Gender differences in associations between obesity and hypertension, diabetes, dyslipidemia: evidence from electronic health records of 3.5 million Chinese senior population by Xuewen Jiang, Yanrong Zhao, Qing Yang, Wei Wang, Tianxiang Lin, Yinwei Qiu

“…We recommended senior population control BMI lower than 28.7 kg/m2 and 23.3 kg/m2, as well as WC lower than 95.9 cm and 83.1 cm for male and female, respectively. Optimal BMI and WC in senior population may be around the overweight or mild obesity range. …”
Get full text

Deep-Learning-Based Reconstruction of Single-Breath-Hold 3 mm HASTE Improves Abdominal Image Quality and Reduces Acquisition Time: A Quantitative Analysis by Felix Kubicka, Qinxuan Tan, Tom Meyer, Dominik Nickel, Elisabeth Weiland, Moritz Wagner, Stephan Rodrigo Marticorena Garcia

“…<b>Results:</b> In the five healthy participants, DL-HASTE-3 mm was identified as the optimal slice (SNR 23.227 ± 3.901). Both DL-HASTE-3 mm and DL-HASTE-5 mm were assigned significantly higher overall image quality scores than standard-HASTE-5 mm (Laplacian variance, both <i>p</i> < 0.001; Likert scale, <i>p</i> < 0.001). …”
Get full text

Exploring agronomic diversity and disease tolerance in soybeans to combat Cowpea mild mottle virus by H. Kuswantoro, S. Zubaidah, E. Uge, K. Rozana, P. Purwantoro, J. Purnomo

“…This positive correlation has been observed, indicating that soybeans possess a mechanism of tolerance that enables them to sustain optimal seed yields even when infected by a virus. …”
Get full text

Dietary Cinnamaldehyde Enhances Growth Performance, Digestion, Immunity, and Lipid Metabolism in Juvenile Fat Greenling (Hexagrammos otakii) by Yixin Gu, Jian Han, Wenjie Wang, Yu Zhan, Huijie Wang, Wenyuan Hua, Yue Liu, Yafeng Guo, Zhuang Xue, Wei Wang

“…The glucose-6-phosphate1-dehydrogenase (G6PD) gene expression levels in the liver were markedly decreased compared with the control (P<0.05). The optimal supplementation level of CNE was shown by curve equation analysis to be 590.90 mg/kg.…”
Get full text

Establishing a radiomics model using contrast-enhanced ultrasound for preoperative prediction of neoplastic gallbladder polyps exceeding 10 mm by Dong Jiang, Yi Qian, Yijun Gu, Ru Wang, Hua Yu, Zhenmeng Wang, Hui Dong, Dongyu Chen, Yan Chen, Haozheng Jiang, Yiran Li

“…The model not only improves diagnostic accuracy and reduces healthcare costs but also optimizes patient management through personalized treatment plans, enhancing clinical outcomes and ensuring resources are more precisely allocated to patients who need surgery.…”
Get full text

Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy by Wenjun Li, Wenjun Li, Junjiang Sun, Susi Feng, Ariana La Rosa, Panli Zhang, Eveline Y. Wu, Richard Loeser, Chengwen Li, Chengwen Li, Chengwen Li

“…To further improve efficacy, we explored AAV-mediated delivery of the soluble PD-L1 (sPD-L1) to CIA mice.ResultAfter intra-articular injection of AAV6 vectors expressing the optimal isoform of sPD-L1 (shPD-L1), more potency was observed when compared to wild type PD-L1, with a lower dose of AAV6/shPD-L1 needed for arthritis improvement. …”
Get full text

Sequential use of low-load-blood-flow-restricted vs. high-load resistance training on neuromuscular activation, hypertrophy and neuromuscular performance by Romina Ledergerber, Paul Ritsche, Eric Lichtenstein, Martin Keller

“…Strength training: In search of optimal strategies to maximize neuromuscular performance. …”
Get full text

Interaction of dietary protein and energy-protein ratio on growth performance of snakehead Channa striata by Hani Wijianti, Muhammad Agus Suprayudi, Nur Bambang Priyo Utomo, Dedi Jusadi

