Isomeric Differentiation of Four Triterpene Acids Using Full Collision Energy Ramp-MS2 Analysis by Li-juan WU, Rui-ru NAN, Qian WANG, Xin CHEN, Wen-jing LIU, Yue-lin SONG

“…The parameters, such as collision energy at the half survival rate (CE50) of precursor ions, the optimal collision energy (OCE) of primary fragment ion species and the maximal relative ion intensity (RIImax) were calculated from those regressive equations, and subsequently were applied for isomers differentiation. …”
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Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors by Laetitia Fend, Eric Quemeneur, Monika Semmrich, Jean-Baptiste Marchand, Matilda Rehn, Nathalie Silvestre, Linda Mårtensson, Johann Foloppe, Ingrid Teige, Björn Frendeus, Petra Holmkvist, Carolin Svensson, Christelle Remy, Patricia Kleinpeter, Jules Deforges, Fred Junghus, Kirstie L Cleary, Mimoza Bodén

“…Remarkably, in a clinically relevant mouse model resistant to systemic ICB, intratumoral VVGM-αCTLA-4 synergized with αPD-1 to reject cold tumors.Conclusion Our findings demonstrate in vivo proof of concept for spatial restriction of Treg depletion-optimized immune checkpoint blocking, vectorized αCTLA-4 as a highly effective and safe strategy to target CTLA-4. …”
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Assessing Mental Illness Referral Request Acceptance: A Nationwide E-Referral Data From Saudi Arabia by Alharbi AA, Aljerian NA, Alghamdi HA, Binhotan MS, Alsultan AK, Arafat MS, Aldhabib A, Aloqayli AI, Alwahbi EB, Horner RD

“…External referrals were half as likely to be accepted as internal ones (aOR = 0.51; 95% CI = 0.42– 0.64).Conclusion: SMARC demonstrates effectiveness in optimizing mental healthcare access through strategic matching of patient needs with available resources. …”
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Perfusion mode as a factor of appearance of cognitive dysfunction in patients after on-pump coronary artery bypass grafting by S.M. Sudakevych, О.А. Loskutov, І.P. Shlapak, V.V. Babenko, B.М. Todurov

“…Conclusions. The support of optimal parameters of perfusion pressure during artificial blood circulation in patients undergoing coronary artery bypass grafting, namely maintaining it at a level above 60 mm Hg, is an extremely important criterion and it can reduce the incidence of postoperative cognitive dysfunction in the early postoperative period and 3 months after surgery. …”
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Growth performance and survival of snakehead Channa striata juvenile with different stocking density reared in recirculation system by Adang Saputra, Tatag Budiardi, Reza Samsudin, Naufal Dwi Rahmadya

“…This study was conducted to determine the best stocking density on snakehead juvenile rearing to achieve optimal production. The treatments used in this study were stocking density of 1 juvenile/L, 2 juveniles/L, and 3 juveniles/L. …”
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Reproduction performance of climbing perch Anabas testudineus F1 and F2 broodstock with different dietary supplementation by Helmizuryani, Helmizuryani, Boby Muslimin, Khusnul Khotimah

“…This species is potential to create the sustainability production in the future because they offer a promising price, so it needs a further study for optimizing the quality of broodstock and its offsprings. …”
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Machine learning for predicting neoadjuvant chemotherapy effectiveness using ultrasound radiomics features and routine clinical data of patients with breast cancer by Pu Zhou, Pu Zhou, Hongyan Qian, Pengfei Zhu, Jiangyuan Ben, Jiangyuan Ben, Guifang Chen, Qiuyi Chen, Lingli Chen, Jia Chen, Ying He, Ying He

“…Subsequently, construction of clinical predictive models and Rad score joint clinical predictive models using ML algorithms for optimal diagnostic performance. The diagnostic process of the ML model was visualized and analyzed using SHapley Additive exPlanation (SHAP).ResultsOut of 231 participants with BC, 98 (42.42%) achieved pCR, and 133 (57.58%) did not. …”
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Optimasi Algoritma Naive Bayes dengan Diskritisasi K-Means pada Diagnosis Penyakit Jantung by Nafa Fajriati, Budi Prasetiyo

“…This shows that K-means discretization plays a role in optimizing the performance of the Naïve Bayes algorithm to produce better accuracy. …”
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Whole lung radiomic features are associated with overall survival in patients with locally advanced non-small cell lung cancer treated with definitive radiotherapy by Meng Yan, Zhen Zhang, Jia Tian, Jiaqi Yu, Andre Dekker, Dirk de Ruysscher, Leonard Wee, Lujun Zhao

“…The combination of tumor- and lung-based radiomic features can achieve optimal performance.…”
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THE PUBLIC DEBT OF UKRAINE: A NEW DIMENSION OF DYNAMICS AND ARCHITECTURE OF THE MODEL FRAMEWORK OF THE MANAGEMENT SYSTEM by Serhii Petrukha, Nina Petrukha, Roman Miakota

“…The conclusions emphasise the necessity to approximate the optimal practices of fiscal consolidation and to implement measures, including those envisaged by the National Revenue Strategy until 2030, in order to increase the revenues of the state budget of Ukraine. …”
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Enhancing deep learning methods for brain metastasis detection through cross-technique annotations on SPACE MRI by Tassilo Wald, Benjamin Hamm, Julius C. Holzschuh, Rami El Shafie, Andreas Kudak, Balint Kovacs, Irada Pflüger, Bastian von Nettelbladt, Constantin Ulrich, Michael Anton Baumgartner, Philipp Vollmuth, Jürgen Debus, Klaus H. Maier-Hein, Thomas Welzel

