hongmei Tang, Yanyan Jiang, Xiangyang Xing, Shaoping Deng, Dengke Pan, Dengke Pan, Dengke Pan

“…IntroductionGenetically edited pigs, modified using CRISPR-Cas9 technology, hold promise as potential sources for xenotransplantation. However, the optimal combination of genetic modifications and their expression levels for initial clinical trials remains unclear. …”
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Bilateral Virtual Water Trade Balance and Sustainable Development using the Gravity Model An Explanation by sepideh ameri golestan, sadegh bakhtiari, Sara Ghobadi

“…Since access to water resources and its optimal use and food production are among the benefits of human societies, sustainable development is considered an excellent approach that emphasizes the necessity of water resources management and its impact on human societies…”
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Zolpidem: Efficacy and Side Effects for Insomnia by Amber N. Edinoff, Natalie Wu, Yahya T. Ghaffar, Rosemary Prejean, Rachel Gremillion, Mark Cogburn, Azem A. Chami, Adam M. Kaye, Alan D. Kaye

“… # Summary Insomnia is linked to fatigue, distractibility, mood instability, decreased satisfaction, and overall decreased quality of life. Optimal therapy can aid patients in returning to baseline and increase their quality of life. …”
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Effects of taurine on growth performance, body composition and physiological responses of western white shrimp, Litopenaeus vannamei broodstock by Vahid Morshedi, Mahmoud Nafisi Bahabadi, Mansour Torfi Mozanzadeh, Amin Oujifard, Naser Agh, Khalegh Maneii, Ahmad Qasemi, Nehzat Bakhshi, Hadi Ebrahimi, Rezvan Tamadoni, Shirin Hamedi, Reza Bagherpour, Fatemeh Solimani

“…In aquaculture, the balance of nutrients in the diet of aquatic animals guarantees optimal growth and health improvement. Taurine (Tau = 2-aminoethanesulfonic acid) is an amino sulfonic acid, which has been proven to be conditionally essential for some aquatic animals when these animals are fed with diets containing high plant protein levels, due to taurine deficiency in plant-based protein sources. …”
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The HFA‐PEFF score identifies ‘early‐HFpEF’ phenogroups associated with distinct biomarker profiles by Michiel T.H.M. Henkens, Anne‐Mar vanOmmen, Sharon Remmelzwaal, Gideon B. Valstar, Ping Wang, Job A.J. Verdonschot, Mark R. Hazebroek, Leonard Hofstra, Vanessa P.M. vanEmpel, Joline W.J. Beulens, Hester M. denRuijter, Stephane R.B. Heymans

“…Abstract Aims The HFA‐PEFF score was developed to optimize diagnosis and to aid in early recognition of heart failure (HF) with preserved ejection fraction (HFpEF) in patients who present with HF‐like symptoms. …”
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THE ORGANIZATION WORKS TO IMPROVE THE CLINICAL AND ECONOMIC OUTCOMES OF CARE FOR PROSTATE CANCER by O. I. Apolikhin, A. V. Sivkov, I. V. Chernishov, M. I. Katibov, O. V. Zolotukhin, I. A. Shaderkin, S. A. Leonov, D. A. Vojtko, M. Y. Prosyannikov

“…Improving health outcomes in prostate cancer by developing optimal approaches to early detection, staging and treatment of disease. …”
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FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis by Amaya Lopez-Pascual, Eva Santamaria, Nuria Ardaiz, Iker Uriarte, Tiffany Palmer, Anne-Renee Graham, Celia Gomar, Roberto C. Barbero, M. Ujue Latasa, Maria Arechederra, Jesus M. Urman, Carmen Berasain, Antonio Fontanellas, Carlos L. del Rio, Maite G. Fernandez-Barrena, Paolo G.V. Martini, Joshua R. Schultz, Pedro Berraondo, Matias A. Avila

“…Further research is warranted to elucidate the mechanisms underlying their therapeutic efficacy and optimize treatment regimens for clinical translation.…”
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<i>ACE</i> I/D Genotype and Risk of Non-Contact Injury in Moroccan Elite Athletes: A Pilot Study by El Mokhtar El Ouali, Jihan Kartibou, Juan Del Coso, Rashmi Supriya, Ismail Laher, Zineb El Kettani, Hassan Ghazal, Najib Al Idrissi, Ayoub Saeidi, Abdelhalem Mesfioui, Hassane Zouhal

“…Further research is warranted to validate these findings and to investigate their broader implications for advancing knowledge in sports injury prevention and optimizing athlete management strategies.…”
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Efficiency of lung cancer screening in early diagnosis and treatment program among community residents in Nanshan district, Shenzhen city: a cross-sectional and 2-year follow-up su... by Yarui YANG, Xujun GUO, Yuzheng FAN, Han WANG, Shengbin LI, Juan HE, Chang MA, Junbo BAI, Shengyuan LIU

“…ObjectiveTo evaluate the effectiveness of a lung cancer screening program for early diagnosis and treatment of the disease among community residents in Nanshan district, Shenzhen city, Guangdong province, and to provide evidence for optimizing regional lung cancer prevention and control policies. …”
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Laffer Curve and Taxable Revenue Elasticity: The Impact of Tax Deductions on a Dynamic General Equilibrium Model by Nahid Gohartash, Rouhollah shahnazi, Ahmad Sadraei javaheri, Mahboubeh Jafari, Parviz Rostamzadeh

“…Findings from this research show that, in the absence of tax deductions, the optimal tax rate for maximizing tax revenue in terms of labor income is below 45%, while for capital income, it is below 40%. …”
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Short-Interval Self-Learning to Improve Retention of Resuscitation Skills: A Randomized Controlled Trial

“…The optimal interval and methods for cardiopulmonary resuscitation (CPR) retraining remain unclear. …”
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