“…Kesimpulan yang didapat adalah kinerja pertumbuhan optimal dihasilkan oleh kadar protein pakan 37,33% dan rasio energi protein pakan 12,07 kkal GE/g. …”
Get full text

Presenting the evaluation model of financial technology policies in National Bank of Iran by Vahid moradi, changiz mohammadi zadeh, ali farhadi mahali

“…New technologies are optimizing various aspects of banking firms' operations, and it is very important to assess whether they can accelerate green financing while supporting bank profitability. …”
Get full text

Developing and presenting a mathematical model for the purpose of organizational culture architecture based on creating alignment between the strategic reference points of organiza... by Elyas hasanzadeh Shweili, Mir Mehrdad peidaie, Ali reza Rezghi Rostami

“…It is recommended according to the strategic orientation of the studied organizations; by observing the standard principles and designing of the organizational structure of the upstream institution, as well as the results of the analysis of organizational processes using the APQC model, information systems and employee capabilities, to revise and optimize the organizational structure of the studied organization.…”
Get full text

A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity by Da-yan Zhang, Zhi-hua Zhang, Wen-ting Liu, Wei-ming Zhou, Peng-fei Zhou, Juan-juan Wei, Xue-jing Dai, Xiao-li Zeng, Yu-qiong Zhou, Han-wang Li, Heng Zhang, Ao-lin Shen, Lian-sheng Cheng, Guo-dong Shen, Yi-fu He

“…In addition, the mean half-life of HK013-G1 was approximately 61 and 97 h at single doses of 3 and 30 mg/kg, respectively. Conclusion The optimal anti-MSLN×4-1BB bsAb HK013-G1 exhibited synergistic antitumour effects by inducing an ADCC effect (innate immunity) and stimulating the 4-1BB signaling pathway (adaptive immunity) upon cross-bridging with MSLN with no systemic toxicity, which may offer the promise of an improved therapeutic window relative to that of 4-1BB agonists.…”
Get full text

Bioassays for the evaluation of the attractiveness of attractive targeted sugar bait (ATSB) against Anopheles mosquitoes in controlled semi-field systems by Frank S. C. Tenywa, Ummi A. Kibondo, Julian Entwistle, Osward Dogan, Mapipi Haruna, Restuta P. Phisoo, Jason Moore, Jane J. Machange, Haji Makame, Frederic Tripet, Pie Müller, Mathias Mondy, Derric Nimmo, Jennifer C. Stevenson, Sarah J. Moore

“…Abstract Background Sugar feeding is an essential aspect of mosquito biology that may be exploited for mosquito control by adding insecticides to sugar attractants, so-called ‘attractive targeted sugar baits’ (ATSBs). To optimize their effectiveness, ATSB products need to be maximally attractive at both short and long range and induce high levels of feeding. …”
Get full text

Association between interpregnancy interval and adverse perinatal outcomes according to maternal age in the context of China’s two-child policy by SiQin Xiu, Li Tang, Chengjie Qin, Di Tian, Yuhong Chen, Lingling Gu, Liu Yang, Yuhao Sun, Xinghui Liu, Yonghong Lin, Yumei Wang

“…Medical professionals should advise women an optimal IPI to mitigate these risks. With China’s shift from a “one-child” to a “three-child” policy, future research will focus on analyzing this new fertility pattern to refine IPI recommendations.…”
Get full text

Sustainability index analysis for environmentally low-input integrated farming by E. Widjaja, B.N. Utomo, A.D. Santoso, Y.P. Erlambang, . Surono, M.A. Firmansyah, S. Handoko, E. Erythrina, M.N. Rofiq, D. Iskandar, N.A. Sasongko, T. Rochmadi, N. Abbas, M. Hanif, Y.S. Garno, F.D. Arianti, N.D. Suretno, M. Askinatin, C.O.I. Hastuti, F. Fahrodji

“…These results indicated that the integration of organic fertilizer, corn, and layer hen farming in the area had successfully optimized the available resources, created a sustainable farming model, and had the potential for adoption in various locations and future periods. …”
Get full text