“…Abstract Background Gadolinium-enhanced “sampling perfection with application-optimized contrasts using different flip angle evolution” (SPACE) sequence allows better visualization of brain metastases (BMs) compared to “magnetization-prepared rapid acquisition gradient echo” (MPRAGE). …”
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Effect of seed priming and foliar application of organic liquid manure on germination, growth, yield and quality of late-sown wheat by Okram Ricky Devi, Omvati Verma, Bibek Laishram, S. Anbarasan, Abhijit Debnath, Narinder Panotra, Priyanka Elumle, Sunita T. Pandey, R. Ajaykumar, Samreen

“…The sub-optimal temperature during sowing results in delayed germination, poor crop establishment, and constrained vegetative development, which results in forced maturity, low yield, and wheat with poorer quality grains in north India. …”
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Clinical characteristics and prognosis of amyopathic dermatomyositis patients with interstitial lung disease: insights from a retrospective cohort by Yanan Ying, Tingting Wu, Long Wang, Yun Zhang, Yiming Yu, Zaichun Deng, Qunli Ding

“…The identified prognostic factors underscore the importance of early detection and personalized management strategies for optimizing outcomes in patients with ADM-ILD.…”
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Testicular cells transplantation of neon tetra Paracheirodon innesi in common carp Cyprinus carpio by Muhammad Firdaus, . Alimuddin, Komar Sumantadinata

“…We developed testicular cell transplantation by optimizing the size of donor that have highest spermatogonia proportion and testicular cell colonization level. …”
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Reduction in <i>Aedes aegypti</i> Population After a Year-Long Application of Targeted Sterile Insect Releases in the West Valley Region of Southern California by Solomon Kibret Birhanie, Jacob Hans, Jennifer Thieme Castellon, Ale Macias, Rubi Casas, Huy Hoang, Deanna Mormile, Kecia Pitts-Love, Michelle Q. Brown

“…<i>Aedes</i>-related service requests made by the District’s residents were also compared between the pre-intervention and intervention periods to indirectly determine the effect of optimizing the control strategies on overall mosquito problems. …”
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Immune-related adverse events with PD-1/PD-L1 inhibitors: insights from a real-world cohort of 2523 patients by Ting Yan, Minghui Long, Chaoyi Liu, Jiwen Zhang, Jiwen Zhang, Xingyu Wei, Xingyu Wei, Fei Li, Fei Li, Dehua Liao

“…This study aims to investigate the prevalence and associated risk factors of irAEs in a real-world setting, as well as to assess their effects on optimal therapeutic outcomes.MethodsA retrospective analysis involved 2523 patients with cancer who received inpatient PD-1/PD-L1 inhibitors treatment between January 2018 and December 2022. …”
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Study on the aquaculture capacity of whiteleg shrimp (Litopenaeus vannamei)-razor clam (Sinonovacula constricta) tandem mariculture pond by Chunpu Zhao, Gege Bao, Bocheng Mei, Yunhui Luo, Jilin Xu, Shanliang Xu, Danli Wang

“…Tandem aquaculture mode is an innovative and burgeoning approach in aquaculture, designed to enhance aquatic biological production while achieving zero discharge of aquaculture effluent. By optimizing aquaculture density, this mode can fully exploit its potential advantages. …”
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Evaluation of Yield, Yield Component and Usefulness Indices of Bean (Phaseolus vulgaris) and Maize (Zea mays) Intercropping under Inoculation with Rhizobium phaseoli by Ebrahim Zolfagari Kotbehsara, Peyman Sharifi, Mohammad Hossein Ansari

“…The Relative Value Total (RVT), which combines the RVT values of beans and maize, was greater than 1 in all intercropping ratios, highlighting the economic benefits of mixed cropping compared to monocropping of either species.ConclusionIn general, for the sustainable production of crops, the intercropping of bean and maize under inoculation with rhizobium bacteria can be one of the suitable solutions to reach the optimal yield performance.…”
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Water and nitrogen regulation strategy for wolfberry farmland based on nitrogen balance in the Yellow River irrigation districts of Gansu Province, China by Minhua Yin, Rongrong Tian, Yi Ling, Yuqing Yang, Yanlin Ma, Yanxia Kang, Guangping Qi, Jinghai Wang

“…Overall, a combination of 392.40 mm of irrigation and 150 kg·ha−1 of nitrogen represented the optimal strategy for efficient and sustainable wolfberry production in the Yellow River irrigation districts of Gansu and similar regions.…”
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Analysis of postoperative atrial fibrillation and its associated factors in Morrow procedures with cardiopulmonary bypass by Zhibin Hu, Wenshuai Mao, Lijun Guo, Zhiwei Liu, Xujie Hu, Yong Cui

“…This study investigated the CPB-related factors associated with postoperative atrial fibrillation (POAF) in patients undergoing minimally invasive ventricular septal myectomy (Morrow procedure) to optimize CPB strategies, reduce the incidence of POAF, and enhance recovery. …”
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