Does pregabalin offer potential as a first-line therapy for generalized anxiety disorder? A meta-analysis of efficacy, safety, and cost-effectiveness by Narcis Cardoner, Narcis Cardoner, Narcis Cardoner, Narcis Cardoner, Luis Gutiérrez-Rojas, Luis Gutiérrez-Rojas, Pilar Saiz, Pilar Saiz, Pilar Saiz, Pilar Saiz, Pilar Saiz, Guillermo Lahera, Guillermo Lahera, Guillermo Lahera, Guillermo Lahera, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Pino Alonso Ortega, Pino Alonso Ortega, Pino Alonso Ortega, Pino Alonso Ortega, María Pérez-Páramo

“…This study aimed to assess the efficacy, safety, and optimal pregabalin dosage for the treatment of GAD.MethodsThis meta-analysis followed PRISMA guidelines. …”
Get full text

Coal mining-induced composite damage to geological bodies and geological guarantee against damage reduction by Shuangming WANG, Qiang SUN, Xin HU, Jishi GENG, Enke HOU, Shengquan WANG, Shutao ZHOU, Qingmin SHI, Shihao YUAN, Kai CHEN, Shijie SONG

“…The purpose is to achieve transparent geological structure conditions, effective evaluation models and methods, optimized coal development models, advanced prediction of risk dynamics, and scientific strategies for geological security. …”
Get full text

Utilization of patient-reported outcomes to assess adherence to relugolix when combined with stereotactic body radiation therapy for intermediate to high-risk prostate cancer by Kelly Gaudian, Min Jung Koh, Min Ji Koh, Ryan R. Collins, Shaine Eden, Zoya Zwart, Malika Danner, Alan Zwart, Mark Fallick, Deepak Kumar, Paul Leger, Nancy A. Dawson, Simeng Suy, Sean P. Collins

“…Future studies should focus on how to optimally incorporate this questionnaire into patient management.…”
Get full text

Local and distant response to intratumoral immunotherapy assessed by immunoPET in mice by Aurélien Marabelle, Louis Meyblum, Lambros Tselikas, Thierry de Baere, Sandrine Susini, Fréderic Deschamps, Baptiste Bonnet, Céline Chevaleyre, Benoit Jego, Dimitri Kereselidze, Vincent Lebon, Charles Truillet

“…However, a comprehensive understanding of the local and systemic distribution of ICBs following intratumoral administration, as well as their impact on distant tumors, remains crucial for optimizing their therapeutic potential.To comprehensively investigate the distribution patterns following the intratumoral and intravenous administration of radiolabeled anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and to assess its corresponding efficacy in both injected and non-injected tumors, we conducted an immunoPET imaging study.Methods CT26 and MC38 syngeneic colorectal tumor cells were implanted subcutaneously on both flanks of Balb/c and C57Bl/6 mice, respectively. …”
Get full text

Liver Elastography for Liver Fibrosis Stratification: A Comparison of Three Techniques in a Biopsy-Controlled MASLD Cohort by Antonio Liguori, Giorgio Esposto, Maria Elena Ainora, Irene Mignini, Raffaele Borriello, Linda Galasso, Mattia Paratore, Maria Cristina Giustiniani, Laura Riccardi, Matteo Garcovich, Antonio Gasbarrini, Luca Miele, Maria Assunta Zocco

“…The fibrosis diagnostic accuracy of both S-Shearwave Imaging and 2D-SWE was good to optimal with AUROCs of 0.81 and 0.70 for significant fibrosis (≥F2), 0.94 and 0.91 for severe fibrosis (≥F3), respectively. …”
Get full text

Micro-nano aerated subsurface drip irrigation and biochar promote photosynthesis, dry matter accumulation and yield of cucumbers in greenhouse by Zan Ouyang, Jie Zhang, Xueli Liang, Hui Wang, Zhenfeng Yang, Rong Tang, Qihua Yu, Yong Zhang

“…The ''oxidation-porous'' qualities of micro-nano bubble water and biochar combined to enhance clay soil aeration, promote cucumber development, accelerate photosynthetic rate and dry matter buildup, and enhance yield and quality.O3B3 (O3 14–15 mg/L, B3 60 t/hm2) was the optimal treatment when factors like yield and quality were taken into consideration. …”
Get full text